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Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.

Publication ,  Journal Article
Mosher, CL; Osazuwa-Peters, OL; Nanna, MG; MacIntyre, NR; Que, LG; Palmer, SM; Jones, WS; O'Brien, EC
Published in: Journal of the American Heart Association
January 2025

Meta-analyses have suggested that the risk of cardiovascular disease events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation, but the populations at highest risk have not been well characterized to date.The authors analyzed the risk of atherosclerotic cardiovascular disease (ASCVD) hospitalizations after COPD hospitalization compared with before COPD hospitalization and patient factors associated with ASCVD hospitalizations after COPD hospitalization among 2 high-risk patient cohorts. The primary outcome was risk of an ASCVD hospitalization composite outcome (myocardial infarction, coronary artery bypass graft, percutaneous coronary intervention, stroke, transient ischemic accident) after COPD hospitalization relative to before COPD hospitalization. Additional analyses evaluated for risk factors associated with the composite ASCVD hospitalization outcome. In the high-risk primary prevention cohort, the hazard ratio (HR) estimate following adjustment for the composite ASCVD hospitalization outcome after COPD hospitalization versus before COPD hospitalization for 30 days was 0.74 (95% CI, 0.66-0.82; P≤0.0001); for 90 days, 0.69 (95% CI, 0.64-0.75; P≤0.0001); and for 1 year, 0.78 (95% CI, 0.73-0.82; P≤0.0001). In the secondary prevention cohort, the HR for 30-day hospitalization was 1.15 (95% CI, 1.05-1.26; P=0.0036); 90-day hospitalization, 1.08 (95% CI, 1.01-1.15; P=0.0178); and 1-year hospitalization, 1.07 (95% CI, 1.02-1.11; P=0.0026). Among the 19 characteristics evaluated, hyperlipidemia and history of acute ASCVD event were associated with the highest risk of ASCVD events 1 year after COPD hospitalization in the high-risk primary and secondary prevention cohorts.The risk of ASCVD hospitalization was higher in patients with established ASCVD and lower among high-risk patients without established ASCVD after-COPD hospitalization relative to before hospitalization. We identified multiple risk factors for ASCVD hospitalization after COPD hospitalization.

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Published In

Journal of the American Heart Association

DOI

EISSN

2047-9980

ISSN

2047-9980

Publication Date

January 2025

Volume

14

Issue

2

Start / End Page

e035010

Related Subject Headings

  • Time Factors
  • Secondary Prevention
  • Risk Factors
  • Risk Assessment
  • Pulmonary Disease, Chronic Obstructive
  • Primary Prevention
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
 

Citation

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Chicago
ICMJE
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Mosher, C. L., Osazuwa-Peters, O. L., Nanna, M. G., MacIntyre, N. R., Que, L. G., Palmer, S. M., … O’Brien, E. C. (2025). Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal of the American Heart Association, 14(2), e035010. https://doi.org/10.1161/jaha.124.035010
Mosher, Christopher L., Oyomoare L. Osazuwa-Peters, Michael G. Nanna, Neil R. MacIntyre, Loretta G. Que, Scott M. Palmer, W Schuyler Jones, and Emily C. O’Brien. “Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.Journal of the American Heart Association 14, no. 2 (January 2025): e035010. https://doi.org/10.1161/jaha.124.035010.
Mosher CL, Osazuwa-Peters OL, Nanna MG, MacIntyre NR, Que LG, Palmer SM, et al. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal of the American Heart Association. 2025 Jan;14(2):e035010.
Mosher, Christopher L., et al. “Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.Journal of the American Heart Association, vol. 14, no. 2, Jan. 2025, p. e035010. Epmc, doi:10.1161/jaha.124.035010.
Mosher CL, Osazuwa-Peters OL, Nanna MG, MacIntyre NR, Que LG, Palmer SM, Jones WS, O’Brien EC. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal of the American Heart Association. 2025 Jan;14(2):e035010.
Journal cover image

Published In

Journal of the American Heart Association

DOI

EISSN

2047-9980

ISSN

2047-9980

Publication Date

January 2025

Volume

14

Issue

2

Start / End Page

e035010

Related Subject Headings

  • Time Factors
  • Secondary Prevention
  • Risk Factors
  • Risk Assessment
  • Pulmonary Disease, Chronic Obstructive
  • Primary Prevention
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans