Jonathan Ball Mark | Scholars@Duke

Jonathan Ball Mark
Professor of Anesthesiology

1. Technology assessment defining the accuracy, clinical performance, and utility of new forms of cardiovascular monitoring during the perioperative period

2. New clinical applications of transesophageal echocardiography

3. Role of cardiovascular monitoring in reducing morbidity associated with cardiac surgery

4. Practice guideline development, training, and certification for perioperative transesophageal echocardiography, pulmonary artery catheterization, and cardiovascular monitoring

5. Patient safety improvement through clinician training and education and medical device design

Current Appointments & Affiliations

Professor of Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 2002
Chief, Division of VA Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 1992
Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1999

Contact Information

Box 3094 Med Ctr, Durham, NC 27710
D5005 VA Med Ctr, 508 Fulton St, Durham, NC 27705
mark0003@mc.duke.edu (919) 286-6938

Background
Education, Training, & Certifications
- M.D., Stanford University 1978
Duke Appointment History
- Associate Professor of Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 1999 - 2002
- Assistant Professor in Medicine, Medicine, Clinical Science Departments 1994 - 1999
- Associate Professor of Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 1992 - 1999
Research
Selected Grants
- Nurse Anesthetist Program awarded by Department of Health and Human Services 2000 - 2003
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hatton, KW, Yalamuri, S, McCartney, S, Hessel, EA, and Mark, JB. "Oscillating Continuous Cardiac Output in Postoperative Critically Ill Patients: Is this Phenomenon Accurate, Artifact, or Error?." Journal of cardiothoracic and vascular anesthesia 31, no. 4 (August 2017): e61-e62. (Letter) Full Text
  - Mark, JB. "Use of Pressure Transducers." The New England journal of medicine 377, no. 4 (July 2017): 400-401. (Letter) Full Text
  - Segall, N, Bonifacio, AS, Barbeito, A, Schroeder, RA, Perfect, SR, Wright, MC, Emery, JD, Atkins, BZ, Taekman, JM, and Mark, JB. "Operating Room-to-ICU Patient Handovers: A Multidisciplinary Human-Centered Design Approach." Joint Commission journal on quality and patient safety 42, no. 9 (September 2016): 400-414. Full Text
  - Asgarian, CD, Martinelli, SM, Mark, JB, and Kumar, PA. "Partial Anomalous Hepatic Venous Return: A Systematic Intraoperative Exclusion of Other Serious Diagnoses." Anesthesia and analgesia 122, no. 2 (February 2016): 349-353. Full Text
  - "Emerging Concepts in Transesophageal Echocardiography." F1000research 5 (January 1, 2016). (Review) Full Text
  - Barbeito, A, Bonifacio, A, Holtschneider, M, Segall, N, Schroeder, R, Mark, J, and Durham Veterans Affairs Medical Center Patient Safety Center of Inquiry, . "In situ simulated cardiac arrest exercises to detect system vulnerabilities." Simulation in healthcare : journal of the Society for Simulation in Healthcare 10, no. 3 (June 2015): 154-162. Full Text
  - Whitener, S, Konoske, R, and Mark, JB. "Pulmonary artery catheter." Best practice & research. Clinical anaesthesiology 28, no. 4 (December 2014): 323-335. Full Text
  - Barbeito, A, Lau, WT, Weitzel, N, Abernathy, JH, Wahr, J, and Mark, JB. "FOCUS: the Society of Cardiovascular Anesthesiologists' initiative to improve quality and safety in the cardiovascular operating room." Anesthesia and analgesia 119, no. 4 (October 2014): 777-783. Full Text
  - Bonifacio, AS, Segall, N, Barbeito, A, Taekman, J, Schroeder, R, and Mark, JB. "Handovers from the OR to the ICU." International Anesthesiology Clinics 51, no. 1 (January 2013): 43-61. Full Text
  - Segall, N, Bonifacio, AS, Schroeder, RA, Barbeito, A, Rogers, D, Thornlow, DK, Emery, J, Kellum, S, Wright, MC, Mark, JB, and Durham VA Patient Safety Center of Inquiry, . "Can we make postoperative patient handovers safer? A systematic review of the literature." Anesthesia and Analgesia 115, no. 1 (July 2012): 102-115. (Review) Full Text
