Roger D. Madison

Journal Article Neuroscience · November 1, 2019 Extracellular vesicles are lipid bilayer-enclosed extracellular structures. Although the term extracellular vesicles is quite inclusive, it generally refers to exosomes (<200 nm), and microvesicles (~100-1000 nm). Such vesicles are resistant to degradation ... Full text Link to item Cite

The title and data of Robinson and Madison (2016) are valid.

Journal Article J Neurosci Res · March 2017 Full text Link to item Cite

Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.

Journal Article J Neurosci Res · July 2016 Functional recovery following a peripheral nerve injury is made easier when regenerating axons correctly reinnervate their original targets. Polyethylene glycol (PEG) has recently been used in attempts to fuse severed peripheral axons during suture-based r ... Full text Link to item Cite

Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.

Journal Article Alcohol Clin Exp Res · December 2015 BACKGROUND: Adolescent intermittent alcohol exposure (AIE) has profound effects on neuronal function. We have previously shown that AIE causes aberrant hippocampal structure and function that persists into adulthood. However, the possible contributions of ... Full text Link to item Cite

Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.

Journal Article J Neurosci · October 8, 2014 Large-conductance calcium-activated potassium BK channels are widely expressed in the brain and are involved in the regulation of neuronal functions such as neurotransmitter release. However, their possible role in mediating ethanol-induced GABA release is ... Full text Link to item Cite

Accuracy of regenerating motor neurons: influence of diffusion in denervated nerve.

Journal Article Neuroscience · July 25, 2014 Following injury to a peripheral nerve the denervated distal nerve segment undergoes remarkable changes including loss of the blood-nerve barrier, Schwann cell proliferation, macrophage invasion, and the production of many cytokines and neurotrophic factor ... Full text Link to item Cite

In vitro electrophoresis and in vivo electrophysiology of peripheral nerve using DC field stimulation.

Journal Article J Neurosci Methods · March 30, 2014 BACKGROUND: Given the movement of molecules within tissue that occurs naturally by endogenous electric fields, we examined the possibility of using a low-voltage DC field to move charged substances in rodent peripheral nerve in vitro. NEW METHOD: Labeled s ... Full text Link to item Cite

Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34).

Journal Article J Extracell Vesicles · 2014 INTRODUCTION: There is renewed interest in extracellular vesicles over the past decade or 2 after initially being thought of as simple cellular garbage cans to rid cells of unwanted components. Although there has been intense research into the role of extr ... Full text Link to item Cite

Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.

Journal Article Alcohol Clin Exp Res · December 2013 BACKGROUND: Chronic alcohol use, especially exposure to alcohol during adolescence or young adulthood, is closely associated with cognitive deficits that may persist into adulthood. Therefore, it is essential to identify possible neuronal mechanisms underl ... Full text Link to item Cite

The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.

Journal Article J Biol Chem · May 10, 2013 BACKGROUND: The necessity for, or redundancy of, distinctive KChIP proteins is not known. RESULTS: Deletion of KChIP2 leads to increased susceptibility to epilepsy and to a reduction in IA and increased excitability in pyramidal hippocampal neurons. CONCLU ... Full text Link to item Cite

Polysialic acid expression is not necessary for motor neuron target selectivity.

Journal Article Muscle Nerve · March 2013 INTRODUCTION: Recovery after peripheral nerve lesions depends on guiding axons back to their targets. Polysialic acid upregulation by regrowing axons has been proposed recently as necessary for this target selectivity. METHODS: We reexamined this propositi ... Full text Link to item Cite

Motor neuron target selectivity and survival after prolonged axotomy.

Journal Article Restor Neurol Neurosci · 2013 PURPOSE: After a cut peripheral nerve is repaired, motor neurons usually regenerate across the lesion site, however they often enter an inappropriate Schwann cell tube and may be directed to an inappropriate target organ such as skin, resulting in continue ... Full text Link to item Cite

Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats.

Journal Article J Pharmacol Exp Ther · October 2010 Ethanol (EtOH) promotes GABAergic synaptic transmission in the central nervous system. We have shown that EtOH enhances the frequency of GABA(A) receptor-mediated spontaneous inhibitory postsynaptic currents less powerfully in hippocampal CA1 pyramidal neu ... Full text Link to item Cite

Schwann cell influence on motor neuron regeneration accuracy.

Journal Article Neuroscience · September 29, 2009 Extensive peripheral nerve injuries can result in the effective paralysis of the entire limb or distal portions of the limb. The major determinant of functional recovery after lesions in the peripheral nervous system is the accurate regeneration of axons t ... Full text Link to item Cite

Influence of terminal nerve branch size on motor neuron regeneration accuracy.

Journal Article Exp Neurol · February 2009 A necessary prerequisite for recovery of motor function following a peripheral nerve injury is the correct choice by regenerating motor neurons to reinnervate the original distal nerve branch to denervated muscle. The present studies use the mouse femoral ... Full text Link to item Cite

Applications of proteomics to nerve regeneration research

Chapter · January 1, 2009 Peripheral nerve injury is a major clinical and public health challenge. Although a common and increasingly prevalent wartime condition (1), injury to peripheral nerves, plexuses, and roots is present in 5% of patients seen in civilian trauma centers (2). ... Cite

Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.

Journal Article J Neurophysiol · January 2009 Ethanol (EtOH) has powerful effects on GABA(A) receptor-mediated neurotransmission, and we have previously shown that EtOH-induced enhancement of GABA(A) receptor-mediated synaptic transmission in the hippocampus is developmentally regulated. Because synap ... Full text Link to item Cite

Allopregnanolone and pregnenolone alterations following pharmacological agents in rodents and clinic populations

Journal Article · December 1, 2008 Recent research has revealed potential roles for neuroactive steroids in the pathophysiology and treatment of a number of psychiatric and neurological disorders. A wide array of preclinical investigations also reports neuroactive steroid actions in areas r ... Full text Cite

Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

Journal Article J Clin Endocrinol Metab · August 2008 OBJECTIVE: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain neurosteroid levels in humans. CSF and brain dehydroepiandrosterone (DHEA) levels are elevated in patients with Alzheimer's disease (AD), but it i ... Full text Link to item Cite

Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.

Journal Article Int J Neuropsychopharmacol · June 2008 Many neuroactive steroids (NS) demonstrate neurotrophic and neuroprotective actions, including protection against apoptosis via Bcl-2 protein. NS are altered in post-mortem brain tissue from subjects with bipolar disorder, and several agents with efficacy ... Full text Link to item Cite

Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy.

The title and data of Robinson and Madison (2016) are valid.

Journal Article J Neurosci Res · March 2017 Full text Link to item Cite

Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.

Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.

Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.

Accuracy of regenerating motor neurons: influence of diffusion in denervated nerve.

In vitro electrophoresis and in vivo electrophysiology of peripheral nerve using DC field stimulation.

Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34).

Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.

The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.

Polysialic acid expression is not necessary for motor neuron target selectivity.

Motor neuron target selectivity and survival after prolonged axotomy.

Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats.

Schwann cell influence on motor neuron regeneration accuracy.

Influence of terminal nerve branch size on motor neuron regeneration accuracy.

Applications of proteomics to nerve regeneration research

Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.

Allopregnanolone and pregnenolone alterations following pharmacological agents in rodents and clinic populations

Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.

Topographic specificity within membranes of a single muscle detected in vitro.

Journal Article J Neurosci · December 19, 2007 Spinal motor pools project to target muscles forming distinct rostrocaudal topographic maps during development and regeneration. To define the mechanisms underlying these neuromuscular maps we studied the preferential outgrowth of embryonic spinal cord neu ... Full text Link to item Cite

Motor neuron regeneration accuracy: balancing trophic influences between pathways and end-organs.

Journal Article Exp Neurol · May 2007 The key to recovery of function following peripheral nerve lesions is guiding axons back to their original target end-organs. The parent femoral nerve splits into two comparable terminal pathways: one to the muscle and the other to the skin. Normally, moto ... Full text Link to item Cite

The specificity of motor neurone regeneration (preferential reinnervation).

Journal Article Acta Physiol (Oxf) · February 2007 The major determinant of functional recovery after lesions in the peripheral nervous system is the accurate regeneration of axons to their original target end-organs. Unfortunately, regenerating motor axons are often misrouted to sensory target end-organs, ... Full text Link to item Cite

New developments in proteomics.

Journal Article N C Med J · 2007 Link to item Cite

Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?

