Scholars@Duke
Martin Seeber

Martin Seeber

Assistant Professor in Neurosurgery
Neurosurgery

Selected Publications

High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome.

Journal Article Sci Data · August 16, 2025 Electroencephalographic source localisation (ESL) of interictal epileptiform discharges is a valuable tool for presurgical evaluation of pharmacoresistant focal epilepsy. Various forward models, inverse solutions algorithms, and software packages have been ... Full text Link to item Cite

Human neural dynamics of real-world and imagined navigation.

Journal Article Nat Hum Behav · April 2025 The ability to form episodic memories and later imagine them is integral to the human experience, influencing our recollection of the past and envisioning of the future. While rodent studies suggest the medial temporal lobe, especially the hippocampus, is ... Full text Link to item Cite

Combined effects of neuroticism and negative emotional context on spontaneous EEG dynamics.

Journal Article Soc Cogn Affect Neurosci · February 16, 2024 Neuroticism is a personality trait with great clinical relevance, defined as a tendency to experience negative affect, sustained self-generated negative thoughts and impaired emotion regulation. Here, we investigated spontaneous brain dynamics in the after ... Full text Link to item Cite

Electrophysiological correlates of distance and direction processing during cognitive map retrieval: A source analysis.

Journal Article Front Hum Neurosci · 2023 INTRODUCTION: The cognitive map is an internal representation of the environment and allows us to navigate through familiar environments. It preserves the distances and directions between landmarks which help us orient ourselves in our surroundings. The ai ... Full text Link to item Cite

Oscillatory Neural Signatures of Visual Perception Across Developmental Stages in Individuals With 22q11.2 Deletion Syndrome.

Journal Article Biol Psychiatry · September 1, 2022 BACKGROUND: Numerous behavioral studies have highlighted the contribution of visual perceptual deficits to the nonverbal cognitive profile of individuals with 22q11.2 deletion syndrome. However, the neurobiological processes underlying these widespread beh ... Full text Link to item Cite

EEG microstate dynamics indicate a U-shaped path to propofol-induced loss of consciousness.

Journal Article Neuroimage · August 1, 2022 Evidence suggests that the stream of consciousness is parsed into transient brain states manifesting themselves as discrete spatiotemporal patterns of global neuronal activity. Electroencephalographical (EEG) microstates are proposed as the neurophysiologi ... Full text Link to item Cite

Beyond broadband: Towards a spectral decomposition of electroencephalography microstates.

Journal Article Hum Brain Mapp · July 2022 Originally applied to alpha oscillations in the 1970s, microstate (MS) analysis has since been used to decompose mainly broadband electroencephalogram (EEG) signals (e.g., 1-40 Hz). We hypothesised that MS decomposition within separate, narrow frequency ba ... Full text Link to item Cite

Aberrant Developmental Patterns of Gamma-Band Response and Long-Range Communication Disruption in Youths With 22q11.2 Deletion Syndrome.

Journal Article Am J Psychiatry · March 2022 OBJECTIVE: Brain oscillations play a pivotal role in synchronizing responses of local and global ensembles of neurons. Patients with schizophrenia exhibit impairments in oscillatory response, which are thought to stem from abnormal maturation during critic ... Full text Link to item Cite

Phase-Amplitude Coupling and Phase Synchronization Between Medial Temporal, Frontal and Posterior Brain Regions Support Episodic Autobiographical Memory Recall.

Journal Article Brain Topogr · March 2022 Episodic autobiographical memory (EAM) is a complex cognitive function that emerges from the coordination of specific and distant brain regions. Specific brain rhythms, namely theta and gamma oscillations and their synchronization, are thought of as putati ... Full text Link to item Cite

Linear distributed inverse solutions for interictal EEG source localisation.

Journal Article Clin Neurophysiol · January 2022 OBJECTIVE: To compare the spatial accuracy of 6 linear distributed inverse solutions for EEG source localisation of interictal epileptic discharges: Minimum Norm, Weighted Minimum Norm, Low-Resolution Electromagnetic Tomography (LORETA), Local Autoregressi ... Full text Link to item Cite

Time to move: Brain dynamics underlying natural action and cognition.

Journal Article Eur J Neurosci · December 2021 Advances in Mobile Brain/Body Imaging (MoBI) technology allows for real-time measurements of human brain dynamics during every day, natural, real-life situations. This special issue Time to Move brings together a collection of experimental papers, targeted ... Full text Link to item Cite

Enhancing visual motion discrimination by desynchronizing bifocal oscillatory activity.

Journal Article Neuroimage · October 15, 2021 Visual motion discrimination involves reciprocal interactions in the alpha band between the primary visual cortex (V1) and mediotemporal areas (V5/MT). We investigated whether modulating alpha phase synchronization using individualized multisite transcrani ... Full text Link to item Cite

Synchronous Brain Dynamics Establish Brief States of Communality in Distant Neuronal Populations.

Journal Article eNeuro · 2021 Intrinsic brain dynamics co-fluctuate between distant regions in an organized manner during rest, establishing large-scale functional networks. We investigate these brain dynamics on a millisecond time scale by focusing on electroencephalographic (EEG) sou ... Full text Link to item Cite

High-density Electric Source Imaging of interictal epileptic discharges: How many electrodes and which time point?

Journal Article Clin Neurophysiol · December 2020 OBJECTIVE: To assess the value of caudal EEG electrodes over cheeks and neck for high-density electric source imaging (ESI) in presurgical epilepsy evaluation, and to identify the best time point during averaged interictal epileptic discharges (IEDs) for o ... Full text Link to item Cite

ECoG Beta Suppression and Modulation During Finger Extension and Flexion.

Journal Article Front Neurosci · 2020 Neural oscillations originate predominantly from interacting cortical neurons and consequently reflect aspects of cortical information processing. However, their functional role is not yet fully understood and their interpretation is debatable. Amplitude m ... Full text Link to item Cite

Using structural connectivity to augment community structure in EEG functional connectivity.

Journal Article Netw Neurosci · 2020 Recently, EEG recording techniques and source analysis have improved, making it feasible to tap into fast network dynamics. Yet, analyzing whole-cortex EEG signals in source space is not standard, partly because EEG suffers from volume conduction: Function ... Full text Link to item Cite

Estimating EEG Source Dipole Orientation Based on Singular-value Decomposition for Connectivity Analysis.

Journal Article Brain Topogr · July 2019 In the last decade, the use of high-density electrode arrays for EEG recordings combined with the improvements of source reconstruction algorithms has allowed the investigation of brain networks dynamics at a sub-second scale. One powerful tool for investi ... Full text Link to item Cite

Subcortical electrophysiological activity is detectable with high-density EEG source imaging.

Journal Article Nat Commun · February 14, 2019 Subcortical neuronal activity is highly relevant for mediating communication in large-scale brain networks. While electroencephalographic (EEG) recordings provide appropriate temporal resolution and coverage to study whole brain dynamics, the feasibility t ... Full text Link to item Cite

ORCID Identifiers: Personalized Authorship

Journal Article Clinical Nursing Research · October 2017 Full text Cite

Estimation of gait parameters from EEG source oscillations

Conference 2016 IEEE International Conference on Systems Man and Cybernetics Smc 2016 Conference Proceedings · February 6, 2017 Long-term impairment, disability and handicap are major issues after stroke. A wide range of interventions have been developed that aim to promote motor recovery in affected persons. High-intensity and task-specific training protocols show promising result ... Full text Cite

EEG Oscillations Are Modulated in Different Behavior-Related Networks during Rhythmic Finger Movements.

Journal Article J Neurosci · November 16, 2016 UNLABELLED: Sequencing and timing of body movements are essential to perform motoric tasks. In this study, we investigate the temporal relation between cortical oscillations and human motor behavior (i.e., rhythmic finger movements). High-density EEG recor ... Full text Link to item Cite

High and low gamma EEG oscillations in central sensorimotor areas are conversely modulated during the human gait cycle.

Journal Article Neuroimage · May 15, 2015 Investigating human brain function is essential to develop models of cortical involvement during walking. Such models could advance the analysis of motor impairments following brain injuries (e.g., stroke) and may lead to novel rehabilitation approaches. I ... Full text Link to item Cite

EEG beta suppression and low gamma modulation are different elements of human upright walking.

Journal Article Front Hum Neurosci · 2014 Cortical involvement during upright walking is not well-studied in humans. We analyzed non-invasive electroencephalographic (EEG) recordings from able-bodied volunteers who participated in a robot-assisted gait-training experiment. To enable functional neu ... Full text Link to item Cite

Computational sensemaking on examples of knowledge discovery from neuroscience data: Towards enhancing stroke rehabilitation

Conference Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · September 5, 2012 Strokes are often associated with persistent impairment of a lower limb. Functional brain mapping is a set of techniques from neuroscience for mapping biological quantities (computational maps) into spatial representations of the human brain as functional ... Full text Cite