  - American Society of Anesthesiologists Task Force on Central Venous Access, , Rupp, SM, Apfelbaum, JL, Blitt, C, Caplan, RA, Connis, RT, Domino, KB, Fleisher, LA, Grant, S, Mark, JB, Morray, JP, Nickinovich, DG, and Tung, A. "Practice guidelines for central venous access: a report by the American Society of Anesthesiologists Task Force on Central Venous Access." Anesthesiology 116, no. 3 (March 2012): 539-573. Full Text
  - Wright, MC, Segall, N, Mark, JB, and Taekman, JM. "Qualitative and Task Analytic Methods to Support Comprehensible Intelligent System Design." 2009 Ninth International Conference on Intelligent Systems Design and Applications (2009). Full Text
  - Barbeito, A, Bar-Yosef, S, Lowe, JE, Atkins, BZ, and Mark, JB. "Unusual cause of superior vena cava syndrome diagnosed with transesophageal echocardiography." Can J Anaesth 55, no. 11 (November 2008): 774-778. Full Text Link to Item
  - Welsby, IJ, Jones, R, Pylman, J, Mark, JB, Brudney, CS, Phillips-Bute, B, Mathew, JP, Campbell, ML, Stafford-Smith, M, Cardiothoracic Anesthesiology Research Endeavours (C.A.R.E.), Department of Anesthesiology, and Duke University Medical Center, . "ABO blood group and bleeding after coronary artery bypass graft surgery." Blood Coagul Fibrinolysis 18, no. 8 (December 2007): 781-785. Full Text Link to Item
  - Segall, N, Taekman, JM, Mark, JB, Hobbs, G, and Wright, MC. "Coding and visualizing eye tracking data in simulated anesthesia care." Proceedings of the Human Factors and Ergonomics Society 2 (2007): 765-769.
  - Barbeito, A, and Mark, JB. "Arterial and central venous pressure monitoring." Anesthesiol Clin 24, no. 4 (December 2006): 717-735. Link to Item
  - Wright, MC, Phillips-Bute, B, Mark, JB, Stafford-Smith, M, Grichnik, KP, Andregg, BC, and Taekman, JM. "Time of day effects on the incidence of anesthetic adverse events." Qual Saf Health Care 15, no. 4 (August 2006): 258-263. Full Text Link to Item
  - "Effects of time of day and surgery duration on adverse events in anaesthesia." Healthcare Systems Ergonomics and Patient Safety: Human Factor, a Bridge Between Care and Cure Proceedings of the International Conference Heps 2005 (December 1, 2005): 377-380.
  - Schroeder, RA, and Mark, JB. "Is the valve OK or not? Immediate evaluation of a replaced aortic valve." Anesth Analg 101, no. 5 (November 2005): 1288-1291. Full Text Link to Item
  - Melnick, AH, Brzezinski, M, and Mark, JB. "Incidental cor triatriatum sinister during coronary artery bypass surgery." Anesth Analg 101, no. 3 (September 2005): 637-638. Full Text Link to Item
  - Pittman, J, Bar-Yosef, S, SumPing, J, Sherwood, M, and Mark, J. "Continuous cardiac output monitoring with pulse contour analysis: a comparison with lithium indicator dilution cardiac output measurement." Critical Care Medicine 33, no. 9 (September 2005): 2015-2021. Full Text
  - Mark, JB. "Multimodal detection of perioperative myocardial ischemia." Tex Heart Inst J 32, no. 4 (2005): 461-466. (Review) Link to Item
  - Pittman, JAL, Ping, JS, and Mark, JB. "Arterial and central venous pressure monitoring." Int Anesthesiol Clin 42, no. 1 (2004): 13-30. (Review) Link to Item
  - Mark, JB. "Interpretation of hemodynamic monitoring." ANESTHESIA AND ANALGESIA 96, no. 3 (March 2003): 56-59. Link to Item
  - Faehnrich, JA, Noone, RB, White, WD, Leone, BJ, Hilton, AK, Sreeram, GM, and Mark, JB. "Effects of positive-pressure ventilation, pericardial effusion, and cardiac tamponade on respiratory variation in transmitral flow velocities." J Cardiothorac Vasc Anesth 17, no. 1 (February 2003): 45-50. Full Text Link to Item
  - Roizen, MF, Berger, DL, Gabel, RA, Gerson, J, Mark, JB, Jr, RIP, Paulus, DA, Smith, JS, and Woolf, SH. "Practice guidelines for pulmonary artery catheterization: An updated report by the American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization." Anesthesiology 99, no. 4 (2003): 988-1014. Full Text