Journal Article Pharmacol Biochem Behav · August 2006 Clozapine demonstrates superior efficacy in patients with schizophrenia, but the precise mechanisms contributing to this clinical advantage are not clear. Clozapine and olanzapine increase the GABAergic neuroactive steroid (NS) allopregnanolone, and it has ... Full text Link to item Cite

Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.

Journal Article Pharmacol Biochem Behav · August 2006 Olanzapine and fluoxetine elevate the GABAergic neuroactive steroid allopregnanolone to physiologically relevant concentrations in rodent cerebral cortex. It is unknown if these agents also alter pregnenolone or deoxycorticosterone. Since olanzapine and fl ... Full text Link to item Cite

Developmentally regulated changes in femoral nerve regeneration in the mouse and rat.

Journal Article Exp Neurol · February 2006 The attractive influence of muscle on regenerating motor neuron axons is well-known. Less is known, however, about the intrinsic abilities of different nerve pathways to support these axons prior to end-organ contact. The age at which a nerve injury is sus ... Full text Link to item Cite

Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons.

Journal Article Exp Neurol · March 2005 Previous studies using the femoral nerve model in both mice and rats have shown that regenerating motor axons prefer to reinnervate the terminal nerve branch to muscle versus a terminal nerve branch to skin, a process that has been termed preferential moto ... Full text Link to item Cite

Motor neurons can preferentially reinnervate cutaneous pathways.

Journal Article Exp Neurol · December 2004 Previous work in the rat femoral nerve has shown that regenerating motor neurons preferentially reinnervate a terminal nerve branch to muscle as opposed to skin. This process has been termed preferential motor reinnervation (PMR) and has been interpreted a ... Full text Link to item Cite

Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft.

Journal Article Vision Res · October 2004 Melanopsin is found in only approximately 2% of mouse retinal ganglion cells (RGCs), making these RGCs uniquely and directly photosensitive. Given that the majority of RGCs die after axotomy and that grafting of a peripheral nerve to the eye provides a per ... Full text Link to item Cite

Advances in treatment of spinal cord and peripheral nerve injury

Chapter · January 1, 2004 An estimated 400,000 people in the U.S. have permanent paralysis as a consequence of spinal cord injury and an additional 10,000 are injured each year. Patients with spinal cord injuries (SCI) can live 25 to 30 years after their initial injuries. Each pati ... Cite

Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture.

Journal Article Muscle Nerve · August 2003 Previous studies in rat femoral nerve demonstrated that regenerating motor axons preferentially reinnervate a nerve branch to muscle as opposed to skin, a process that has been termed preferential motor reinnervation (PMR). This process has not been previo ... Full text Link to item Cite

Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve.

Journal Article Ann Neurol · January 2002 Featured Publication Regeneration in the peripheral nervous system is often incomplete though it is uncertain which factors, such as the type and extent of the injury or the method or timing of repair, determine the degree of functional recovery. Serial electrophysiological te ... Full text Link to item Cite

Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue.

Journal Article J Neurosurg · August 2000 Featured Publication OBJECT: The goal of this study was to examine whether the method of attachment of a peripheral nerve graft would have an effect on retinal ganglion cell (RGC) regeneration. METHODS: The number of adult rat RGCs with regrown axons in a peripheral nerve graf ... Full text Link to item Cite

Netrin-1 and peripheral nerve regeneration in the adult rat.

Journal Article Exp Neurol · February 2000 Featured Publication Axonal guidance during development of the nervous system is thought to be highly regulated through interactions of axons with attractive, repulsive, and trophic cues. Similar mechanisms regulate axonal regeneration after injury. The netrins have been shown ... Full text Link to item Cite

Factors contributing to preferential motor reinnervation in the primate peripheral nervous system.

Journal Article J Neurosci · December 15, 1999 Featured Publication Functional recovery after nerve lesions in the peripheral nervous system requires the accurate regeneration of axons to their original target end organs. This paper examines axonal regeneration of the primate median nerve lesioned at the wrist over nerve g ... Full text Link to item Cite

lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling.

Journal Article Biotechniques · September 1998 Featured Publication There is an increasing interest in being able to document simultaneous levels of multiple mRNAs from limited amounts of mammalian tissue. The combination of amplified antisense RNA (aRNA) and reverse Northern blot analysis is one technology that allows the ... Full text Link to item Cite

Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.

