Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Higher urine desmosine levels are associated with mortality in patients with acute lung injury.

Publication ,  Journal Article
McClintock, DE; Starcher, B; Eisner, MD; Thompson, BT; Hayden, DL; Church, GD; Matthay, MA ...
Published in: Am J Physiol Lung Cell Mol Physiol
October 2006

Desmosine is a stable breakdown product of elastin that can be reliably measured in urine samples. We tested the hypothesis that higher baseline urine desmosine would be associated with higher mortality in 579 of 861 patients included in the recent Acute Respiratory Distress Syndrome Network trial of lower tidal volume ventilation (1). We also correlated urine desmosine levels with indexes of disease severity. Finally, we assessed whether urine desmosine was lower in patients who received lower tidal volumes. Desmosine was measured by radioimmunoassay in urine samples from days 0, 1, and 3 of the study. The data were expressed as a ratio of urine desmosine to urine creatinine to control for renal dilution. The results show that higher baseline (day 0) urine desmosine-to-creatinine concentration was associated with a higher risk of death on adjusted analysis (odds ratio 1.36, 95% confidence interval 1.02-1.82, P=0.03). Urine desmosine increased in both ventilator groups from day 0 to day 3, but the average rise was higher in the 12-ml/kg predicted body weight group compared with the 6-ml/kg predicted body weight group (P=0.053, repeated-measures model). In conclusion, patients with acute lung injury ventilated with lower tidal volumes have lower urine desmosine levels, a finding that may reflect reduced extracellular matrix breakdown. These results illustrate the value of evaluating urinary biological markers that may have prognostic and pathogenetic significance in acute lung injury.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

October 2006

Volume

291

Issue

4

Start / End Page

L566 / L571

Location

United States

Related Subject Headings

  • Ultrasonography
  • Tissue Survival
  • Time Factors
  • Tidal Volume
  • Severity of Illness Index
  • Respiratory System
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Predictive Value of Tests
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McClintock, D. E., Starcher, B., Eisner, M. D., Thompson, B. T., Hayden, D. L., Church, G. D., … National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network, . (2006). Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol, 291(4), L566–L571. https://doi.org/10.1152/ajplung.00457.2005
McClintock, Dana E., Barry Starcher, Mark D. Eisner, B Taylor Thompson, Doug L. Hayden, Gwynne D. Church, Michael A. Matthay, and Michael A. National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. “Higher urine desmosine levels are associated with mortality in patients with acute lung injury.Am J Physiol Lung Cell Mol Physiol 291, no. 4 (October 2006): L566–71. https://doi.org/10.1152/ajplung.00457.2005.
McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, et al. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L566–71.
McClintock, Dana E., et al. “Higher urine desmosine levels are associated with mortality in patients with acute lung injury.Am J Physiol Lung Cell Mol Physiol, vol. 291, no. 4, Oct. 2006, pp. L566–71. Pubmed, doi:10.1152/ajplung.00457.2005.
McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L566–L571.

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

October 2006

Volume

291

Issue

4

Start / End Page

L566 / L571

Location

United States

Related Subject Headings

  • Ultrasonography
  • Tissue Survival
  • Time Factors
  • Tidal Volume
  • Severity of Illness Index
  • Respiratory System
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Predictive Value of Tests
  • Middle Aged