  - Garcia-Rodriguez, C, Pittman, J, Cassell, CH, Sum-Ping, J, El-Moalem, H, Young, C, and Mark, JB. "Lithium dilution cardiac output measurement: a clinical assessment of central venous and peripheral venous indicator injection." Crit Care Med 30, no. 10 (October 2002): 2199-2204. Link to Item
  - Aronson, S, Butler, A, Subhiyah, R, Jr, REB, Cahalan, MK, Konstandt, S, Mark, J, Ramsay, J, Savage, R, Savino, J, Shanewise, JS, Smith, J, and Thys, D. "Development and analysis of a new certifying examination in perioperative transesophageal echocardiography." Anesthesia and Analgesia 95, no. 6 (2002): 1476-1482.
  - Slaughter, TF, Mark, JB, El-Moalem, H, Hayward, KA, Hilton, AK, Hodgins, LP, and Greenberg, CS. "Hemostatic effects of antithrombin III supplementation during cardiac surgery: results of a prospective randomized investigation." Blood Coagul Fibrinolysis 12, no. 1 (January 2001): 25-31. Link to Item
  - "Heparin-mediated hypotension associated with cardiac surgery [8] (multiple letters)." Anesthesia and Analgesia 91, no. 3 (September 19, 2000): 766-767. (Letter)
  - Garcia-Rodriguez, C, Cassell, C, Young, C, Ping, JS, and Mark, JB. "Cardiac output measurement without pulmonary artery or central venous catheterization: A clinical assessment of the lithium dilution method." ANESTHESIOLOGY 93, no. 3A (September 2000): U166-U166. Link to Item
  - Garcia-Rodriguez, C, Cassell, C, Young, C, Ping, JS, and Mark, JB. "Cardiac output measurement without pulmonary artery or central venous catheterization: A clinical assessment of the lithium dilution method." ANESTHESIOLOGY (September 2000). Link to Item
  - Slaughter, TF, and Mark, JB. "Heparin-mediated hypotension associated with cardiac surgery." Anesth Analg 91, no. 3 (September 2000): 766-767. (Letter) Link to Item
  - Young, CC, Garcia-Rodriguez, CR, Cassell, C, El-Moalem, H, and Mark, JB. "Lithium dilution versus thermodilution cardiac output measurement in cardiac surgery patients." ANESTHESIOLOGY 93, no. 3A (September 2000): U166-U166. Link to Item
  - Young, CC, Garcia-Rodriguez, CR, Cassell, C, El-Moalem, H, and Mark, JB. "Lithium dilution versus thermodilution cardiac output measurement in cardiac surgery patients." ANESTHESIOLOGY (September 2000). Link to Item
  - Shanewise, JS, Cheung, AT, Aronson, S, Stewart, WJ, Weiss, RL, Mark, JB, Savage, RM, Sears-Rogan, P, Mathew, JP, Quiñones, MA, Cahalan, MK, and Savino, JS. "ASE/SCA guidelines for performing a comprehensive intraoperative multiplane transesophageal echocardiography examination: recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography." J Am Soc Echocardiogr 12, no. 10 (October 1999): 884-900. Link to Item
  - Shanewise, JS, Cheung, AT, Aronson, S, Stewart, WJ, Weiss, RL, Mark, JB, Savage, RM, Sears-Rogan, P, Mathew, JP, Quiñones, MA, Cahalan, MK, and Savino, JS. "ASE/SCA guidelines for performing a comprehensive intraoperative multiplane transesophageal echocardiography examination: recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography." Anesthesia and Analgesia 89, no. 4 (October 1999): 870-884. Full Text
  - Heine, TA, Halambeck, BL, and Mark, JB. "Fatal pulmonary fat embolism in the early postoperative period." Anesthesiology 89, no. 6 (December 1998): 1589-1591. Link to Item
  - "Anesthesia education class sizes: Estimates from the workforce perspective." Problems in Anesthesia 10, no. 3 (July 1, 1998): 351-360. (Review)
  - Watke, CM, Mark, JB, Hilton, AK, Hodgins, LR, El-Moalem, H, and Slaughter, TF. "Effects of antithrombin III supplementation on hemostatic activation in cardiac surgical patients." ANESTHESIA AND ANALGESIA 86, no. 4 (April 1998): SCA30-SCA30. Link to Item
  - Faehnrich, JA, Noone, RB, White, WD, Leone, BJ, Hilton, AK, and Mark, JB. "Is increased respiratory variation in transmitral flow a reliable sign of cardiac tamponade during positive pressure ventilation?." ANESTHESIOLOGY 85, no. 3A (September 1996): A89-A89. Link to Item
