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Roger D. Madison

Associate Professor Emeritus in Neurosurgery
Neurosurgery
Box 2609 Med Ctr, Durham, NC 27710
38 VAMC Bldg 16, 508 Fulton St, Durham, NC 27705

Overview


Neuronal Plasticity: especially as related to the accuracy of peripheral nerve regeneration. My laboratory is currently involved in studying the efficacy of prosthetic "nerve guides" in rodents and non-human primates. The results suggest that such nerve guides can be as effective as a nerve graft to repair transected peripheral nerves. Limited clinical trials of the nerve guide prostheses are underway, in collaboration with a colleague in Denmark. The nerve regeneration work has more recently taken a molecular turn, and my laboratory is currently looking at the differential expression of genes that may underlie the accuracy of peripheral nerve regeneration. We have developed a double labeling technique which allows us to assess the accuracy of nerve regeneration at the single neuron level. We are finding that motor axons and sensory afferents to muscle display a greater than chance level to grow back to muscle as opposed to skin (ie. regeneration specificity). To identify genes and gene products that may be involved in this process, we are using classical subtractive hybridization, the PCR-based differential display of mRNAs, and amplified antisense RNA (aRNA) for √äexpression profiling√č.

Current Appointments & Affiliations


Associate Professor Emeritus in Neurosurgery · 2017 - Present Neurosurgery, Neurosurgery

Education, Training & Certifications


Duke University · 1981 Ph.D.