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Matthew William Luedke

Associate Professor of Neurology
Hospital Neurology
2424 Erwin Rd, DUMC 2720, Dept of Neurology, Durham, NC 27710-2720
2424 Erwin Rd Suite 1001, DUMC 2720, Durham, NC 27705-3858

Selected Publications


Of Hearth and Home: Professional Wellness After Hours

Journal Article Epilepsy Currents · January 1, 2024 Burnout is a prevalent problem in the contemporary practice of medicine. Defined by the Agency for Healthcare Research and Quality as, “a long-term stress reaction marked by emotional exhaustion, depersonalization, and a lack of sense of personal accomplis ... Full text Cite

Association Between Neighborhood Socioeconomic Status and 30-Day Mortality and Readmission for Patients With Common Neurologic Conditions.

Journal Article Neurology · April 25, 2023 BACKGROUND AND OBJECTIVES: Patients of low individual socioeconomic status (SES) are at a greater risk of unfavorable health outcomes. However, the association between neighborhood socioeconomic deprivation and health outcomes for patients with neurologic ... Full text Link to item Cite

Abstract 78: Neighborhood Socioeconomic Deprivation Is Associated With Increased 30-day Mortality After Stroke: Results From A Nationwide Study Of 755,899 Medicare Patients

Conference Stroke · February 2023 Introduction: The relationship between neighborhood socioeconomic deprivation- a reflection of the general economic and environmental conditions of a neighborhood- and outcomes after stroke is not kno ... Full text Cite

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review.

Journal Article J Med Internet Res · August 26, 2022 BACKGROUND: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of t ... Full text Link to item Cite

Association of time-temperature curves with outcomes in temperature management for cardiac arrest.

Journal Article BMJ Neurol Open · 2022 BACKGROUND/PURPOSE: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the con ... Full text Open Access Link to item Cite

Characteristics of strokes associated with centrifugal flow left ventricular assist devices.

Journal Article Sci Rep · January 18, 2021 Stroke is a devastating complication of left ventricular assist device (LVAD) therapy. Understanding the characteristics, risk factors and outcomes of strokes associated with the centrifugal flow LVADs is important to devise better strategies for managemen ... Full text Link to item Cite

Genetic or Autoimmune: POLG-Related Epilepsy Initially Treated as an Autoimmune Encephalitis, a Case Report.

Journal Article Neurohospitalist · January 2021 Hospital neurologists participate at the forefront of managing fulminant acute and subacute onset epilepsy, frequently attributed to autoimmune encephalitis (AE). As the recognition of antibody-mediated AE grows, there is a growing number of patients who a ... Full text Link to item Cite

Barriers and facilitators to implementation of epilepsy self-management programs: a systematic review using qualitative evidence synthesis methods.

Journal Article Syst Rev · April 25, 2020 BACKGROUND: Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting a self-management program requires ... Full text Open Access Link to item Cite

Self-management of Epilepsy: A Systematic Review.

Journal Article Ann Intern Med · July 16, 2019 BACKGROUND: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain. PURPOSE: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwe ... Full text Open Access Link to item Cite

Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy.

Journal Article Neurohospitalist · April 2019 Cefepime is a fourth-generation cephalosporin antibiotic known to have neurotoxic side effects. Recent reports have described patients on cefepime presenting with altered mentation and concurrent triphasic wave discharges on electroencephalogram (EEG). Som ... Full text Link to item Cite

Neurologic complications after kidney transplantation

Chapter · January 1, 2019 Neurologic complications are common in patients with chronic kidney disease and patients who have received a kidney transplant. Diagnosis is often dependent on determination of the timing of onset and localization of signs and symptoms. ... Full text Cite

Atypical teratoid rhabdoid tumor in a 65-year-old man presenting with disseminated leptomeningeal disease: A case report and review of the literature.

Journal Article SAGE Open Med Case Rep · 2018 Central nervous system atypical teratoid rhabdoid tumors are very rare aggressive tumor of childhood, primarily occurring at age of less than 3 years old. The prognosis of these tumors is very poor, with a reported median survival of 6-12 months in most ca ... Full text Link to item Cite

Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma.

Journal Article Case Rep Neurol Med · 2018 Immune checkpoint inhibitors have improved patient survival outcomes in a variety of advanced malignancies. However, they can cause a number of immune-related adverse effects (irAEs) through lymphocyte dysregulation. Central nervous system (CNS) irAEs are ... Full text Open Access Link to item Cite

Intraoperative ECoG During MRI-Guided Laser-Interstitial Thermal Therapy for Intractable Epilepsy.

Journal Article J Clin Neurophysiol · August 2016 MRI-guided laser-interstitial thermal therapy is a new modality for epilepsy surgery. In patients with intractable localization-related seizures, it has been used to ablate epileptogenic lesions with less morbidity than conventional craniotomies, and with ... Full text Link to item Cite

Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature.

Journal Article SAGE Open Med Case Rep · 2016 BACKGROUND: We report a novel case of a rare disease: spontaneous Creutzfeldt-Jakob disease in a patient with well-controlled HIV. We explore the relationship between spontaneous Creutzfeldt-Jakob disease and HIV. CASE REPORT: A 66-year-old man with long-s ... Full text Link to item Cite

Of Hearth and Home: Professional Wellness After Hours

Journal Article Epilepsy Currents · January 1, 2024 Burnout is a prevalent problem in the contemporary practice of medicine. Defined by the Agency for Healthcare Research and Quality as, “a long-term stress reaction marked by emotional exhaustion, depersonalization, and a lack of sense of personal accomplis ... Full text Cite

Association Between Neighborhood Socioeconomic Status and 30-Day Mortality and Readmission for Patients With Common Neurologic Conditions.

Journal Article Neurology · April 25, 2023 BACKGROUND AND OBJECTIVES: Patients of low individual socioeconomic status (SES) are at a greater risk of unfavorable health outcomes. However, the association between neighborhood socioeconomic deprivation and health outcomes for patients with neurologic ... Full text Link to item Cite

Abstract 78: Neighborhood Socioeconomic Deprivation Is Associated With Increased 30-day Mortality After Stroke: Results From A Nationwide Study Of 755,899 Medicare Patients

Conference Stroke · February 2023 Introduction: The relationship between neighborhood socioeconomic deprivation- a reflection of the general economic and environmental conditions of a neighborhood- and outcomes after stroke is not kno ... Full text Cite

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review.

Journal Article J Med Internet Res · August 26, 2022 BACKGROUND: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of t ... Full text Link to item Cite

Association of time-temperature curves with outcomes in temperature management for cardiac arrest.

Journal Article BMJ Neurol Open · 2022 BACKGROUND/PURPOSE: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the con ... Full text Open Access Link to item Cite

Characteristics of strokes associated with centrifugal flow left ventricular assist devices.

Journal Article Sci Rep · January 18, 2021 Stroke is a devastating complication of left ventricular assist device (LVAD) therapy. Understanding the characteristics, risk factors and outcomes of strokes associated with the centrifugal flow LVADs is important to devise better strategies for managemen ... Full text Link to item Cite

Genetic or Autoimmune: POLG-Related Epilepsy Initially Treated as an Autoimmune Encephalitis, a Case Report.

Journal Article Neurohospitalist · January 2021 Hospital neurologists participate at the forefront of managing fulminant acute and subacute onset epilepsy, frequently attributed to autoimmune encephalitis (AE). As the recognition of antibody-mediated AE grows, there is a growing number of patients who a ... Full text Link to item Cite

Barriers and facilitators to implementation of epilepsy self-management programs: a systematic review using qualitative evidence synthesis methods.

Journal Article Syst Rev · April 25, 2020 BACKGROUND: Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting a self-management program requires ... Full text Open Access Link to item Cite

Self-management of Epilepsy: A Systematic Review.

Journal Article Ann Intern Med · July 16, 2019 BACKGROUND: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain. PURPOSE: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwe ... Full text Open Access Link to item Cite

Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy.

Journal Article Neurohospitalist · April 2019 Cefepime is a fourth-generation cephalosporin antibiotic known to have neurotoxic side effects. Recent reports have described patients on cefepime presenting with altered mentation and concurrent triphasic wave discharges on electroencephalogram (EEG). Som ... Full text Link to item Cite

Neurologic complications after kidney transplantation

Chapter · January 1, 2019 Neurologic complications are common in patients with chronic kidney disease and patients who have received a kidney transplant. Diagnosis is often dependent on determination of the timing of onset and localization of signs and symptoms. ... Full text Cite

Atypical teratoid rhabdoid tumor in a 65-year-old man presenting with disseminated leptomeningeal disease: A case report and review of the literature.

Journal Article SAGE Open Med Case Rep · 2018 Central nervous system atypical teratoid rhabdoid tumors are very rare aggressive tumor of childhood, primarily occurring at age of less than 3 years old. The prognosis of these tumors is very poor, with a reported median survival of 6-12 months in most ca ... Full text Link to item Cite

Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma.

Journal Article Case Rep Neurol Med · 2018 Immune checkpoint inhibitors have improved patient survival outcomes in a variety of advanced malignancies. However, they can cause a number of immune-related adverse effects (irAEs) through lymphocyte dysregulation. Central nervous system (CNS) irAEs are ... Full text Open Access Link to item Cite

Intraoperative ECoG During MRI-Guided Laser-Interstitial Thermal Therapy for Intractable Epilepsy.

Journal Article J Clin Neurophysiol · August 2016 MRI-guided laser-interstitial thermal therapy is a new modality for epilepsy surgery. In patients with intractable localization-related seizures, it has been used to ablate epileptogenic lesions with less morbidity than conventional craniotomies, and with ... Full text Link to item Cite

Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature.

Journal Article SAGE Open Med Case Rep · 2016 BACKGROUND: We report a novel case of a rare disease: spontaneous Creutzfeldt-Jakob disease in a patient with well-controlled HIV. We explore the relationship between spontaneous Creutzfeldt-Jakob disease and HIV. CASE REPORT: A 66-year-old man with long-s ... Full text Link to item Cite

Epileptic Seizures

Chapter · September 28, 2015 The first section of the book introduces the clinical aspects of the science of epileptology with chapters on pathophysiology, genetics, classification, syndromes, epidemiology, etiology, and differential diagnosis. ... Cite

Structural Neuroimaging

Chapter · September 28, 2015 The first section of the book introduces the clinical aspects of the science of epileptology with chapters on pathophysiology, genetics, classification, syndromes, epidemiology, etiology, and differential diagnosis. ... Cite

How do you titrate sedation in the post cardiac arrest protocol when the patient is paralyzed?

Journal Article THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT · 2011 Cite