Roger D. Madison | Scholars@Duke

Roger D. Madison
Associate Professor Emeritus in Neurosurgery

Neuronal Plasticity: especially as related to the accuracy of peripheral nerve regeneration. My laboratory is currently involved in studying the efficacy of prosthetic "nerve guides" in rodents and non-human primates. The results suggest that such nerve guides can be as effective as a nerve graft to repair transected peripheral nerves. Limited clinical trials of the nerve guide prostheses are underway, in collaboration with a colleague in Denmark. The nerve regeneration work has more recently taken a molecular turn, and my laboratory is currently looking at the differential expression of genes that may underlie the accuracy of peripheral nerve regeneration. We have developed a double labeling technique which allows us to assess the accuracy of nerve regeneration at the single neuron level. We are finding that motor axons and sensory afferents to muscle display a greater than chance level to grow back to muscle as opposed to skin (ie. regeneration specificity). To identify genes and gene products that may be involved in this process, we are using classical subtractive hybridization, the PCR-based differential display of mRNAs, and amplified antisense RNA (aRNA) for Êexpression profilingË.

Current Appointments & Affiliations

Associate Professor Emeritus in Neurosurgery, Neurosurgery, Neurosurgery 2017

Contact Information

38 VAMC Bldg 16, 508 Fulton St, Durham, NC 27705
Box 2609 Med Ctr, Durham, NC 27710
madis001@mc.duke.edu (919) 286-6956

Background
Education, Training, & Certifications
- Research Fellow, Neuroscience, Harvard University 1981 - 1983
- Ph.D., Duke University 1981
Previous Appointments & Affiliations
- Associate Professor of Neurosurgery, Neurosurgery, Neurosurgery 2010 - 2017
- Associate Research Professor of Neurobiology, Neurobiology, Basic Science Departments 1994 - 2013
- Associate Professor in Surgical Sciences in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2006 - 2010
- Associate Research Professor in Experimental Surgery in the Department of Surgery, Surgery, Surgical Sciences, Surgery 1996 - 2006
- Associate Research Professor in Experimental Surgery in the Department of Surgery, Neurosurgery, Neurosurgery 1994 - 1996
- Assistant Research Professor of Neurobiology, Neurobiology, Basic Science Departments 1994
Academic Positions Outside Duke
- Assistant Professor, Harvard University. 1984 - 1988
- Instructor, Harvard University. 1983 - 1984
Research
Selected Grants
- IPA - Grant Robinson awarded by Durham Veterans Affairs Medical Center 2018
- International Symposium on Neural Regeneration awarded by National Institutes of Health 2013 - 2015
- Low-Voltage Nerve Electrophoresis In Vivo: Role in Peripheral Nerve Regeneration awarded by National Institutes of Health 2010 - 2015
- IPA - Grant Robinson awarded by Durham Veterans Affairs Medical Center 2012 - 2014
- International Symposium on Neural Regeneration Conference awarded by National Institutes of Health 2011 - 2013
- IPA - Grant Robinson awarded by Durham Veterans Affairs Medical Center 2010 - 2012
- IPA Agreement - Grant Robinson awarded by Veterans Administration Medical Center 2008 - 2010
- International Symposium on Neural Regeneration awarded by National Institutes of Health 2009 - 2010
- Enhancing Motor Neuron Regeneration Accuracy awarded by National Institutes of Health 2008 - 2010
- IPA - S. R. Chadaram awarded by Veterans Administration Medical Center 2007 - 2009
- International Symposium on Neural Regeneration awarded by National Institutes of Health 2007 - 2008
- International Symposium on Neural Regeneration awarded by National Institutes of Health 2005 - 2007
- International Symposium on Neural Regeneration awarded by National Institutes of Health 2001 - 2004
- Mechanisms Influencing The Accuracy Of Pns Regeneration awarded by National Institutes of Health 1986 - 1999
- Display Memoryeration In Lesioned, Grafted Hippocampus awarded by National Institutes of Health 1997 - 1999
- Mechanisms Influencing The Accuracy Of Pns Regulation awarded by National Institutes of Health 1995 - 1998
- Nerve Guide:Neurosurgical Alternative For Nerve Repair awarded by National Institutes of Health 1993 - 1995
- Synaptic Integration And Lesioning Of Pre-Labeled Grafts awarded by National Institutes of Health 1993 - 1994
- Nerve Guide: Neurosurgical Alternative For Nerve Repair awarded by National Institutes of Health 1992 - 1994
- Nerve Guide: Neurosurgical Alternative For Nerve Repair awarded by National Institutes of Health 1991 - 1994
- Micro-Environmental Influences On Pns Regeneration awarded by National Institutes of Health 1988 - 1989
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Madison, Roger D., and Grant A. Robinson. “Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy.” Neuroscience 419 (November 1, 2019): 46–59. https://doi.org/10.1016/j.neuroscience.2019.08.028.
