Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Aerosol delivery in intubated, mechanically ventilated patients.

Publication ,  Journal Article
MacIntyre, NR; Silver, RM; Miller, CW; Schuler, F; Coleman, RE
Published in: Crit Care Med
February 1985

To study the effects of respiratory failure and mechanical ventilation on aerosol delivery to the lungs, we performed nuclear scans after aerosolization of 5 to 9 mCi of Tc-99m diethylenetriamine pentaacetic acid in seven stable, intubated, and mechanically ventilated patients. The radioactivity reaching the lungs was 2.9 +/- .7% (mean +/- SD) of the administered dose, an amount significantly less than that in three healthy nonintubated subjects and also less than what would be expected in nonintubated subjects from other published reports. We then performed a subsequent study in 15 additional mechanically ventilated patients who were receiving aerosolized bronchodilators through their endotracheal tube. In these patients, heart rate and lung mechanical function values before and after treatment were not significantly different. We conclude from these studies that aerosol delivery in mechanically ventilated patients is significantly reduced and that this is probably due to a combination of suboptimal breathing pattern, intrinsic airway disease, and the endotracheal tube functioning as both a site for aerosol deposition through impaction as well as a barrier to gastrointestinal absorption.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Crit Care Med

DOI

ISSN

0090-3493

Publication Date

February 1985

Volume

13

Issue

2

Start / End Page

81 / 84

Location

United States

Related Subject Headings

  • Vital Capacity
  • Technetium
  • Respiratory Insufficiency
  • Respiration, Artificial
  • Respiration
  • Pentetic Acid
  • Middle Aged
  • Metaproterenol
  • Male
  • Intubation, Intratracheal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
MacIntyre, N. R., Silver, R. M., Miller, C. W., Schuler, F., & Coleman, R. E. (1985). Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med, 13(2), 81–84. https://doi.org/10.1097/00003246-198502000-00005
MacIntyre, N. R., R. M. Silver, C. W. Miller, F. Schuler, and R. E. Coleman. “Aerosol delivery in intubated, mechanically ventilated patients.Crit Care Med 13, no. 2 (February 1985): 81–84. https://doi.org/10.1097/00003246-198502000-00005.
MacIntyre NR, Silver RM, Miller CW, Schuler F, Coleman RE. Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med. 1985 Feb;13(2):81–4.
MacIntyre, N. R., et al. “Aerosol delivery in intubated, mechanically ventilated patients.Crit Care Med, vol. 13, no. 2, Feb. 1985, pp. 81–84. Pubmed, doi:10.1097/00003246-198502000-00005.
MacIntyre NR, Silver RM, Miller CW, Schuler F, Coleman RE. Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med. 1985 Feb;13(2):81–84.

Published In

Crit Care Med

DOI

ISSN

0090-3493

Publication Date

February 1985

Volume

13

Issue

2

Start / End Page

81 / 84

Location

United States

Related Subject Headings

  • Vital Capacity
  • Technetium
  • Respiratory Insufficiency
  • Respiration, Artificial
  • Respiration
  • Pentetic Acid
  • Middle Aged
  • Metaproterenol
  • Male
  • Intubation, Intratracheal