Neil Ross MacIntyre Jr. | Scholars@Duke

Neil Ross MacIntyre Jr.
Professor of Medicine

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1995

Contact Information

1120 Hosp North, Durham, NC 27710
Duke Box 3911, Durham, NC 27710
macin001@mc.duke.edu (919) 681-2720

Background
Education, Training, & Certifications
- M.D., Cornell University 1972
Duke Appointment History
- Vice-Chair for Clinical Affairs - Hospital, Medicine, Clinical Science Departments 2005 - 2007
- Interim Chief, Division of Pulmonary, Allergy and Critical Care Medical, Medicine, Clinical Science Departments 2004 - 2006
- Acting Chief, Division of Pulm and Critical Care Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999 - 2000
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1989 - 1995
Research
Selected Grants
- COPD Genetic Epidemiology Program - Clinical Center Site Agreement awarded by National Jewish Medical and Research Center 2007 - 2021
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- Effects of Teleflex Catheter on Ventilator Mechanics awarded by Teleflex, Inc. 2018 - 2020
- Vyaire Educational Workshop awarded by Vyaire Medical, Inc. 2017 - 2020
- Medtronic Education Course 2019 awarded by Medtronic, Inc. 2019 - 2020
- Respiratory Compromise & Unplanned Intubations awarded by Respiratory Compromise Institute 2018 - 2019
- Clinical Calibration of a Digital, Low Cost Spirometry Device awarded by Vigor Medical Systems 2018
- Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health 2012 - 2018
- Mallinckrodt Educational Workshop awarded by Mallinckrodt Pharmaceuticals 2017
- GSK Study CTT116855 awarded by GlaxoSmithKline 2015 - 2017
- LOTT Option IV Core awarded by National Institutes of Health 2006 - 2016
- LOTT Option 1 awarded by National Institutes of Health 2006 - 2016
- LOTT Option II awarded by National Institutes of Health 2006 - 2016
- LOTT Option III awarded by National Institutes of Health 2006 - 2016
- ARDSNet Option 5 extension awarded by National Institutes of Health 2005 - 2014
- Idiopathic Pulmonary Fibrosis Clinical Research Network awarded by National Institutes of Health 2005 - 2014
- Telephone-based coping skills training for COPD awarded by National Institutes of Health 2000 - 2014
- SAILS awarded by National Institutes of Health 2010 - 2014
- ARDSNet Option 4 awarded by National Institutes of Health 2011 - 2013
- Long-term Oxygen Treatment Trial (LOTT) - Regional Clinical Centers (RCCs) awarded by National Institutes of Health 2006 - 2012
- Clinical Centers for a Clinical Research Network for the Treatment of Acute Lung Injury and Adult Respiratory Distress Syndrome awarded by National Institutes of Health 2005 - 2011
- Measuring/Improving Quality of Life in Acute Lung Injury awarded by National Institutes of Health 2005 - 2010
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 1982 - 2009
- Weaning Preterm Infants from Mechanical Ventilation awarded by National Institutes of Health 2003 - 2006
- Clinical Centers For A Clinical Network For The Treatment awarded by National Institutes of Health 1994 - 2006
- Clinical Centers For Lung Volume Reduction Surgery For Emp awarded by National Institutes of Health 1996 - 2005
External Relationships
- GlaxoSmithKline
- Inspirx
- Ventec
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bedoya, Armando D., Nrupen A. Bhavsar, Bhargav Adagarla, Courtney B. Page, Benjamin A. Goldstein, and Neil R. MacIntyre. “Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.” Respir Care 65, no. 9 (September 2020): 1233–40. https://doi.org/10.4187/respcare.07438.
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  - MacIntyre, Neil R., and Yuh Chin Huang. “Cut to the Chase: Cut-Points for Use in Interpretation of Pulmonary Function Tests.” Chest 158, no. 2 (August 2020): 435–36. https://doi.org/10.1016/j.chest.2020.04.039.
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  - MacIntyre, Neil R. “Toward Reducing COPD Hospitalization.” Respir Care 65, no. 1 (January 2020): 127–28. https://doi.org/10.4187/respcare.07491.
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  - Balasubramanian, Aparna, Neil R. MacIntyre, Robert J. Henderson, Robert L. Jensen, Gregory Kinney, William W. Stringer, Craig P. Hersh, et al. “Diffusing Capacity of Carbon Monoxide in Assessment of COPD.” Chest 156, no. 6 (December 2019): 1111–19. https://doi.org/10.1016/j.chest.2019.06.035.
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  - Kim, Victor, Huaqing Zhao, Elizabeth Regan, MeiLan K. Han, Barry J. Make, James D. Crapo, Paul W. Jones, et al. “The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition.” Chest 156, no. 4 (October 2019): 685–95. https://doi.org/10.1016/j.chest.2019.03.041.
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  - Rackley, Craig R., and Neil R. MacIntyre. “Low Tidal Volumes for Everyone?” Chest 156, no. 4 (October 2019): 783–91. https://doi.org/10.1016/j.chest.2019.06.007.
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  - MacIntyre, Neil R. “Physiologic Effects of Noninvasive Ventilation.” Respir Care 64, no. 6 (June 2019): 617–28. https://doi.org/10.4187/respcare.06635.
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  - Kaminsky, David, Allan Coates, Bruce Culver, Donald Cockcroft, Teal Hallstrand, Jeffrey Haynes, Neil MacIntyre, and Jack Wanger. “Reply to Amirav and Newhouse: PC20 versus PD20: Why Change a Scientifically Well-Established and Clinically Relevant Test?” Am J Respir Crit Care Med 199, no. 8 (April 15, 2019): 1038. https://doi.org/10.1164/rccm.201811-2216LE.
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  - MacIntyre, Neil R. “Early Mobilization of Patients on Mechanical Ventilation: Worth the Effort and Expense?” Respir Care 64, no. 1 (January 2019): 112–13. https://doi.org/10.4187/respcare.06801.
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  - Wan, Emily S., Spyridon Fortis, Elizabeth A. Regan, John Hokanson, MeiLan K. Han, Richard Casaburi, Barry J. Make, et al. “Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study.” Am J Respir Crit Care Med 198, no. 11 (December 1, 2018): 1397–1405. https://doi.org/10.1164/rccm.201804-0663OC.
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  - “"2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung." Brian L. Graham, Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson and Jack Wanger. Eur Respir J 2017; 49: 1600016.” Eur Respir J 52, no. 5 (November 2018). https://doi.org/10.1183/13993003.50016-2016.
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  - Coates, Allan, Bruce Culver, Donald Cockcroft, Teal Hallstrand, Jeffrey Haynes, David Kaminsky, Neil MacIntyre, and Jack Wanger. “Characterizing Nebulizer Performance for Methacholine Challenge Tests.” Am J Respir Crit Care Med 198, no. 8 (October 15, 2018): 988–90. https://doi.org/10.1164/rccm.201805-0942ED.
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  - Ekström, Magnus, Anna Bornefalk-Hermansson, Nicholas Wysham, David C. Currow, Neil MacIntyre, and Neil COPDGene Investigators: Core Units. “Spirometric Volumes and Breathlessness across Levels of Airflow Limitation: The COPDGene Study.” Am J Respir Crit Care Med 198, no. 5 (September 1, 2018): 678–81. https://doi.org/10.1164/rccm.201803-0594LE.
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  - MacIntyre, Neil. “Rebuttal From Dr MacIntyre.” Chest 154, no. 3 (September 2018): 485–86. https://doi.org/10.1016/j.chest.2018.06.011.
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  - MacIntyre, Neil. “COUNTERPOINT: Should Computerized Protocols Replace Physicians for Managing Mechanical Ventilation? No.” Chest 154, no. 3 (September 2018): 481–84. https://doi.org/10.1016/j.chest.2018.06.014.
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  - Yun, Jeong H., Andrew Lamb, Robert Chase, Dave Singh, Margaret M. Parker, Aabida Saferali, Jørgen Vestbo, et al. “Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.” J Allergy Clin Immunol 141, no. 6 (June 2018): 2037-2047.e10. https://doi.org/10.1016/j.jaci.2018.04.010.
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  - Giovacchini, Coral X., Anne M. Mathews, Brian R. Lawlor, and Neil R. MacIntyre. “Titrating Oxygen Requirements During Exercise: Evaluation of a Standardized Single Walk Test Protocol.” Chest 153, no. 4 (April 2018): 922–28. https://doi.org/10.1016/j.chest.2017.11.009.
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  - Zapol, Warren M., H Cecil Charles, Andrew R. Martin, Rui C. Sá, Binglan Yu, Fumito Ichinose, Neil MacIntyre, et al. “Pulmonary Delivery of Therapeutic and Diagnostic Gases.” J Aerosol Med Pulm Drug Deliv 31, no. 2 (April 2018): 78–87. https://doi.org/10.1089/jamp.2017.1431.
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  - MacIntyre, Neil R., Michael Gentile, John Davies, Stephen Bergin, Craig Rackley, and Anne Mathews. “Airway pressure release ventilation: a step forward?” Intensive Care Med 44, no. 2 (February 2018): 272. https://doi.org/10.1007/s00134-017-5012-9.
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  - Boueiz, Adel, Yale Chang, Michael H. Cho, George R. Washko, Raul San José Estépar, Russell P. Bowler, James D. Crapo, et al. “Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.” Chest 153, no. 1 (January 2018): 65–76. https://doi.org/10.1016/j.chest.2017.09.022.
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  - MacIntyre, Neil R., Andrew G. Miller, Michael A. Gentile, and John D. Davies. “Airway Pressure Release Ventilation Letter-Reply.” Respir Care 63, no. 1 (January 2018): 128–29. https://doi.org/10.4187/respcare.06014.
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  - Narewski, E. R., A. L. Blackford, M. R. Lammi, A. L. Fuhlbrigge, X. Soler, R. Albert, G. J. Criner, et al. “Clinical differences in COPD patients with variable patterns of hypoxemia.” Chronic Obstructive Pulmonary Diseases 5, no. 3 (January 1, 2018): 167–78. https://doi.org/10.15326/jcopdf.5.3.2017.0175.
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  - Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya.” Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.
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  - Yusen, Roger D., Gerard J. Criner, Alice L. Sternberg, David H. Au, Anne L. Fuhlbrigge, Richard K. Albert, Richard Casaburi, et al. “The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned.” Ann Am Thorac Soc 15, no. 1 (January 2018): 89–101. https://doi.org/10.1513/AnnalsATS.201705-374SD.
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  - Culver, Bruce H., Brian L. Graham, Allan L. Coates, Jack Wanger, Cristine E. Berry, Patricia K. Clarke, Teal S. Hallstrand, et al. “Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement.” Am J Respir Crit Care Med 196, no. 11 (December 1, 2017): 1463–72. https://doi.org/10.1164/rccm.201710-1981ST.
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  - MacIntyre, Neil R. “Humidified High-Flow Nasal Cannula Oxygen-More Than Just Supplemental Oxygen.” Crit Care Med 45, no. 12 (December 2017): 2103–4. https://doi.org/10.1097/CCM.0000000000002725.
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  - Miller, Andrew G., Michael A. Gentile, John D. Davies, and Neil R. MacIntyre. “Clinical Management Strategies for Airway Pressure Release Ventilation: A Survey of Clinical Practice.” Respir Care 62, no. 10 (October 2017): 1264–68. https://doi.org/10.4187/respcare.05494.
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  - Graham, Brian L., Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson, and Jack Wanger. “DLCO: adjust for lung volume, standardised reporting and interpretation.” Eur Respir J 50, no. 2 (August 2017). https://doi.org/10.1183/13993003.01144-2017.
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  - Morris, Timothy A., Peter C. Gay, Neil R. MacIntyre, Dean R. Hess, Sandra K. Hanneman, James P. Lamberti, Dennis E. Doherty, Lydia Chang, and Maureen A. Seckel. “Respiratory Compromise as a New Paradigm for the Care of Vulnerable Hospitalized Patients.” Respir Care 62, no. 4 (April 2017): 497–512. https://doi.org/10.4187/respcare.05021.
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  - Hardin, Megan, Michael H. Cho, Sunita Sharma, Kimberly Glass, Peter J. Castaldi, Merry-Lynn McDonald, Hugues Aschard, et al. “Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.” Am J Respir Cell Mol Biol 56, no. 3 (March 2017): 332–41. https://doi.org/10.1165/rcmb.2016-0172OC.
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  - Miller, Andrew G., and Neil R. MacIntyre. “Initial Ventilator Settings in the Emergency Department.” Ann Emerg Med 69, no. 2 (February 2017): 266–67. https://doi.org/10.1016/j.annemergmed.2016.09.043.
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  - Graham, Brian L., Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson, and Jack Wanger. “2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung.” Eur Respir J 49, no. 1 (January 2017). https://doi.org/10.1183/13993003.00016-2016.
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  - Graham, Brian L., Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson, and Jack Wanger. “Executive Summary: 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung.” Eur Respir J 49, no. 1 (January 2017). https://doi.org/10.1183/13993003.E0016-2016.
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  - MacIntyre, Neil. “Design Features of Modern Mechanical Ventilators.” Clin Chest Med 37, no. 4 (December 2016): 607–13. https://doi.org/10.1016/j.ccm.2016.07.002.
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  - MacIntyre, Neil. “Evolving Concepts in Mechanical Ventilation.” Clin Chest Med 37, no. 4 (December 2016): xiii. https://doi.org/10.1016/j.ccm.2016.09.001.
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  - Long-Term Oxygen Treatment Trial Research Group, William, Richard K. Albert, David H. Au, Amanda L. Blackford, Richard Casaburi, J Allen Cooper, Gerard J. Criner, et al. “A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.” N Engl J Med 375, no. 17 (October 27, 2016): 1617–27. https://doi.org/10.1056/NEJMoa1604344.
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  - MacIntyre, Neil. “Spontaneous Breathing During Mechanical Ventilation: A Two-Edged Sword.” Crit Care Med 44, no. 8 (August 2016): 1625–26. https://doi.org/10.1097/CCM.0000000000001765.
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  - Sun, Wei, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A. Hawkins, Jenny Yang, Ting-Huei Chen, et al. “Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.” Plos Genet 12, no. 8 (August 2016): e1006011. https://doi.org/10.1371/journal.pgen.1006011.
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  - MacIntyre, Neil. “Measuring Clinical Performance: Make Sure the Ruler Is Accurate.” Crit Care Med 44, no. 6 (June 2016): 1230. https://doi.org/10.1097/CCM.0000000000001682.
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  - Nguyen, Albert P., Ulrich H. Schmidt, and Neil R. MacIntyre. “Should High-Frequency Ventilation in the Adult Be Abandoned?” Respir Care 61, no. 6 (June 2016): 791–800. https://doi.org/10.4187/respcare.04584.
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  - Schmidt, Ulrich H., Lauren Knecht, and Neil R. MacIntyre. “Should Early Mobilization Be Routine in Mechanically Ventilated Patients?” Respir Care 61, no. 6 (June 2016): 867–75. https://doi.org/10.4187/respcare.04566.
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  - Vaz Fragoso, Carlos A., Gail McAvay, Peter H. Van Ness, Richard Casaburi, Robert L. Jensen, Neil MacIntyre, H Klar Yaggi, Thomas M. Gill, and John Concato. “Phenotype of Spirometric Impairment in an Aging Population.” Am J Respir Crit Care Med 193, no. 7 (April 1, 2016): 727–35. https://doi.org/10.1164/rccm.201508-1603OC.
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  - MacIntyre, Neil. “Oxygen: Providing Too Much of a Good Thing?” Crit Care Med 44, no. 3 (March 2016): 641. https://doi.org/10.1097/CCM.0000000000001543.
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  - Busch, Robert, MeiLan K. Han, Russell P. Bowler, Mark T. Dransfield, J Michael Wells, Elizabeth A. Regan, Craig P. Hersh, and Craig P. COPDGene Investigators. “Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort.” Bmc Pulm Med 16 (February 10, 2016): 28. https://doi.org/10.1186/s12890-016-0191-7.
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  - MacIntyre, Neil R. “Lung Protective Ventilator Strategies: Beyond Scaling Tidal Volumes to Ideal Lung Size.” Crit Care Med 44, no. 1 (January 2016): 244–45. https://doi.org/10.1097/CCM.0000000000001454.
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  - Andrade, Joao de, Marvin Schwarz, Harold R. Collard, Tedryl Gentry-Bumpass, Thomas Colby, David Lynch, Robert J. Kaner, and Robert J. IPFnet Investigators. “The Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet): diagnostic and adjudication processes.” Chest 148, no. 4 (October 2015): 1034–42. https://doi.org/10.1378/chest.14-2889.
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  - Vaz Fragoso, Carlos A., Gail McAvay, Peter H. Van Ness, Richard Casaburi, Robert L. Jensen, Neil MacIntyre, Thomas M. Gill, H Klar Yaggi, and John Concato. “Phenotype of normal spirometry in an aging population.” Am J Respir Crit Care Med 192, no. 7 (October 1, 2015): 817–25. https://doi.org/10.1164/rccm.201503-0463OC.
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  - MacIntyre, Neil. “Take a Deep Breath-or Not.” Crit Care Med 43, no. 9 (September 2015): 2021–22. https://doi.org/10.1097/CCM.0000000000001123.
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  - Regan, Elizabeth A., David A. Lynch, Douglas Curran-Everett, Jeffrey L. Curtis, John H. M. Austin, Philippe A. Grenier, Hans-Ulrich Kauczor, et al. “Clinical and Radiologic Disease in Smokers With Normal Spirometry.” Jama Intern Med 175, no. 9 (September 2015): 1539–49. https://doi.org/10.1001/jamainternmed.2015.2735.
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  - Fink, J. B., N. R. Macintyre, and J. A. Suggett. “Discussion.” Respiratory Care 60, no. 6 (June 1, 2015): 821–24.
  - Fink, J. B., and N. R. Macintyre. “Discussion.” Respiratory Care 60, no. 6 (June 1, 2015): 790–93.
  - Macintyre, N. R., and J. B. Fink. “Discussion.” Respiratory Care 60, no. 6 (June 1, 2015): 891–93.
  - Grissom, Colin K., Eliotte L. Hirshberg, Justin B. Dickerson, Samuel M. Brown, Michael J. Lanspa, Kathleen D. Liu, David Schoenfeld, et al. “Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.” Crit Care Med 43, no. 2 (February 2015): 288–95. https://doi.org/10.1097/CCM.0000000000000715.
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  - Fink, J. B., and N. R. Macintyre. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 874–79.
  - Macintyre, N. R. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 802–5.
  - Macintyre, N. R., and J. B. Fink. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 955–57.
  - Macintyre, N. R., and J. B. Fink. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 771–73.
  - Macintyre, N. R., and J. B. Fink. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 847–49.
  - Schell-Chaple, Hildy M., Kathleen A. Puntillo, Michael A. Matthay, Kathleen D. Liu, and Kathleen D. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. “Body temperature and mortality in patients with acute respiratory distress syndrome.” Am J Crit Care 24, no. 1 (January 2015): 15–23. https://doi.org/10.4037/ajcc2015320.
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  - Suggett, J. A., J. B. Fink, and N. R. Macintyre. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 830–32.
  - Holland, Anne E., Martijn A. Spruit, Thierry Troosters, Milo A. Puhan, Véronique Pepin, Didier Saey, Meredith C. McCormack, et al. “An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease.” Eur Respir J 44, no. 6 (December 2014): 1428–46. https://doi.org/10.1183/09031936.00150314.
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  - Miller, Andrew G., Jhaymie L. Cappiello, Michael A. Gentile, Andrew M. Almond, Janice J. Thalman, and Neil R. MacIntyre. “Analysis of radial artery catheter placement by respiratory therapists using ultrasound guidance.” Respir Care 59, no. 12 (December 2014): 1813–16. https://doi.org/10.4187/respcare.02905.
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  - Singh, Sally J., Milo A. Puhan, Vasileios Andrianopoulos, Nidia A. Hernandes, Katy E. Mitchell, Catherine J. Hill, Annemarie L. Lee, et al. “An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease.” Eur Respir J 44, no. 6 (December 2014): 1447–78. https://doi.org/10.1183/09031936.00150414.
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  - Hobbs, Brian D., Marilyn G. Foreman, Russell Bowler, Francine Jacobson, Barry J. Make, Peter J. Castaldi, Raúl San José Estépar, Edwin K. Silverman, Craig P. Hersh, and Craig P. COPDGene Investigators. “Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.” Ann Am Thorac Soc 11, no. 9 (November 2014): 1387–94. https://doi.org/10.1513/AnnalsATS.201405-224OC.
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  - McDonald, Merry-Lynn N., Michael H. Cho, Inga-Cecilie Sørheim, Sharon M. Lutz, Peter J. Castaldi, David A. Lomas, Harvey O. Coxson, et al. “Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.” Am J Respir Cell Mol Biol 51, no. 5 (November 2014): 678–87. https://doi.org/10.1165/rcmb.2014-0135OC.
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  - Hersh, Craig P., Barry J. Make, David A. Lynch, R Graham Barr, Russell P. Bowler, Peter M. A. Calverley, Peter J. Castaldi, et al. “Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.” Bmc Pulm Med 14 (October 24, 2014): 164. https://doi.org/10.1186/1471-2466-14-164.
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  - Bowler, Russell P., Victor Kim, Elizabeth Regan, André A. A. Williams, Stephanie A. Santorico, Barry J. Make, David A. Lynch, et al. “Prediction of acute respiratory disease in current and former smokers with and without COPD.” Chest 146, no. 4 (October 2014): 941–50. https://doi.org/10.1378/chest.13-2946.
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  - MacIntyre, Neil R. “Tissue hypoxia: implications for the respiratory clinician.” Respir Care 59, no. 10 (October 2014): 1590–96. https://doi.org/10.4187/respcare.03357.
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  - Sottile, Peter D., Marc Moss, Jayshil J. Patel, Jonathon D. Truwit, Maryam Sheikh, Janice L. Zimmerman, Amit Diwakar, et al. “ATS Core Curriculum 2014: Part II. Adult critical care medicine.” Ann Am Thorac Soc 11, no. 8 (October 2014): 1307–15. https://doi.org/10.1513/AnnalsATS.201407-322CME.
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  - Lee, Jin Hwa, Michael H. Cho, Craig P. Hersh, Merry-Lynn N. McDonald, James D. Crapo, Per S. Bakke, Amund Gulsvik, et al. “Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.” Respir Res 15 (September 21, 2014): 113. https://doi.org/10.1186/s12931-014-0113-2.
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  - Lee, Jin Hwa, Merry-Lynn N. McDonald, Michael H. Cho, Emily S. Wan, Peter J. Castaldi, Gary M. Hunninghake, Nathaniel Marchetti, et al. “DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.” Respir Res 15 (August 20, 2014): 97. https://doi.org/10.1186/s12931-014-0097-y.
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  - Wan, E. S., P. J. Castaldi, M. H. Cho, J. E. Hokanson, E. A. Regan, B. J. Make, T. H. Beaty, et al. “Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.” Respiratory Research 15, no. 1 (August 6, 2014). https://doi.org/10.1186/s12931-014-0089-y.
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  - Wan, Emily S., Peter J. Castaldi, Michael H. Cho, John E. Hokanson, Elizabeth A. Regan, Barry J. Make, Terri H. Beaty, et al. “Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.” Respir Res 15 (August 6, 2014): 89. https://doi.org/10.1186/s12931-014-0089-y.
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  - Pathak, Vikas, Ian Welsby, Kamran Mahmood, Momen Wahidi, Neil MacIntyre, and Scott Shofer. “Ventilation and anesthetic approaches for rigid bronchoscopy.” Ann Am Thorac Soc 11, no. 4 (May 2014): 628–34. https://doi.org/10.1513/AnnalsATS.201309-302FR.
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  - Kim, V., A. Davey, A. P. Comellas, M. K. Han, G. Washko, C. H. Martinez, D. Lynch, et al. “Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study.” Respiratory Research 15, no. 1 (April 27, 2014). https://doi.org/10.1186/1465-9921-15-52.
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  - Kim, Victor, Adam Davey, Alejandro P. Comellas, Meilan K. Han, George Washko, Carlos H. Martinez, David Lynch, et al. “Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study.” Respir Res 15 (April 27, 2014): 52. https://doi.org/10.1186/1465-9921-15-52.
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  - Cho, Michael H., Merry-Lynn N. McDonald, Xiaobo Zhou, Manuel Mattheisen, Peter J. Castaldi, Craig P. Hersh, Dawn L. Demeo, et al. “Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.” Lancet Respir Med 2, no. 3 (March 2014): 214–25. https://doi.org/10.1016/S2213-2600(14)70002-5.
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  - Swigris, Jeffrey J., David L. Streiner, Kevin K. Brown, Amanda Belkin, Kathy E. Green, Frederick S. Wamboldt, and Frederick S. IPFnet Investigators. “Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis.” Respir Med 108, no. 1 (January 2014): 181–88. https://doi.org/10.1016/j.rmed.2013.12.009.
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  - Matthay, M. A., R. G. Brower, S. Carson, I. S. Douglas, M. Eisner, D. Hite, S. Holets, R. H. Kallet, K. D. Liu, and N. MacIntyre. “Erratum: Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury (American Journal of Respiratory and Critical Care Medicine (2011) 184 (561-568)).” American Journal of Respiratory and Critical Care Medicine 188, no. 11 (December 1, 2013): 1378. https://doi.org/10.1164/rccm.2013.188111378a.
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  - Gilstrap, Daniel, and Neil MacIntyre. “Patient-ventilator interactions. Implications for clinical management.” Am J Respir Crit Care Med 188, no. 9 (November 1, 2013): 1058–68. https://doi.org/10.1164/rccm.201212-2214CI.
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  - Halaweish, Ahmed F., Richard E. Moon, W Michael Foster, Brian J. Soher, H Page McAdams, James R. MacFall, Maureen D. Ainslie, Neil R. MacIntyre, and H Cecil Charles. “Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.” Chest 144, no. 4 (October 2013): 1300–1310. https://doi.org/10.1378/chest.12-2597.
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  - Al-Hegelan, Mashael, and Neil R. MacIntyre. “Novel modes of mechanical ventilation.” Semin Respir Crit Care Med 34, no. 4 (August 2013): 499–507. https://doi.org/10.1055/s-0033-1351123.
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  - Collard, Harold R., Eric Yow, Luca Richeldi, Kevin J. Anstrom, Craig Glazer, and Craig IPFnet investigators. “Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials.” Respir Res 14 (July 13, 2013): 73. https://doi.org/10.1186/1465-9921-14-73.
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  - MacIntyre, Neil. “Patient-ventilator trigger dys-synchrony: a common phenomenon with important implications.” Crit Care 17, no. 3 (June 18, 2013): 157. https://doi.org/10.1186/cc12729.
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  - MacIntyre, Neil R. “The ventilator discontinuation process: an expanding evidence base.” Respir Care 58, no. 6 (June 2013): 1074–86. https://doi.org/10.4187/respcare.02284.
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  - Scott, J Brady, Michael A. Gentile, Stacey N. Bennett, MaryAnn Couture, and Neil R. MacIntyre. “Apnea testing during brain death assessment: a review of clinical practice and published literature.” Respir Care 58, no. 3 (March 2013): 532–38. https://doi.org/10.4187/respcare.01962.
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  - MacIntyre, Neil R. “Supporting oxygenation in acute respiratory failure.” Respir Care 58, no. 1 (January 2013): 142–50. https://doi.org/10.4187/respcare.02087.
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  - Shaked, N. T., Z. Zalevsky, and L. L. Satterwhite. “Preface.” Biomedical Optical Phase Microscopy and Nanoscopy, January 1, 2013. https://doi.org/10.1016/B978-0-12-415871-9.00023-5.
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  - Macintyre, Neil R. “Evidence-based assessments in the ventilator discontinuation process.” Respir Care 57, no. 10 (October 2012): 1611–18. https://doi.org/10.4187/respcare.02055.
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  - MacIntyre, Neil R. “Mechanical ventilation in the context of a "bag-in-box" respiratory system.” Crit Care Med 40, no. 6 (June 2012): 1988–89. https://doi.org/10.1097/CCM.0b013e3182515092.
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  - Macintyre, Neil R. “Chronic critical illness: the growing challenge to health care.” Respir Care 57, no. 6 (June 2012): 1021–27. https://doi.org/10.4187/respcare.01768.
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  - Miller, Russell R., Neil R. MacIntyre, R Duncan Hite, Jonathon D. Truwit, Roy G. Brower, and Alan H. Morris. “Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes.” Chest 141, no. 6 (June 2012): 1379–82. https://doi.org/10.1378/chest.12-0155.
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  - Martinez, Carlos H., Ya-Hong Chen, Phillip M. Westgate, Lyrica X. Liu, Susan Murray, Jeffrey L. Curtis, Barry J. Make, et al. “Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease.” Thorax 67, no. 5 (May 2012): 399–406. https://doi.org/10.1136/thoraxjnl-2011-201185.
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  - Dunne, Patrick J., Neil R. Macintyre, Ulrich H. Schmidt, Carl F. Haas, Kathy Jones-Boggs Rye, Garry W. Kauffman, and Dean R. Hess. “Respiratory care year in review 2011: long-term oxygen therapy, pulmonary rehabilitation, airway management, acute lung injury, education, and management.” Respir Care 57, no. 4 (April 2012): 590–606. https://doi.org/10.4187/respcare.01776.
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  - Rambod, Mehdi, Janos Porszasz, Barry J. Make, James D. Crapo, Richard Casaburi, and Richard COPDGene Investigators. “Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.” Chest 141, no. 4 (April 2012): 867–75. https://doi.org/10.1378/chest.11-0870.
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  - Hegewald, Matthew J., Robert L. Jensen, John G. Teeter, Robert A. Wise, Richard J. Riese, Richard D. England, Richard C. Ahrens, Robert O. Crapo, and Neil R. MacIntyre. “Long-term intersession variability for single-breath diffusing capacity.” Respiration 84, no. 5 (2012): 377–84. https://doi.org/10.1159/000334699.
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  - MacIntyre, Neil R. “The future of pulmonary function testing.” Respir Care 57, no. 1 (January 2012): 154–61. https://doi.org/10.4187/respcare.01422.
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  - Lau, R., T. K. Shih, F. Li, and N. Y. Yen. “Foreword.” Mm’11 Proceedings of the 2011 Acm Multimedia Conference and Co Located Workshops Acm International Workshop on Multimedia Technologies for Distance Learning, Mtdl’11, December 1, 2011.
  - MacIntyre, Neil. “Airway pressure release ventilation: hope or hype?” Crit Care Med 39, no. 10 (October 2011): 2376–77. https://doi.org/10.1097/CCM.0b013e31822a5a67.
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  - Siedlinski, Mateusz, Michael H. Cho, Per Bakke, Amund Gulsvik, David A. Lomas, Wayne Anderson, Xiangyang Kong, et al. “Genome-wide association study of smoking behaviours in patients with COPD.” Thorax 66, no. 10 (October 2011): 894–902. https://doi.org/10.1136/thoraxjnl-2011-200154.
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  - National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, B Taylor, Michael A. Matthay, Roy G. Brower, Shannon Carson, Ivor S. Douglas, Mark Eisner, Duncan Hite, et al. “Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.” Am J Respir Crit Care Med 184, no. 5 (September 1, 2011): 561–68. https://doi.org/10.1164/rccm.201012-2090OC.
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  - Hess, Dean R., and Neil R. MacIntyre. “Ventilator discontinuation: why are we still weaning?” Am J Respir Crit Care Med 184, no. 4 (August 15, 2011): 392–94. https://doi.org/10.1164/rccm.201105-0894ED.
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  - MacIntyre, Neil. “Counterpoint: Is pressure assist-control preferred over volume assist-control mode for lung protective ventilation in patients with ARDS? No.” Chest 140, no. 2 (August 2011): 290–92. https://doi.org/10.1378/chest.11-1052.
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  - Marini, John J. “Point: Is pressure assist-control preferred over volume assist-control mode for lung protective ventilation in patients with ARDS? Yes.” Chest 140, no. 2 (August 2011): 286–90. https://doi.org/10.1378/chest.11-1060.
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  - Turner, David A., Walter L. Williford, Michelle A. Peters, Janice J. Thalman, Ian R. Shearer, Richard J. Walczak, Michael Griffis, et al. “Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory hypoxemia within the framework of a pandemic.” Pediatr Crit Care Med 12, no. 4 (July 2011): 426–30. https://doi.org/10.1097/PCC.0b013e3181ff41c1.
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  - Macintyre, Neil R., Stefano Nava, Robert M. Diblasi, Ruben D. Restrepo, and Dean R. Hess. “Respiratory care year in review 2010: part 2. Invasive mechanical ventilation, noninvasive ventilation, pediatric mechanical ventilation, aerosol therapy.” Respir Care 56, no. 5 (May 2011): 667–80. https://doi.org/10.4187/respcare.01310.
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  - MacIntyre, Neil R. “Patient-ventilator interactions: optimizing conventional ventilation modes.” Respir Care 56, no. 1 (January 2011): 73–84. https://doi.org/10.4187/respcare.00953.
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  - Miller, M. R., J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, P. Enright, et al. “Standardisation of lung function testing: the authors' replies to readers' comments.” Eur Respir J 36, no. 6 (December 2010): 1496–98. https://doi.org/10.1183/09031936.00130010.
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  - Idiopathic Pulmonary Fibrosis Clinical Research Network, Gary W., David A. Zisman, Marvin Schwarz, Kevin J. Anstrom, Harold R. Collard, Kevin R. Flaherty, and Gary W. Hunninghake. “A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis.” N Engl J Med 363, no. 7 (August 12, 2010): 620–28. https://doi.org/10.1056/NEJMoa1002110.
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  - Unroe, Mark, and Neil MacIntyre. “Evolving approaches to assessing and monitoring patient-ventilator interactions.” Curr Opin Crit Care 16, no. 3 (June 2010): 261–68. https://doi.org/10.1097/MCC.0b013e328338661e.
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  - Branson, Richard D., and Neil R. MacIntyre. “Respiratory care controversies II: 44th journal conference.” Respir Care 55, no. 2 (February 2010): 121.
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  - MacIntyre, Neil R., and Curtis N. Sessler. “Are there benefits or harm from pressure targeting during lung-protective ventilation?” Respir Care 55, no. 2 (February 2010): 175–80.
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  - MacIntyre, Neil. “Talk to me! Toward better patient-ventilator communication.” Crit Care Med 38, no. 2 (February 2010): 714–15. https://doi.org/10.1097/CCM.0b013e3181c0ddef.
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  - Ware, Lorraine B., Tatsuki Koyama, D Dean Billheimer, William Wu, Gordon R. Bernard, B Taylor Thompson, Roy G. Brower, et al. “Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury.” Chest 137, no. 2 (February 2010): 288–96. https://doi.org/10.1378/chest.09-1484.
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  - MacIntyre, Neil R., and Paul A. Selecky. “Is there a role for screening spirometry?” Respir Care 55, no. 1 (January 2010): 35–42.
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  - MacIntyre, Neil R., and Richard D. Branson. “Respiratory care controversies II.” Respir Care 55, no. 1 (January 2010): 34.
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  - MacIntyre, N. R. “The author responds.” Respiratory Care 54, no. 11 (December 4, 2009).
  - MacIntyre, N. R. “Spirometry for the diagnosis and management of chronic obstructive pulmonary disease (Respiratory Care (2009) 54, 8, 1050-1057).” Respiratory Care 54, no. 11 (December 4, 2009): 1501.
  - Peno-Green, Laura, David Verrill, Mark Vitcenda, Neil Macintyre, Helen Graham, and Helen American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). “Patient and program outcome assessment in pulmonary rehabilitation: an AACVPR statement.” J Cardiopulm Rehabil Prev 29, no. 6 (November 2009): 402–10. https://doi.org/10.1097/HCR.0b013e3181b4c8a6.
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  - Macintyre, Neil R. “Spirometry for the diagnosis and management of chronic obstructive pulmonary disease.” Respir Care 54, no. 8 (August 2009): 1050–57.
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  - Panettieri, Reynold A., Neil MacIntyre, Michael Sims, Edward Kerwin, Charles Fogarty, Michael Noonan, Raymond Claus, and William T. Andrews. “Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study.” Clin Ther 31, no. 8 (August 2009): 1716–23. https://doi.org/10.1016/j.clinthera.2009.08.012.
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  - MacIntyre, Neil. “Pulse oximetry in critical care scoring systems.” Crit Care Med 37, no. 4 (April 2009): 1505–6. https://doi.org/10.1097/CCM.0b013e31819d2d93.
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  - Dunlap, C. “Foreword,” 2009.
  - Glassberg, Andrea E., John M. Luce, Michael A. Matthay, and Michael A. National Heart, Lung, and Blood Institute Clinical Trials Network. “Reasons for nonenrollment in a clinical trial of acute lung injury.” Chest 134, no. 4 (October 2008): 719–23. https://doi.org/10.1378/chest.08-0633.
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  - MacIntyre, Neil R. “Mechanisms of functional loss in patients with chronic lung disease.” Respir Care 53, no. 9 (September 2008): 1177–84.
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  - MacIntyre, Neil R. “The 23rd annual New Horizons Symposium. Pulmonary rehabilitation: the expanding evidence base. Foreword.” Respir Care 53, no. 9 (September 2008): 1176.
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  - Drummond, Michael B., Pamela F. Schwartz, William T. Duggan, John G. Teeter, Richard J. Riese, Richard C. Ahrens, Robert O. Crapo, et al. “Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease.” Am J Respir Crit Care Med 178, no. 3 (August 1, 2008): 225–32. https://doi.org/10.1164/rccm.200801-090OC.
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  - MacIntyre, N. R., and T. R. Myers. “The authors respond.” Respiratory Care 53, no. 7 (July 1, 2008): 923.
  - Lugogo, Njira L., and Neil R. MacIntyre. “Life-threatening asthma: pathophysiology and management.” Respir Care 53, no. 6 (June 2008): 726–35.
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  - MacIntyre, Neil R. “Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?” Clin Chest Med 29, no. 2 (June 2008): 233–v. https://doi.org/10.1016/j.ccm.2008.01.005.
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  - MacIntyre, Neil R. “Is there a best way to set tidal volume for mechanical ventilatory support?” Clin Chest Med 29, no. 2 (June 2008): 225–v. https://doi.org/10.1016/j.ccm.2008.01.004.
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  - MacIntyre, N. R., and T. R. Myers. “Meeting the challenges of asthma.” Respiratory Care 53, no. 5 (May 1, 2008): 560.
  - MacIntyre, Neil, and Yuh Chin Huang. “Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease.” Proc Am Thorac Soc 5, no. 4 (May 1, 2008): 530–35. https://doi.org/10.1513/pats.200707-088ET.
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  - Banner, Michael J., Neil R. Euliano, Neil R. Macintyre, A Joseph Layon, Steven Bonett, Michael A. Gentile, Zoheir Bshouty, Carl Peters, and Andrea Gabrielli. “Ventilator advisory system employing load and tolerance strategy recommends appropriate pressure support ventilation settings: multisite validation study.” Chest 133, no. 3 (March 2008): 697–703. https://doi.org/10.1378/chest.07-2011.
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  - Pellegrino, R., V. Brusasco, G. Viegi, R. O. Crapo, F. Burgos, R. Casaburi, A. Coates, et al. “Definition of COPD: based on evidence or opinion?” Eur Respir J 31, no. 3 (March 2008): 681–82. https://doi.org/10.1183/09031936.00154307.
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  - MacIntyre, N. R. “Preface.” Clinics in Chest Medicine 29, no. 2 (January 1, 2008). https://doi.org/10.1016/j.ccm.2008.02.005.
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  - MacIntyre, Neil. “Ventilator discontinuation process: evidence and guidelines.” Crit Care Med 36, no. 1 (January 2008): 329–30. https://doi.org/10.1097/01.CCM.0000297958.82589.E2.
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  - Wise, Robert A., John G. Teeter, Robert L. Jensen, Richard D. England, Pamela F. Schwartz, Donald R. Giles, Richard C. Ahrens, Neil R. MacIntyre, Richard J. Riese, and Robert O. Crapo. “Standardization of the single-breath diffusing capacity in a multicenter clinical trial.” Chest 132, no. 4 (October 2007): 1191–97. https://doi.org/10.1378/chest.07-0455.
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  - MacIntyre, Neil. “Discontinuing mechanical ventilatory support.” Chest 132, no. 3 (September 2007): 1049–56. https://doi.org/10.1378/chest.06-2862.
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  - Yang, Li-Yu, Yuh-Chin T. Huang, and Neil R. Macintyre. “Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation.” J Crit Care 22, no. 3 (September 2007): 252–57. https://doi.org/10.1016/j.jcrc.2006.12.003.
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  - Macintyre, Neil. “Finding signals amidst the noise in pulmonary function testing.” Chest 132, no. 2 (August 2007): 367–68. https://doi.org/10.1378/chest.07-0937.
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  - Ware, Lorraine B., Michael A. Matthay, Polly E. Parsons, B Taylor Thompson, James L. Januzzi, Mark D. Eisner, and Mark D. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. “Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome.” Crit Care Med 35, no. 8 (August 2007): 1821–28. https://doi.org/10.1097/01.CCM.0000221922.08878.49.
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  - Phua, Ghee-Chee, and Neil R. Macintyre. “Inhaled corticosteroids in obstructive airway disease.” Respir Care 52, no. 7 (July 2007): 852–58.
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  - Cheifetz, I. M., and N. R. MacIntyre. “Respiratory controversies in the critical care setting.” Respiratory Care 52, no. 5 (May 1, 2007): 636–44.
  - Cheifetz, Ira M., and Neil R. MacIntyre. “Respiratory controversies in the critical care setting. Conference summary.” Respir Care 52, no. 5 (May 2007): 636–44.
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  - Cheifetz, Ira M., and Neil R. MacIntyre. “Respiratory controversies in the critical care setting. Part I.” Respir Care 52, no. 4 (April 2007): 406–7.
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  - MacIntyre, N. R., and B. K. Rubin. “Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?” Respiratory Care 52, no. 4 (April 1, 2007): 416–21.
  - MacIntyre, Neil R., and Bruce K. Rubin. “Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?” Respir Care 52, no. 4 (April 2007): 416–21.
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  - Myers, T. R., and N. R. MacIntyre. “Does airway pressure release ventilation offer important new advantages in mechanical ventilator support?” Respiratory Care 52, no. 4 (April 1, 2007): 452–58.
  - Myers, Timothy R., and Neil R. MacIntyre. “Respiratory controversies in the critical care setting. Does airway pressure release ventilation offer important new advantages in mechanical ventilator support?” Respir Care 52, no. 4 (April 2007): 452–58.
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  - MacIntyre, N., R. O. Crapo, G. Viegi, D. C. Johnson, C. P. M. Van Der Grinten, V. Brusasco, F. Burgos, et al. “Standardisation of the single-breath determination of carbon monoxide uptake in the lung.” Revue Des Maladies Respiratoires 24, no. 3 C2 (March 1, 2007).
  - Miller, M. R., J. Hankinson, V. Brusasco, F. Burgo, R. Casaburi, A. Coates, R. Crapo, et al. “Standardisation of spirometry.” Revue Des Maladies Respiratoires 24, no. 3 C2 (March 1, 2007).
  - Miller, M. R., R. Crapo, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, et al. “General considerations for lung function testing.” Revue Des Maladies Respiratoires 24, no. 3 C2 (March 1, 2007).
  - Pellegrino, R., G. Viegi, V. Brusasco, R. O. Crapo, F. Burgos, R. Casaburi, A. Coates, et al. “Interpretative strategies for lung function tests.” Revue Des Maladies Respiratoires 24, no. 3 C2 (March 1, 2007).