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  - Robinson, Grant A., and Roger D. Madison. “The title and data of Robinson and Madison (2016) are valid.” J Neurosci Res 95, no. 3 (March 2017): 867–68. https://doi.org/10.1002/jnr.23867.
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  - Robinson, Grant A., and Roger D. Madison. “Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.” J Neurosci Res 94, no. 7 (July 2016): 636–44. https://doi.org/10.1002/jnr.23734.
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  - Risher, Mary-Louise, Hannah G. Sexton, W Christopher Risher, Wilkie A. Wilson, Rebekah L. Fleming, Roger D. Madison, Scott D. Moore, Cagla Eroglu, and H Scott Swartzwelder. “Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.” Alcohol Clin Exp Res 39, no. 12 (December 2015): 2403–13. https://doi.org/10.1111/acer.12913.
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  - Li, Qiang, Roger Madison, and Scott D. Moore. “Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.” J Neurosci 34, no. 41 (October 8, 2014): 13714–24. https://doi.org/10.1523/JNEUROSCI.5284-13.2014.
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  - Madison, R. D., and G. A. Robinson. “Accuracy of regenerating motor neurons: influence of diffusion in denervated nerve.” Neuroscience 273 (July 25, 2014): 128–40. https://doi.org/10.1016/j.neuroscience.2014.05.016.
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  - Madison, Roger D., Grant A. Robinson, Christian Krarup, Mihai Moldovan, Qiang Li, and Wilkie A. Wilson. “In vitro electrophoresis and in vivo electrophysiology of peripheral nerve using DC field stimulation.” J Neurosci Methods 225 (March 30, 2014): 90–96. https://doi.org/10.1016/j.jneumeth.2014.01.018.
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  - Madison, Roger D., Christopher McGee, Renee Rawson, and Grant A. Robinson. “Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34).” J Extracell Vesicles 3 (2014). https://doi.org/10.3402/jev.v3.22865.
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  - Li, Qiang, Rebekah L. Fleming, Shawn K. Acheson, Roger D. Madison, Scott D. Moore, Mary-Louise Risher, Wilkie A. Wilson, and H Scott Swartzwelder. “Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.” Alcohol Clin Exp Res 37, no. 12 (December 2013): 2074–85. https://doi.org/10.1111/acer.12204.
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  - Wang, Hong-Gang, Xiao Ping He, Qiang Li, Roger D. Madison, Scott D. Moore, James O. McNamara, and Geoffrey S. Pitt. “The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.” J Biol Chem 288, no. 19 (May 10, 2013): 13258–68. https://doi.org/10.1074/jbc.M112.434548.
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  - Robinson, Grant A., and Roger D. Madison. “Polysialic acid expression is not necessary for motor neuron target selectivity.” Muscle Nerve 47, no. 3 (March 2013): 364–71. https://doi.org/10.1002/mus.23526.
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  - Robinson, Grant A., and Roger D. Madison. “Motor neuron target selectivity and survival after prolonged axotomy.” Restor Neurol Neurosci 31, no. 4 (2013): 451–60. https://doi.org/10.3233/RNN-120301.
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  - Yan, Haidun, Qiang Li, Roger Madison, Wilkie A. Wilson, and H Scott Swartzwelder. “Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats.” J Pharmacol Exp Ther 335, no. 1 (October 2010): 51–60. https://doi.org/10.1124/jpet.110.168450.
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  - Madison, R. D., M. V. Sofroniew, and G. A. Robinson. “Schwann cell influence on motor neuron regeneration accuracy.” Neuroscience 163, no. 1 (September 29, 2009): 213–21. https://doi.org/10.1016/j.neuroscience.2009.05.073.
