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Body temperature and mortality in patients with acute respiratory distress syndrome.

Publication ,  Journal Article
Schell-Chaple, HM; Puntillo, KA; Matthay, MA; Liu, KD; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network,
Published in: Am J Crit Care
January 2015

BACKGROUND: Little is known about the relationship between body temperature and outcomes in patients with acute respiratory distress syndrome (ARDS). A better understanding of this relationship may provide evidence for fever suppression or warming interventions, which are commonly applied in practice. OBJECTIVE: To examine the relationship between body temperature and mortality in patients with ARDS. METHODS: Secondary analysis of body temperature and mortality using data from the ARDS Network Fluid and Catheter Treatment Trial (n = 969). Body temperature at baseline and on study day 2, primary cause of ARDS, severity of illness, and 90-day mortality were analyzed by using multiple logistic regression. RESULTS: Mean baseline temperature was 37.5°C (SD, 1.1°C; range, 27.2°C-40.7°C). At baseline, fever (≥ 38.3°C) was present in 23% and hypothermia (< 36°C) in 5% of the patients. Body temperature was a significant predictor of 90-day mortality after primary cause of ARDS and score on the Acute Physiology and Chronic Health Evaluation III were adjusted for. Higher temperature was associated with decreased mortality: for every 1°C increase in baseline temperature, the odds of death decreased by 15% (odds ratio, 0.85; 95% CI, 0.73-0.98, P = .03). When patients were divided into 5 temperature groups, mortality was lower with higher temperature (P for trend = .02). CONCLUSIONS: Early in ARDS, fever is associated with improved survival rates. Fever in the acute phase response to lung injury and its relationship to recovery may be an important factor in determining patients' outcome and warrants further study.

Duke Scholars

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Published In

Am J Crit Care

DOI

EISSN

1937-710X

Publication Date

January 2015

Volume

24

Issue

1

Start / End Page

15 / 23

Location

United States

Related Subject Headings

  • Survival Rate
  • Respiratory Distress Syndrome
  • Nursing
  • Middle Aged
  • Male
  • Humans
  • Hospital Mortality
  • Female
  • Body Temperature
  • 4205 Nursing
 

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Schell-Chaple, H. M., Puntillo, K. A., Matthay, M. A., Liu, K. D., & National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, . (2015). Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care, 24(1), 15–23. https://doi.org/10.4037/ajcc2015320
Schell-Chaple, Hildy M., Kathleen A. Puntillo, Michael A. Matthay, Kathleen D. Liu, and Kathleen D. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. “Body temperature and mortality in patients with acute respiratory distress syndrome.Am J Crit Care 24, no. 1 (January 2015): 15–23. https://doi.org/10.4037/ajcc2015320.
Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan;24(1):15–23.
Schell-Chaple, Hildy M., et al. “Body temperature and mortality in patients with acute respiratory distress syndrome.Am J Crit Care, vol. 24, no. 1, Jan. 2015, pp. 15–23. Pubmed, doi:10.4037/ajcc2015320.
Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan;24(1):15–23.

Published In

Am J Crit Care

DOI

EISSN

1937-710X

Publication Date

January 2015

Volume

24

Issue

1

Start / End Page

15 / 23

Location

United States

Related Subject Headings

  • Survival Rate
  • Respiratory Distress Syndrome
  • Nursing
  • Middle Aged
  • Male
  • Humans
  • Hospital Mortality
  • Female
  • Body Temperature
  • 4205 Nursing