  - Wanger, J., J. L. Clausen, A. Coates, O. F. Pedersen, V. Brusasco, F. Burgos, R. Casaburi, et al. “Standardisation of the measurement of lung volumes.” Revue Des Maladies Respiratoires 24, no. 3 C2 (March 1, 2007).
  - McClintock, Dana E., Lorraine B. Ware, Mark D. Eisner, Nancy Wickersham, B Taylor Thompson, Michael A. Matthay, and Michael A. National Heart, Lung, and Blood Institute ARDS Network. “Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.” Am J Respir Crit Care Med 175, no. 3 (February 1, 2007): 256–62. https://doi.org/10.1164/rccm.200607-947OC.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 12, no. 4 (December 1, 2006). https://doi.org/10.1016/j.rcc.2006.10.002.
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  - MacIntyre, Neil. “Discontinuing mechanical ventilatory support: removing positive pressure ventilation vs removing the artificial airway.” Chest 130, no. 6 (December 2006): 1635–36. https://doi.org/10.1378/chest.130.6.1635.
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  - McClintock, Dana E., Barry Starcher, Mark D. Eisner, B Taylor Thompson, Doug L. Hayden, Gwynne D. Church, Michael A. Matthay, and Michael A. National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. “Higher urine desmosine levels are associated with mortality in patients with acute lung injury.” Am J Physiol Lung Cell Mol Physiol 291, no. 4 (October 2006): L566–71. https://doi.org/10.1152/ajplung.00457.2005.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 12, no. 3 (September 1, 2006). https://doi.org/10.1016/j.rcc.2006.08.002.
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  - MacIntyre, Neil R. “Muscle dysfunction associated with chronic obstructive pulmonary disease.” Respir Care 51, no. 8 (August 2006): 840–47.
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  - MacIntyre, Neil. “Ventilatory Management of ALI/ARDS.” Semin Respir Crit Care Med 27, no. 4 (August 2006): 396–403. https://doi.org/10.1055/s-2006-948293.
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  - Huang, Yuh-Chin T., Sharon R. O’brien, James Vredenburgh, Rodney J. Folz, and Neil R. Macintyre. “Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury.” Respir Med 100, no. 7 (July 2006): 1226–33. https://doi.org/10.1016/j.rmed.2005.10.018.
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  - Nici, Linda, Claudio Donner, Emiel Wouters, Richard Zuwallack, Nicolino Ambrosino, Jean Bourbeau, Mauro Carone, et al. “American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation.” Am J Respir Crit Care Med 173, no. 12 (June 15, 2006): 1390–1413. https://doi.org/10.1164/rccm.200508-1211ST.
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  - Branson, R. D., and N. R. MacIntyre. “Humidification and Filtration in Anesthesia and Intensive Care.” Respiratory Care Clinics of North America 12, no. 2 (June 1, 2006). https://doi.org/10.1016/j.rcc.2006.04.001.
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  - Branson, R. D., and N. R. MacIntyre. “Polysomnography II.” Respiratory Care Clinics of North America 12, no. 1 (March 1, 2006). https://doi.org/10.1016/j.rcc.2005.11.003.
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  - MacIntyre, Neil R. “Corticosteroid therapy and chronic obstructive pulmonary disease.” Respir Care 51, no. 3 (March 2006): 289–96.
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  - Roggli, Victor L., Claude A. Piantadosi, Neil R. MacIntyre, Stephen L. Young, Peter S. Kussin, Mark P. Steele, Martha Sue Carraway, et al. “Physician subsidies for tobacco advertising.” Am J Respir Crit Care Med 173, no. 2 (January 15, 2006): 246. https://doi.org/10.1164/ajrccm.173.2.246.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 11, no. 4 (December 1, 2005). https://doi.org/10.1016/j.rcc.2005.10.002.
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  - MacIntyre, Neil R., Scott K. Epstein, Shannon Carson, David Scheinhorn, Kent Christopher, Sean Muldoon, and Sean National Association for Medical Direction of Respiratory Care. “Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference.” Chest 128, no. 6 (December 2005): 3937–54. https://doi.org/10.1378/chest.128.6.3937.
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  - MacIntyre, Neil R. “Current issues in mechanical ventilation for respiratory failure.” Chest 128, no. 5 Suppl 2 (November 2005): 561S-567S. https://doi.org/10.1378/chest.128.5_suppl_2.561S.
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  - Pellegrino, R., G. Viegi, V. Brusasco, R. O. Crapo, F. Burgos, R. Casaburi, A. Coates, et al. “Interpretative strategies for lung function tests.” Eur Respir J 26, no. 5 (November 2005): 948–68. https://doi.org/10.1183/09031936.05.00035205.
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  - Macintyre, N., R. O. Crapo, G. Viegi, D. C. Johnson, C. P. M. van der Grinten, V. Brusasco, F. Burgos, et al. “Standardisation of the single-breath determination of carbon monoxide uptake in the lung.” Eur Respir J 26, no. 4 (October 2005): 720–35. https://doi.org/10.1183/09031936.05.00034905.
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  - Branson, R. D., and N. R. MacIntyre. “State-of-the-art respiratory care education.” Respiratory Care Clinics of North America 11, no. 3 (September 1, 2005). https://doi.org/10.1016/j.rcc.2005.05.002.
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  - Dhand, R., and N. R. MacIntyre. “Metered-dose inhalers and dry powder inhalers in aerosol therapy.” Respiratory Care 50, no. 9 (September 1, 2005).
  - Wanger, J., J. L. Clausen, A. Coates, O. F. Pedersen, V. Brusasco, F. Burgos, R. Casaburi, et al. “Standardisation of the measurement of lung volumes.” Eur Respir J 26, no. 3 (September 2005): 511–22. https://doi.org/10.1183/09031936.05.00035005.
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  - Miller, M. R., J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, R. Crapo, et al. “Standardisation of spirometry.” Eur Respir J 26, no. 2 (August 2005): 319–38. https://doi.org/10.1183/09031936.05.00034805.
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  - Ashmore, Jamile A., Charles F. Emery, Emily R. Hauck, and Neil R. MacIntyre. “Marital adjustment among patients with chronic obstructive pulmonary disease who are participating in pulmonary rehabilitation.” Heart Lung 34, no. 4 (July 2005): 270–78. https://doi.org/10.1016/j.hrtlng.2004.12.005.
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  - Miller, M. R., R. Crapo, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, et al. “General considerations for lung function testing.” Eur Respir J 26, no. 1 (July 2005): 153–61. https://doi.org/10.1183/09031936.05.00034505.
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  - MacIntyre, Neil R. “Ventilator-associated pneumonia: the role of ventilator management strategies.” Respir Care 50, no. 6 (June 2005): 766–72.
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  - Branson, R. D., and N. R. MacIntyre. “Community-acquired pneumonia: An illness with great diversity.” Respiratory Care Clinics of North America 11, no. 1 (March 1, 2005). https://doi.org/10.1016/j.rcc.2004.10.010.
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  - Levy, Mitchell M., Edward Abraham, Marya Zilberberg, and Neil R. MacIntyre. “A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation.” Chest 127, no. 3 (March 2005): 928–35. https://doi.org/10.1378/chest.127.3.928.
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  - MacIntyre, Neil R. “Respiratory mechanics in the patient who is weaning from the ventilator.” Respir Care 50, no. 2 (February 2005): 275–86.
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  - Branson, R. D., and N. R. MacIntyre. “Patient-ventilator interaction.” Respiratory Care Clinics of North America 11, no. 2 SPEC. ISS. (January 1, 2005). https://doi.org/10.1016/j.rcc.2005.02.010.
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  - Plankeel, John F., Barbara McMullen, and Neil R. MacIntyre. “Exercise outcomes after pulmonary rehabilitation depend on the initial mechanism of exercise limitation among non-oxygen-dependent COPD patients.” Chest 127, no. 1 (January 2005): 110–16. https://doi.org/10.1378/chest.127.1.110.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 10, no. 4 (December 1, 2004). https://doi.org/10.1016/j.rcc.2004.07.002.
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  - Branson, R. D., and N. R. MacIntyre. “Current clinical controversies in respiratory care.” Respiratory Care Clinics of North America 10, no. 3 (September 1, 2004). https://doi.org/10.1016/j.rcc.2004.05.002.
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  - MacIntyre, Neil R. “The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.” Respiratory Care Clinics of North America 10, no. 3 (September 2004): 309–v. https://doi.org/10.1016/j.rcc.2004.04.007.
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  - MacIntyre, Neil R. “Setting the positive expiratory-end pressure-FIO2 in acute lung injury/acute respiratory distress syndrome.” Respiratory Care Clinics of North America 10, no. 3 (September 2004): 301–v. https://doi.org/10.1016/j.rcc.2004.04.006.
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  - Brower, Roy G., Paul N. Lanken, Neil MacIntyre, Michael A. Matthay, Alan Morris, Marek Ancukiewicz, David Schoenfeld, B Taylor Thompson, and B Taylor National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. “Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.” N Engl J Med 351, no. 4 (July 22, 2004): 327–36. https://doi.org/10.1056/NEJMoa032193.
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  - MacIntyre, Neil R. “Evidence-based ventilator weaning and discontinuation.” Respir Care 49, no. 7 (July 2004): 830–36.
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  - Branson, R. D., and N. R. MacIntyre. “Managing respiratory care services.” Respiratory Care Clinics of North America 10, no. 2 (June 1, 2004). https://doi.org/10.1016/j.rcc.2004.02.002.
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  - MacIntyre, Neil R., and Neil R. American Association for Respiratory Care, National Lung Health Education Program. “The American Association for Respiratory Care and the National Lung Health Education Program: assuring quality in spirometry.” Respir Care 49, no. 6 (June 2004): 587–88.
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  - MacIntyre, N. R. “Chronic Obstructive Pulmonary Disease.” Pharmacotherapy 24, no. 5 II (May 1, 2004). https://doi.org/10.1592/phco.24.7.33S.34756.
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  - MacIntyre, Neil R. “Respiratory system simulations and modeling.” Respir Care 49, no. 4 (April 2004): 401–8.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 10, no. 1 (January 1, 2004). https://doi.org/10.1016/S1078-5337(03)00056-X.
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  - Corwin, Howard L., Andrew Gettinger, Ronald G. Pearl, Mitchell P. Fink, Mitchell M. Levy, Edward Abraham, Neil R. MacIntyre, M Michael Shabot, Mei-Sheng Duh, and Marc J. Shapiro. “The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States.” Crit Care Med 32, no. 1 (January 2004): 39–52. https://doi.org/10.1097/01.CCM.0000104112.34142.79.
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  - MacIntyre, Neil R. “Chronic obstructive pulmonary disease: emerging medical therapies.” Respir Care 49, no. 1 (January 2004): 64–69.
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  - Brower, Roy G., Alan Morris, Neil MacIntyre, Michael A. Matthay, Douglas Hayden, Taylor Thompson, Terry Clemmer, Paul N. Lanken, David Schoenfeld, and David ARDS Clinical Trials Network, National Heart, Lung, and Blood Institute, National Institutes of Health. “Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure.” Crit Care Med 31, no. 11 (November 2003): 2592–97. https://doi.org/10.1097/01.CCM.0000090001.91640.45.
