Scholars@Duke
Roger D. Madison

Roger D. Madison

Associate Professor Emeritus in Neurosurgery
Neurosurgery
madis001@mc.duke.edu
Box 2609 Med Ctr, Durham, NC 27710
38 VAMC Bldg 16, 508 Fulton St, Durham, NC 27705

Overview

Neuronal Plasticity: especially as related to the accuracy of peripheral nerve regeneration. My laboratory is currently involved in studying the efficacy of prosthetic "nerve guides" in rodents and non-human primates. The results suggest that such nerve guides can be as effective as a nerve graft to repair transected peripheral nerves. Limited clinical trials of the nerve guide prostheses are underway, in collaboration with a colleague in Denmark. The nerve regeneration work has more recently taken a molecular turn, and my laboratory is currently looking at the differential expression of genes that may underlie the accuracy of peripheral nerve regeneration. We have developed a double labeling technique which allows us to assess the accuracy of nerve regeneration at the single neuron level. We are finding that motor axons and sensory afferents to muscle display a greater than chance level to grow back to muscle as opposed to skin (ie. regeneration specificity). To identify genes and gene products that may be involved in this process, we are using classical subtractive hybridization, the PCR-based differential display of mRNAs, and amplified antisense RNA (aRNA) for Êexpression profilingË.

Current Appointments & Affiliations

Associate Professor Emeritus in Neurosurgery · 2017 - Present Neurosurgery, Neurosurgery

Recent Publications

Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy.

Journal Article Neuroscience · November 1, 2019 Extracellular vesicles are lipid bilayer-enclosed extracellular structures. Although the term extracellular vesicles is quite inclusive, it generally refers to exosomes (<200 nm), and microvesicles (~100-1000 nm). Such vesicles are resistant to degradation ... Full text Link to item Cite

Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.

Journal Article J Neurosci Res · July 2016 Functional recovery following a peripheral nerve injury is made easier when regenerating axons correctly reinnervate their original targets. Polyethylene glycol (PEG) has recently been used in attempts to fuse severed peripheral axons during suture-based r ... Full text Link to item Cite
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Recent Grants

IPA - Grant Robinson

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2018 - 2018

International Symposium on Neural Regeneration

ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2015

Low-Voltage Nerve Electrophoresis In Vivo: Role in Peripheral Nerve Regeneration

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2015

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Education, Training & Certifications

Duke University · 1981 Ph.D.