Journal ArticleSurg Infect (Larchmt) · April 2023
The use of medical implants continues to grow as the population ages. Biofilm-related implant infection is the leading cause of medical implant failure and remains difficult to diagnose and treat. Recent technologies have enhanced our understanding of the ...
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Journal ArticleAnesthesiol Clin · March 2023
The bipartite relationship between nutrition and the intestinal microbiome represents an exciting frontier in critical care medicine. In this review, the authors first address these topics independently, leading with a summary of recent clinical studies as ...
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Journal ArticleA A Pract · November 2020
Iatrogenic aortic injury is a rare but potentially lethal complication of cardiac surgery. While sometimes resulting in aortic dissection or intramural hematoma, injury more frequently results in subadventitial hematoma, a more benign pathology. Here, we d ...
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Journal ArticleAnesth Analg · October 2019
Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this firs ...
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Journal ArticleTransfusion · October 2018
BACKGROUND: Blood transfusion can be lifesaving for patients with hemorrhage; however, transfusion requirements for victims of gun violence are poorly understood. STUDY DESIGN AND METHODS: In an urban, Level 1 trauma center, 23,422 trauma patients were ana ...
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Journal ArticleJ Leukoc Biol · November 2016
CD8 T cell loss and dysfunction have been implicated in the increased susceptibility to opportunistic infections during the later immunosuppressive phase of sepsis, but CD8 T cell activation and attrition in early sepsis remain incompletely understood. Wit ...
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Journal ArticlePLoS One · 2016
Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use are asso ...
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Chapter · November 26, 2015
Alterations in the gut and immune function are proposed
to play an important role in the pathophysiology and progression of critical illness, especially in sepsis.1-6 Because
the treatment of most aspects of critical illness is supportive, significant rese ...
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