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  - Emery, Charles F., Rebecca L. Shermer, Emily R. Hauck, Evana T. Hsiao, and Neil R. MacIntyre. “Cognitive and psychological outcomes of exercise in a 1-year follow-up study of patients with chronic obstructive pulmonary disease.” Health Psychol 22, no. 6 (November 2003): 598–604. https://doi.org/10.1037/0278-6133.22.6.598.
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  - MacIntyre, N. R. “New horizons in respiratory care pulmonary function testing: Updates and answers.” Respiratory Care 48, no. 8 (August 1, 2003).
  - MacIntyre, Neil R., and Catherine M. Foss. “Pulmonary function testing: coding and billing issues.” Respir Care 48, no. 8 (August 2003): 786–90.
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  - Shapiro, Marc J., Andrew Gettinger, Howard L. Corwin, Lena Napolitano, Mitchell Levy, Edward Abraham, Mitchell P. Fink, Neil MacIntyre, Ronald G. Pearl, and M Michael Shabot. “Anemia and blood transfusion in trauma patients admitted to the intensive care unit.” J Trauma 55, no. 2 (August 2003): 269–73. https://doi.org/10.1097/01.TA.0000080530.77566.04.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 9, no. 4 (January 1, 2003). https://doi.org/10.1016/S1078-5337(03)00091-1.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 9, no. 3 (January 1, 2003). https://doi.org/10.1016/S1078-5337(03)00044-3.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 9, no. 2 (January 1, 2003). https://doi.org/10.1016/S1078-5337(03)00017-0.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 9, no. 1 (January 1, 2003). https://doi.org/10.1016/S1078-5337(03)00002-9.
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  - MacIntyre, N. R. “Diagnosis and management of severe sepsis.” International Congress and Symposium Series Royal Society of Medicine, no. 249 (December 1, 2002): 17–38.
  - MacIntyre, Neil R. “Aerosol delivery through an artificial airway.” Respir Care 47, no. 11 (November 2002): 1279–88.
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  - Branson, R. D., and N. R. MacIntyre. “Long-term ventilatory support, part I.” Respiratory Care Clinics of North America 8, no. 3 (September 1, 2002). https://doi.org/10.1016/S1078-5337(02)00043-6.
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  - Branson, R. D., and N. R. MacIntyre. “Transport of the mechanically ventilated patient.” Respiratory Care Clinics of North America 8, no. 1 (August 29, 2002). https://doi.org/10.1016/S1078-5337(02)00035-7.
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  - Branson, R. D., and N. R. MacIntyre. “Adjuncts to mechanical ventilation.” Respiratory Care Clinics of North America 8, no. 2 (August 29, 2002).
  - ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories, Patricia W. “ATS statement: guidelines for the six-minute walk test.” Am J Respir Crit Care Med 166, no. 1 (July 1, 2002): 111–17. https://doi.org/10.1164/ajrccm.166.1.at1102.
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  - Huang, Yuh-Chin T., Sharon R. O’Brien, and Neil R. MacIntyre. “Intrabreath diffusing capacity of the lung in healthy individuals at rest and during exercise.” Chest 122, no. 1 (July 2002): 177–85. https://doi.org/10.1378/chest.122.1.177.
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  - MacIntyre, Neil R. “Invasive mechanical ventilation in adults: conference summary.” Respir Care 47, no. 4 (April 2002): 508–18.
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  - MacIntyre, Neil R. “Setting the frequency-tidal volume pattern.” Respir Care 47, no. 3 (March 2002): 266–74.
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  - Branson, R. D., and N. R. MacIntyre. “Long-term ventilatory support, part II.” Respiratory Care Clinics of North America 8, no. 4 (January 1, 2002). https://doi.org/10.1016/s1078-5337(02)00091-6.
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  - MacIntyre, Neil R. “Bringing scientific evidence to the ventilator weaning and discontinuation process: evidence-based practice guidelines.” Respir Care 47, no. 1 (January 2002): 29–30.
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  - “Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome.” Crit Care Med 30, no. 1 (January 2002): 1–6. https://doi.org/10.1097/00003246-200201000-00001.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 7, no. 3 (December 1, 2001). https://doi.org/10.1016/S1078-5337(05)70038-1.
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  - MacIntyre, N. R. “High-frequency jet ventilation.” Respir Care Clin N Am 7, no. 4 (December 2001): 599–610. https://doi.org/10.1016/s1078-5337(05)70008-3.
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  - MacIntyre, N. R. “Evidence-based guidelines for weaning and discontinuing ventilatory support: A collective task force facilitated by the American college of chest physicians; the American association for respiratory care; and the American college of critical medicine.” Chest 120, no. 6 SUPPL. (December 1, 2001).
  - MacIntyre, N. R., D. J. Cook, E. W. Ely, S. K. Epstein, J. B. Fink, J. E. Heffner, D. Hess, et al. “Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine.” Chest 120, no. 6 Suppl (December 2001): 375S-395S. https://doi.org/10.1378/chest.120.6_suppl.375s.
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  - MacIntyre, N. R. “Chronic obstructive pulmonary disease management: the evidence base.” Respir Care 46, no. 11 (November 2001): 1294–1303.
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  - MacIntyre, N. R. “Innovations in mechanical ventilation: what are (and what should be) the drivers? The Roger C. Bone Memorial Lecture.” Respir Care 46, no. 3 (March 2001): 267–72.
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  - MacIntyre, N. R. “Innovations in mechanical ventilation: What are (and what should be) the drivers?” Respiratory Care 46, no. 3 (March 1, 2001): 267–72.
  - Hess, D. R., and N. R. MacIntyre. “Tracheal gas insufflation: overcoming obstacles to clinical implementation.” Respir Care 46, no. 2 (February 2001): 198–99.
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  - MacIntyre, N. R. “Intratracheal catheters as drug delivery systems.” Respir Care 46, no. 2 (February 2001): 193–97.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 7, no. 4 (January 1, 2001): xi–xii. https://doi.org/10.1016/S1078-5337(05)70002-2.
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  - Branson, R. D., and N. R. MacIntyre. “Foreword.” Respiratory Care Clinics of North America 7, no. 2 (January 1, 2001). https://doi.org/10.1016/S1078-5337(05)70027-7.
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  - McCrory, D. C., C. Brown, R. N. Gray, R. E. Goslin, J. T. Kolimaga, N. R. MacIntyre, E. Z. Oddone, and D. B. Matchar. “Management of acute exacerbations of chronic obstructive pulmonary disease.” Evid Rep Technol Assess (Summ), no. 19 (September 2000): 1–4.
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  - Dolovich, M. A., N. R. MacIntyre, P. J. Anderson, J. Camargo, N. Chew, C. H. Cole, R. Dhand, et al. “Consensus statement: Aerosols and delivery devices.” Respiratory Care 45, no. 6 (August 7, 2000): 589–96.
  - Dolovich, M. A., N. R. MacIntyre, P. J. Anderson, C. A. Camargo, N. Chew, C. H. Cole, R. Dhand, et al. “Consensus statement: aerosols and delivery devices. American Association for Respiratory Care.” Respir Care 45, no. 6 (June 2000): 589–96.
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  - MacIntyre, N. R. “Aerosolized medications for altering lung surface active properties.” Respir Care 45, no. 6 (June 2000): 676–83.
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  - Angus, D. C., M. C. Birmingham, R. A. Balk, P. J. Scannon, D. Collins, J. A. Kruse, D. R. Graham, H. V. Dedhia, S. Homann, and N. MacIntyre. “E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators.” Jama 283, no. 13 (April 5, 2000): 1723–30. https://doi.org/10.1001/jama.283.13.1723.
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  - MacIntyre, N. R. “Oxygen therapy and exercise response in lung disease.” Respir Care 45, no. 2 (February 2000): 194–200.
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  - MacIntyre, N. R. “Long-term oxygen therapy: conference summary.” Respir Care 45, no. 2 (February 2000): 237–45.
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  - MacIntyre, N. “Of Goldilocks and ventilatory muscle loading.” Crit Care Med 28, no. 2 (February 2000): 588–89. https://doi.org/10.1097/00003246-200002000-00059.
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  - Angus, D. C., M. C. Birmingham, R. A. Balk, P. J. Scannon, D. Collins, J. A. Kruse, D. R. Graham, H. V. Dedhia, S. Homann, and N. Macintyre. “E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: A randomized controlled trial.” Journal of the American Medical Association 283, no. 13 (2000): 1723–30.
  - Crapo, R. O., R. Casaburi, A. L. Coates, P. L. Enright, J. L. Hankinson, C. G. Irvin, N. R. MacIntyre, et al. “Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999.” Am J Respir Crit Care Med 161, no. 1 (January 2000): 309–29. https://doi.org/10.1164/ajrccm.161.1.ats11-99.
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  - Dolovich, M. B., N. R. Macintyre, P. J. Anderson, C. A. Camargo, N. Chew, C. H. Cole, R. Dhand, et al. “Consensus statement: aerosols and delivery devices.” J Aerosol Med 13, no. 3 (2000): 291–300. https://doi.org/10.1089/jam.2000.13.291.
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  - Hijazi, M. H., and N. R. MacIntyre. “Advances in infection control: ventilator-associated pneumonia.” Semin Respir Crit Care Med 21, no. 3 (2000): 245–62. https://doi.org/10.1055/s-2000-9855.
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  - MacIntyre, N. R. “Mechanical ventilation strategies for lung protection.” Semin Respir Crit Care Med 21, no. 3 (2000): 215–22. https://doi.org/10.1055/s-2000-9850.
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  - MacIntyre, N. R. “High-frequency ventilation.” Semin Respir Crit Care Med 21, no. 3 (2000): 167–73. https://doi.org/10.1055/s-2000-9851.
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  - MacIntyre, N. R. “Scope of mechanical ventilation and need for innovations.” Seminars in Respiratory and Critical Care Medicine 21, no. 3 (January 1, 2000): 155–59.
  - MacIntyre, N. R. “Preface: Innovations in mechanical ventilation.” Seminars in Respiratory and Critical Care Medicine 21, no. 3 (January 1, 2000): 153–54.
  - McConnell, R., and N. R. MacIntyre. “Tracheal gas insufflation.” Semin Respir Crit Care Med 21, no. 3 (2000): 211–14. https://doi.org/10.1055/s-2000-9853.
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  - MacIntyre, N. R., M. Helms, R. Wunderink, G. Schmidt, and S. A. Sahn. “Automated rotational therapy for the prevention of respiratory complications during mechanical ventilation.” Respiratory Care 44, no. 12 (December 1, 1999): 1447–51.
  - MacIntyre, N. R. “Issues in ventilator weaning.” Chest 115, no. 4 (April 1999): 1215–16. https://doi.org/10.1378/chest.115.4.1215.
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  - MacIntyre, N. R. “High-frequency ventilation.” Crit Care Med 26, no. 12 (December 1998): 1955–56. https://doi.org/10.1097/00003246-199812000-00017.
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  - Brown, C. D., N. R. MacIntyre, and Y. C. Huang. “Diffusing capacity and pulmonary capillary blood flow during maximal exercise.” Chest 114, no. 4 SUPPL. (October 1, 1998).
  - Emery, C. F., R. L. Schein, E. R. Hauck, and N. R. MacIntyre. “Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease.” Health Psychol 17, no. 3 (May 1998): 232–40. https://doi.org/10.1037//0278-6133.17.3.232.
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  - Crouch, R., and N. R. MacIntyre. “Pulmonary rehabilitation of the patient with nonobstructive lung disease.” Respir Care Clin N Am 4, no. 1 (March 1998): 59–70.
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  - MacIntyre, N. R. “Mechanical ventilation: The next 50 years.” Respiratory Care 43, no. 6 (January 1, 1998): 490–93.
  - MacIntyre, N. R., R. McConnell, K. C. Cheng, and A. Sane. “Patient-ventilator flow dyssynchrony: flow-limited versus pressure-limited breaths.” Crit Care Med 25, no. 10 (October 1997): 1671–77. https://doi.org/10.1097/00003246-199710000-00016.
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  - MacIntyre, N. R. “Ventilatory muscles and mechanical ventilatory support.” Crit Care Med 25, no. 7 (July 1997): 1106–7. https://doi.org/10.1097/00003246-199707000-00005.
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  - MacIntyre, N. R. “Diffusing capacity of the lung for carbon monoxide.” Respir Care Clin N Am 3, no. 2 (June 1997): 221–33.
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  - Bach, J. R., P. Brougher, D. R. Hess, N. S. Hill, R. M. Kacmarek, D. Kreimer, N. R. MacIntyre, et al. “Consensus conference: Noninvasive positive pressure ventilation.” Respiratory Care 42, no. 4 (January 1, 1997): 362–69.
  - MacIntyre, N. R., K. C. Cheng, and R. McConnell. “Applied PEEP during pressure support reduces the inspiratory threshold load of intrinsic PEEP.” Chest 111, no. 1 (January 1997): 188–93. https://doi.org/10.1378/chest.111.1.188.
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  - Mishoe, S. C., and N. R. MacIntyre. “Expanding professional roles for respiratory care practitioners.” Respiratory Care 42, no. 1 (January 1, 1997): 71–91.
  - MacIntyre, N. R. “New modes of mechanical ventilation.” Clin Chest Med 17, no. 3 (September 1996): 411–21. https://doi.org/10.1016/s0272-5231(05)70324-5.
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  - MacIntyre, N. R., B. Lawlor, D. Carstens, and D. Yetsko. “Accuracy and precision of a point-of-care blood gas analyzer incorporating optodes.” Respiratory Care 41, no. 9 (September 1, 1996): 800–804.
  - Abou-Shala, N., and N. MacIntyre. “Emergent management of acute asthma.” Med Clin North Am 80, no. 4 (July 1996): 677–99. https://doi.org/10.1016/s0025-7125(05)70463-6.
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  - Rosenberg, E. “The 1995 update of recommendations for a standard technique for measuring the single-breath carbon monoxide diffusing capacity (transfer factor).” Am J Respir Crit Care Med 154, no. 1 (July 1996): 265–66. https://doi.org/10.1164/ajrccm.154.1.8680694.
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  - MacIntyre, N. R. “What is tracheal pressure-triggering? - And do we need it? Yes! We do need it!.” Respiratory Care 41, no. 6 (June 1, 1996): 524–25.
  - MacIntyre, N. R. “Minimizing alveolar stretch injury during mechanical ventilation.” Respiratory Care 41, no. 4 (April 1, 1996): 318–23.
  - O’Donohue, W. J. “Guidelines for the use of nebulizers in the home and at domiciliary sites. Report of a consensus conference. National Association for Medical Direction of Respiratory Care (NAMDRC) Consensus Group.” Chest 109, no. 3 (March 1996): 814–20. https://doi.org/10.1378/chest.109.3.814.
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  - Fulkerson, W. J., N. MacIntyre, J. Stamler, and J. D. Crapo. “Pathogenesis and treatment of the adult respiratory distress syndrome.” Arch Intern Med 156, no. 1 (January 8, 1996): 29–38.
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  - Branson, R. D., N. R. MacIntyre, N. R. Kacmarek, N. R. W. T. Peruzzi MacIntyre, T. D. East, and T. D. Haas. “Dual-control modes of mechanical ventilation.” Respiratory Care 41, no. 4 (January 1, 1996): 294–305.
  - Crouch, R., and N. MacIntyre. “Asthma rehabilitation program.” Respir Care Clin N Am 1, no. 2 (December 1995): 345–55.
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  - MacIntyre, N. “Mechanical ventilation in asthma.” Respir Care Clin N Am 1, no. 2 (December 1995): 333–43.
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  - MacIntyre, N. R. “Efficacy assessment criteria based on risk and cost.” Respir Care 40, no. 9 (September 1995): 968–70.
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  - “Consensus Conference III: Assessing innovations in mechanical ventilatory support. Conference held January 13-15, 1995 in Ixtapa, Mexico.” Respir Care 40, no. 9 (September 1995): 926–93.
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  - “Standardization of Spirometry, 1994 Update. American Thoracic Society.” Am J Respir Crit Care Med 152, no. 3 (September 1995): 1107–36. https://doi.org/10.1164/ajrccm.152.3.7663792.
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  - Bone, R. C., R. A. Balk, A. M. Fein, T. M. Perl, R. P. Wenzel, H. D. Reines, R. W. Quenzer, T. J. Iberti, N. Macintyre, and R. M. Schein. “A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group.” Crit Care Med 23, no. 6 (June 1995): 994–1006. https://doi.org/10.1097/00003246-199506000-00003.
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  - MacIntyre, N. R. “Controversies in mechanical ventilation.” Contemp Intern Med 7, no. 4 (April 1995): 10–15.
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  - MacIntyre, N. R. “Psychological factors in weaning from mechanical ventilatory support.” Respir Care 40, no. 3 (March 1995): 277–81.
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  - Armstrong, B. W., and N. R. MacIntyre. “Pressure-controlled, inverse ratio ventilation that avoids air trapping in the adult respiratory distress syndrome.” Crit Care Med 23, no. 2 (February 1995): 279–85. https://doi.org/10.1097/00003246-199502000-00013.
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  - Crapo, R. O., J. L. Hankinson, C. Irvin, N. R. MacIntyre, K. Z. Voter, and R. A. Wise. “Single-breath carbon monoxide diffusing capacity (transfer factor): Recommendations for a standard technique - 1995 update.” American Journal of Respiratory and Critical Care Medicine 152, no. 6 I (January 1, 1995): 2185–98.
  - MacIntyre, N. R. “Breathing comfort during weaning with two ventilatory modes.” Am J Respir Crit Care Med 151, no. 1 (January 1995): 254–55. https://doi.org/10.1164/ajrccm.151.1.7812566.
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  - MacIntyre, N. R. “Respiratory factors in weaning from mechanical ventilatory support.” Respiratory Care 40, no. 3 (January 1, 1995): 244–48.
  - Weg, J. G., R. A. Balk, R. S. Tharratt, S. G. Jenkinson, J. B. Shah, D. Zaccardelli, J. Horton, and E. N. Pattishall. “Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome.” Jama 272, no. 18 (November 9, 1994): 1433–38.
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  - Chiang, A. A., A. Steinfeld, C. Gropper, and N. MacIntyre. “Demand-flow airway pressure release ventilation as a partial ventilatory support mode: comparison with synchronized intermittent mandatory ventilation and pressure support ventilation.” Crit Care Med 22, no. 9 (September 1994): 1431–37. https://doi.org/10.1097/00003246-199409000-00013.
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  - Roggli, V. L., P. G. Coin, N. R. MacIntyre, and D. Y. Bell. “Asbestos content of bronchoalveolar lavage fluid. A comparison of light and scanning electron microscopic analysis.” Acta Cytol 38, no. 4 (July 1994): 502–10.
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  - Coleman, R. E., N. MacIntyre, G. Snyder, E. Pattishall, and D. Zaccardelli. “Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf).” Chest 105, no. 6 (June 1994): 1765–69. https://doi.org/10.1378/chest.105.6.1765.
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  - Huang, Y. C., M. J. Helms, and N. R. MacIntyre. “Normal values for single exhalation diffusing capacity and pulmonary capillary blood flow in sitting, supine positions, and during mild exercise.” Chest 105, no. 2 (February 1994): 501–8. https://doi.org/10.1378/chest.105.2.501.
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  - MacIntyre, N. R., C. Gropper, and T. Westfall. “Combining pressure-limiting and volume-cycling features in a patient-interactive mechanical breath.” Crit Care Med 22, no. 2 (February 1994): 353–57. https://doi.org/10.1097/00003246-199402000-00030.
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  - Emery, C. F. “Psychological functioning among middle-aged and older adult pulmonary patients in exercise rehabilitation.” Physical and Occupational Therapy in Geriatrics 12, no. 2 (January 1, 1994): 13–26. https://doi.org/10.1080/J148V12N02_02.
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  - MacIntyre, N. R. “Pressure-limited versus volume-cycled breath delivery strategies.” Crit Care Med 22, no. 1 (January 1994): 4–5.
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  - MacIntyre, N. R. “Automated lateral rotational therapy in the intensive care unit.” Care of the Critically Ill 10, no. 5 (January 1, 1994).
  - MacIntyre, N. R. “Erratum: Building consensus on the use of mechanical ventilation (Chest (1993) 104 (334-335)).” Chest 105, no. 2 (January 1, 1994): 648.
  - MacIntyre, N. R. “Clinically available new strategies for mechanical ventilatory support.” Chest 104, no. 2 (August 1993): 560–65. https://doi.org/10.1378/chest.104.2.560.
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  - MacIntyre, N. R. “Building consensus on the use of mechanical ventilation.” Chest 104, no. 2 (August 1993): 334–35. https://doi.org/10.1378/chest.104.2.334.
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  - Hazinski, M. F., T. J. Iberti, N. R. MacIntyre, M. M. Parker, D. Tribett, S. Prion, and H. Chmel. “Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis.” Am J Crit Care 2, no. 3 (May 1993): 224–35.
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  - Thalman, J. J., S. Rinaldo-Gallo, and N. R. MacIntyre. “Analysis of an endotracheal intubation service provided by respiratory care practitioners.” Respir Care 38, no. 5 (May 1993): 469–73.
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  - Reihsaus, E., M. Innis, N. MacIntyre, and S. B. Liggett. “Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.” Am J Respir Cell Mol Biol 8, no. 3 (March 1993): 334–39. https://doi.org/10.1165/ajrcmb/8.3.334.
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  - MacIntyre, N. R. “Pressure support: Coming of age.” Seminars in Respiratory Medicine 14, no. 4 (January 1, 1993): 293–98. https://doi.org/10.1055/s-2007-1006330.
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  - Huang, Y. C., and N. R. Macintyre. “Real-time gas analysis improves the measurement of single-breath diffusing capacity.” Am Rev Respir Dis 146, no. 4 (October 1992): 946–50. https://doi.org/10.1164/ajrccm/146.4.946.
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  - MacIntyre, N. R., and S. Day. “Essentials for ventilator-alarm systems.” Respir Care 37, no. 9 (September 1992): 1108–12.
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  - Day, S. L., L. Wooton, and N. MacIntyre. “Rapid analysis of exhaled CO2 to assess endotracheal tube placement.” Respiratory Care 37, no. 10 (January 1, 1992): 1161–65.
  - Sherman, C. R., H. Fernandez, N. MacIntyre, and P. Brougher. “ICN spokesmen emphasize virazole (ribavirin) efficacy and safety [1].” Respiratory Care 36, no. 12 (December 1, 1991): 1439–41.
  - Emery, C. F., N. E. Leatherman, E. J. Burker, and N. R. MacIntyre. “Psychological outcomes of a pulmonary rehabilitation program.” Chest 100, no. 3 (September 1991): 613–17. https://doi.org/10.1378/chest.100.3.613.
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  - Greenman, R. L., R. M. Schein, M. A. Martin, R. P. Wenzel, N. R. MacIntyre, G. Emmanuel, H. Chmel, R. B. Kohler, M. McCarthy, and J. Plouffe. “A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group.” Jama 266, no. 8 (August 28, 1991): 1097–1102.
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  - Banner, M. J., R. R. Kirby, and N. R. MacIntyre. “Patient and ventilator work of breathing and ventilatory muscle loads at different levels of pressure support ventilation.” Chest 100, no. 2 (August 1991): 531–33. https://doi.org/10.1378/chest.100.2.531.
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  - MacIntyre, N. R., and L. I. Ho. “Effects of initial flow rate and breath termination criteria on pressure support ventilation.” Chest 99, no. 1 (January 1991): 134–38. https://doi.org/10.1378/chest.99.1.134.
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  - MacIntyre, N., M. Nishimura, Y. Usada, H. Tokioka, J. Takezawa, and Y. Shimada. “The Nagoya conference on system design and patient-ventilator interactions during pressure support ventilation.” Chest 97, no. 6 (June 1990): 1463–66. https://doi.org/10.1378/chest.97.6.1463.
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  - MacIntyre, N. R. “Importance of trigger sensitivity to ventilator response delay in advanced chronic obstructive pulmonary disease with respiratory failure.” Crit Care Med 18, no. 5 (May 1990): 581–82. https://doi.org/10.1097/00003246-199005000-00025.
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  - MacIntyre, N. R., and N. E. Leatherman. “Ventilatory muscle loads and the frequency-tidal volume pattern during inspiratory pressure-assisted (pressure-supported) ventilation.” Am Rev Respir Dis 141, no. 2 (February 1990): 327–31. https://doi.org/10.1164/ajrccm/141.2.327.
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  - Gray, J. E., N. R. MacIntyre, and W. G. Kronenberger. “The effects of bolus normal-saline instillation in conjunction with endotracheal suctioning.” Respiratory Care 35, no. 8 (January 1, 1990): 785–90.
  - MacIntyre, N. R. “Pressure support ventilation.” Problems in Critical Care 4, no. 2 (January 1, 1990): 225–31.
  - MacIntyre, N. R. “Respiratory monitoring without machinery.” Respiratory Care 35, no. 6 (January 1, 1990): 546–56.
  - MacIntyre, N. R. “Oxygen uptake and mechanical ventilation.” Chest 96, no. 2 (August 1989): 446–47. https://doi.org/10.1378/chest.96.2.446-a.
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  - Bergin, C. J., D. Y. Bell, C. L. Coblentz, C. Chiles, G. Gamsu, N. R. MacIntyre, R. E. Coleman, and C. E. Putman. “Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests.” Radiology 171, no. 3 (June 1989): 619–24. https://doi.org/10.1148/radiology.171.3.2717731.
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  - MacIntyre, N. R., and N. E. Leatherman. “Mechanical loads on the ventilatory muscles. A theoretical analysis.” Am Rev Respir Dis 139, no. 4 (April 1989): 968–73. https://doi.org/10.1164/ajrccm/139.4.968.
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  - MacIntyre, N. R. “Diffusing capacity of the lung for carbon monoxide.” Respiratory Care 34, no. 6 (January 1, 1989): 489–99.
  - Marini, J. J., C. S. Roussos, M. J. Tobin, N. R. MacIntyre, M. J. Belman, and J. Moxham. “Weaning from mechanical ventilation.” Am Rev Respir Dis 138, no. 4 (October 1988): 1043–46.
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  - MacIntyre, N. R. “New forms of mechanical ventilation in the adult.” Clin Chest Med 9, no. 1 (March 1988): 47–54.
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  - MacIntyre, N. R. “Weaning from mechanical ventilatory support: Volume-assisting intermittent breaths versus pressure-assisting every breath.” Respiratory Care 33, no. 2 (January 1, 1988): 121–25.
  - MacIntyre, N. R. “Does positive end-expiratory pressure (PEEP) affect the natural history of acute lung injury?...Yes!.” Respiratory Care 33, no. 6 (January 1, 1988): 487–92.
  - Ramage, J. E., R. E. Coleman, and N. R. MacIntyre. “Rest and exercise cardiac output and diffusing capacity assessed by a single slow exhalation of methane, acetylene, and carbon monoxide.” Chest 92, no. 1 (July 1987): 44–50. https://doi.org/10.1378/chest.92.1.44.
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  - MacIntyre, N. R., J. E. Ramage, and J. V. Follett. “Jet ventilation in support of fiberoptic bronchoscopy.” Crit Care Med 15, no. 4 (April 1987): 303–7. https://doi.org/10.1097/00003246-198704000-00004.
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  - MacIntyre, N. R. “Pressure support ventilation: Effects on ventilatory reflexes and ventilatory-muscle workloads.” Respiratory Care 32, no. 6 (January 1, 1987): 447–53.
  - MacIntyre, N. R., J. V. Follett, J. L. Deitz, and B. R. Lawlor. “Jet ventilation at 100 breaths per minute in adult respiratory failure.” Am Rev Respir Dis 134, no. 5 (November 1986): 897–901. https://doi.org/10.1164/arrd.1986.134.5.897.
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  - MacIntyre, N. R. “Respiratory function during pressure support ventilation.” Chest 89, no. 5 (May 1986): 677–83. https://doi.org/10.1378/chest.89.5.677.
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  - MacIntyre, N. R., N. Leatherman, J. L. Deitz, R. Wagoner, and M. Friedman. “Distribution and uptake of helium, carbon monoxide, and acetylene in the lungs during high frequency oscillatory ventilation.” Respir Physiol 63, no. 2 (February 1986): 201–12. https://doi.org/10.1016/0034-5687(86)90114-3.
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  - MacIntyre, N. R., R. M. Silver, C. W. Miller, F. Schuler, and R. E. Coleman. “Aerosol delivery in intubated, mechanically ventilated patients.” Crit Care Med 13, no. 2 (February 1985): 81–84. https://doi.org/10.1097/00003246-198502000-00005.
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  - DeMott, D. “Foreword.” Law & Contemporary Problems, 1985, 1–4.
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  - MacIntyre, N. R., J. L. Deitz, B. R. Lawlor, and R. S. Nagy. “DETERMINANTS OF ARTERIAL OXYGENATION DURING VENTILATION WITH A HIGH FREQUENCY JET VENTILATOR.,” December 1, 1984, 50.
  - Harlan, W. R., C. C. Cowie, A. Oberman, R. E. Mitchell, and N. R. MacIntyre. “Prediction of subsequent ischemic heart disease using serial resting electrocardiograms.” Am J Epidemiol 119, no. 2 (February 1984): 208–17. https://doi.org/10.1093/oxfordjournals.aje.a113739.
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  - Lawlor, B. R., H. R. Anderson, and N. R. MacIntyre. “Accuracy and precision of arterial blood gas measurements from the AVL 940 microsample analyzer.” Respiratory Care 29, no. 10 (January 1, 1984): 1006–8.
  - Osgood, C. F., M. H. Watson, M. S. Slaughter, and N. R. MacIntyre. “Hemodynamic monitoring in respiratory care.” Respir Care 29, no. 1 (January 1984): 25–34.
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  - MacIntyre, N. R., H. R. Anderson, R. M. Silver, F. R. Schuler, and R. E. Coleman. “Pulmonary function in mechanically-ventilated patients during 24-hour use of a hygroscopic condensor humidifier.” Chest 84, no. 5 (November 1983): 560–64. https://doi.org/10.1378/chest.84.5.560.
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  - MacIntyre, N. R., and J. A. Nadel. “Regional diffusing capacity in normal lungs during a slow exhalation.” J Appl Physiol Respir Environ Exerc Physiol 52, no. 6 (June 1982): 1487–92. https://doi.org/10.1152/jappl.1982.52.6.1487.
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  - Stokes, D. L., N. R. MacIntyre, and J. A. Nadel. “Nonlinear increases in diffusing capacity during exercise by seated and supine subjects.” J Appl Physiol Respir Environ Exerc Physiol 51, no. 4 (October 1981): 858–63. https://doi.org/10.1152/jappl.1981.51.4.858.
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  - MacIntyre, N. R., J. R. Kunkler, R. E. Mitchell, A. Oberman, and A. Graybiel. “Eight-year follow-up of exercise electrocardiograms in healthy, middle-aged aviators.” Aviat Space Environ Med 52, no. 4 (April 1981): 256–59.
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  - MacIntyre, N. R., R. E. Mitchell, A. Oberman, W. R. Harlan, and A. Graybiel. “Long-term follow-up of lung volume measurements in initially healthy young aviators.” Aviat Space Environ Med 52, no. 1 (January 1981): 1–5.
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  - MacIntyre, N. R., R. E. Mitchell, A. Oberman, W. R. Harlan, A. Graybiel, and E. Johnson. “Longevity in military pilots: 37-year followup of the Navy's "1000 aviators".” Aviat Space Environ Med 49, no. 9 (September 1978): 1120–22.
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- Book Sections
  - Radcliff, V., and N. MacIntyre. “Mechanical ventilation.” In Surgical Intensive Care Medicine, Third Edition, 335–47, 2016. https://doi.org/10.1007/978-3-319-19668-8_25.
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- Other Articles
  - Kim, Woo Jin, Edwin K. Silverman, Eric Hoffman, Gerard J. Criner, Zab Mosenifar, Frank C. Sciurba, Barry J. Make, et al. “CT metrics of airway disease and emphysema in severe COPD.” Chest, August 2009. https://doi.org/10.1378/chest.08-2858.
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- Conference Papers
  - Criner, Rachel N., Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, et al. “Relationship between diffusion capacity and small airway abnormality in COPDGene.” In Respir Res, 20:269, 2019. https://doi.org/10.1186/s12931-019-1237-1.
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  - Schoenberg, Noah C., Alan F. Barker, John Bernardo, Robin R. Deterding, Jerrold J. Ellner, Dean R. Hess, Neil R. MacIntyre, Fernando J. Martinez, and Kevin C. Wilson. “A Comparative Analysis of Pulmonary and Critical Care Medicine Guideline Development Methodologies.” In Am J Respir Crit Care Med, 196:621–27, 2017. https://doi.org/10.1164/rccm.201705-0926OC.
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  - MacIntyre, N. R. “Respiratory mechanics in the patient who is weaning from the ventilator.” In Respiratory Care, 50:275–84, 2005.

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