Journal Article Mol Cell Neurosci · 1997 Featured Publication Cellular adhesion molecules can influence a variety of biological mechanisms in the nervous system. These range from the processes of normal development and maintenance to neural plasticity and recovery following injury. The elucidation of the intricate co ... Full text Link to item Cite

Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons.

Journal Article J Neurosci · September 15, 1996 Featured Publication Previous studies in the rat femoral nerve have shown that regenerating motor neurons preferentially reinnervate a terminal nerve branch to muscle as opposed to skin, a process that has been called preferential motor reinnervation. However, the ability of s ... Full text Link to item Cite

Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore.

Journal Article Neuroscience · November 1995 Featured Publication Selective removal of grafted tissue is critical to assess the functional role of that tissue in the host, yet is technically difficult for well-dispersed neural grafts. We labeled fetal hippocampal cells with both a nuclear marker (5'-bromodeoxyuridine) an ... Full text Link to item Cite

Monkey median nerve repaired by nerve graft or collagen nerve guide tube.

Journal Article J Neurosci · May 1995 Featured Publication Nerve regeneration was followed in 15 median and 1 ulnar nerve of eight Macaca fascicularis monkeys by serial electrophysiological assessments over a period of three and a half years. Nerve gaps of 5 mm at the wrist were bridged by collagen-based nerve gui ... Full text Link to item Cite

Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing.

Journal Article Exp Neurol · August 1994 Featured Publication Axonal regeneration in the peripheral nervous system requires the comigration of Schwann cells along with or ahead of the growing neurites. The present studies were undertaken to elucidate some of the parameters that influence Schwann cell migration into a ... Full text Link to item Cite

Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus.

Journal Article Exp Neurol · April 1994 Featured Publication Quantitative studies of neural graft development require: (1) a cell label which is both preferential for neurons and can be measured in terms of specific labeling; (2) a serial reconstruction method for identifying labeled cells in a three-dimensional pat ... Full text Link to item Cite

Infrared mapping microspectroscopy of a latex neuroanatomical probe in brain tissue

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 31, 1994 The feasibility of using IR mapping microspectroscopy to locate and identify a neuroanatomical probe in brain tissue has been demonstrated. Frequency specific IR maps were generated from a latex nanosphere injection site in brain tissue. The 2240 cm-1 νCN ... Full text Cite

Fetal transplants in rat hippocampus following kainic acid lesions: influence of post-lesion delay on graft survival and integration.

Journal Article Restor Neurol Neurosci · January 1, 1994 Host brain receptivity to fetal hippocampal grafts was investigated following transplantation into unilateral kainic acid (KA) lesions of adult rat hippocampus. E18-E19 hippocampal cell suspensions were labeled with rhodamine dextran amine and transplanted ... Full text Link to item Cite

Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore.

Journal Article Exp Neurol · June 1993 Interactions among neuronal subpopulations determine brain development and function. The present study illustrates the ability to noninvasively and selectively lesion targeted subpopulations of neurons in a highly specific, temporally defined, and geograph ... Full text Link to item Cite

Induction of neuronal morphology in adrenal chromaffin cells cocultured with denervated Schwann cells.

Journal Article Exp Neurol · June 1993 We have studied the interactions of adrenal chromaffin and Schwann cells in a coculture system to observe whether denervated Schwann cells induce and support chromaffin cell differentiation in a manner analogous to nerve growth factor (NGF). Schwann cells ... Full text Link to item Cite

Fluorescent labeling of dissociated fetal cells for tissue culture.

Journal Article J Neurosci Methods · August 1992 The ability to pre-label cells used in transplantation experiments would have the potential benefits of identification of cell type and associated processes and the analysis of graft migration in the host. We have used an in vitro tissue culture system as ... Full text Link to item Cite

Anatomical and physiological localization of prelabeled grafts in rat hippocampus.

Journal Article Exp Neurol · May 1992 Dissociated rat fetal hippocampal cells were grafted into normal adult rats. The fetal cells were incubated with one of a number of fluorescent compounds at the time of the dissociation to facilitate identification of the individual grafted cells. The fluo ... Full text Link to item Cite

Peripheral nerve repair with collagen tubes

Journal Article Neurosurgery · January 1, 1992 Full text Cite

Peripheral nerve repair with collagen conduits.