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  - Robinson, Grant A., and Roger D. Madison. “Influence of terminal nerve branch size on motor neuron regeneration accuracy.” Exp Neurol 215, no. 2 (February 2009): 228–35. https://doi.org/10.1016/j.expneurol.2008.10.002.
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  - Yan, Haidun, Qiang Li, Rebekah Fleming, Roger D. Madison, Wilkie A. Wilson, and H Scott Swartzwelder. “Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.” J Neurophysiol 101, no. 1 (January 2009): 67–83. https://doi.org/10.1152/jn.90557.2008.
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  - Payne, V. M., J. D. Kilts, J. C. Naylor, J. L. Strauss, P. S. Calhoun, R. D. Madison, and C. E. Marx. “Allopregnanolone and pregnenolone alterations following pharmacological agents in rodents and clinic populations,” December 1, 2008, 369–83. https://doi.org/10.1007/978-1-4020-6854-6_18.
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  - Naylor, Jennifer C., Christine M. Hulette, David C. Steffens, Lawrence J. Shampine, John F. Ervin, Victoria M. Payne, Mark W. Massing, et al. “Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.” J Clin Endocrinol Metab 93, no. 8 (August 2008): 3173–78. https://doi.org/10.1210/jc.2007-1229.
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  - Marx, Christine E., Peixiong Yuan, Jason D. Kilts, Roger D. Madison, Lawrence J. Shampine, and Husseini K. Manji. “Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.” Int J Neuropsychopharmacol 11, no. 4 (June 2008): 547–52. https://doi.org/10.1017/S1461145708008444.
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  - Chadaram, Srinivas Rao, Michael B. Laskowski, and Roger D. Madison. “Topographic specificity within membranes of a single muscle detected in vitro.” J Neurosci 27, no. 51 (December 19, 2007): 13938–48. https://doi.org/10.1523/JNEUROSCI.3055-07.2007.
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  - Uschold, Timothy, Grant A. Robinson, and Roger D. Madison. “Motor neuron regeneration accuracy: balancing trophic influences between pathways and end-organs.” Exp Neurol 205, no. 1 (May 2007): 250–56. https://doi.org/10.1016/j.expneurol.2007.02.005.
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  - Madison, R. D., G. A. Robinson, and S. R. Chadaram. “The specificity of motor neurone regeneration (preferential reinnervation).” Acta Physiol (Oxf) 189, no. 2 (February 2007): 201–6. https://doi.org/10.1111/j.1748-1716.2006.01657.x.
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  - Massing, Mark W., Judyta Misiurek, Srinivas R. Chadaram, Christine E. Marx, and Roger Madison. “New developments in proteomics.” N C Med J 68, no. 2 (2007): 119–22.
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  - Marx, Christine E., Lawrence J. Shampine, Gary E. Duncan, Margaret J. VanDoren, A Chistina Grobin, Mark W. Massing, Roger D. Madison, et al. “Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?” Pharmacol Biochem Behav 84, no. 4 (August 2006): 598–608. https://doi.org/10.1016/j.pbb.2006.07.026.
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  - Marx, Christine E., Lawrence J. Shampine, Rahul T. Khisti, William T. Trost, Daniel W. Bradford, A Chistina Grobin, Mark W. Massing, et al. “Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.” Pharmacol Biochem Behav 84, no. 4 (August 2006): 609–17. https://doi.org/10.1016/j.pbb.2006.07.032.
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  - Robinson, Grant A., and Roger D. Madison. “Developmentally regulated changes in femoral nerve regeneration in the mouse and rat.” Exp Neurol 197, no. 2 (February 2006): 341–46. https://doi.org/10.1016/j.expneurol.2005.10.007.
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  - Robinson, Grant A., and Roger D. Madison. “Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons.” Exp Neurol 192, no. 1 (March 2005): 39–45. https://doi.org/10.1016/j.expneurol.2004.10.013.
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  - Robinson, Grant A., and Roger D. Madison. “Motor neurons can preferentially reinnervate cutaneous pathways.” Exp Neurol 190, no. 2 (December 2004): 407–13. https://doi.org/10.1016/j.expneurol.2004.08.007.
