Scholars@Duke
Jonathan Ball Mark

Jonathan Ball Mark

Professor Emeritus of Anesthesiology
Anesthesiology, VA Anesthesiology Service
jonathan.mark@duke.edu
Box 3094 Med Ctr, Durham, NC 27710
D5005 VA Med Ctr, 508 Fulton St, Durham, NC 27705

Selected Publications

Cardiovascular Monitoring

Chapter · January 1, 2020 When the rapid detection of haemodynamic change is imperative, the ‘gold standard’ is direct arterial pressure monitoring. Other indications for invasive arterial pressure monitoring include severe underlying cardiovascular disease, the inability to obtain ... Full text Cite

Use of Pressure Transducers.

Journal Article N Engl J Med · July 27, 2017 Full text Link to item Cite

Operating Room-to-ICU Patient Handovers: A Multidisciplinary Human-Centered Design Approach.

Journal Article Jt Comm J Qual Patient Saf · September 2016 BACKGROUND: Patient handovers (handoffs) following surgery have often been characterized by poor teamwork, unclear procedures, unstructured processes, and distractions. A study was conducted to apply a human-centered approach to the redesign of operating r ... Full text Link to item Cite

Emerging Concepts in Transesophageal Echocardiography

Journal Article F1000Research · January 1, 2016 Introduced in 1977, transesophageal echocardiography (TEE) offered imaging through a new acoustic window sitting directly behind the heart, allowing improved evaluation of many cardiac conditions. Shortly thereafter, TEE was applied to the intraoperative e ... Full text Cite

In situ simulated cardiac arrest exercises to detect system vulnerabilities.

Journal Article Simul Healthc · June 2015 INTRODUCTION: Sudden cardiac arrest is the leading cause of death in the United States. Despite new therapies, progress in this area has been slow, and outcomes remain poor even in the hospital setting, where providers, drugs, and devices are readily avail ... Full text Link to item Cite

Pulmonary artery catheter.

Journal Article Best Pract Res Clin Anaesthesiol · December 2014 Since its inception, the pulmonary artery catheter has enjoyed widespread use in both medical and surgical critically ill patients. It has also endured criticism and skepticism about its benefit in these patient populations. By providing information such a ... Full text Link to item Cite

FOCUS: the Society of Cardiovascular Anesthesiologists' initiative to improve quality and safety in the cardiovascular operating room.

Journal Article Anesth Analg · October 2014 The Society of Cardiovascular Anesthesiologists (SCA) introduced the FOCUS initiative (Flawless Operative Cardiovascular Unified Systems) in 2005 in response to the need for a rigorous scientific approach to improve quality and safety in the cardiovascular ... Full text Link to item Cite

Handovers from the OR to the ICU.

Journal Article Int Anesthesiol Clin · 2013 Full text Link to item Cite

Can we make postoperative patient handovers safer? A systematic review of the literature.

Journal Article Anesth Analg · July 2012 Postoperative patient handovers are fraught with technical and communication errors and may negatively impact patient safety. We systematically reviewed the literature on handover of care from the operating room to postanesthesia or intensive care units an ... Full text Link to item Cite

A Program to Teach Moderate Sedation in the Gastrointestinal Endoscopy Suite

Conference BRITISH JOURNAL OF ANAESTHESIA · March 1, 2012 Link to item Cite

Routine clinical monitoring

Chapter · January 1, 2012 Clinical examination. The complexity of conditions encountered during cardiac surgery combined with relatively restricted patient access mandates the use of reliable, objective monitoring. Decision-making should always incorporate whatever clinical observa ... Full text Cite

Invasive hemodynamic monitoring

Chapter · January 1, 2012 Arterial blood pressure monitoring. Direct arterial pressure monitoring is ideal for beat-to-beat monitoring when rapid detection of hemodynamic changes is imperative. Although the direct technique requires additional expertise, equipment and expense, it i ... Full text Cite

Right-Sided Valvular Disease

Chapter · December 7, 2011 Full text Cite

Cardiomyopathy, Ischemic

Chapter · January 1, 2010 Full text Cite

Qualitative and task analytic methods to support comprehensible intelligent system design

Journal Article ISDA 2009 - 9th International Conference on Intelligent Systems Design and Applications · December 1, 2009 We argue that a critical component of designing comprehensible intelligent systems is finding the right applications for intelligence and designing intelligent solutions toward those applications. While we do not refute the value of good attention to later ... Full text Cite

Unusual cause of superior vena cava syndrome diagnosed with transesophageal echocardiography.

Journal Article Can J Anaesth · November 2008 PURPOSE: An unusual case of superior vena cava (SVC) syndrome caused by an infected right atrial-SVC junction thrombus may be diagnosed using transesophageal echocardiography. CLINICAL FEATURES: A 59-yr-old male with end-stage renal disease requiring hemod ... Full text Link to item Cite

ABO blood group and bleeding after coronary artery bypass graft surgery.

Journal Article Blood Coagul Fibrinolysis · December 2007 Low circulating von Willebrand factor levels increase the risk of bleeding after cardiac surgery. Patients with blood group O may be at greatest risk owing to lower baseline levels of von Willebrand factor compared with patients with other blood groups, an ... Full text Link to item Cite

Coding and visualizing eye tracking data in simulated anesthesia care

Journal Article Proceedings of the Human Factors and Ergonomics Society · December 1, 2007 Eye tracking can be a valuable tool for collecting data about perception and attention in task performance, but its use in human factors research has been limited. This may be due to the fact that the coding and visualization of eye tracking data can be di ... Cite

Arterial and central venous pressure monitoring.

Journal Article Anesthesiol Clin · December 2006 Pressure monitoring systems influence the contour of the displayed wave-forms and, on occasion, can introduce significant artifact in the pressure traces. It is important to understand the technical details of invasive pressure monitoring to interpret bett ... Full text Link to item Cite

Time of day effects on the incidence of anesthetic adverse events.

Journal Article Qual Saf Health Care · August 2006 BACKGROUND: We hypothesized that time of day of surgery would influence the incidence of anesthetic adverse events (AEs). METHODS: Clinical observations reported in a quality improvement database were categorized into different AEs that reflected (1) error ... Full text Link to item Cite

Is the valve OK or not? Immediate evaluation of a replaced aortic valve.

Journal Article Anesth Analg · November 2005 Transesophageal echocardiography is a crucial tool in intraoperative evaluation of newly implanted/repaired heart valves because suspected valvular malfunction needs to be identified and sometimes surgically corrected. Although color Doppler is often adequ ... Full text Link to item Cite

Continuous cardiac output monitoring with pulse contour analysis: a comparison with lithium indicator dilution cardiac output measurement.

Journal Article Crit Care Med · September 2005 OBJECTIVE: Pulse contour analysis can be used to provide beat-to-beat cardiac output (CO) measurement. The current study sought to evaluate this technique by comparing its results with lithium dilution CO (LiCO) measurements. DESIGN: Prospective, observati ... Full text Link to item Cite

Multimodal detection of perioperative myocardial ischemia.

Journal Article Tex Heart Inst J · 2005 Cardiac anesthesiologists have the responsibility to detect myocardial ischemia in a timely manner, which can be a challenging task in the perioperative environment. Transesophageal echocardiography pulmonary artery catheterization, and electrocardiography ... Link to item Cite

Effects of time of day and surgery duration on adverse events in anaesthesia

Journal Article Healthcare Systems Ergonomics and Patient Safety: Human Factor, a Bridge Between Care and Cure - Proceedings of the International Conference HEPS 2005 · 2005 While the effects of fatigue on clinical performance are measurable, these decrements in performance have not been clearly linked to adverse clinical outcomes for patients. This research evaluated existing peri-operative data from 90, 159 surgical procedur ... Cite

Interpretation of hemodynamic monitoring

Journal Article ANESTHESIA AND ANALGESIA · March 1, 2003 Link to item Cite

Effects of positive-pressure ventilation, pericardial effusion, and cardiac tamponade on respiratory variation in transmitral flow velocities.

Journal Article J Cardiothorac Vasc Anesth · February 2003 Featured Publication OBJECTIVE: To determine the effects of positive-pressure ventilation and experimentally induced pericardial effusion and tamponade on transmitral flow velocities in dogs. DESIGN: Descriptive. SETTING: University laboratory. PARTICIPANTS: Eleven tracheally ... Full text Link to item Cite

Development and analysis of a new certifying examination in perioperative transesophageal echocardiography.

Journal Article Anesth Analg · December 2002 UNLABELLED: A key element in developing a process to determine knowledge and ability in applying perioperative echocardiography has included an examination. We report on the development of a certifying examination in perioperative echocardiography. In addi ... Full text Link to item Cite

Lithium dilution cardiac output measurement: a clinical assessment of central venous and peripheral venous indicator injection.

Journal Article Crit Care Med · October 2002 Featured Publication OBJECTIVE: The lithium indicator dilution technique has been shown to measure cardiac output (CO) accurately by using central venous injection of lithium chloride (Li-CCO). This study aimed to compare the measurement of CO by using peripheral venous admini ... Full text Link to item Cite

Hemostatic effects of antithrombin III supplementation during cardiac surgery: results of a prospective randomized investigation.

Journal Article Blood Coagul Fibrinolysis · January 2001 Failure to suppress thrombin generation during cardiac surgery promotes fibrin generation, fibrinolysis, and a consumptive coagulopathy. Acquired deficiencies of antithrombin III may play a contributory role. We hypothesized that antithrombin III supplemen ... Full text Link to item Cite

Anesthesia education class sizes: Estimates from the workforce perspective

Journal Article Problems in Anesthesia · July 1, 1998 During the 1980s and early 1990s the number of anesthesiologists trained in the United States increased dramatically. This increase seemed to be more in response to market demand and service needs of academic hospitals than in planned expansion of anesthes ... Cite

Accelerated TPA for treatment of prosthetic valve thrombosis.

Journal Article Clin Cardiol · August 1996 The first case of prosthetic valve thrombosis treated with an accelerated regimen of TPA is reported. The experience suggests that this therapeutic approach is feasible and may produce higher rates of patency for thrombosed prosthetic valves than other thr ... Full text Link to item Cite

Clinical evaluation of continuous noninvasive blood pressure monitoring: accuracy and tracking capabilities.

Journal Article J Clin Monit · July 1995 A continuous, noninvasive device for blood pressure measurement using pulse transit time has been recently introduced. We compared blood pressure measurement determined using this device with simultaneous invasive blood pressure measurements in 35 patients ... Full text Link to item Cite

Influence of jet direction on pulmonary vein flow patterns in severe mitral regurgitation.

Journal Article Anesth Analg · March 1995 Pulmonary vein flow patterns measured with transesophageal echocardiography have been used recently to assess the severity of mitral valve regurgitation. This study was designed to determine whether regurgitant jet direction selectively influences the patt ... Full text Link to item Cite

Flow reversal in the descending aorta: a guide to intraoperative assessment of aortic regurgitation with transesophageal echocardiography.

Journal Article J Thorac Cardiovasc Surg · September 1994 This study assessed the value of biplane transesophageal echocardiographic assessment of diastolic flow reversal in the descending aorta as an alternative to Doppler color flow imaging in determining severity of aortic regurgitation. In 45 patients undergo ... Link to item Cite

Intraoperative somatosensory evoked potential monitoring predicts peripheral nerve injury during cardiac surgery.

Journal Article Anesthesiology · January 1993 BACKGROUND: Brachial plexus injury may occur without obvious cause in patients undergoing cardiac surgery. To determine whether such peripheral nerve injury can be predicted intraoperatively, we monitored somatosensory evoked potentials (SEPs) from bilater ... Full text Link to item Cite

Improved surgical approach to left atrial appendage aneurysm.

Journal Article J Card Surg · June 1992 Left atrial appendage aneurysm is a rare anomaly, which usually presents with arrhythmia or cerebral embolism. Diagnostic evaluation traditionally required cardiac catheterization, and surgical resection required cardiopulmonary bypass. Utilizing intraoper ... Full text Link to item Cite

Electrocardiographic R-wave changes during cardiac surgery.

Journal Article Anesth Analg · January 1992 The diagnostic accuracy of exercise electrocardiography has been improved by incorporation of R-wave gain factor to correct the measured ST-segment changes. If marked changes in R-wave amplitude occur in individual patients during cardiac operations, a sim ... Full text Link to item Cite

Continuous arterial and venous blood gas monitoring during cardiopulmonary bypass.

Journal Article J Thorac Cardiovasc Surg · September 1991 A new monitoring technique, based on optical fluorescence chemistry, allows continuous monitoring of all blood gas variables during cardiopulmonary bypass. To evaluate the clinical performance of this monitor, we drew 220 arterial and 216 venous blood samp ... Link to item Cite

Central venous pressure monitoring: clinical insights beyond the numbers.

Journal Article J Cardiothorac Vasc Anesth · April 1991 CVP monitoring as a safe, cost-effective alternative to PA monitoring continues to have strong advocates. Recent reports suggest that outcome following major aortic reconstructive and cardiac surgery may be equivalent with either CVP or PA monitoring, thus ... Full text Link to item Cite

The cardiac cycle [4]

Journal Article Journal of Cardiothoracic and Vascular Anesthesia · 1991 Full text Cite

Response

Journal Article Journal of Cardiothoracic and Vascular Anesthesia · January 1, 1991 Full text Cite

Mechanism of arterial hypotension during spinal anesthesia

Journal Article Regional Anesthesia · January 1, 1990 Cite

Evaluation of a new cutaneous topical anesthesia preparation.

Journal Article Reg Anesth · 1990 Topical anesthetic agents are usually not effective on intact skin because of poor penetration. EMLA is a new topical anesthetic formulation consisting of a eutectic mixture of the local anesthetics lidocaine 5% and prilocaine 5%. We evaluated the ability ... Link to item Cite

Cardiovascular effects of spinal anesthesia.

Journal Article Int Anesthesiol Clin · 1989 Full text Link to item Cite

Anesthetic induction with fentanyl and intravenous lidocaine for coronary artery surgery.

Journal Article J Cardiothorac Anesth · December 1987 In a randomized, double-blind trial, 59 patients undergoing coronary artery surgery received fentanyl 10, 15, or 25 microg/kg infused over 5 minutes for anesthetic induction. Half of the patients received intravenous lidocaine, 1.5 mg/kg, 1 minute before l ... Full text Link to item Cite

Reoperation for coronary artery bypass grafting: anesthetic challenge.

Journal Article J Cardiothorac Anesth · October 1987 The problem of caring for patients undergoing reoperative coronary revascularization is one that cardiac anesthesiologists will face with increasing frequency. Many thousands of CABG procedures continue to be performed annually with ever-increasing surviva ... Full text Link to item Cite

Nitrous oxide for blood pressure control after coronary artery surgery: a dose-response hemodynamic study in postoperative patients.

Journal Article Ann Thorac Surg · August 1987 The inhaled anesthetic nitrous oxide is used for sedation in the coronary care unit and has been advocated as an antihypertensive agent in patients after a cardiac operation. To delineate the hemodynamic effects of nitrous oxide after cardiac surgery, we s ... Full text Link to item Cite

Continuous noninvasive monitoring of cardiac output with esophageal Doppler ultrasound during cardiac surgery.

Journal Article Anesth Analg · October 1986 Esophageal Doppler ultrasonography offers a continuous and noninvasive alternative to standard thermodilution cardiac output monitoring. A total of 372 simultaneous measurements of Doppler and thermodilution cardiac output were compared in 16 patients unde ... Link to item Cite

A new surgical monitoring and resuscitation cart.

Journal Article Med Instrum · 1984 To enhance patient safety after cardiac surgery, a new surgical cart has been designed to allow monitoring and resuscitation during transport of patients from operating room to intensive care unit. ... Link to item Cite