  - Slaughter, TF, Grocott, H, Greenblo, K, BennettGuerrero, E, Hilton, A, Hodgins, L, and Mark, JB. "The heparin management test (HMT): An improved method for monitoring anticoagulation during cardiac surgery." ANESTHESIOLOGY 85, no. 3A (September 1996): A148-A148. Link to Item
  - DeNofrio, D, Ament, AF, Mark, JB, and George, SE. "Accelerated TPA for treatment of prosthetic valve thrombosis." Clin Cardiol 19, no. 8 (August 1996): 665-668. Link to Item
  - Hilton, AK, Botz, GH, Krucoff, MW, and Mark, JB. "Continuous 12-lead ECG fingerprint of the post-coronary artery bypass graft (CABG) patient." ANESTHESIA AND ANALGESIA 82, no. 4 (April 1996): SCA44-SCA44. Link to Item
  - Young, CC, Mark, JB, White, W, DeBree, A, Vender, JS, and Fleming, A. "Clinical evaluation of continuous noninvasive blood pressure monitoring: accuracy and tracking capabilities." J Clin Monit 11, no. 4 (July 1995): 245-252. Link to Item
  - Mark, JB, Ahmed, SU, Kluger, R, and Robinson, SM. "Influence of jet direction on pulmonary vein flow patterns in severe mitral regurgitation." Anesth Analg 80, no. 3 (March 1995): 486-491. Link to Item
  - Dentz, ME, Slaughter, TF, and Mark, JB. "Early thrombus formation on heparin-bonded pulmonary artery catheters in patients receiving epsilon aminocaproic acid." Anesthesiology 82, no. 2 (February 1995): 583-586. Full Text
  - Hodgins, L, Kisslo, JA, and Mark, JB. "Perioperative transesophageal echocardiography: the anesthesiologist as cardiac diagnostician." Anesth Analg 80, no. 1 (January 1995): 4-6. Link to Item
  - Sutton, DC, Kluger, R, Ahmed, SU, Reimold, SC, and Mark, JB. "Flow reversal in the descending aorta: a guide to intraoperative assessment of aortic regurgitation with transesophageal echocardiography." J Thorac Cardiovasc Surg 108, no. 3 (September 1994): 576-582. Link to Item
  - Mark, JB, and Spillane, R. "Interluminal communication in a pulmonary artery catheter causing artifactual pressure measurement." Anesth Analg 78, no. 6 (June 1994): 1184-1186. Link to Item
  - Slaughter, TF, Mark, JB, and Reves, JG. "Pituitary apoplexy and the conflicting perioperative goals of anticoagulation and hemostasis." Anesth Analg 76, no. 3 (March 1993): 470-471. Link to Item
  - Hickey, C, Gugino, LD, Aglio, LS, Mark, JB, Son, SL, and Maddi, R. "Intraoperative somatosensory evoked potential monitoring predicts peripheral nerve injury during cardiac surgery." Anesthesiology 78, no. 1 (January 1993): 29-35. Link to Item
  - Roizen, MF, Berger, DL, Gabel, RA, Gerson, J, Mark, JB, Jr, RIP, Paulus, DA, Smith, JS, and Woolf, SH. "Practice guidelines for pulmonary artery catheterization: A report by the American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization." Anesthesiology 78, no. 2 (1993): 380-394.
  - Burke, RP, Mark, JB, Collins, JJ, and Cohn, LH. "Improved surgical approach to left atrial appendage aneurysm." J Card Surg 7, no. 2 (June 1992): 104-107. Link to Item
  - Mark, JB, Chien, GL, Steinbrook, RA, and Fenton, T. "Electrocardiographic R-wave changes during cardiac surgery." Anesth Analg 74, no. 1 (January 1992): 26-31. Link to Item
  - Grayzel, J. "The cardiac cycle." Journal of Cardiothoracic and Vascular Anesthesia 5, no. 6 (December 1991): 649-650. Full Text
  - Mark, JB. "Response." Journal of Cardiothoracic and Vascular Anesthesia 5, no. 6 (December 1991): 651-651. Full Text
  - Mark, JB, FitzGerald, D, Fenton, T, Fosberg, AM, Camann, W, Maffeo, N, and Winkelman, J. "Continuous arterial and venous blood gas monitoring during cardiopulmonary bypass." J Thorac Cardiovasc Surg 102, no. 3 (September 1991): 431-439. Link to Item
  - Steinbrook, RA, Goldman, DB, Mark, JB, Philip, JH, and Raemer, DB. "How best to monitor for detection of myocardial ischemia?." Anesthesiology 74, no. 6 (June 1991): 1171-1172. (Letter) Link to Item
  - Mark, JB. "Central venous pressure monitoring: clinical insights beyond the numbers." J Cardiothorac Vasc Anesth 5, no. 2 (April 1991): 163-173. (Review) Link to Item
