Scholars@Duke
Neil Ross MacIntyre Jr.

Neil Ross MacIntyre Jr.

Professor Emeritus of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
macin001@mc.duke.edu
Duke Box 3911, Durham, NC 27710
1120 Hosp North, Durham, NC 27710

Selected Publications

A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease.

Journal Article JAMA · June 24, 2025 IMPORTANCE: Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung disease on chest computed tomography. Current guidelines recommend COPD diagnosti ... Full text Link to item Cite

Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.

Journal Article J Am Heart Assoc · January 21, 2025 BACKGROUND: Meta-analyses have suggested that the risk of cardiovascular disease events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation, but the populations at highest risk have not been well characterized to date. ... Full text Link to item Cite

Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring.

Journal Article Int J Chron Obstruct Pulmon Dis · 2025 OBJECTIVE: Fewer than 3% of adults with Chronic Obstructive Pulmonary Disease (COPD) attend in-person, center-based pulmonary rehabilitation (PR) despite demonstrated health benefits and reduction in mortality. This study evaluated the feasibility and usab ... Full text Link to item Cite

Let It Breathe: Mastering Spontaneous Breathing Trials

Journal Article Respiratory Care · December 1, 2024 Full text Cite

Risk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults.

Journal Article Ann Am Thorac Soc · November 2024 Rationale: Meta-analyses have suggested the risk of cardiovascular disease (CVD) events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation. However, many of these studies have included a broad array of CVD events or h ... Full text Link to item Cite

AARC Clinical Practice Guideline: Spontaneous Breathing Trials for Liberation From Adult Mechanical Ventilation.

Journal Article Respir Care · June 28, 2024 Despite prior publications of clinical practice guidelines related to ventilator liberation, some questions remain unanswered. Many of these questions relate to the details of bedside implementation. We, therefore, formed a guidelines committee of individu ... Full text Link to item Cite

Pulmonary Rehabilitation: A Look Back, a Look Forward.

Journal Article Respiratory care · May 2024 Pulmonary rehabilitation (PR) is a comprehensive approach to the management of patients with chronic lung disease that encompasses exercise, education, and psychosocial support. The development of PR programs began in the mid-20th century with the apprecia ... Full text Cite

Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial - A Randomized Clinical Trial.

Journal Article Am J Respir Crit Care Med · March 1, 2024 Rationale: It is unclear whether extracorporeal CO2 removal (ECCO2R) can reduce the rate of intubation or the total time on invasive mechanical ventilation (IMV) in adults experiencing an exacerbation of chronic obstructive pulmonary disease (COPD). Object ... Full text Link to item Cite

Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations.

Journal Article American journal of respiratory and critical care medicine · January 2024 Rationale: The identification of early chronic obstructive pulmonary disease (COPD) is essential to appropriately counsel patients regarding smoking cessation, provide symptomatic treatment, and eventually develop disease-modifying treatments. Disea ... Full text Cite

Do Breath Types and Modes Matter?

Journal Article Respir Care · October 2023 Full text Link to item Cite

Prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya: a single-centre, prospective cohort study.

Journal Article BMJ Open · September 18, 2023 OBJECTIVE: Global medical oxygen security is limited by knowledge gaps in hypoxaemia burden and oxygen access in low-income and middle-income countries. We examined the prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya ... Full text Open Access Link to item Cite

Acute Hypercapnic Respiratory Failure in COPD.

Journal Article Respir Care · July 2023 COPD is a progressive inflammatory process affecting both the airways and alveolar structures of the lungs. Exacerbations of COPD are episodes of acute worsening of this inflammatory process, often triggered by infections. The most severe exacerbations are ... Full text Link to item Cite

Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease.

Journal Article Ann Am Thorac Soc · January 2023 Rationale: Chronic obstructive pulmonary disease (COPD) mortality risk is often estimated using the BODE (body mass index, obstruction, dyspnea, exercise capacity) index, including body mass index, forced expiratory volume in 1 second, dyspnea score, and 6 ... Full text Link to item Cite

Basic principles of mechanical ventilation

Chapter · January 1, 2023 Positive-pressure mechanical ventilatory support is a critical component in the management of patients with respiratory failure. However, it is important to note that this technology is supportive, not therapeutic, and it cannot cure lung injury. Indeed, t ... Full text Cite

Timing of Treatment Outcomes and Risk Factors for Failure of BPAP in Patients Hospitalized for COPD Exacerbation.

Journal Article Respir Care · December 2022 BACKGROUND: Patients hospitalized for COPD exacerbation have an increased risk of mortality, particularly among those who fail bi-level positive airway pressure (BPAP) for hypercapnic respiratory failure subsequently requiring invasive mechanical ventilati ... Full text Link to item Cite

ERS/ATS technical standard on interpretive strategies for routine lung function tests.

Journal Article Eur Respir J · July 2022 BACKGROUND: Appropriate interpretation of pulmonary function tests (PFTs) involves the classification of observed values as within/outside the normal range based on a reference population of healthy individuals, integrating knowledge of physiological deter ... Full text Link to item Cite

Best Practice Management of Patients With Chronic Obstructive Pulmonary Disease: A Case-Based Review

Journal Article Journal for Nurse Practitioners · July 1, 2022 Chronic obstructive pulmonary disease (COPD) is associated with a high clinical and economic burden and is the fourth leading cause of death in the United States. The management of patients with COPD aims to minimize and control symptoms, prevent exacerbat ... Full text Cite

Cost-effectiveness of Pulmonary Rehabilitation Among US Adults With Chronic Obstructive Pulmonary Disease.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Pulmonary rehabilitation (PR) after exacerbation of chronic obstructive pulmonary disease (COPD) is effective in reducing COPD hospitalizations and mortality while improving health-related quality of life, yet use of PR remains low. Estimates o ... Full text Link to item Cite

Managing Patient-Ventilator Dyssynchrony.

Journal Article Crit Care Med · December 1, 2021 Full text Link to item Cite

Optimal NIV Medicare Access Promotion: Patients With COPD: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Journal Article Chest · November 2021 This document summarizes the work of the COPD Technical Expert Panel working group. For patients with COPD, the most pressing current coverage barriers identified were onerous diagnostic requirements focused on oxygenation (rather than ventilation) and dif ... Full text Link to item Cite

Optimal NIV Medicare Access Promotion: Patients With Central Sleep Apnea: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Journal Article Chest · November 2021 This document summarizes suggestions of the central sleep apnea (CSA) Technical Expert Panel working group. This paper shares our vision for bringing the right device to the right patient at the right time. For patients with CSA, current coverage criteria ... Full text Link to item Cite

Optimal NIV Medicare Access Promotion: Patients With Hypoventilation Syndromes: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Journal Article Chest · November 2021 The existing coverage criteria for home noninvasive ventilation (NIV) do not recognize the diversity of hypoventilation syndromes and advances in technologies. This document summarizes the work of the hypoventilation syndromes Technical Expert Panel workin ... Full text Link to item Cite

Optimal NIV Medicare Access Promotion: Patients With OSA: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Journal Article Chest · November 2021 This document summarizes the work of the CPAP and bilevel PAP therapy for OSA Technical Expert Panel working group. For positive airway pressure (PAP) therapy, the most pressing current coverage barriers identified were: an insufficient symptom list descri ... Full text Link to item Cite

Optimal NIV Medicare Access Promotion: Patients With Thoracic Restrictive Disorders: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Journal Article Chest · November 2021 The existing coverage criteria for noninvasive ventilation (NIV) do not recognize the benefits of early initiation of NIV for those with thoracic restrictive disorders and do not address the unique needs for daytime support as the patients progress to vent ... Full text Link to item Cite

Executive Summary: Optimal NIV Medicare Access Promotion: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Journal Article Chest · November 2021 The current national coverage determinations (NCDs) for noninvasive ventilation for patients with thoracic restrictive disorders, COPD, and hypoventilation syndromes were formulated in 1998. New original research, updated formal practice guidelines, and cu ... Full text Link to item Cite

Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort.

Journal Article Chest · October 2021 BACKGROUND: Attenuation of transforming growth factor β by blocking angiotensin II has been shown to reduce emphysema in a murine model. General population studies have demonstrated that the use of angiotensin converting enzyme inhibitors (ACEis) and angio ... Full text Link to item Cite

The Association Between Lung Hyperinflation and Coronary Artery Disease in Smokers.

Journal Article Chest · September 2021 BACKGROUND: Smokers manifest varied phenotypes of pulmonary impairment. RESEARCH QUESTION: Which pulmonary phenotypes are associated with coronary artery disease (CAD) in smokers? STUDY DESIGN AND METHODS: We analyzed data from the University of Pittsburgh ... Full text Link to item Cite

Impact of a Formal Research Committee on Respiratory Therapists' Publications.

Journal Article Respir Care · August 2021 BACKGROUND: Presenting research at national and international meetings is an important aspect of the practice of respiratory care. Our department regularly presented abstracts but few projects were written up as manuscripts. We also noted that we did not h ... Full text Link to item Cite

Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease.

Journal Article ERJ Open Res · July 2021 In COPD, anaemia is associated with increased morbidity, but the relationship between haemoglobin over its entire observed range and morbidity is poorly understood. Such an understanding could guide future therapeutic targeting of haemoglobin in COPD manag ... Full text Link to item Cite

Oxygen delivery systems for adults in Sub-Saharan Africa: A scoping review.

Journal Article J Glob Health · May 8, 2021 BACKGROUND: Respiratory diseases are the leading cause of death and disability worldwide. Oxygen is an essential medicine used to treat hypoxemia from respiratory diseases. However, the availability and utilization of oxygen delivery systems for adults in ... Full text Open Access Link to item Cite

Application of Machine Learning in Pulmonary Function Assessment Where Are We Now and Where Are We Going?

Journal Article Front Physiol · 2021 Analysis of pulmonary function tests (PFTs) is an area where machine learning (ML) may benefit clinicians, researchers, and the patients. PFT measures spirometry, lung volumes, and carbon monoxide diffusion capacity of the lung (DLCO). The results are usua ... Full text Open Access Link to item Cite

Evaluation of a novel endotracheal tube suctioning system incorporating an inflatable sweeper.

Journal Article Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · January 2021 IntroductionAccumulation of secretions in an endotracheal tube can increase the resistance to flow resulting in an increased patient work of breathing when the patient is interacting with the ventilator. Retained secretions can also serve as an in ... Full text Cite

Cardio-Respiratory tolerability of perfluoropropaneEnhanced MRI of pulmonary ventilation

Conference Journal of Lung, Pulmonary & Respiratory Research · December 30, 2020 Rationale: Recent advances in perfluoropropane magnetic resonance imaging of the lung have provided the means to assess pulmonary ventilation and gas distribution throughout the pulmonary airways and acini in a non-invasive manner. Objectives: The ... Full text Cite

Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens. From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force.

Journal Article Ann Am Thorac Soc · November 2020 Background: In March 2020, many elective medical services were canceled in response to the coronavirus disease 2019 (COVID-19) pandemic. The daily case rate is now declining in many states and there is a need for guidance about the resumption of elective c ... Full text Link to item Cite

Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-analysis.