Journal Article Clin Mater · 1992 This paper describes the repair of peripheral nerves with a tubular conduit fabricated from collagen. The tubular collagen matrix was made semipermeable to permit nutrient exchange and accessibility of neurotrophic factors to the axonal growth zone during ... Full text Link to item Cite

Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level.

Journal Article J Neurosci Methods · September 1991 We have developed a labeling procedure which accurately and consistently labels the original sensory pools projecting to their respective nerve branches as a model to quantify the accuracy of nerve regeneration at the single neuron level. Adult and juvenil ... Full text Link to item Cite

Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore.

Journal Article J Neurosci · July 1991 Studies of neural cell transplantation would be aided by the ability to damage or destroy, noninvasively and extremely selectively, grafted cells at defined times following their initial implantation. Mechanisms of graft integration and performance could b ... Full text Link to item Cite

Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading.

Journal Article Exp Cell Res · May 1991 The substrate properties were compared between normal and myelin-deficient central nervous system (CNS) tissues by an in vitro assay of cell attachment and spreading. Fibroblasts (3T3) were plated onto culture substrata consisting of optic nerve tissue sec ... Full text Link to item Cite

A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates.

Journal Article J Comp Neurol · April 22, 1991 When a peripheral nerve is severed and left untreated, the most likely result is the formation of an endbulb neuroma; this tangled mass of disorganized nerve fibers blocks functional recovery following nerve injury. Although there are several different app ... Full text Link to item Cite

Collagen nerve guide tubes in the rat septohippocampal pathway.

Journal Article Restor Neurol Neurosci · January 1, 1991 Synthetic porous collagen tubes were implanted into the rat fimbria in order to determine whether such prostheses will permit axonal growth in the mature mammalian central nervous system (CNS). The tubes were found to slowly degrade over 4 weeks. In the ma ... Full text Link to item Cite

Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport.

Journal Article Brain Res · July 2, 1990 A wide range of latex particles are described which are capable of carrying high concentrations of fluorescent dyes, drugs, and photoactive agents selectively to subpopulations of neurons in vitro and in vivo. Particle size, charge, and concentration were ... Full text Link to item Cite

Semipermeable collagen nerve conduits for peripheral nerve regeneration

Journal Article Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering · January 1, 1990 In order to study the effect of the permeability of the conduit membrane on nerve regeneration, two types of nerve conduits from bovine tendon collagen were prepared which have distinctly different permeability properties. The authors report here the resul ... Cite

Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity.

Journal Article J Neurosci Methods · January 1990 We describe a visual assay of neuronal electrophysiologic status for use with cultured neurons, based on the exclusion of propidium iodide (PI) by intact cellular membranes. We use this fluorescent dye, which binds to nucleic acids, at concentrations suita ... Full text Link to item Cite

Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres.

Journal Article Science · September 1, 1989 The cholinergic agonist carbachol was conjugated to latex microspheres that were fluorescently labeled with rhodamine and used as neuroanatomical probes that show little diffusion from their injection site and retrogradely label neurons projecting to the i ... Full text Link to item Cite

Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo.

Journal Article Plast Reconstr Surg · June 1989 When added to a collagen-filled nerve guide, purified acidic fibroblast growth factor (aFGF) increased the number of myelinated axons that regenerated across a 5-mm nerve gap distance. In addition, a greater number of primary sensory and motor neurons exte ... Link to item Cite

Rabbit retinal ganglion cells survive optic nerve transection and entubulation repair with type I collagen nerve guide tubes

Journal Article Restorative Neurology and Neuroscience · January 1, 1989 The major objective of the experiments reported in this paper was to qualitatively test the hypothesis that rabbit retinal ganglion cells survive optic nerve transection and entubulation repair of the proximal optic nerve stump. The optic nerve of rabbits ... Full text Cite

Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses.

Journal Article Brain Res · May 3, 1988 The major objective of the experiments reported in this paper was to test the hypothesis that the maximum distance that peripheral nervous system (PNS) axons can regenerate through a tubular prosthesis may be increased by specific modifications to the inte ... Full text Link to item Cite

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

Journal Article Proc Natl Acad Sci U S A · April 1988 Postnatal rat retinal ganglion cells (RGCs) were identified with specific fluorescent labels and placed in culture. Under these conditions, the outgrowth of processes by RGCs was found to be promoted to a far greater degree by acidic fibroblast growth fact ... Full text Link to item Cite

Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption.

Journal Article Brain Res · March 29, 1988 Selective photothermolysis (SP) is a novel technique by which brief, unfocused laser pulses are selectively absorbed by, and cause selective thermal damage to, endogenously pigmented structures. This report describes the use of an exogenous non-fluorescent ... Full text Link to item Cite

Use of a nerve guide and purified protein growth factor to trophically enhance peripheral nerve regeneration

Journal Article Surgical Forum · January 1, 1988 Cite

Colloidal gold fluorescent microspheres: a new retrograde marker visualized by light and electron microscopy.

Journal Article Exp Neurol · April 1987 A new retrograde tracer, rhodamine latex microspheres, permits labeled neurons to be visualized with fluorescence light microscopy. However, their use has been limited to the light microscope. We now have developed colloidal gold fluorescent microspheres w ... Full text Link to item Cite

Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel.

Journal Article Exp Neurol · February 1987 These experiments present quantitative data concerning peripheral nerve regeneration in vivo. We used entubulation repair as a model to compare two different types of tubular prostheses, one nonbiodegradable and the other biodegradable. We modified the mic ... Full text Link to item Cite

Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis.

Journal Article Brain Res · December 16, 1985 Selective photothermolysis (SP) is a novel technique by which brief, unfocused laser pulses are selectively absorbed by, and cause selective thermal damage to, endogenously pigmented structures. The present experiments demonstrate the feasibility of using ... Full text Link to item Cite

An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes.

Journal Article Brain Res · September 9, 1985 An in vivo preparation is presented to study the rate and time course of motor and sensory axonal regeneration. The cut ends of a transected sciatic nerve were inserted into each end of a 5-6 mm non-toxic and bioresorbable nerve guide tube to create a 4 mm ... Full text Link to item Cite

Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.

Journal Article Exp Neurol · June 1985 The sciatic nerve of adult mice was transected and proximal and distal nerve stumps were sutured into a nontoxic bioresorbable nerve guide. Nerve guide lumens were either empty or filled with a gel containing 80% laminin and additional extracellular matrix ... Full text Link to item Cite

Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve.

Journal Article Exp Neurol · December 1984 Nontoxic, bioresorbable "nerve guide" tubes were used to bridge the transected optic nerves of adult rats. Nerve guides were fabricated as polymers of synthetic poly D,L-lactates with 2% triethyl citrate added as a plasticizer. The local environment was ma ... Full text Link to item Cite

Retinal ganglion cells and axons survive optic nerve transection.

Journal Article Int J Neurosci · March 1984 The effects of optic nerve transection on optic axon and retinal cell survival was studied in C57BL/6J mice. The optic nerve was transected either intracranially or intraorbitally . Data are presented which show that an intracranial transection of the opti ... Full text Link to item Cite

Regulation of hippocampal sympathetic ingrowth: role of afferent input.

Journal Article Brain Res · June 27, 1983 Peripheral noradrenergic fibers from the superior cervical ganglion (SCG) appear in the hippocampal formation of the adult rat central nervous system following damage to the medial septal nucleus or its afferent fibers. The appearance of these fibers coinc ... Full text Link to item Cite

Sprouting of noradrenergic fibers in hippocampus after medial septal lesions: contributions of the central and peripheral nervous systems.

Journal Article Exp Neurol · April 1983 The neuronal sprouting of noradrenergic fibers was studied in the hippocampal formation. The extent and time course of lesion-induced plasticity of both central and peripheral noradrenergic neurons was determined by assaying norepinephrine (NE) concentrati ... Full text Link to item Cite

Peripheral nerve repair with bioresorbable prosthesis.

Journal Article Trans Am Soc Artif Intern Organs · 1983 Using the transected sciatic nerve model in adult mice, regeneration of a large bundle of axons organized into the form of a nerve with myelinated and unmyelinated axons, Schwann cells, fibroblasts, collagen, blood vessels, and connective tissue sheaths ha ... Link to item Cite

Sympathohippocampal neurons are inside the blood--brain barrier.

Journal Article Brain Res · May 25, 1981 Full text Link to item Cite

A study of the rat septohippocampal pathway using anterograde transport of horseradish peroxidase.

Journal Article Neuroscience · 1981 Full text Link to item Cite