Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pulmonary and Critical Care Fellowship, Johns Hopkins University School of Medicine 2006 - 2010
  • Internal Medicine Residency, Johns Hopkins University School of Medicine 2003 - 2006
  • M.D., Johns Hopkins University School of Medicine 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hoji, Aki, Iulia D. Popescu, Matthew R. Pipeling, Pali D. Shah, Spencer A. Winters, and John F. McDyer. “Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.” Journal of Immunology (Baltimore, Md. : 1950) 203, no. 8 (October 2019): 2063–75. https://doi.org/10.4049/jimmunol.1900399.
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    • Popescu, Iulia, Hannah Mannem, Spencer A. Winters, Aki Hoji, Fernanda Silveira, Emily McNally, Matthew R. Pipeling, et al. “Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.” Am J Respir Crit Care Med 199, no. 3 (February 1, 2019): 362–76. https://doi.org/10.1164/rccm.201805-0825OC.
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    • Naik, Chetan, Cody Moore, Matthew Pipeling, Jonathan D’Cunha, Kristine Ruppert, Christopher Ensor, and Matthew Morrell. “Cyclophosphamide for Refractory Acute Cellular Rejection After Lung Transplantation.” Transplant Direct 4, no. 5 (May 2018): e350. https://doi.org/10.1097/TXD.0000000000000790.
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    • Popescu, Iulia, Matthew R. Pipeling, Hannah Mannem, Pali D. Shah, Jonathan B. Orens, Mark Connors, Stephen A. Migueles, and John F. McDyer. “IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.” J Immunol 196, no. 2 (January 15, 2016): 877–90. https://doi.org/10.4049/jimmunol.1501589.
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    • Shah, Pali D., Qiong Zhong, Elizabeth A. Lendermon, Matthew R. Pipeling, and John F. McDyer. “Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis.” Viral Immunol 28, no. 5 (June 2015): 255–64. https://doi.org/10.1089/vim.2015.0005.
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    • Gashouta, Mohamed A., Christian A. Merlo, Matthew R. Pipeling, John F. McDyer, JW Awori Hayanga, Jonathan B. Orens, and Reda E. Girgis. “Serial monitoring of exhaled nitric oxide in lung transplant recipients.” J Heart Lung Transplant 34, no. 4 (April 2015): 557–62. https://doi.org/10.1016/j.healun.2014.09.026.
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    • Morrell, Matthew R., Joseph M. Pilewski, Cynthia J. Gries, Matthew R. Pipeling, Maria M. Crespo, Christopher R. Ensor, Samuel A. Yousem, et al. “De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation.” J Heart Lung Transplant 33, no. 12 (December 2014): 1288–94. https://doi.org/10.1016/j.healun.2014.07.018.
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    • Popescu, Iulia, Matthew R. Pipeling, Pali D. Shah, Jonathan B. Orens, and John F. McDyer. “T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control.” J Immunol 193, no. 11 (December 1, 2014): 5709–22. https://doi.org/10.4049/jimmunol.1401436.
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    • Popescu, Iulia, Matthew Pipeling, Jason Akulian, and John McDyer. “Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry.” Methods Mol Biol 1186 (2014): 21–47. https://doi.org/10.1007/978-1-4939-1158-5_3.
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    • Akulian, J. A., M. R. Pipeling, E. R. John, J. B. Orens, N. Lechtzin, and J. F. McDyer. “High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control.” Am J Transplant 13, no. 1 (January 2013): 146–56. https://doi.org/10.1111/j.1600-6143.2012.04282.x.
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    • George, Timothy J., George J. Arnaoutakis, Claude A. Beaty, Matthew R. Pipeling, Christian A. Merlo, John V. Conte, and Ashish S. Shah. “Acute kidney injury increases mortality after lung transplantation.” Ann Thorac Surg 94, no. 1 (July 2012): 185–92. https://doi.org/10.1016/j.athoracsur.2011.11.032.
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    • Pipeling, Matthew R., Emily R. John, Jonathan B. Orens, Noah Lechtzin, and John F. McDyer. “Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients.” J Infect Dis 204, no. 11 (December 1, 2011): 1663–71. https://doi.org/10.1093/infdis/jir624.
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    • Pipeling, Matthew R., and Eddy Fan. “Therapies for refractory hypoxemia in acute respiratory distress syndrome.” Jama 304, no. 22 (December 8, 2010): 2521–27. https://doi.org/10.1001/jama.2010.1752.
