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Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.

Publication ,  Journal Article
Grissom, CK; Hirshberg, EL; Dickerson, JB; Brown, SM; Lanspa, MJ; Liu, KD; Schoenfeld, D; Tidswell, M; Hite, RD; Rock, P; Miller, RR ...
Published in: Crit Care Med
February 2015

OBJECTIVES: In the Fluid and Catheter Treatment Trial (FACTT) of the National Institutes of Health Acute Respiratory Distress Syndrome Network, a conservative fluid protocol (FACTT Conservative) resulted in a lower cumulative fluid balance and better outcomes than a liberal fluid protocol (FACTT Liberal). Subsequent Acute Respiratory Distress Syndrome Network studies used a simplified conservative fluid protocol (FACTT Lite). The objective of this study was to compare the performance of FACTT Lite, FACTT Conservative, and FACTT Liberal protocols. DESIGN: Retrospective comparison of FACTT Lite, FACTT Conservative, and FACTT Liberal. Primary outcome was cumulative fluid balance over 7 days. Secondary outcomes were 60-day adjusted mortality and ventilator-free days through day 28. Safety outcomes were prevalence of acute kidney injury and new shock. SETTING: ICUs of Acute Respiratory Distress Syndrome Network participating hospitals. PATIENTS: Five hundred three subjects managed with FACTT Conservative, 497 subjects managed with FACTT Liberal, and 1,124 subjects managed with FACTT Lite. INTERVENTIONS: Fluid management by protocol. MEASUREMENTS AND MAIN RESULTS: Cumulative fluid balance was 1,918 ± 323 mL in FACTT Lite, -136 ± 491 mL in FACTT Conservative, and 6,992 ± 502 mL in FACTT Liberal (p < 0.001). Mortality was not different between groups (24% in FACTT Lite, 25% in FACTT Conservative and Liberal, p = 0.84). Ventilator-free days in FACTT Lite (14.9 ± 0.3) were equivalent to FACTT Conservative (14.6 ± 0.5) (p = 0.61) and greater than in FACTT Liberal (12.1 ± 0.5, p < 0.001 vs Lite). Acute kidney injury prevalence was 58% in FACTT Lite and 57% in FACTT Conservative (p = 0.72). Prevalence of new shock in FACTT Lite (9%) was lower than in FACTT Conservative (13%) (p = 0.007 vs Lite) and similar to FACTT Liberal (11%) (p = 0.18 vs Lite). CONCLUSIONS: FACTT Lite had a greater cumulative fluid balance than FACTT Conservative but had equivalent clinical and safety outcomes. FACTT Lite is an alternative to FACTT Conservative for fluid management in Acute Respiratory Distress Syndrome.

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Published In

Crit Care Med

DOI

EISSN

1530-0293

Publication Date

February 2015

Volume

43

Issue

2

Start / End Page

288 / 295

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • United States
  • Shock
  • Retrospective Studies
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Random Allocation
  • Middle Aged
  • Male
  • Intensive Care Units
 

Citation

APA
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Grissom, C. K., Hirshberg, E. L., Dickerson, J. B., Brown, S. M., Lanspa, M. J., Liu, K. D., … National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network, . (2015). Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med, 43(2), 288–295. https://doi.org/10.1097/CCM.0000000000000715
Grissom, Colin K., Eliotte L. Hirshberg, Justin B. Dickerson, Samuel M. Brown, Michael J. Lanspa, Kathleen D. Liu, David Schoenfeld, et al. “Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.Crit Care Med 43, no. 2 (February 2015): 288–95. https://doi.org/10.1097/CCM.0000000000000715.
Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, et al. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med. 2015 Feb;43(2):288–95.
Grissom, Colin K., et al. “Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.Crit Care Med, vol. 43, no. 2, Feb. 2015, pp. 288–95. Pubmed, doi:10.1097/CCM.0000000000000715.
Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR, Morris AH, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med. 2015 Feb;43(2):288–295.

Published In

Crit Care Med

DOI

EISSN

1530-0293

Publication Date

February 2015

Volume

43

Issue

2

Start / End Page

288 / 295

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • United States
  • Shock
  • Retrospective Studies
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Random Allocation
  • Middle Aged
  • Male
  • Intensive Care Units