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  - Robinson, G. A., and R. D. Madison. “Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft.” Vision Res 44, no. 23 (October 2004): 2667–74. https://doi.org/10.1016/j.visres.2004.06.010.
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  - Robinson, Grant A., and Roger D. Madison. “Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture.” Muscle Nerve 28, no. 2 (August 2003): 227–31. https://doi.org/10.1002/mus.10422.
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  - Krarup, Christian, Simon J. Archibald, and Roger D. Madison. “Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve.” Ann Neurol 51, no. 1 (January 2002): 69–81. https://doi.org/10.1002/ana.10054.
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  - Robinson, G. A., and R. D. Madison. “Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue.” J Neurosurg 93, no. 2 (August 2000): 275–78. https://doi.org/10.3171/jns.2000.93.2.0275.
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  - Madison, R. D., A. Zomorodi, and G. A. Robinson. “Netrin-1 and peripheral nerve regeneration in the adult rat.” Exp Neurol 161, no. 2 (February 2000): 563–70. https://doi.org/10.1006/exnr.1999.7292.
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  - Madison, R. D., S. J. Archibald, R. Lacin, and C. Krarup. “Factors contributing to preferential motor reinnervation in the primate peripheral nervous system.” J Neurosci 19, no. 24 (December 15, 1999): 11007–16. https://doi.org/10.1523/JNEUROSCI.19-24-11007.1999.
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  - Madison, R. D., and G. A. Robinson. “lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling.” Biotechniques 25, no. 3 (September 1998): 504-passim. https://doi.org/10.2144/98253rr06.
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  - Ackley, R. L., R. D. Madison, S. J. Archibald, and J. J. Hemperly. “Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.” Mol Cell Neurosci 10, no. 1–2 (1997): 117–29. https://doi.org/10.1006/mcne.1997.0645.
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  - Madison, R. D., S. J. Archibald, and T. M. Brushart. “Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons.” J Neurosci 16, no. 18 (September 15, 1996): 5698–5703. https://doi.org/10.1523/JNEUROSCI.16-18-05698.1996.
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  - Shetty, A. K., D. Rapoza, R. D. Madison, and D. A. Turner. “Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore.” Neuroscience 69, no. 2 (November 1995): 407–16. https://doi.org/10.1016/0306-4522(95)00279-r.
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  - Archibald, S. J., J. Shefner, C. Krarup, and R. D. Madison. “Monkey median nerve repaired by nerve graft or collagen nerve guide tube.” J Neurosci 15, no. 5 Pt 2 (May 1995): 4109–23. https://doi.org/10.1523/JNEUROSCI.15-05-04109.1995.
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  - Madison, R. D., and S. J. Archibald. “Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing.” Exp Neurol 128, no. 2 (August 1994): 266–75. https://doi.org/10.1006/exnr.1994.1136.
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  - Shetty, A. K., R. D. Madison, J. Bradley, and D. A. Turner. “Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus.” Exp Neurol 126, no. 2 (April 1994): 205–24. https://doi.org/10.1006/exnr.1994.1059.
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  - Pyapali, G. K., D. A. Turner, and R. D. Madison. “Fetal transplants in rat hippocampus following kainic acid lesions: influence of post-lesion delay on graft survival and integration.” Restor Neurol Neurosci 6, no. 2 (January 1, 1994): 113–26. https://doi.org/10.3233/RNN-1994-6205.
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  - Paramore, C. G., D. A. Turner, and R. D. Madison. “Induction of neuronal morphology in adrenal chromaffin cells cocultured with denervated Schwann cells.” Exp Neurol 121, no. 2 (June 1993): 288–94. https://doi.org/10.1006/exnr.1993.1099.
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  - Madison, R. D., and J. D. Macklis. “Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore.” Exp Neurol 121, no. 2 (June 1993): 153–59. https://doi.org/10.1006/exnr.1993.1082.
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  - Paramore, C. G., D. A. Turner, and R. D. Madison. “Fluorescent labeling of dissociated fetal cells for tissue culture.” J Neurosci Methods 44, no. 1 (August 1992): 7–17. https://doi.org/10.1016/0165-0270(92)90108-p.