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    • D’Alessio, Franco R., Kenji Tsushima, Neil R. Aggarwal, Erin E. West, Matthew H. Willett, Martin F. Britos, Matthew R. Pipeling, et al. “CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.” J Clin Invest 119, no. 10 (October 2009): 2898–2913. https://doi.org/10.1172/JCI36498.
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    • Jagannathan, Prasanna, Christine M. Osborne, Cassandra Royce, Maura M. Manion, John C. Tilton, Li Li, Steven Fischer, et al. “Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness.” J Virol 83, no. 6 (March 2009): 2728–42. https://doi.org/10.1128/JVI.02128-08.
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    • Pipeling, Matthew R., Erin E. West, Christine M. Osborne, Amanda B. Whitlock, Lesia K. Dropulic, Matthew H. Willett, Michael Forman, et al. “Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection.” J Immunol 181, no. 1 (July 1, 2008): 546–56. https://doi.org/10.4049/jimmunol.181.1.546.
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    • Wung, Peter K., Matthew R. Pipeling, and Fredrick M. Wigley. “"Still" ill?” Am J Med 121, no. 6 (June 2008): 491–93. https://doi.org/10.1016/j.amjmed.2008.02.010.
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    • Jordan, Kimberly R., Rachel H. McMahan, Jason Z. Oh, Matthew R. Pipeling, Drew M. Pardoll, Ross M. Kedl, John W. Kappler, and Jill E. Slansky. “Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity.” J Immunol 180, no. 1 (January 1, 2008): 188–97. https://doi.org/10.4049/jimmunol.180.1.188.
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    • Nettles, Richard E., Lynette S. Nichols, Katherine Bell-McGuinn, Matthew R. Pipeling, Paul J. Scheel, and William G. Merz. “Successful treatment of Trichosporon mucoides infection with fluconazole in a heart and kidney transplant recipient.” Clin Infect Dis 36, no. 4 (February 15, 2003): E63–66. https://doi.org/10.1086/367665.
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    • Pulaski, B. A., V. K. Clements, M. R. Pipeling, and S. Ostrand-Rosenberg. “Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma.” Cancer Immunol Immunother 49, no. 1 (April 2000): 34–45. https://doi.org/10.1007/s002620050024.
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    • Ostrand-Rosenberg, S., B. A. Pulaski, V. K. Clements, L. Qi, M. R. Pipeling, and L. A. Hanyok. “Cell-based vaccines for the stimulation of immunity to metastatic cancers.” Immunol Rev 170 (August 1999): 101–14. https://doi.org/10.1111/j.1600-065x.1999.tb01332.x.
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  • Conference Papers

    • Davis, Haley, David Howell, Elizabeth Pavlisko, John Carney, Matthew Pipeling, and Carolyn Glass. “Conida in Post-Transplant Lung Biopsies and Associated Infections.” In Laboratory Investigation, 100:1767–1767. NATURE PUBLISHING GROUP, 2020.
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    • Davis, Haley, David Howell, Elizabeth Pavlisko, John Carney, Matthew Pipeling, and Carolyn Glass. “Conida in Post-Transplant Lung Biopsies and Associated Infections.” In Modern Pathology, 33:1767–1767. NATURE PUBLISHING GROUP, 2020.
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    • Hoji, A., I. Popescu, M. Pipeling, H. Mannem, and J. McDyer. “Regulation of KLRG1 Gene Expression by T-bet Correlates with Human Cytomegalovirus-Specific CD8(+) T Cells Effector Function.” In Journal of Heart and Lung Transplantation, 36:S201–S201. ELSEVIER SCIENCE INC, 2017.
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    • Popescu, I., M. R. Pipeling, H. Mannem, P. D. Shah, J. B. Orens, and J. F. McDyer. “Interleukin 12-Dependent CMV-Specific CD4+ T Cell Proliferation, T-bet Induction and Effector Function During Primary Infection Are Key Determinants for Early Immune Control in Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 35:S137–S137. Elsevier BV, 2016. https://doi.org/10.1016/j.healun.2016.01.377.
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    • Popescu, I., M. R. Pipeling, H. Otepka, P. Shah, J. B. Orens, and J. F. McDyer. “CMV-Specific CD8+ T Cells Persist During Early Chronic Infection With Impaired Function and an EomeshiPD-1hi Exhausted Phenotype in Lung Transplant Recipients With Relapsing Viremia.” In The Journal of Heart and Lung Transplantation, 34:S124–S124. Elsevier BV, 2015. https://doi.org/10.1016/j.healun.2015.01.329.
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    • Pipeling, M. R., I. D. Popescu, J. B. Orens, J. M. Pilewski, and J. F. McDyer. “Dynamic Changes in Dominant Antigen Responses Following Primary CMV Infection in Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 32:S298–S298. Elsevier BV, 2013. https://doi.org/10.1016/j.healun.2013.01.849.
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    • Akulian, J. A., M. R. Pipeling, E. R. John, and J. F. McDyer. “401 Differential Distribution and Functional Quality of CMV-Specific T Cell Effector Memory in High-Risk Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 31:S142–43. Elsevier BV, 2012. https://doi.org/10.1016/j.healun.2012.01.411.
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    • Gashouta, M. A., M. R. Pipeling, J. F. McDyer, C. A. Merlo, A. A. Shah, J. B. Orens, and R. E. Girgis. “717 Increased Distal Airway Nitric Oxide (NO) Release during Acute Complications in Lung Transplant Recipients (LTxR).” In The Journal of Heart and Lung Transplantation, 31:S245–46. Elsevier BV, 2012. https://doi.org/10.1016/j.healun.2012.01.732.
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    • Akulian, J. A., M. R. Pipeling, E. John, and J. F. McDyer. “404 Differential Phenotype and Distribution of CMV-Specific T Cell Effector Memory between the Lung Allograft and Blood in High-Risk Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 30:S138–S138. Elsevier BV, 2011. https://doi.org/10.1016/j.healun.2011.01.413.
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    • Akulian, J., M. Pipeling, E. John, and J. McDyer. “Differences In The Distribution And Effector Polyfunction Of CMV-Specific CD4+Versus CD8+T Cell Memory Between The Lung Allograft And Blood In High-Risk Lung Transplant Recipients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.
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    • Pipeling, M. R., E. R. John, N. Lechtzin, and J. F. McDyer. “186: CD8+ pp65-Specific T Cell Responses and T-Bet Levels Predict Relapsing Viremia Following Primary CMV Infection in Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 29:S66–S66. Elsevier BV, 2010. https://doi.org/10.1016/j.healun.2009.11.196.
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    • Lee, Jessica B., Matthew Pipeling, Mathias Oelke, John McDyer, Lakshmi Ramachandra, David Canaday, and Jonathan Schneck. “Changes in the repertoire of influenza-specific CD8+T cell responses.” In Journal of Immunology, Vol. 182. AMER ASSOC IMMUNOLOGISTS, 2009.
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    • Pipeling, M. R., A. B. Whitlock, S. A. Migueles, M. Connors, and J. F. McDyer. “539: Striking Expansion and Persistence of T-bet+CD8+ CMV-Specific T Cells with Primary Infection in Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 28:S253–S253. Elsevier BV, 2009. https://doi.org/10.1016/j.healun.2008.11.546.
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    • Pipeling, M. R., E. E. West, A. B. Whitlock, M. Forman, A. Valsamakis, N. Lechtzin, J. B. Orens, and J. F. McDyer. “541: Increased CMV-Specific CD8+ Effectors and Viral Loads in the Lung Allograft Predict Viral Pneumonitis during Primary Infection.” In The Journal of Heart and Lung Transplantation, 28:S254–S254. Elsevier BV, 2009. https://doi.org/10.1016/j.healun.2008.11.548.
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    • Pipeling, M. R., E. E. West, A. B. Whitlock, M. Forman, A. Valsamakis, N. Lechtzin, J. B. Orens, and J. F. McDyer. “Increased CMV-Specific CD8(+) Effectors and Viral Loads in the Lung Allograft Predict Pneumonitis during Primary Infection.” In American Journal of Respiratory and Critical Care Medicine, Vol. 179. AMER THORACIC SOC, 2009.
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    • Pipeling, M. R., E. E. West, N. Lechtzin, S. A. Migueles, M. Connors, and J. F. McDyer. “119: Dissecting CMV-Specific Immunity in High-Risk Lung Transplant Recipients: Differences between the Lung Allograft and Blood Effector Memory T Cells.” In The Journal of Heart and Lung Transplantation, 27:S102–S102. Elsevier BV, 2008. https://doi.org/10.1016/j.healun.2007.11.125.
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    • Pipeling, M. R., E. E. West, C. M. Osborne, S. A. Migueles, M. Connors, and J. F. McDyer. “240: Acquisition of CMV-specific CD8+ T cell memory during primary CMV infection in lung transplant recipients.” In The Journal of Heart and Lung Transplantation, 26:S146–S146. Elsevier BV, 2007. https://doi.org/10.1016/j.healun.2006.11.258.
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