  - Mark, JB, and Chetham, PM. "Ventricular pacing can induce hemodynamically significant mitral valve regurgitation." Anesthesiology 74, no. 2 (February 1991): 375-377. Link to Item
  - Maddi, R, Horrow, JC, Mark, JB, Concepcion, M, and Murray, E. "Evaluation of a new cutaneous topical anesthesia preparation." Regional Anesthesia 15, no. 3 (May 1990): 109-112.
  - "Mechanism of arterial hypotension during spinal anesthesia." Regional Anesthesia 15, no. 1 (January 1, 1990): 54-55.
  - Mushlin, PS, Mark, JB, Elliott, WR, Striz, S, Goldman, DB, and Philip, J. "Inadvertent development of subatmospheric airway pressure during cardiopulmonary bypass." Anesthesiology 71, no. 3 (September 1989): 459-462. Link to Item
  - Mark, JB. "Systolic venous waves cause spurious signs of arterial hemoglobin desaturation." Anesthesiology 71, no. 1 (July 1989): 158-160. Link to Item
  - Mark, JB, and Steele, SM. "Cardiovascular effects of spinal anesthesia." Int Anesthesiol Clin 27, no. 1 (1989): 31-39. (Review) Link to Item
  - Camann, WR, Wojtowicz, SR, and Mark, JB. "Reoperation for coronary artery bypass grafting: anesthetic challenge." J Cardiothorac Anesth 1, no. 5 (October 1987): 458-467. (Review) Link to Item
  - Cohen, MB, Mark, JB, Morris, RW, and Frank, E. "Introducer sheath malfunction producing insidious air embolism." Anesthesiology 67, no. 4 (October 1987): 573-575. Link to Item
  - DiSesa, VJ, Mark, JB, Gold, JP, Kidwell, F, Shemin, RJ, Collins, JJ, and Cohn, LH. "Nitrous oxide for blood pressure control after coronary artery surgery: a dose-response hemodynamic study in postoperative patients." Ann Thorac Surg 44, no. 2 (August 1987): 189-191. Link to Item
  - Mark, JB, Horrow, JC, Eckenbrecht, PD, Smalky, M, Arthur, GR, Dhingra, U, and Murray, E. "Anesthetic induction with fentanyl and intravenous lidocaine for coronary artery surgery." Journal of Cardiothoracic Anesthesia 1, no. 6 (1987): 517-523.
  - Mark, JB, Steinbrook, RA, Gugino, LD, Maddi, R, Hartwell, B, Shemin, R, DiSesa, V, and Rida, WN. "Continuous noninvasive monitoring of cardiac output with esophageal Doppler ultrasound during cardiac surgery." Anesth Analg 65, no. 10 (October 1986): 1013-1020. Link to Item
  - Hartwell, BL, and Mark, JB. "Combinations of beta-blockers and calcium channel blockers: a cause of malignant perioperative conduction disturbances?." Anesth Analg 65, no. 8 (August 1986): 905-907. Link to Item
  - Mark, JB. "Respiratory and hemodynamic effects of nitrous oxide: A dose-response study in patients following cardiac operation." Surgical Forum VOL. 36 (January 1, 1985): 243-245.
  - Raemer, DB, Horrow, JC, Mark, JB, Maddi, R, Collins, JJ, and Son, SL. "A new surgical monitoring and resuscitation cart." Med Instrum 18, no. 3 (May 1984): 189-190. Link to Item
  - Mark, JB, and Greenberg, LM. "Intraoperative awareness and hypertensive crisis during high-dose fentanyl-diazepam-oxygen anesthesia." Anesthesia and Analgesia 62, no. 7 (July 1983): 698-700.
- Book Sections
  - "Standard anesthesia monitoring techniques and instruments." In Clinical Anesthesia Fundamentals. April 28, 2015.
  - Atkins, ME, and Mark, JB. "Invasive hemodynamic monitoring." In Core Topics in Cardiac Anesthesia, 141-146.: Cambridge University Press,. Full Text
  - Karhausen, J, and Mark, JB. "Routine clinical monitoring." In Core Topics in Cardiac Anesthesia, 133-140.: Cambridge University Press,. Full Text
- Conference Papers
  - Pyati, S, Barbeito, A, Bonifacio, A, Schroeder, R, and Mark, JB. "A Program to Teach Moderate Sedation in the Gastrointestinal Endoscopy Suite." March 2012. Link to Item
  - Pittman, JAL, Sum-Ping, JS, Sherwood, MW, El-Moalem, H, and Mark, JB. "The accuracy of cardiac output monitoring by pulse contour analysis in intensive care." 15th Annual Congress on European-Society-of-Internsive-Care-Medicine. BARCELONA, SPAIN. September 29, 2002 - October 2, 2002. SPRINGER-VERLAG, September 1, 2002. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers