Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow, Pulmonary And Critical Care, Duke University School of Medicine 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine 2006 - 2008
  • M.B.B.S., King Saud University (Saudi Arabia) 2001
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2021
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2012 - 2020
• 

  Leadership & Clinical Positions at Duke

  • Medical Director of Respiratory Care Services- Duke Regional Hospital. 2015-Present
    Medical Director, Intensive Care Unit- Duke Regional Hospital. 2016- Present
    
    
• Expertise
• 

  Subject Headings

  • Adult
  • Altitude Sickness
  • Asthma
  • Community-Acquired Infections
  • Critical care medicine
  • Environmental Pollutants
  • Extracorporeal Membrane Oxygenation
  • Immunity, Innate
  • Influenza, Human
  • Lung
  • Occupational Medicine
  • Oxygen
  • Respiration, Artificial
  • Respiratory Insufficiency
  • Sepsis
  • Ventilators, Mechanical
• Research
• 

  Selected Grants

  • PCplanner: Operationalizing needs-focused palliative care for older adults in ICUs awarded by National Institutes of Health 2019 - 2024
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Cox, Christopher E., Jessie Gu, Deepshikha Charan Ashana, Elias H. Pratt, Krista Haines, Jessica Ma, Maren K. Olsen, et al. “Trajectories of Palliative Care Needs in the ICU and Long-Term Psychological Distress Symptoms.” Crit Care Med 51, no. 1 (January 1, 2023): 13–24. https://doi.org/10.1097/CCM.0000000000005701.
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    • Cox, Christopher E., Maren K. Olsen, Alice Parish, Jessie Gu, Deepshikha Charan Ashana, Elias H. Pratt, Krista Haines, et al. “Palliative care phenotypes among critically ill patients and family members: intensive care unit prospective cohort study.” Bmj Support Palliat Care, September 27, 2022. https://doi.org/10.1136/spcare-2022-003622.
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    • Cox, Christopher E., Deepshikha Charan Ashana, Krista L. Haines, David Casarett, Maren K. Olsen, Alice Parish, Yasmin Ali O’Keefe, et al. “Assessment of Clinical Palliative Care Trigger Status vs Actual Needs Among Critically Ill Patients and Their Family Members.” Jama Netw Open 5, no. 1 (January 4, 2022): e2144093. https://doi.org/10.1001/jamanetworkopen.2021.44093.
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    • Cox, Christopher E., Isaretta L. Riley, Deepshikha C. Ashana, Krista Haines, Maren K. Olsen, Jessie Gu, Elias H. Pratt, et al. “Improving racial disparities in unmet palliative care needs among intensive care unit family members with a needs-targeted app intervention: The ICUconnect randomized clinical trial.” Contemp Clin Trials 103 (April 2021): 106319. https://doi.org/10.1016/j.cct.2021.106319.
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    • Cox, Christopher E., Maren K. Olsen, David Casarett, Krista Haines, Mashael Al-Hegelan, Raquel R. Bartz, Jason N. Katz, et al. “Operationalizing needs-focused palliative care for older adults in intensive care units: Design of and rationale for the PCplanner randomized clinical trial.” Contemp Clin Trials 98 (November 2020): 106163. https://doi.org/10.1016/j.cct.2020.106163.
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    • Khanna, Ashish, Shane W. English, Xueyuan S. Wang, Kealy Ham, James Tumlin, Harold Szerlip, Laurence W. Busse, et al. “Angiotensin II for the Treatment of Vasodilatory Shock.” N Engl J Med 377, no. 5 (August 3, 2017): 419–30. https://doi.org/10.1056/NEJMoa1704154.
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    • Al-Hegelan, Mashael, and Neil R. MacIntyre. “Novel modes of mechanical ventilation.” Semin Respir Crit Care Med 34, no. 4 (August 2013): 499–507. https://doi.org/10.1055/s-0033-1351123.
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    • Huang, Y. C. T., and M. Al-Hegelan. “Adverse effects of outdoor air pollution.” Clinical Pulmonary Medicine 19, no. 1 (January 1, 2012): 14–20. https://doi.org/10.1097/CPM.0b013e318240524b.
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    • Turner, David A., Kyle J. Rehder, Stacey L. Peterson-Carmichael, Caroline P. Ozment, Mashael S. Al-Hegelan, Walter L. Williford, Michelle A. Peters, Paul W. Noble, and Ira M. Cheifetz. “Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A.” Respir Care 56, no. 7 (July 2011): 941–46. https://doi.org/10.4187/respcare.01066.
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    • Al-Hegelan, Mashael, Robert M. Tighe, Christian Castillo, and John W. Hollingsworth. “Ambient ozone and pulmonary innate immunity.” Immunol Res 49, no. 1–3 (April 2011): 173–91. https://doi.org/10.1007/s12026-010-8180-z.
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    • Caram, L. B., J. P. Linefsky, K. M. Read, D. R. Murdoch, T. Lalani, C. W. Woods, L. B. Reller, et al. “Leptotrichia endocarditis: report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases.” Eur J Clin Microbiol Infect Dis 27, no. 2 (February 2008): 139–43. https://doi.org/10.1007/s10096-007-0406-1.
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    • Morpeth, Susan, David Murdoch, Christopher H. Cabell, Adolf W. Karchmer, Paul Pappas, Donald Levine, Francisco Nacinovich, et al. “Non-HACEK gram-negative bacillus endocarditis.” Ann Intern Med 147, no. 12 (December 18, 2007): 829–35. https://doi.org/10.7326/0003-4819-147-12-200712180-00002.
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    • Linefsky, J. P., L. B. Caram, K. M. Read, D. R. Murdoch, T. Lalani, C. W. Woods, L. B. Reller, et al. “Leptotrichia endocarditis: Report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases.” Clinical Research in Cardiology 96, no. 6 (June 1, 2007): 405–405.
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  • Journal Issues

    • Paul, Devon W., Nigel B. Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, et al. “Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.” J Am Med Inform Assoc, February 1, 2018. https://doi.org/10.1093/jamia/ocx061.
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  • Conference Papers

    • Cox, C. E., J. Gu, E. H. Pratt, D. C. Ashana, I. L. Riley, A. Parish, M. Olsen, et al. “Palliative Care Triggers vs Actual Unmet Needs Among ICU Patients and Family Members.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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• Scholarly, Clinical, & Service Activities
• 

  Service to the Profession

  • Steering committee member. Occupational and Environmental Health Network. CHEST. October 2014 - October 2016  2014 - 2016

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