Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Validation of spirometry prediction equations in western Kenya.

Publication ,  Journal Article
Paul, DW; Lagat, DK; MacIntyre, N; Egger, JR; Murdoch, DM; Que, LG; Kussin, PS
Published in: Int J Tuberc Lung Dis
January 1, 2018

SETTING: Community of Eldoret, Kenya. OBJECTIVE: To test the performance of three commonly used spirometry prediction equations in a healthy Kenyan population. DESIGN: Cross-sectional assessment of healthy adults in Eldoret. RESULTS: Of the 331 subjects enrolled in the study, 282 subjects aged 18-85 years (45% males, 55% females) produced high-quality spirograms. Lung function predictions were made using the Global Lung Initiative 2012 (GLI 2012) prediction equations for African Americans, the National Health and Nutrition Examination Survey III (NHANES III) prediction equations for African Americans, and the Crapo prediction equation. Bland-Altman analyses were performed to measure the agreement between observed and predicted spirometry parameters. Overall, the GLI 2012 and NHANES equations for African Americans performed similarly for forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), significantly overestimating FVC while accurately predicting observed FEV1 values. CONCLUSION: The study brings into question the utility of three major spirometry prediction equations in a Kenyan population. The significant overestimation of FVC by the best-performing equations despite accurate prediction of FEV1 suggests poor performance of these equations in our population.

Duke Scholars

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

January 1, 2018

Volume

22

Issue

1

Start / End Page

112 / 118

Location

France

Related Subject Headings

  • Young Adult
  • Vital Capacity
  • Spirometry
  • Respiratory Function Tests
  • Reference Values
  • Middle Aged
  • Microbiology
  • Male
  • Kenya
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Paul, D. W., Lagat, D. K., MacIntyre, N., Egger, J. R., Murdoch, D. M., Que, L. G., & Kussin, P. S. (2018). Validation of spirometry prediction equations in western Kenya. Int J Tuberc Lung Dis, 22(1), 112–118. https://doi.org/10.5588/ijtld.17.0005
Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya.Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.
Paul DW, Lagat DK, MacIntyre N, Egger JR, Murdoch DM, Que LG, et al. Validation of spirometry prediction equations in western Kenya. Int J Tuberc Lung Dis. 2018 Jan 1;22(1):112–8.
Paul, D. W., et al. “Validation of spirometry prediction equations in western Kenya.Int J Tuberc Lung Dis, vol. 22, no. 1, Jan. 2018, pp. 112–18. Pubmed, doi:10.5588/ijtld.17.0005.
Paul DW, Lagat DK, MacIntyre N, Egger JR, Murdoch DM, Que LG, Kussin PS. Validation of spirometry prediction equations in western Kenya. Int J Tuberc Lung Dis. 2018 Jan 1;22(1):112–118.

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

January 1, 2018

Volume

22

Issue

1

Start / End Page

112 / 118

Location

France

Related Subject Headings

  • Young Adult
  • Vital Capacity
  • Spirometry
  • Respiratory Function Tests
  • Reference Values
  • Middle Aged
  • Microbiology
  • Male
  • Kenya
  • Humans