Journal Article Chest · October 2020 BACKGROUND: Hypogammaglobulinemia (serum IgG levels < 7.0 g/L) has been associated with increased risk of COPD exacerbations but has not yet been shown to predict hospitalizations. RESEARCH QUESTION: To determine the relationship between hypogammaglobuline ... Full text Link to item Cite

Hypercapnia in Advanced Chronic Obstructive Pulmonary Disease: A Secondary Analysis of the National Emphysema Treatment Trial.

Journal Article Chronic Obstr Pulm Dis · October 2020 RATIONALE: Hypercapnia develops in one third of patients with advanced chronic obstructive pulmonary disease (COPD) and is associated with increased morbidity and mortality. Multiple factors in COPD are thought to contribute to the development of hypercapn ... Full text Link to item Cite

Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.

Journal Article Respir Care · September 2020 BACKGROUND: Unanticipated respiratory compromise that lead to unplanned intubations is a known phenomenon in hospitalized patients. Most events occur in patients at high risk in well-monitored units; less is known about the incidence, risk factors, and tra ... Full text Link to item Cite

Toward Reducing COPD Hospitalization.

Journal Article Respir Care · January 2020 Full text Link to item Cite

Evaluation of Hypoxemia Among Patients Admitted to a Tertiary Referral Hospital in Western Kenya

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Relationship between diffusion capacity and small airway abnormality in COPDGene.

Conference Respir Res · December 2, 2019 Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, ... Full text Link to item Cite

Diffusing Capacity of Carbon Monoxide in Assessment of COPD.

Journal Article Chest · December 2019 BACKGROUND: Diffusing capacity of the lung for carbon monoxide (Dlco) is inconsistently obtained in patients with COPD, and the added benefit of Dlco testing beyond that of more common tools is unknown. OBJECTIVE: The goal of this study was to determine wh ... Full text Link to item Cite

The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition.

Journal Article Chest · October 2019 BACKGROUND: Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George's Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ C ... Full text Link to item Cite

Low Tidal Volumes for Everyone?

Journal Article Chest · October 2019 Since the first description of mechanical ventilation, our understanding of the positive and negative effects of this form of life support has continued to evolve. To maintain "normal" aeration of the lungs and "normal" blood gas measurements, patients oft ... Full text Link to item Cite

Physiologic Effects of Noninvasive Ventilation.

Journal Article Respir Care · June 2019 Noninvasive ventilation (NIV) has a number of physiologic effects similar to invasive ventilation. The major effects are to augment minute ventilation and reduce muscle loading. These effects, in turn, can have profound effects on the patient's ventilator ... Full text Link to item Cite

Hemoglobin as a Biomarker for Clinical Outcomes in Chronic Obstructive Pulmonary Disease

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Respiratory Failure and Unplanned Intubations in General Floor Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Measurement of single-breath diffusing capacity of the lungs for carbon monoxide: New standards of European respiratory society and American thoracic society (part 1)

Journal Article Pulmonologiya · January 1, 2019 This document is updated technical standards of European Respiratory Society (ERS) and American Thoracic Society (ATS) for single-breath carbon monoxide diffusing capacity measurement. The previous version of this document was published in 2005. Both terms ... Full text Cite

Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study.

Journal Article Am J Respir Crit Care Med · December 1, 2018 RATIONALE: Increasing awareness of the prevalence and significance of Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded the ... Full text Link to item Cite

Pulmonary rehabilitation: Mechanisms of benefits

Chapter · October 24, 2018 Pulmonary rehabilitation increases exercise tolerance and improves general well-b eing o f patients with chronic lung disease. The m echanism s o f these benefits, how ever, are not clear. This paper w ill review the rationale and supporting data for physi ... Cite

Pulmonary rehabilitation: Current status and future trends

Chapter · October 24, 2018 Pulmonary rehabilitation is a relatively new approach to the treatment o f patients with chronic lung disease. These programs are designed to m axim ize the functional capabilities o f such patients through a formal program o f education, exercise, physica ... Cite

Characterizing Nebulizer Performance for Methacholine Challenge Tests.

Journal Article Am J Respir Crit Care Med · October 15, 2018 Full text Link to item Cite

Rebuttal From Dr MacIntyre.

Journal Article Chest · September 2018 Full text Link to item Cite

Reply to Johnson: Improve Pulmonary Function Test Reporting.

Journal Article Am J Respir Crit Care Med · July 1, 2018 Full text Link to item Cite

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

Journal Article J Allergy Clin Immunol · June 2018 BACKGROUND: Eosinophilic airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting potential shared mechanisms with eosinophilic asthma. However, there is no ... Full text Link to item Cite

Titrating Oxygen Requirements During Exercise: Evaluation of a Standardized Single Walk Test Protocol.

Journal Article Chest · April 2018 BACKGROUND: Oxygen supplementation for exercise-induced hypoxemia is a common clinical practice that improves exercise tolerance. However, we know of no standardized exercise oxygen titration protocol using a single walk test. We report our experience with ... Full text Link to item Cite

Pulmonary Delivery of Therapeutic and Diagnostic Gases.

Journal Article J Aerosol Med Pulm Drug Deliv · April 2018 The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseo ... Full text Open Access Link to item Cite

Clinical Differences in COPD Patients with Variable Patterns of Hypoxemia.

Journal Article Chronic obstructive pulmonary diseases (Miami, Fla.) · April 2018 Background: Chronic obstructive pulmonary disease (COPD) patients enrolled into the Long-term Oxygen Treatment Trial had hypoxemia at rest, hypoxemia on exertion, or hypoxemia both at rest and on exertion. We hypothesized that patients with differen ... Full text Cite

Airway pressure release ventilation: a step forward?

Journal Article Intensive Care Med · February 2018 Full text Link to item Cite

Validation of spirometry prediction equations in western Kenya.

Journal Article Int J Tuberc Lung Dis · January 1, 2018 SETTING: Community of Eldoret, Kenya. OBJECTIVE: To test the performance of three commonly used spirometry prediction equations in a healthy Kenyan population. DESIGN: Cross-sectional assessment of healthy adults in Eldoret. RESULTS: Of the 331 subjects en ... Full text Link to item Cite

The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned.

Journal Article Ann Am Thorac Soc · January 2018 The Long-Term Oxygen Treatment Trial demonstrated that long-term supplemental oxygen did not reduce time to hospital admission or death for patients who have stable chronic obstructive pulmonary disease and resting and/or exercise-induced moderate oxyhemog ... Full text Link to item Cite

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.

Journal Article Chest · January 2018 BACKGROUND: Emphysema has considerable variability in its regional distribution. Craniocaudal emphysema distribution is an important predictor of the response to lung volume reduction. However, there is little consensus regarding how to define upper lobe-p ... Full text Link to item Cite

DLCO Is Associated with COPD Morbidity Beyond Spirometry and CT Evidence of Emphysema in COPDGene

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement.

Journal Article Am J Respir Crit Care Med · December 1, 2017 BACKGROUND: The American Thoracic Society committee on Proficiency Standards for Pulmonary Function Laboratories has recognized the need for a standardized reporting format for pulmonary function tests. Although prior documents have offered guidance on the ... Full text Link to item Cite

Clinical Management Strategies for Airway Pressure Release Ventilation: A Survey of Clinical Practice.

Journal Article Respir Care · October 2017 BACKGROUND: Airway pressure release ventilation (APRV) is a commonly used mode of ventilation designed to increase mean airway pressure and thus oxygenation. Different strategies for clinical management have been described in the literature but are largely ... Full text Link to item Cite

A Comparative Analysis of Pulmonary and Critical Care Medicine Guideline Development Methodologies.

Conference Am J Respir Crit Care Med · September 1, 2017 RATIONALE: The Institute of Medicine (IOM) standards for guideline development have had unintended negative consequences. A more efficient approach is desirable. OBJECTIVES: To determine whether a modified Delphi process early during guideline development ... Full text Link to item Cite

Respiratory Compromise as a New Paradigm for the Care of Vulnerable Hospitalized Patients.

Journal Article Respir Care · April 2017 Acute respiratory compromise describes a deterioration in respiratory function with a high likelihood of rapid progression to respiratory failure and death. Identifying patients at risk for respiratory compromise coupled with monitoring of patients who hav ... Full text Link to item Cite

Another Look at Outcomes from Mechanical Ventilation.

Journal Article Am J Respir Crit Care Med · March 15, 2017 Full text Link to item Cite

Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

Journal Article Am J Respir Cell Mol Biol · March 2017 Chronic obstructive pulmonary disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the heritability remains unexplained. S ... Full text Link to item Cite

2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung.

Journal Article Eur Respir J · January 2017 This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both DLCO (diffusing capacity) and T ... Full text Link to item Cite

Executive Summary: 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung.

Journal Article Eur Respir J · January 2017 This document summarises an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. The full standards are also available onlin ... Full text Link to item Cite

Design Features of Modern Mechanical Ventilators.

Journal Article Clin Chest Med · December 2016 A positive-pressure breath ideally should provide a VT that is adequate for gas exchange and appropriate muscle unloading while minimizing any risk for injury or discomfort. The latest generation of ventilators uses sophisticated feedback systems to sculpt ... Full text Link to item Cite

Evolving Concepts in Mechanical Ventilation.

Journal Article Clin Chest Med · December 2016 Full text Link to item Cite

A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.

Journal Article N Engl J Med · October 27, 2016 BACKGROUND: Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. METHODS: We originally designed the trial to test whet ... Full text Link to item Cite

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Journal Article PLoS Genet · August 2016 Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental variations contribute to phenotypic di ... Full text Link to item Cite

Should High-Frequency Ventilation in the Adult Be Abandoned?

Journal Article Respir Care · June 2016 High-frequency oscillatory ventilation (HFOV) can improve ventilation-perfusion matching without excessive alveolar tidal stretching or collapse-reopening phenomenon. This is an attractive feature in the ventilation of patients with ARDS. However, two rece ... Full text Link to item Cite

Should Early Mobilization Be Routine in Mechanically Ventilated Patients?

Journal Article Respir Care · June 2016 ICU-acquired weakness is a major complication of critical illness requiring mechanical ventilation. Early mobilization has been shown to decrease the negative consequences of ICU-acquired weakness. However, early mobilization might entail risks to the pati ... Full text Link to item Cite

Phenotype of Spirometric Impairment in an Aging Population.

Journal Article Am J Respir Crit Care Med · April 1, 2016 RATIONALE: The Global Lung Initiative (GLI) provides age-appropriate criteria for establishing spirometric impairment, including mild, moderate, and severe chronic obstructive pulmonary disease (COPD) and restrictive pattern, but its association with respi ... Full text Link to item Cite

Oxygen: Providing Too Much of a Good Thing?

Journal Article Crit Care Med · March 2016 Full text Link to item Cite

Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort.

Journal Article BMC Pulm Med · February 10, 2016 BACKGROUND: Despite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study taking inhaled medications. METHODS ... Full text Link to item Cite

Mechanical ventilation

Chapter · January 1, 2016 Mechanical ventilation in modern intensive care units is the process of using positive-pressure devices to support the transport of O2 and CO2 between the environment and the pulmonary capillary bed. The desired effect of mechanical v ... Full text Cite

The Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet): diagnostic and adjudication processes.

Journal Article Chest · October 2015 BACKGROUND: The National Heart, Lung, and Blood Institute-sponsored IPF Clinical Research Network (IPFnet) studies enrolled subjects with idiopathic pulmonary fibrosis (IPF) to evaluate drug therapies in treatment trials. An adjudication committee (AC) pro ... Full text Link to item Cite

Phenotype of normal spirometry in an aging population.

Journal Article Am J Respir Crit Care Med · October 1, 2015 RATIONALE: In aging populations, the commonly used Global Initiative for Chronic Obstructive Lung Disease (GOLD) may misclassify normal spirometry as respiratory impairment (airflow obstruction and restrictive pattern), including the presumption of respira ... Full text Link to item Cite

Clinical and Radiologic Disease in Smokers With Normal Spirometry.

Journal Article JAMA Intern Med · September 2015 IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and r ... Full text Link to item Cite

Take a Deep Breath-or Not.

Journal Article Crit Care Med · September 2015 Full text Link to item Cite

Aerosol Therapy in Pulmonary Critical Care Discussion

Journal Article RESPIRATORY CARE · June 1, 2015 Link to item Cite

Aerosolized Antibiotics Discussion

Journal Article RESPIRATORY CARE · June 1, 2015 Link to item Cite

Patient Education and Adherence to Aerosol Therapy Discussion

Journal Article RESPIRATORY CARE · June 1, 2015 Link to item Cite

Inhaled Therapies for Pulmonary Hypertension Discussion

Journal Article RESPIRATORY CARE · June 1, 2015 Link to item Cite

Discussion

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Pneumonia

Chapter · April 6, 2015 With foundations in evidence-based practice, this essential resource reviews respiratory assessment, respiratory therapeutics, respiratory diseases, basic sciences and their application to respiratory care, the respiratory care profession, ... ... Cite

Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.

Journal Article Crit Care Med · February 2015 OBJECTIVES: In the Fluid and Catheter Treatment Trial (FACTT) of the National Institutes of Health Acute Respiratory Distress Syndrome Network, a conservative fluid protocol (FACTT Conservative) resulted in a lower cumulative fluid balance and better outco ... Full text Link to item Cite

Body temperature and mortality in patients with acute respiratory distress syndrome.

Journal Article Am J Crit Care · January 2015 BACKGROUND: Little is known about the relationship between body temperature and outcomes in patients with acute respiratory distress syndrome (ARDS). A better understanding of this relationship may provide evidence for fever suppression or warming interven ... Full text Link to item Cite

Short Term Repeatability Of Perfluorinated Gas Imaging In A Series Of Subjects With Asthma (mild And Moderate/severe)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Mechanical Ventilation

Chapter · January 1, 2015 Full text Cite

Analysis of radial artery catheter placement by respiratory therapists using ultrasound guidance.

Journal Article Respir Care · December 2014 BACKGROUND: The use of ultrasound (US) guidance for radial artery cannulation has been shown to improve first attempt success rate, reduce time to successful cannulation, and reduce complications. We sought to determine whether properly trained respiratory ... Full text Link to item Cite

An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease.

Journal Article Eur Respir J · December 2014 Field walking tests are commonly employed to evaluate exercise capacity, assess prognosis and evaluate treatment response in chronic respiratory diseases. In recent years, there has been a wealth of new literature pertinent to the conduct of the 6-min walk ... Full text Link to item Cite

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease.

Journal Article Eur Respir J · December 2014 This systematic review examined the measurement properties of the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease. Studies that report the evaluation or use of t ... Full text Link to item Cite

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.

Journal Article Am J Respir Cell Mol Biol · November 2014 Hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among patien ... Full text Link to item Cite

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.

Journal Article Ann Am Thorac Soc · November 2014 RATIONALE: The demographic, physiological, and computed tomography (CT) features associated with pneumothorax in smokers with and without chronic obstructive pulmonary disease (COPD) are not clearly defined. OBJECTIVES: We evaluated the hypothesis that pne ... Full text Link to item Cite

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.

Journal Article BMC Pulm Med · October 24, 2014 BACKGROUND: Chronic obstructive pulmonary disease (COPD) has been classically divided into blue bloaters and pink puffers. The utility of these clinical subtypes is unclear. However, the broader distinction between airway-predominant and emphysema-predomin ... Full text Link to item Cite

Tissue hypoxia: implications for the respiratory clinician.

Journal Article Respir Care · October 2014 Oxygen is essential for normal aerobic metabolism in mammals. Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low blood oxygen content and pressure), impaired oxygen delivery, and i ... Full text Link to item Cite

Prediction of acute respiratory disease in current and former smokers with and without COPD.

Journal Article Chest · October 2014 BACKGROUND: The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown. METHODS: Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epid ... Full text Link to item Cite

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.

Journal Article Respir Res · September 21, 2014 BACKGROUND: Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and to assess for genetic differences ... Full text Link to item Cite

DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.

Journal Article Respir Res · August 20, 2014 BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of life in COPD patients. Total lung ... Full text Link to item Cite

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.

Journal Article Respir Res · August 6, 2014 BACKGROUND: Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies invest ... Full text Link to item Cite

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

Journal Article Respiratory Research · August 6, 2014 Background: Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mor ... Full text Cite

Ventilation and anesthetic approaches for rigid bronchoscopy.

Journal Article Ann Am Thorac Soc · May 2014 Due to growing interest in management of central airway obstruction, rigid bronchoscopy is undergoing a resurgence in popularity among pulmonologists. Performing rigid bronchoscopy requires use of deep sedation or general anesthesia to achieve adequate pat ... Full text Link to item Cite

Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study.

Journal Article Respir Res · April 27, 2014 BACKGROUND: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more ... Full text Link to item Cite

Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study

Journal Article Respiratory Research · April 27, 2014 Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more ... Full text Cite

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Journal Article Lancet Respir Med · March 2014 BACKGROUND: The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified by genome-wide association studies in larger cohorts or specific subg ... Full text Link to item Cite

Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis.

Journal Article Respir Med · January 2014 BACKGROUND: Dyspnea is a hallmark symptom of idiopathic pulmonary fibrosis (IPF), and dyspnea induced physical activity limitation is a prominent driver of quality of life impairment among IPF patients. METHODS: We examined response data for the 21 physica ... Full text Link to item Cite

Patient-ventilator interactions. Implications for clinical management.

Journal Article Am J Respir Crit Care Med · November 1, 2013 Assisted/supported modes of mechanical ventilation offer significant advantages over controlled modes in terms of ventilator muscle function/recovery and patient comfort (and sedation needs). However, assisted/supported breaths must interact with patient d ... Full text Link to item Cite

Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.

Journal Article Chest · October 2013 BACKGROUND: Fluorine-enhanced MRI is a relatively inexpensive and straightforward technique that facilitates regional assessments of pulmonary ventilation. In this report, we assess its suitability through the use of perfluoropropane (PFP) in a cohort of h ... Full text Link to item Cite

Novel modes of mechanical ventilation.

Journal Article Semin Respir Crit Care Med · August 2013 The overarching goal of positive pressure mechanical ventilation is to provide adequate gas exchange support while not causing harm. Indeed, positive pressure mechanical ventilators are only support technologies, not therapeutic technologies. As such they ... Full text Link to item Cite

Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials.

Journal Article Respir Res · July 13, 2013 BACKGROUND: Acute exacerbation of idiopathic pulmonary fibrosis has become an important outcome measure in clinical trials. This study aimed to explore the concept of suspected acute exacerbation as an outcome measure. METHODS: Three investigators retrospe ... Full text Link to item Cite

Patient-ventilator trigger dys-synchrony: a common phenomenon with important implications.

Journal Article Crit Care · June 18, 2013 Patient-ventilator trigger dys-synchronies are common with the use of assisted forms of mechanical ventilatory support, including non-invasive mechanical ventilatory support (NIV). Future system designs need to address this in order to improve the effectiv ... Full text Link to item Cite

The ventilator discontinuation process: an expanding evidence base.

Journal Article Respir Care · June 2013 The ventilator discontinuation process is an essential component of overall ventilator management. Undue delay leads to excess stay, iatrogenic lung injury, unnecessary sedation, and even higher mortality. On the other hand, premature withdrawal can lead t ... Full text Link to item Cite

Apnea testing during brain death assessment: a review of clinical practice and published literature.

Journal Article Respir Care · March 2013 The diagnosis of brain death is a complex process. Strong knowledge of neurophysiology and an understanding of brain death etiology must be used to confidently determine brain death. The key findings in brain death are unresponsiveness, and absence of brai ... Full text Link to item Cite

Multi-Breath Steady-State Ventilation Distribution Via 19fluorine-Enhanced Mri

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

A systematic approach to analyse the sequelae of LCPD.

Journal Article Hip Int · 2013 The analysis and treatment of hips with healed Legg-Calvé-Perthes disease (LCPD) differs substantially from the treatment in the acute phase of the disease. More specifically, the treating orthopaedic surgeon is often faced with a complex three-dimensional ... Full text Link to item Cite

Preface

Journal Article Biomedical Optical Phase Microscopy and Nanoscopy · January 1, 2013 Full text Cite

Supporting oxygenation in acute respiratory failure.

Journal Article Respir Care · January 2013 Strategies to support oxygenation can cause substantial harm through lung stretch injury, oxygen toxicity, transfusion risks and cardiac over-stimulation. Traditional goals of maintaining near normal cardiorespiratory parameters are most likely overly simp ... Full text Link to item Cite

Evidence-based assessments in the ventilator discontinuation process.

Journal Article Respir Care · October 2012 The ventilator discontinuation process is an essential component of overall ventilator management. Undue delay leads to excess stay, iatrogenic lung injury, unnecessary sedation, and even higher mortality. On the other hand, premature withdrawal can lead t ... Full text Link to item Cite

Chronic critical illness: the growing challenge to health care.

Journal Article Respir Care · June 2012 The chronically critically ill (CCI) comprise a rapidly growing population of patients who have survived acute critical illness, only to be left with ongoing organ dysfunctions requiring high levels of specialized care for months or years. In many ways, CC ... Full text Link to item Cite

Rebuttal From Dr Miller et al

Journal Article Chest · June 1, 2012 Full text Cite

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease.

Journal Article Thorax · May 2012 BACKGROUND: The value of quantitative CT (QCT) to identify chronic obstructive pulmonary disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Q ... Full text Link to item Cite

Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.

Journal Article Chest · April 2012 BACKGROUND: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV(1). We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) ... Full text Link to item Cite

Respiratory care year in review 2011: long-term oxygen therapy, pulmonary rehabilitation, airway management, acute lung injury, education, and management.

Journal Article Respir Care · April 2012 For the busy clinician, educator, or manager, it is becoming an increasing challenge to filter the literature to what is relevant to one's practice and then update one's practice based on the current evidence. The purpose of this paper is to review the rec ... Full text Link to item Cite

Long-term intersession variability for single-breath diffusing capacity.

Journal Article Respiration · 2012 BACKGROUND: Characterizing long-term diffusing capacity (DL(CO)) variability is important in assessing quality control for DL(CO) equipment and patient management. Long-term DL(CO) variability has not been reported. OBJECTIVES: It was the aim of this study ... Full text Link to item Cite

The future of pulmonary function testing.

Journal Article Respir Care · January 2012 The pulmonary function lab of today is heavily focused on describing pathophysiology and quantifying the extent of disease. As we move forward, it is important that the results of pulmonary function tests go beyond this and be linked to important outcomes ... Full text Link to item Cite

Foreword

Journal Article Mm 11 Proceedings of the 2011 ACM Multimedia Conference and Co Located Workshops ACM International Workshop on Multimedia Technologies for Distance Learning Mtdl 11 · December 1, 2011 Cite

Genome-wide association study of smoking behaviours in patients with COPD.

Journal Article Thorax · October 2011 Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the numb ... Full text Link to item Cite

Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.

Journal Article Am J Respir Crit Care Med · September 1, 2011 RATIONALE: β₂-Adrenergic receptor agonists accelerate resolution of pulmonary edema in experimental and clinical studies. OBJECTIVES: This clinical trial was designed to test the hypothesis that an aerosolized β₂-agonist, albuterol, would improve clinical ... Full text Link to item Cite

Ventilator discontinuation: why are we still weaning?

Journal Article Am J Respir Crit Care Med · August 15, 2011 Full text Link to item Cite

Rebuttal From Dr MacIntyre

Journal Article Chest · August 1, 2011 Full text Cite

Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory hypoxemia within the framework of a pandemic.

Journal Article Pediatr Crit Care Med · July 2011 OBJECTIVE: We report the process used to rapidly develop a collaborative adult respiratory extracorporeal membrane oxygenation program as a response to caring for young adult patients with refractory hypoxemia in the setting of the pH1N1 pandemic. DESIGN: ... Full text Link to item Cite

Respiratory care year in review 2010: part 2. Invasive mechanical ventilation, noninvasive ventilation, pediatric mechanical ventilation, aerosol therapy.

Journal Article Respir Care · May 2011 The purpose of this paper is to review the recent literature related to invasive mechanical ventilation, NIV, pediatric mechanical ventilation, and aerosol therapy. Topics covered related to invasive mechanical ventilation topics include the role of PEEP i ... Full text Link to item Cite

Patient-ventilator interactions: optimizing conventional ventilation modes.

Journal Article Respir Care · January 2011 Assisted (interactive) breathing is generally preferred to controlled breaths in patients on mechanical ventilators. Assisted breaths allow the patient's respiratory muscles to be used, and ventilatory muscle atrophy can be prevented. Moreover, the respira ... Full text Link to item Cite

A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis.

Journal Article N Engl J Med · August 12, 2010 BACKGROUND: Sildenafil, a phosphodiesterase-5 inhibitor, may preferentially improve blood flow to well-ventilated regions of the lung in patients with advanced idiopathic pulmonary fibrosis, which could result in improvements in gas exchange. We tested the ... Full text Link to item Cite

Evolving approaches to assessing and monitoring patient-ventilator interactions.

Journal Article Curr Opin Crit Care · June 2010 PURPOSE OF REVIEW: Patient-ventilator dyssynchrony (PVD) is prevalent in critically ill patients and causes increased work of breathing, which can lead to ventilatory muscle overload and fatigue as well as impairment in sleep efficiency, both important fac ... Full text Link to item Cite

Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury.

Journal Article Chest · February 2010 BACKGROUND: No single clinical or biologic marker reliably predicts clinical outcomes in acute lung injury (ALI)/ARDS. We hypothesized that a combination of biologic and clinical markers would be superior to either biomarkers or clinical factors alone in p ... Full text Link to item Cite

Are there benefits or harm from pressure targeting during lung-protective ventilation?

Journal Article Respir Care · February 2010 Mechanically, breath design is usually either flow/volume-targeted or pressure-targeted. Both approaches can effectively provide lung-protective ventilation, but they prioritize different ventilation parameters, so their responses to changing respiratory-s ... Link to item Cite

Respiratory care controversies II.

Journal Article Respir Care · January 2010 Link to item Cite

Is there a role for screening spirometry?

Journal Article Respir Care · January 2010 In obstructive lung disease, the characteristic change in spirometry is a reduction in the forced expiratory volume in the first second (FEV(1)) with respect to the vital capacity. Moreover, the severity of the obstruction can be graded by referencing spir ... Link to item Cite

Respiratory Care Controversies II Foreword

Journal Article RESPIRATORY CARE · January 1, 2010 Link to item Cite

Bronchodilator Response In Asthmatics To Short Course Nebulization With A Breath Actuated Nebulizer

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

The author responds

Journal Article Respiratory Care · December 4, 2009 Cite

Don't Use the Flawed Fixed Ratio to Diagnosis COPD Response

Journal Article RESPIRATORY CARE · November 1, 2009 Link to item Cite

Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study.

Journal Article Clin Ther · August 2009 OBJECTIVE: The aim of this study was to compare the efficacy and safety of nebulized arformoterol 15 microg/2 mL twice daily (ARF15 BID) and 30 microg/4 mL once daily (ARF30 QD) in subjects with moderate to severe chronic obstructive pulmonary disease (COP ... Full text Link to item Cite

Spirometry for the diagnosis and management of chronic obstructive pulmonary disease.

Journal Article Respir Care · August 2009 Spirometric testing is one of the oldest clinical tests still in use today. It is a straightforward test that has the patient maximally exhale from total lung capacity. The key measurements are the forced expiratory volume in the first second (FEV(1)) and ... Link to item Cite

CT metrics of airway disease and emphysema in severe COPD.

Other Chest · August 2009 BACKGROUND: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respir ... Full text Link to item Cite

Foreword

Journal Article · 2009 Cite

Patient and program outcome assessment in pulmonary rehabilitation: an AACVPR statement.

Journal Article J Cardiopulm Rehabil Prev · 2009 Quantifying and analyzing pulmonary rehabilitation (PR) results in the form of an outcome assessment are a means of evaluating patient performance and program effectiveness. Implementation of a structured outcome assessment is feasible and parallels many a ... Full text Link to item Cite

Reasons for nonenrollment in a clinical trial of acute lung injury.

Journal Article Chest · October 2008 BACKGROUND: Enrolling critically ill patients in clinical trials is challenging. We observed that eligible patients at San Francisco General Hospital (SFGH), a public hospital that cares largely for indigent patients, were less likely to be enrolled in a c ... Full text Link to item Cite

Mechanisms of functional loss in patients with chronic lung disease.

Journal Article Respir Care · September 2008 Functional loss (often quantified as exercise limitation) is common in patients with chronic lung disease. The factors involved are multiple and many may be present together in a given patient. Ventilatory factors involve an imbalance in load/capacity rela ... Link to item Cite

Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease.

Journal Article Am J Respir Crit Care Med · August 1, 2008 RATIONALE: American Thoracic Society guidelines state that a 10% or greater intersession change in diffusing capacity of the lung (DL(CO)) should be considered clinically significant. However, little is known about the short-term intersession variability i ... Full text Link to item Cite

The authors respond

Journal Article Respiratory Care · July 1, 2008 Cite

Airway pressure-release ventilation - Response

Journal Article RESPIRATORY CARE · July 1, 2008 Link to item Cite

Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?

Journal Article Clin Chest Med · June 2008 Airspace collapse is a hallmark of parenchymal lung injury. Strategies to reopen and maintain patency of these regions offer three advantages: improved gas exchange, less lung injury, and improved lung compliance. Elevations in intrathoracic pressure to ac ... Full text Link to item Cite

Life-threatening asthma: pathophysiology and management.

Journal Article Respir Care · June 2008 Asthma prevalence and mortality have been increasing over the past 2 decades, despite advances in medical therapy. In 2003 the National Health Interview Survey reported over 4,000 asthma-related deaths. A small proportion of people with severe asthma use a ... Link to item Cite

Is there a best way to set tidal volume for mechanical ventilatory support?

Journal Article Clin Chest Med · June 2008 Tidal breaths are an important component of mechanical ventilation. However, an inappropriate tidal volume setting can overstretch and injure the lung. Maximal stretch, tidal stretch, frequency of stretch, and rate of stretch are all implicated in such inj ... Full text Link to item Cite

Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease.

Journal Article Proc Am Thorac Soc · May 1, 2008 Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) describe the phenomenon of sudden worsening in airway function and respiratory symptoms in patients with COPD. These exacerbations can range from self-limited diseases to episodes of flo ... Full text Link to item Cite

Meeting the challenges of asthma

Journal Article Respiratory Care · May 1, 2008 Cite

Meeting the challenges of asthma - Foreword

Journal Article RESPIRATORY CARE · May 1, 2008 Link to item Cite

Ventilator advisory system employing load and tolerance strategy recommends appropriate pressure support ventilation settings: multisite validation study.

Journal Article Chest · March 2008 BACKGROUND: Loads on the respiratory muscles, reflected by noninvasive measurement of the real-time power of breathing (POBn), and tolerance of these loads, reflected by spontaneous breathing frequency (f) and tidal volume (Vt), should be considered when e ... Full text Link to item Cite

Principles of Positive Pressure Mechanical Ventilatory Support

Chapter · January 1, 2008 Positive pressure mechanical ventilation (PPMV) uses positive pressure tidal breaths to either totally or partially affect O2 and CO2 transport between the environment and the alveolar spaces. Positive pressure is also used to maintain alveolar patency dur ... Full text Cite

Preface

Journal Article Clinics in Chest Medicine · January 1, 2008 Full text Cite

Standardization of the single-breath diffusing capacity in a multicenter clinical trial.

Journal Article Chest · October 2007 BACKGROUND: Standardization of the measurement of single-breath diffusing capacity of the lung for carbon monoxide (DLCO) is difficult to implement in multicenter trials as differences in equipment, training, and performance guidelines have led to high var ... Full text Link to item Cite

Discontinuing mechanical ventilatory support.

Journal Article Chest · September 2007 The ventilator discontinuation process is a critical component of ICU care. Ongoing ventilator dependency is caused by both disease factors (eg, respiratory, cardiac, metabolic, and neuromuscular) and clinician management factors (eg, failing to recognize ... Full text Link to item Cite

Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation.

Journal Article J Crit Care · September 2007 Featured Publication PURPOSE: Low tidal volume (V(T)) delivered by flow-targeted breaths reduces ventilator-induced lung injury but may increase patient breathing effort because of limited flow. We hypothesized that a variable-flow, pressure-targeted breath would improve breat ... Full text Link to item Cite

Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome.

Journal Article Crit Care Med · August 2007 OBJECTIVE: The coagulation and inflammatory cascades may be linked in the pathogenesis of acute lung injury and acute respiratory distress syndrome. However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to ... Full text Link to item Cite

Inhaled corticosteroids in obstructive airway disease.

Journal Article Respir Care · July 2007 Inhaled corticosteroids play an important role in the management of obstructive airway disease, by suppressing airway inflammation that is central to the pathophysiology of these conditions. In asthma there is strong clinical evidence supporting the use of ... Link to item Cite

Respiratory controversies in the critical care setting. Conference summary.

Journal Article Respir Care · May 2007 Definitive evidence to settle the important clinical controversies we debated in this Journal Conference are not yet available. More randomized controlled trials are clearly needed for all of the topics presented. Additionally, neonatal and pediatric data ... Link to item Cite

Respiratory controversies in the critical care setting

Journal Article Respiratory Care · May 1, 2007 Definitive evidence to settle the important clinical controversies we debated in this Journal Conference are not yet available. More randomized controlled trials are clearly needed for all of the topics presented. Additionally, neonatal and pediatric data ... Cite

Respiratory controversies in the critical care setting. Does airway pressure release ventilation offer important new advantages in mechanical ventilator support?

Journal Article Respir Care · April 2007 Airway pressure-release ventilation (APRV) is a mechanical ventilation strategy that is usually time-triggered but can be patient-triggered, pressure-limited, and time-cycled. APRV provides 2 levels of airway pressure (P(high) and P(low)) during 2 time per ... Link to item Cite

Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?

Journal Article Respir Care · April 2007 Ventilator-associated pneumonia (VAP) significantly increases intensive care unit morbidity, mortality, and costs. VAP is thought to be caused by bacterial entry into injured airways, which produces tracheobronchitis that evolves into diffuse pneumonia. Th ... Link to item Cite

Does airway pressure release ventilation offer important new advantages in mechanical ventilator support?

Journal Article Respiratory Care · April 1, 2007 Airway pressure-release ventilation (APRV) is a mechanical ventilation strategy that is usually time-triggered but can be patient-triggered, pressure-limited, and time-cycled. APRV provides 2 levels of airway pressure (Phigh and Plow) ... Cite

Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?

Journal Article Respiratory Care · April 1, 2007 Ventilator-associated pneumonia (VAP) significantly increases intensive care unit morbidity, mortality, and costs. VAP is thought to be caused by bacterial entry into injured airways, which produces tracheobronchitis that evolves into diffuse pneumonia. Th ... Cite

Standardisation of the measurement of lung volumes

Journal Article Revue Des Maladies Respiratoires · March 1, 2007 Cite

Standardisation of spirometry

Journal Article Revue Des Maladies Respiratoires · March 1, 2007 Cite

Interpretative strategies for lung function tests

Journal Article Revue Des Maladies Respiratoires · March 1, 2007 Cite

Standardisation of the single-breath determination of carbon monoxide uptake in the lung

Journal Article Revue Des Maladies Respiratoires · March 1, 2007 Cite

General considerations for lung function testing

Journal Article Revue Des Maladies Respiratoires · March 1, 2007 Cite

Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.

Journal Article Am J Respir Crit Care Med · February 1, 2007 RATIONALE: Nitrogen oxide (NO) species are markers for oxidative stress that may be pathogenic in acute lung injury (ALI). OBJECTIVES: We tested two hypotheses in patients with ALI: (1) higher levels of urine NO would be associated with worse clinical outc ... Full text Link to item Cite

AUTOMATIC TUBE COMPENSATION: DOES IT WORK IN NEONATES?

Conference Journal of Investigative Medicine · January 2007 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · December 1, 2006 Full text Cite

Higher urine desmosine levels are associated with mortality in patients with acute lung injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 2006 Desmosine is a stable breakdown product of elastin that can be reliably measured in urine samples. We tested the hypothesis that higher baseline urine desmosine would be associated with higher mortality in 579 of 861 patients included in the recent Acute R ... Full text Link to item Cite

Foreword

Journal Article Respiratory Care Clinics of North America · September 1, 2006 Full text Cite

Ventilatory Management of ALI/ARDS.

Journal Article Semin Respir Crit Care Med · August 2006 Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) describe syndromes of diffuse parenchymal lung injury resulting from a variety of inflammatory triggers. The pathophysiological consequences include stiff, low-compliance lungs with ... Full text Link to item Cite

Muscle dysfunction associated with chronic obstructive pulmonary disease.

Journal Article Respir Care · August 2006 Skeletal-muscle (both respiratory and limb) abnormalities are common and can have profound effects in patients with chronic inflammatory states such as chronic obstructive pulmonary disease (COPD). Causes include direct inflammatory-mediator effects on mus ... Link to item Cite

Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury.

Journal Article Respir Med · July 2006 The single exhalation analysis of carbon monoxide, acetylene, and methane allows the determination of intrabreath (regional) DL, pulmonary capillary blood flow and ventilation inhomogeneities during rest and exercise. We reasoned that this technique might ... Full text Link to item Cite

Humidification and Filtration in Anesthesia and Intensive Care

Journal Article Respiratory Care Clinics of North America · June 1, 2006 Full text Cite

Corticosteroid therapy and chronic obstructive pulmonary disease.

Journal Article Respir Care · March 2006 Chronic obstructive pulmonary disease is characterized in part by a chronic inflammatory state in the airways (largely from chronic noxious stimuli such as tobacco smoke), punctuated with acute inflammatory exacerbations, which are often infectious. Althou ... Link to item Cite

Polysomnography II

Journal Article Respiratory Care Clinics of North America · March 1, 2006 Full text Cite

Physician subsidies for tobacco advertising.

Journal Article Am J Respir Crit Care Med · January 15, 2006 Full text Link to item Cite

Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference.

Journal Article Chest · December 2005 Patients requiring prolonged mechanical ventilation (PMV) are rapidly increasing in number, as improved ICU care has resulted in many patients surviving acute respiratory failure only to then require prolonged mechanical ventilatory assistance during conva ... Full text Link to item Cite

Foreword

Journal Article Respiratory Care Clinics of North America · December 1, 2005 Full text Cite

Current issues in mechanical ventilation for respiratory failure.

Journal Article Chest · November 2005 The morbidity and mortality associated with respiratory failure is, to a certain extent, iatrogenic. Mechanical ventilation, although the mainstay of treatment for respiratory distress syndrome, can result in physical trauma to lung tissue (ventilator-indu ... Full text Link to item Cite

Metered-dose inhalers and dry powder inhalers in aerosol therapy

Journal Article Respiratory Care · September 1, 2005 Cite

State-of-the-art respiratory care education

Journal Article Respiratory Care Clinics of North America · September 1, 2005 Full text Cite

Standardisation of spirometry.

Journal Article Eur Respir J · August 2005 Full text Link to item Cite

Ventilator-associated pneumonia: the role of ventilator management strategies.

Journal Article Respir Care · June 2005 Ventilator management strategies can affect the risk for ventilator-associated pneumonia in 3 ways: the development of ventilator-induced lung injury; the need for potentially harmful tradeoffs in providing lung-protective ventilatory strategies; and the p ... Link to item Cite

A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation.

Journal Article Chest · March 2005 STUDY OBJECTIVES: To characterize and compare transfusion practices in a broad sample of patients receiving mechanical ventilation (MV) and not receiving MV in the ICU. DESIGN: Retrospective subgroup analysis from the prospective, multicenter, observationa ... Full text Link to item Cite

Community-acquired pneumonia: An illness with great diversity

Journal Article Respiratory Care Clinics of North America · March 1, 2005 Full text Cite

Respiratory mechanics in the patient who is weaning from the ventilator

Conference Respiratory Care · February 1, 2005 Ventilator management of the patient recovering from acute respiratory failure must balance competing objectives. On the one hand, aggressive efforts to promptly discontinue support and remove the artificial airway reduce the risk of ventilator-induced lun ... Cite

Respiratory mechanics in the patient who is weaning from the ventilator.

Journal Article Respir Care · February 2005 Ventilator management of the patient recovering from acute respiratory failure must balance competing objectives. On the one hand, aggressive efforts to promptly discontinue support and remove the artificial airway reduce the risk of ventilator-induced lun ... Link to item Cite

Exercise outcomes after pulmonary rehabilitation depend on the initial mechanism of exercise limitation among non-oxygen-dependent COPD patients.

Journal Article Chest · January 2005 STUDY OBJECTIVES: Pulmonary rehabilitation (PR) that includes exercise training can improve exercise tolerance and quality of life for patients with COPD. However, the degree of benefit from PR is variable. We hypothesized that the exercise response to PR ... Full text Link to item Cite

Marital adjustment among patients with chronic obstructive pulmonary disease who are participating in pulmonary rehabilitation.

Journal Article Heart Lung · 2005 BACKGROUND: Marital adjustment has been associated with morbidity and mortality across various chronic diseases but has been largely ignored among patients with chronic obstructive pulmonary disease (COPD). PURPOSE: This study was designed to evaluate the ... Full text Link to item Cite

Patient-ventilator interaction

Journal Article Respiratory Care Clinics of North America · January 1, 2005 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · December 1, 2004 Full text Cite

High versus low PEEP in ARDS.

Journal Article N Engl J Med · November 11, 2004 Link to item Cite

The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.

Journal Article Respir Care Clin N Am · September 2004 An inappropriate tidal volume setting can overstretch and injure the lung. Maximal stretch, tidal stretch, frequency of stretch, and rate of stretch are all implicated in such injury. Moreover, the stretch injury produces systemic injury by liberating cyto ... Full text Link to item Cite

Setting the positive expiratory-end pressure-FIO2 in acute lung injury/acute respiratory distress syndrome.

Journal Article Respir Care Clin N Am · September 2004 Airspace collapse is a hallmark of parenchymal lung injury. Strategies to reopen and maintain patency of these regions offer three advantages: improved gas exchange, less ventilator-induced lung injury, and improved lung compliance. Elevations in intrathor ... Full text Link to item Cite

Current clinical controversies in respiratory care

Journal Article Respiratory Care Clinics of North America · September 1, 2004 Full text Cite

Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.

Journal Article N Engl J Med · July 22, 2004 Featured Publication BACKGROUND: Most patients requiring mechanical ventilation for acute lung injury and the acute respiratory distress syndrome (ARDS) receive positive end-expiratory pressure (PEEP) of 5 to 12 cm of water. Higher PEEP levels may improve oxygenation and reduc ... Full text Link to item Cite

Evidence-based ventilator weaning and discontinuation.

Journal Article Respir Care · July 2004 Ventilator management of a patient who is recovering from acute respiratory failure must balance competing objectives. Discontinuing mechanical ventilation and removing the artificial airway as soon as possible reduces the risk of ventilator-induced lung i ... Link to item Cite

Managing respiratory care services

Journal Article Respiratory Care Clinics of North America · June 1, 2004 Full text Cite

Safety and efficacy of median sternotomy versus video-assisted thoracic surgery for lung volume reduction surgery.

Journal Article J Thorac Cardiovasc Surg · May 2004 BACKGROUND: The National Emphysema Treatment Trial, a randomized trial comparing lung volume reduction surgery with medical therapy for severe emphysema, included randomized and nonrandomized comparisons of the median sternotomy and video-assisted thoracos ... Full text Link to item Cite

Chronic Obstructive Pulmonary Disease

Journal Article Pharmacotherapy · May 1, 2004 Chronic obstructive pulmonary disease (COPD) is characterized primarily by irreversible lung damage resulting in reduced airflow. Approximately 16 million Americans have the disease, which is the fourth leading cause of death in the United States. Current ... Full text Cite

Respiratory system simulations and modeling.

Journal Article Respir Care · April 2004 Simulators and models of the respiratory system range from simple mechanical devices to complex systems that include sophisticated computers. These systems have considerable utility in clinician education, guiding therapies, evaluating new devices and tech ... Link to item Cite

Chronic obstructive pulmonary disease: emerging medical therapies.

Journal Article Respir Care · January 2004 As many as 10 million Americans have chronic obstructive pulmonary disease and as a consequence experience disabling symptoms, high cost of care, and substantial mortality. Several new approaches are being investigated for possible benefit in managing (or ... Link to item Cite

The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States.

Journal Article Crit Care Med · January 2004 OBJECTIVE: To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes. DESIGN: Prospective, multiple center, observational ... Full text Link to item Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2004 Full text Cite

Cognitive and psychological outcomes of exercise in a 1-year follow-up study of patients with chronic obstructive pulmonary disease.

Journal Article Health Psychol · November 2003 This study evaluated outcomes of self-directed exercise activity on cognitive functioning and psychological well-being among 28 adults with chronic obstructive pulmonary disease (COPD). Participants had completed an intensive 10-week program of exercise tr ... Full text Link to item Cite

Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure.

Journal Article Crit Care Med · November 2003 OBJECTIVE: Positive end-expiratory pressure (PEEP) and recruitment maneuvers (RMs) may partially reverse atelectasis and reduce ventilation-associated lung injury. The purposes of this study were to assess a) magnitude and duration of RM effects on arteria ... Full text Link to item Cite

Pulmonary function testing: coding and billing issues.

Journal Article Respir Care · August 2003 Clinicians who conduct pulmonary function tests should understand the principles and rules of the coding and billing system for pulmonary function testing. Certain billing codes will not be paid by most insurance payers. To ensure that your pulmonary funct ... Link to item Cite

Anemia and blood transfusion in trauma patients admitted to the intensive care unit.

Journal Article J Trauma · August 2003 BACKGROUND: Anemia is a common occurrence in the intensive care unit (ICU). Although resuscitation, including the use of blood, is a mainstay of early treatment of trauma victims, the safety and efficacy of red blood cell (RBC) transfusion has come under s ... Full text Link to item Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2003 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2003 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2003 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2003 Full text Cite

Diagnosis and management of severe sepsis

Journal Article International Congress and Symposium Series Royal Society of Medicine · December 1, 2002 Cite

Aerosol delivery through an artificial airway.

Journal Article Respir Care · November 2002 For both lung and systemic diseases, aerosol delivery of drugs into the lungs can often offer substantial advantages over other routes of administration. In the intensive care unit, however, the artificial airway can be a substantial barrier to aerosol del ... Link to item Cite

Long-term ventilatory support, part I

Journal Article Respiratory Care Clinics of North America · September 1, 2002 Full text Cite

Transport of the mechanically ventilated patient

Journal Article Respiratory Care Clinics of North America · August 29, 2002 Full text Cite

Intrabreath diffusing capacity of the lung in healthy individuals at rest and during exercise.

Journal Article Chest · July 2002 Featured Publication BACKGROUND: Traditional approaches to measuring the diffusing capacity of the lung for carbon monoxide (DLCO) treat the lung as a single, well-mixed compartment and produce a single value for DLCO to represent an average diffusing capacity of the lung (DL) ... Full text Link to item Cite

ATS statement: guidelines for the six-minute walk test.

Journal Article Am J Respir Crit Care Med · July 1, 2002 Full text Link to item Cite

Setting the frequency-tidal volume pattern.

Journal Article Respir Care · March 2002 Alveolar (and thus arterial) P(O2) and P(CO2) clearly depend on minute ventilation. However, we need to balance gas exchange goals against the risk of overstretching, especially of the healthier regions of the lung. The plateau pressure is probably the bes ... Link to item Cite

Long-term ventilatory support, part II

Journal Article Respiratory Care Clinics of North America · January 1, 2002 Full text Cite

Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome.

Journal Article Crit Care Med · January 2002 OBJECTIVE: To determine whether the administration of lisofylline (1-[5R-hydroxyhexyl]-3,7-dimethylxanthine) would decrease mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). DESIGN: A prospective, randomized, ... Full text Link to item Cite

Adjuncts to mechanical ventilation

Journal Article Respiratory Care Clinics of North America · January 1, 2002 Full text Cite

High-frequency jet ventilation.

Journal Article Respir Care Clin N Am · December 2001 High-frequency ventilation, including HFJV, is an interesting alternative approach to mechanical ventilatory support that may offer benefits in terms of improved gas exchange and lower maximal alveolar distending pressures. Clinical data demonstrating impr ... Full text Link to item Cite

Chronic obstructive pulmonary disease management: the evidence base.

Journal Article Respir Care · November 2001 In long-term management of stable chronic obstructive pulmonary disease (COPD), a number of medications improve pulmonary function test results. The long-term clinical benefits of those drugs would seem intuitive, but there is very little strong evidence t ... Link to item Cite

Intratracheal catheters as drug delivery systems.

Journal Article Respir Care · February 2001 Medication delivery into the lungs can be used to provide a high therapeutic index for agents targeted to specific lung diseases. In addition, the lung can be used as a portal of entry for other agents targeted to systemic diseases. Delivery of medications ... Link to item Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2001 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2001 Full text Cite

Foreword

Journal Article Respiratory Care Clinics of North America · January 1, 2001 Full text Cite

Management of acute exacerbations of chronic obstructive pulmonary disease.

Journal Article Evid Rep Technol Assess (Summ) · September 2000 Link to item Cite

Consensus statement: Aerosols and delivery devices

Journal Article Respiratory Care · August 7, 2000 Cite

Aerosolized medications for altering lung surface active properties.

Journal Article Respir Care · June 2000 Surface active material is important in the function of both the infant and adult lung. In the premature infant, surfactant depletion results in the requirement for very high distending pressures to open alveoli. As a consequence, shunt, hypoxemia, and rig ... Link to item Cite

E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators.

Journal Article JAMA · April 5, 2000 CONTEXT: Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not. OBJECTIVE: To assess the efficacy and safety of E5 in the treatment of patients with severe gram-ne ... Full text Link to item Cite

Oxygen therapy and exercise response in lung disease.

Journal Article Respir Care · February 2000 Lung disease affects exercise performance through a number of mechanisms, including hypoxemia, abnormal ventilatory mechanics, abnormal ventilatory muscles, abnormal ventilatory patterns, abnormal right heart function and subjective dyspnea. Supplemental o ... Link to item Cite

Of Goldilocks and ventilatory muscle loading.

Journal Article Crit Care Med · February 2000 Full text Link to item Cite

Long-term oxygen therapy: conference summary.

Journal Article Respir Care · February 2000 With Jan's presentation, the conference concluded. In looking back on it, I think it is obvious that the group heard a very comprehensive, state-of-the-art review of this very important topic. Obviously, LTOT has enormous clinical and financial impact for ... Link to item Cite

Advances in infection control: ventilator-associated pneumonia.

Journal Article Semin Respir Crit Care Med · 2000 Mechanically ventilated patients are 6-21 times more likely to develop nosocomial pneumonia. It is estimated that between 6% and 52% of ventilated patients develop ventilator-associated pneumonia (VAP) with attributable mortality of 27-51%. Certain high ri ... Full text Link to item Cite

Mechanical ventilation strategies for lung protection.

Journal Article Semin Respir Crit Care Med · 2000 A large body of animal literature has shown that lungs stretched beyond their normal maximum are likely to be injured and release inflammatory cytokines into the systemic circulation. Moreover, this injury seems to be compounded if alveolar collapse also o ... Full text Link to item Cite

High-frequency ventilation.

Journal Article Semin Respir Crit Care Med · 2000 High-frequency ventilation (HFV) provides respiratory gas exchange using positive airway pressure-driven tidal breaths that are often smaller than anatomic dead space and breathing frequencies several times faster than normal. Gas transport with HFV involv ... Full text Link to item Cite

Tracheal gas insufflation.

Journal Article Semin Respir Crit Care Med · 2000 Tracheal gas insufflation (TGI) is an adjunct to mechanical ventilation that reduces CO (2) present in the anatomic deadspace. This is accomplished by flowing fresh gas (typically 6-10 lpm) directly into the trachea via a catheter placed into the endotrach ... Full text Link to item Cite

Scope of mechanical ventilation and need for innovations

Journal Article Seminars in Respiratory and Critical Care Medicine · January 1, 2000 The concepts underlying airway management and respiratory support have their roots in antiquity. Today, millions of patients worldwide receive mechanical ventilatory support each year. This utilization is likely to grow as the population grows, the populat ... Cite

Preface: Innovations in mechanical ventilation

Journal Article Seminars in Respiratory and Critical Care Medicine · January 1, 2000 Cite

E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: A randomized controlled trial

Journal Article Journal of the American Medical Association · 2000 Context. Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not. Objective. To assess the efficacy and safety of E5 in the treatment of patients with severe gram-ne ... Cite

Automated rotational therapy for the prevention of respiratory complications during mechanical ventilation

Journal Article Respiratory Care · December 1, 1999 OBJECTIVE: Test the hypothesis that automated rotational therapy reduces the incidence of respiratory complications associated with mechanical ventilation. STUDY DESIGN: A prospective, randomized, multicenter trial. METHODS: Intubated mechanically ventilat ... Cite

Issues in ventilator weaning.

Journal Article Chest · April 1999 Full text Link to item Cite

High-frequency ventilation.

Journal Article Crit Care Med · December 1998 Full text Link to item Cite

Diffusing capacity and pulmonary capillary blood flow during maximal exercise

Journal Article Chest · October 1, 1998 Purpose: Normal pulmonary vascular response to exercise is to increase pulmonary capillary blood flow (Qc) and volume. Quantifying this response has been difficult, requiring invasive monitors or cumbersome non-invasive techniques. We previously described ... Cite

Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease.

Journal Article Health Psychol · May 1998 Exercise rehabilitation is recommended increasingly for patients with chronic obstructive pulmonary disease (COPD). This study examined the effect of exercise and education on 79 older adults (M age = 66.6 +/- 6.5 years; 53% female) with COPD, randomly ass ... Full text Link to item Cite

Pulmonary rehabilitation of the patient with nonobstructive lung disease.

Journal Article Respir Care Clin N Am · March 1998 Disability from chronic lung disease is usually associated with COPD and pulmonary rehabilitation programs are designed to address this population. There are a number of chronic nonobstructive lung diseases, however, that can produce disability and that al ... Link to item Cite

Mechanical ventilation: The next 50 years

Journal Article Respiratory Care · January 1, 1998 Cite

Patient-ventilator flow dyssynchrony: flow-limited versus pressure-limited breaths.

Journal Article Crit Care Med · October 1997 OBJECTIVES: Patient-ventilator flow dyssynchrony occurs when ventilator flow delivery is insufficient to meet patient demands. If sufficiently severe, flow dyssynchrony can produce significant imposed loads on ventilatory muscles. Flow dyssynchrony can be ... Full text Link to item Cite

Diffusing capacity of the lung for carbon monoxide.

Journal Article Respir Care Clin N Am · June 1997 The measurement of co uptake (VCO and DLCO) from alveolar gas is a unique way to noninvasively assess pulmonary vascular function, specifically the functional volume of the pulmonary capillary bed. Proper interpretation of results, however, needs to accoun ... Link to item Cite

Applied PEEP during pressure support reduces the inspiratory threshold load of intrinsic PEEP.

Journal Article Chest · January 1997 OBJECTIVES: Mechanical ventilation in patients with obstructive airway disease (OAD) is associated with the development of dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEPi). One of the effects of this form of PEEPi is to act as ... Full text Link to item Cite

Expanding professional roles for respiratory care practitioners

Journal Article Respiratory Care · January 1, 1997 Expanded roles for RCPs in current and future health care delivery systems call for reforms in how we educate, manage, and utilize RCPs. If we desire to be vital health care professionals, then we must embrace issues of responsibility and accountability in ... Cite

Consensus conference: Noninvasive positive pressure ventilation

Journal Article Respiratory Care · January 1, 1997 Cite

New modes of mechanical ventilation.

Journal Article Clin Chest Med · September 1996 Many new approaches to mechanical ventilation have been developed. This article discusses these new strategies and modes. These include lung protection conventional ventilation strategies, long inspiratory time strategies, pressure-targeted breath enhancem ... Full text Link to item Cite

Accuracy and precision of a point-of-care blood gas analyzer incorporating optodes

Journal Article Respiratory Care · September 1, 1996 Background: A new generation of blood gas analyzers has appeared, and these analyzers are said to be easy to use, portable, battery-powered, and potentially less expensive than conventional systems. These systems allow for point-of-care analysis in emergen ... Cite

Emergent management of acute asthma.

Journal Article Med Clin North Am · July 1996 In almost no other field is the gap between diagnostic and therapeutic knowledge and its general application so great as it is in asthma. As previously mentioned, most asthma deaths are preventable. Identification of high-risk patients, intensive education ... Full text Link to item Cite

Minimizing alveolar stretch injury during mechanical ventilation

Journal Article Respiratory Care · April 1, 1996 Cite

Guidelines for the use of nebulizers in the home and at domiciliary sites. Report of a consensus conference. National Association for Medical Direction of Respiratory Care (NAMDRC) Consensus Group.

Journal Article Chest · March 1996 Guidelines for the use of nebulizers outside of the hospital were developed at the request of the Health Care Financing Administration (HCFA) to assist in the preparation of Medicare criteria for reimbursement. The National Association for Medical Directio ... Full text Link to item Cite

Pathogenesis and treatment of the adult respiratory distress syndrome.

Journal Article Arch Intern Med · January 8, 1996 The adult respiratory distress syndrome is an acute clinical illness characterized by noncardiogenic pulmonary edema and refractory hypoxemia. Injury to the alveolar-capillary barrier and lung inflammation lead to intrapulmonary shunting of blood, surfacta ... Link to item Cite

Dual-control modes of mechanical ventilation

Journal Article Respiratory Care · January 1, 1996 Ventilator manufacturers have attempted to answer the concerns of clinicians related to PCV and VCV by providing dual control of breaths or by using closed-loop control. The current literature suggests that VAPSV is a safe and effective method to improve p ... Cite

Mechanical ventilation in asthma.

Journal Article Respir Care Clin N Am · December 1995 The goal of respiratory support in asthma is similar to the goals in other forms of respiratory failure: to support gas exchange while avoiding complications. The specific respiratory support goals for asthmatics are discussed in this article, as well as r ... Link to item Cite

Asthma rehabilitation program.

Journal Article Respir Care Clin N Am · December 1995 Comprehensive management of asthma includes proper use of medication adjustments in patient lifestyle, exercise conditioning, and patient education to maximize self-management capabilities. Pulmonary rehabilitation programs have used these strategies succe ... Link to item Cite

Efficacy assessment criteria based on risk and cost.

Journal Article Respir Care · September 1995 Link to item Cite

Standardization of Spirometry, 1994 Update. American Thoracic Society.

Journal Article Am J Respir Crit Care Med · September 1995 Full text Link to item Cite

A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group.

Journal Article Crit Care Med · June 1995 OBJECTIVE: To evaluate the safety and efficacy of E5, a murine, monoclonal antibody directed against endotoxin, in the treatment of patients with Gram-negative sepsis. DESIGN: A multicenter, randomized, double-blind, placebo-controlled trial. SETTING: Fift ... Full text Link to item Cite

Controversies in mechanical ventilation.

Journal Article Contemp Intern Med · April 1995 Link to item Cite

Pressure-controlled, inverse ratio ventilation that avoids air trapping in the adult respiratory distress syndrome.

Journal Article Crit Care Med · February 1995 OBJECTIVES: To investigate physiologic and outcome data in patients switched from volume-cycled conventional ratio ventilation to pressure-controlled inverse ratio ventilation that did not produce air trapping and intrinsic positive end-expiratory pressure ... Full text Link to item Cite

Breathing comfort during weaning with two ventilatory modes.

Journal Article Am J Respir Crit Care Med · January 1995 Full text Link to item Cite

Respiratory factors in weaning from mechanical ventilatory support

Journal Article Respiratory Care · January 1, 1995 Weaning, or the gradual reduction in partial ventilatory support, is required in only the minority of patients receiving mechanical ventilatory support (those who need prolonged ventilation support, generally more than 72 hours). Weaning techniques involve ... Cite

Single-breath carbon monoxide diffusing capacity (transfer factor): Recommendations for a standard technique-1995 update

Journal Article American Journal of Respiratory and Critical Care Medicine · January 1, 1995 Cite

Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome.

Journal Article JAMA · November 9, 1994 OBJECTIVE: To evaluate the safety and potential efficacy of aerosolized surfactant in intubated patients with adult respiratory distress syndrome (ARDS). DESIGN: A prospective, double-blind, placebo-controlled, randomized, parallel, multicenter pilot clini ... Link to item Cite

Demand-flow airway pressure release ventilation as a partial ventilatory support mode: comparison with synchronized intermittent mandatory ventilation and pressure support ventilation.

Journal Article Crit Care Med · September 1994 OBJECTIVE: To evaluate airway pressure release ventilation as a partial ventilatory support mode by comparing a demand-flow airway pressure release ventilation system with synchronized intermittent mandatory ventilation and pressure support ventilation. DE ... Full text Link to item Cite

Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf).

Journal Article Chest · June 1994 This study evaluated the feasibility of using 99mTc-pentetic acid (DTPA) as a radioactive tracer for aerosolized synthetic surfactant (DPPC, cetyl alcohol, tyloxapol). The 99mTc-DTPA was admixed with surfactant and aerosolized using a nebulizer system inte ... Full text Link to item Cite

Combining pressure-limiting and volume-cycling features in a patient-interactive mechanical breath.

Journal Article Crit Care Med · February 1994 OBJECTIVES: To combine the patient synchrony effects of pressure-limited breath delivery strategies with the volume guarantee of volume-cycled breath delivery strategies, we designed a positive-pressure breath that incorporates both features. This breath i ... Full text Link to item Cite

Normal values for single exhalation diffusing capacity and pulmonary capillary blood flow in sitting, supine positions, and during mild exercise.

Journal Article Chest · February 1994 Previous approaches to the measurements of pulmonary diffusing capacity (DL) and pulmonary capillary blood flow (QC) utilized either the rebreathing or the single inhalation technique in conjunction with radioisotope gas and mass spectrometry. In the prese ... Full text Link to item Cite

Asbestos content of bronchoalveolar lavage fluid. A comparison of light and scanning electron microscopic analysis.

Journal Article Acta Cytol · 1994 We studied the asbestos content of bronchoalveolar lavage fluid (BALF) from 9 patients with asbestosis, 17 asbestos exposed but without asbestosis, 15 with idiopathic pulmonary fibrosis (IPF) and 9 nonexposed volunteers. The cellular lavage pellet was dige ... Link to item Cite

Psychological functioning among middle-aged and older adult pulmonary patients in exercise rehabilitation

Journal Article Physical and Occupational Therapy in Geriatrics · January 1, 1994 Twenty-seven adults (10 men, 17 women) with chronic pulmonary disease participated in a 30-day rehabilitation program including aerobic exercise, education, and stress management. Mean age of the sample was 55.5± 15.8 years (Range:27-83 years). Subjects un ... Full text Cite

Automated lateral rotational therapy in the intensive care unit

Journal Article Care of the Critically Ill · January 1, 1994 Turning patients on a frequent basis reduces some of the respiratory complications associated with immobility. With automated rotational therapy the frequency of turning can be increased to several times per hour. However cost and patient tolerance need to ... Cite

Analysis of an endotracheal intubation service provided by respiratory care practitioners.

Journal Article Respir Care · May 1993 UNLABELLED: Our Respiratory Care Services Department provides an endotracheal intubation service that responds to all intubation requests. Intubation is performed by registered respiratory therapists who complete an 8-hour training program, advanced cardia ... Link to item Cite

Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis.

Journal Article Am J Crit Care · May 1993 OBJECTIVE: To review the epidemiology and pathophysiology of gram-negative sepsis and the new consensus terminology describing the clinical signs of sepsis. DATA SOURCES: Review of the medical literature and compiled data from animal and clinical trials. P ... Link to item Cite

Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.

Journal Article Am J Respir Cell Mol Biol · March 1993 It has long been hypothesized that a defective beta 2-adrenergic receptor (beta 2AR) may be a pathogenic factor in bronchial asthma. We examined the gene encoding the beta 2AR to assess the frequency of polymorphisms in 51 patients with moderate to severe ... Full text Link to item Cite

Pressure support: Coming of age

Journal Article Seminars in Respiratory Medicine · January 1, 1993 Full text Cite

Real-time gas analysis improves the measurement of single-breath diffusing capacity.

Journal Article Am Rev Respir Dis · October 1992 The measurement of single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb) has traditionally used slow-responding analyzers that require large sample volumes for gas analysis. In addition, these measurement systems must use only assumed v ... Full text Link to item Cite

Essentials for ventilator-alarm systems.

Journal Article Respir Care · September 1992 Link to item Cite

Rapid analysis of exhaled CO2 to assess endotracheal tube placement

Journal Article Respiratory Care · January 1, 1992 Background: assessing proper placement of an endotracheal tube can be difficult. Assessment techniques include visualization of the tube in the larynx, auscultation of the chest and abdomen, assessment of compliance by the 'feel' of the resuscitation bag, ... Cite

ICN spokesmen emphasize virazole (ribavirin) efficacy and safety [1]

Journal Article Respiratory Care · December 1, 1991 Cite

Psychological outcomes of a pulmonary rehabilitation program.

Journal Article Chest · September 1991 This study assessed physiologic, psychological, and cognitive functioning in outpatients with COPD. Sixty-four subjects, 53 to 82 years of age, participated in the 30-day exercise rehabilitation program. The program consisted of exercise, education and psy ... Full text Link to item Cite

A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group.

Journal Article JAMA · August 28, 1991 OBJECTIVE: To assess the efficacy of adjunctive monoclonal antibody antiendotoxin immunotherapy in patients with gram-negative sepsis. DESIGN: Double-blind, randomized, placebo-controlled trial. SETTING: Thirty-three university-affiliated centers, includin ... Link to item Cite

Effects of initial flow rate and breath termination criteria on pressure support ventilation.

Journal Article Chest · January 1991 To assess whether adjustments in the initial flow rate or breath termination criteria affected patient-ventilator synchrony, we studied the ventilatory pattern response to PS in 33 patients under two sets of circumstances: during seven different levels of ... Full text Link to item Cite

Ventilatory muscle loads and the frequency-tidal volume pattern during inspiratory pressure-assisted (pressure-supported) ventilation.

Journal Article Am Rev Respir Dis · February 1990 Featured Publication Pressure support ventilation (PSV) is a new form of mechanical ventilatory support that assists a patient's spontaneous ventilatory effort with a clinician-selected amount of inspiratory pressure. In order to assess the muscle unloading effect and the vent ... Full text Link to item Cite

Pressure support ventilation

Journal Article Problems in Critical Care · January 1, 1990 Pressure support ventilation (PSV) in a unique form of pressure based mechanical ventilatory support that supplies a clinician selected level of airway pressure during a spontaneous inspiratory effort. This pressure 'assist' during inspiration can either p ... Cite

Respiratory monitoring without machinery

Journal Article Respiratory Care · January 1, 1990 The clinical examination remains an important tool for monitoring respiratory function in the critically ill. Noninvasive monitors appear to offer little additional accuracy for precision to the results of clinical examination for the assessment of airway ... Cite

The effects of bolus normal-saline instillation in conjunction with endotracheal suctioning

Journal Article Respiratory Care · January 1, 1990 Although the instillation of normal saline into the endotracheal tube prior to suctioning is common practice, the only available clinical data to support this practice were obtained in postoperative patients without apparent pulmonary disease. MATERIALS AN ... Cite

Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests.

Journal Article Radiology · June 1989 The appearances of the lungs on radiographs and computed tomographic (CT) scans were correlated with degree of uptake on gallium scans and results of pulmonary function tests (PFTs) in 27 patients with sarcoidosis. CT scans were evaluated both qualitativel ... Full text Link to item Cite

Mechanical loads on the ventilatory muscles. A theoretical analysis.

Journal Article Am Rev Respir Dis · April 1989 Featured Publication Two indices of the total mechanical load on the ventilatory muscles, i.e., the work per minute (W.min-1) and the inflation pressure time index (PTI), have been developed to better assess muscle energy demands and fatigue potential. However, the relationshi ... Full text Link to item Cite

Diffusing capacity of the lung for carbon monoxide

Journal Article Respiratory Care · January 1, 1989 Cite

Weaning from mechanical ventilation.

Journal Article Am Rev Respir Dis · October 1988 Link to item Cite

New forms of mechanical ventilation in the adult.

Journal Article Clin Chest Med · March 1988 Although mechanical ventilatory support in the 1980s clearly provides adequate gas exchange with minimal side effects, there remains a need for ventilation and oxygenation in those with severe gas exchange abnormalities, for reduced airway pressure effects ... Link to item Cite

Weaning from mechanical ventilatory support: Volume-assisting intermittent breaths versus pressure-assisting every breath

Journal Article Respiratory Care · January 1, 1988 Both IMV and PSV can be used during the weaning process. It is important to note that regardless of which technique one uses, the rate at which the level of ventilatory support is reduced is usually determined by the patient's lung disease and the resoluti ... Cite

Does positive end-expiratory pressure (PEEP) affect the natural history of acute lung injury?...Yes!

Journal Article Respiratory Care · January 1, 1988 A review of the literature regarding PEEP and outcome demonstrates that there are a number of reasons why PEEP should be beneficial in acute lung injury. There is no doubt that it improves oxygenation, decreases the necessity for high oxygen concentrations ... Cite

Rest and exercise cardiac output and diffusing capacity assessed by a single slow exhalation of methane, acetylene, and carbon monoxide.

Journal Article Chest · July 1987 To study rest and exercise pulmonary capillary blood flow (Qc) and diffusing capacity (DLexh) assessed by the rapid analysis of methane, acetylene, and carbon monoxide during a single, slow exhalation, we evaluated 36 subjects during first-pass radionuclid ... Full text Link to item Cite

Jet ventilation in support of fiberoptic bronchoscopy.

Journal Article Crit Care Med · April 1987 Mechanical ventilatory support of bronchoscopic procedures by conventional volume-cycled ventilation (VCV) is technically difficult and can result in unreliable gas delivery or excessive alveolar pressure. An alternate support mode is jet ventilation throu ... Full text Link to item Cite

Using Pressure Support in a Rational Way

Journal Article Chest · January 1987 Full text Cite

Jet ventilation at 100 breaths per minute in adult respiratory failure.

Journal Article Am Rev Respir Dis · November 1986 To compare the ventilation and oxygenation capabilities of jet ventilation at 100 breaths per minute with those of conventional mechanical ventilation (CMV) in adults with respiratory failure, we performed a 2- to 3-h cross-over trial of jet ventilation in ... Full text Link to item Cite

Respiratory function during pressure support ventilation.

Journal Article Chest · May 1986 Featured Publication Pressure support ventilation (PSV) is a pressure assist form of mechanical ventilatory support that augments the patient's spontaneous inspiratory efforts with a clinician selected level of positive airway pressure. To understand the effects of PSV on resp ... Full text Link to item Cite

EARLY INDICATORS OF HYPEROXIC LUNG INJURY IN BABOONS

Conference AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1986 Link to item Cite

Distribution and uptake of helium, carbon monoxide, and acetylene in the lungs during high frequency oscillatory ventilation.

Journal Article Respir Physiol · February 1986 Featured Publication In order to obtain a better understanding of intrapulmonary gas mixing and alveolar-capillary gas transport during high frequency oscillatory ventilation (HFO), we measured insoluble gas (He) equilibration, and soluble gas (CO, C2H2) uptake in the lungs of ... Full text Link to item Cite

Aerosol delivery in intubated, mechanically ventilated patients.

Journal Article Crit Care Med · February 1985 To study the effects of respiratory failure and mechanical ventilation on aerosol delivery to the lungs, we performed nuclear scans after aerosolization of 5 to 9 mCi of Tc-99m diethylenetriamine pentaacetic acid in seven stable, intubated, and mechanicall ... Full text Link to item Cite

Foreword

Journal Article Law and Contemporary Problems · 1985 Open Access Link to item Cite

DETERMINANTS OF ARTERIAL OXYGENATION DURING VENTILATION WITH A HIGH FREQUENCY JET VENTILATOR.

Journal Article undefined · December 1, 1984 High frequency jet ventilation (HFJV) is a new form of positive pressure mechanical ventilatory support that utilizes 200-300cc pulses of gas at frequencies of 100-150 breaths per minute (BPM). The authors have analyzed the results of the first 30 patients ... Cite

Prediction of subsequent ischemic heart disease using serial resting electrocardiograms.

Journal Article Am J Epidemiol · February 1984 To test the hypothesis that subtle changes in the resting electrocardiogram can have predictive value for subsequent cardiovascular disease, the authors evaluated serial electrocardiograms from a cohort of initially healthy men and related these to later d ... Full text Link to item Cite

Hemodynamic monitoring in respiratory care.

Journal Article Respir Care · January 1984 Continuous, invasive hemodynamic monitoring of patients in respiratory failure is an important aspect of total respiratory care. Understanding both the technical and physiological principles underlying hemodynamic monitoring is therefore important for resp ... Link to item Cite

Accuracy and precision of arterial blood gas measurements from the AVL 940 microsample analyzer

Journal Article Respiratory Care · January 1, 1984 We measured the accuracy and precision of the new AVL 940 computerized microsample blood gas analyzer by using 40 40-μL samples of tonometered blood at each of three different levels of PO2 and PCO2. The observed accuracy (as defined ... Cite

Pulmonary function in mechanically-ventilated patients during 24-hour use of a hygroscopic condensor humidifier.

Journal Article Chest · November 1983 Hygroscopic condensor humidifiers (HCH) are reportedly capable of humidifying even the driest of ventilator source gases with at least 30 mg H2O/liter of ventilation. To assess the adequacy of the HCH during mechanical ventilation, we studied 26 patients o ... Full text Link to item Cite

SOLUBLE GAS UPTAKE BY THE LUNG DURING HIGH-FREQUENCY OSCILLATION (HFO)

Conference AMERICAN REVIEW OF RESPIRATORY DISEASE · January 1, 1983 Link to item Cite

Regional diffusing capacity in normal lungs during a slow exhalation.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · June 1982 From an analysis of carbon monoxide uptake and xenon-133 distribution after two bolus inhalations of these gases, we calculated regional diffusing capacity in the upper and lower volume halves of the lungs during the middle 60% of an exhaled vital capacity ... Full text Link to item Cite

REGIONAL LUNG-FUNCTION DURING HIGH-FREQUENCY VENTILATION

Conference AMERICAN REVIEW OF RESPIRATORY DISEASE · January 1, 1982 Link to item Cite

Nonlinear increases in diffusing capacity during exercise by seated and supine subjects.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · October 1981 To study the effects of exercise on pulmonary diffusing capacity, we measured the lungs' diffusing capacity for carbon monoxide (DLCO) during exhalation from 30 to 45% exhaled vital capacity in eight healthy subjects at rest and during exercise while both ... Full text Link to item Cite

Eight-year follow-up of exercise electrocardiograms in healthy, middle-aged aviators.

Journal Article Aviat Space Environ Med · April 1981 To study to prognostic capabilities of the exercise electrocardiogram (ECG) in a fit, healthy, middle-aged population, 548 members of the U.S. Navy's "1000 Aviator" cohort were exercised to 85% predicted maximum heart rate in 1969 and then followed-up in 1 ... Link to item Cite

Long-term follow-up of lung volume measurements in initially healthy young aviators.

Journal Article Aviat Space Environ Med · January 1981 Lung volume measurements on a large number of initially healthy young military aviators (the U.S. Navy's "1000 Aviator" cohort) were recorded periodically in follow-up from 1940-69. Vital capacities were measured spirometrically and total lung capacities w ... Link to item Cite

Longevity in military pilots: 37-year followup of the Navy's "1000 aviators".

Journal Article Aviat Space Environ Med · September 1978 The 37-year nonmilitary mortality rate for initially healthy aviators was determined in a followup program on the U.S. Navy's "1000 Aviator" cohort. Of the 800 survivors of World War II and the Korean conflict, 95 were found to have died from nonmilitary c ... Link to item Cite