Overview
My overall goal is to elucidate mechanisms of and risk factors for perioperative acute kidney injury in patients undergoing heart surgery with emphasis the role of early recovery of kidney function. A special area of interest is the phenomenon of left ventricular diastolic dysfunction. We have successfully developed an algorithm to help simplify the detection of diastolic dysfunction using echocardiography during heart surgery. A future goal is to explore interventions that help prevent or reduce the severity of diastolic dysfunction postoperatively.
Current Appointments & Affiliations
Adjunct Professor in the Department of Anesthesiology
·
2024 - Present
Anesthesiology, Cardiothoracic,
Anesthesiology
Recent Publications
Development of and recovery from acute kidney injury after cardiac surgery: Randomized phase 2 trial of the hepatocyte growth factor mimetic ANG-3777.
Journal Article J Thorac Cardiovasc Surg · October 2025 OBJECTIVES: To investigate the safety and efficacy of ANG-3777, a hepatocyte growth factor mimetic, in mitigating the risk of acute kidney injury (AKI) in patients undergoing cardiac surgery with cardiopulmonary bypass. METHODS: In this double-blind placeb ... Full text Link to item CiteThe Odyssey of Diastolic Function: No Time to Relax.
Journal Article Anesth Analg · January 1, 2025 Full text Link to item CiteAn Automated Machine Learning-Based Quantitative Multiparametric Approach for Mitral Regurgitation Severity Grading.
Journal Article JACC Cardiovasc Imaging · January 2025 BACKGROUND: Considering the high prevalence of mitral regurgitation (MR) and the highly subjective, variable MR severity reporting, an automated tool that could screen patients for clinically significant MR (≥ moderate) would streamline the diagnostic/ther ... Full text Link to item CiteRecent Grants
A randomized, multi-centric, placebo-controlled, participant and investigator-blinded study to evaluate the safety, tolerability and efficacy of TIN816 in adult patients at risk for acute kidney injury following cardiac surgery
Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2023 - 2027Integrated Training in Anesthesiology Research
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2026Examining Confidence Ratings in MOCA Minute
ResearchMentor · Awarded by Foundation for Anesthesia Education and Research · 2023 - 2025View All Grants
Education, Training & Certifications
Delhi University, University College of Medical Sciences (India) ·
1990
M.B.B.S.