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  - Pyapali, G. K., D. A. Turner, and R. D. Madison. “Anatomical and physiological localization of prelabeled grafts in rat hippocampus.” Exp Neurol 116, no. 2 (May 1992): 133–44. https://doi.org/10.1016/0014-4886(92)90161-i.
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  - Friedman, A. H., S. J. Archibald, and R. D. Madison. “Peripheral nerve repair with collagen tubes.” Neurosurgery 30, no. 5 (January 1, 1992): 808. https://doi.org/10.1227/00006123-199205000-00056.
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  - Li, S. T., S. J. Archibald, C. Krarup, and R. D. Madison. “Peripheral nerve repair with collagen conduits.” Clin Mater 9, no. 3–4 (1992): 195–200. https://doi.org/10.1016/0267-6605(92)90100-8.
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  - Harsh, C., S. J. Archibald, and R. D. Madison. “Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level.” J Neurosci Methods 39, no. 2 (September 1991): 123–30. https://doi.org/10.1016/0165-0270(91)90078-e.
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  - Macklis, J. D., and R. D. Madison. “Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore.” J Neurosci 11, no. 7 (July 1991): 2055–62. https://doi.org/10.1523/JNEUROSCI.11-07-02055.1991.
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  - Kljavin, I. J., R. D. Madison, and T. A. Reh. “Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading.” Exp Cell Res 194, no. 1 (May 1991): 135–38. https://doi.org/10.1016/0014-4827(91)90142-h.
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  - Archibald, S. J., C. Krarup, J. Shefner, S. T. Li, and R. D. Madison. “A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates.” J Comp Neurol 306, no. 4 (April 22, 1991): 685–96. https://doi.org/10.1002/cne.903060410.
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  - Weil, S. M., R. D. Madison, and K. A. Crutcher. “Collagen nerve guide tubes in the rat septohippocampal pathway.” Restor Neurol Neurosci 3, no. 4 (January 1, 1991): 167–75. https://doi.org/10.3233/RNN-1991-3401.
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  - Madison, R., J. D. Macklis, and C. Thies. “Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport.” Brain Res 522, no. 1 (July 2, 1990): 90–98. https://doi.org/10.1016/0006-8993(90)91581-z.
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  - Li, S. T., S. J. Archibald, C. Krarup, and R. Madison. “Semipermeable collagen nerve conduits for peripheral nerve regeneration.” Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering 62 (January 1, 1990): 575–82.
  - Macklis, J. D., and R. D. Madison. “Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity.” J Neurosci Methods 31, no. 1 (January 1990): 43–46. https://doi.org/10.1016/0165-0270(90)90007-3.
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  - Quattrochi, J. J., A. N. Mamelak, R. D. Madison, J. D. Macklis, and J. A. Hobson. “Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres.” Science 245, no. 4921 (September 1, 1989): 984–86. https://doi.org/10.1126/science.2475910.
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  - Cordeiro, P. G., B. R. Seckel, S. A. Lipton, P. A. D’Amore, J. Wagner, and R. Madison. “Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo.” Plast Reconstr Surg 83, no. 6 (June 1989): 1013–19.
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  - Rosario, C. M., K. R. Fry, and R. Madison. “Rabbit retinal ganglion cells survive optic nerve transection and entubulation repair with type I collagen nerve guide tubes.” Restorative Neurology and Neuroscience 1, no. 1 (January 1, 1989): 31–37. https://doi.org/10.3233/RNN-1989-1104.
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  - Madison, R. D., C. F. Da Silva, and P. Dikkes. “Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses.” Brain Res 447, no. 2 (May 3, 1988): 325–34. https://doi.org/10.1016/0006-8993(88)91135-3.
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  - Lipton, S. A., J. A. Wagner, R. D. Madison, and P. A. D’Amore. “Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.” Proc Natl Acad Sci U S A 85, no. 7 (April 1988): 2388–92. https://doi.org/10.1073/pnas.85.7.2388.
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  - Madison, R. D., J. D. Macklis, and M. P. Frosch. “Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption.” Brain Res 445, no. 1 (March 29, 1988): 101–10. https://doi.org/10.1016/0006-8993(88)91078-5.
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  - Cordeiro, P. G., R. Madison, and B. R. Seckel. “Use of a nerve guide and purified protein growth factor to trophically enhance peripheral nerve regeneration.” Surgical Forum 39 (January 1, 1988): 635–37.
  - Quattrochi, J. J., R. Madison, R. L. Sidman, and I. Kljavin. “Colloidal gold fluorescent microspheres: a new retrograde marker visualized by light and electron microscopy.” Exp Neurol 96, no. 1 (April 1987): 219–24. https://doi.org/10.1016/0014-4886(87)90184-1.
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  - Madison, R. D., C. da Silva, P. Dikkes, R. L. Sidman, and T. H. Chiu. “Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel.” Exp Neurol 95, no. 2 (February 1987): 378–90. https://doi.org/10.1016/0014-4886(87)90146-4.
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  - Macklis, J. D., and R. Madison. “Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis.” Brain Res 359, no. 1–2 (December 16, 1985): 158–65. https://doi.org/10.1016/0006-8993(85)91424-6.
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  - Silva, C. F. da, R. Madison, P. Dikkes, T. H. Chiu, and R. L. Sidman. “An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes.” Brain Res 342, no. 2 (September 9, 1985): 307–15. https://doi.org/10.1016/0006-8993(85)91130-8.
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  - Madison, R., C. F. da Silva, P. Dikkes, T. H. Chiu, and R. L. Sidman. “Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.” Exp Neurol 88, no. 3 (June 1985): 767–72. https://doi.org/10.1016/0014-4886(85)90087-1.
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  - Madison, R., R. L. Sidman, E. Nyilas, T. H. Chiu, and D. Greatorex. “Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve.” Exp Neurol 86, no. 3 (December 1984): 448–61. https://doi.org/10.1016/0014-4886(84)90080-3.
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  - Madison, R., M. R. Moore, and R. L. Sidman. “Retinal ganglion cells and axons survive optic nerve transection.” Int J Neurosci 23, no. 1 (March 1984): 15–32. https://doi.org/10.3109/00207458408985342.
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  - Madison, R., and J. N. Davis. “Regulation of hippocampal sympathetic ingrowth: role of afferent input.” Brain Res 270, no. 1 (June 27, 1983): 1–9. https://doi.org/10.1016/0006-8993(83)90785-0.
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  - Madison, R., and J. N. Davis. “Sprouting of noradrenergic fibers in hippocampus after medial septal lesions: contributions of the central and peripheral nervous systems.” Exp Neurol 80, no. 1 (April 1983): 167–77. https://doi.org/10.1016/0014-4886(83)90013-4.
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  - Nyilas, E., T. H. Chiu, R. L. Sidman, E. W. Henry, T. M. Brushart, P. Dikkes, and R. Madison. “Peripheral nerve repair with bioresorbable prosthesis.” Trans Am Soc Artif Intern Organs 29 (1983): 307–13.
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  - Madison, R., K. A. Crutcher, and J. N. Davis. “Sympathohippocampal neurons are inside the blood--brain barrier.” Brain Res 213, no. 1 (May 25, 1981): 183–89. https://doi.org/10.1016/0006-8993(81)91259-2.
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  - Crutcher, K. A., R. Madison, and J. N. Davis. “A study of the rat septohippocampal pathway using anterograde transport of horseradish peroxidase.” Neuroscience 6, no. 10 (1981): 1961–73. https://doi.org/10.1016/0306-4522(81)90036-1.
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- Book Sections
  - Massing, M. W., G. A. Robinson, C. E. Marx, O. Alzate, and R. D. Madison. “Applications of proteomics to nerve regeneration research.” In Neuroproteomics, 289–313, 2009.
  - Zomorodi, A., and R. D. Madison. “Advances in treatment of spinal cord and peripheral nerve injury.” In Modern Neurosurgery: Clinical Translation of Neuroscience Advances, 37–58, 2004.
- Conference Papers
  - Schiering, D. W., D. Rapoza, R. D. Madison, R. G. Messerschmidt, and D. T. Kuehl. “Infrared mapping microspectroscopy of a latex neuroanatomical probe in brain tissue.” In Proceedings of Spie the International Society for Optical Engineering, 2089:120–21, 1994. https://doi.org/10.1117/12.166696.
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