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Matthew Robert Pipeling

Instructor in the Department of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
315 Trent Drive Hanes 122A, Box 102352, Durham, NC 27710
315 Trent Drive- Hanes 122A, Box 102352, Durham, NC 27710

Selected Publications


ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements.

Journal Article J Heart Lung Transplant · November 2021 Patients with connective tissue disease (CTD) present unique surgical, perioperative, operative, and postoperative challenges related to the often underlying severe pulmonary hypertension and right ventricular dysfunction. The International Society for Hea ... Full text Link to item Cite

Conida in Post-Transplant Lung Biopsies and Associated Infections

Conference LABORATORY INVESTIGATION · March 1, 2020 Link to item Cite

Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.

Journal Article J Immunol · October 15, 2019 CMV remains an important opportunistic pathogen in high-risk lung transplant recipients. We characterized the phenotype and function of CD8+ T cells from acute/primary into chronic CMV infection in 23 (donor+/recipient-; D+R-) lung transplant recipients an ... Full text Link to item Cite

Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.

Journal Article Am J Respir Crit Care Med · February 1, 2019 RATIONALE: Cytomegalovirus (CMV)-related morbidities remain one of the most common complications after lung transplantation and have been linked to allograft dysfunction, but the factors that predict high risk for CMV complications and effective immunity a ... Full text Link to item Cite

Cyclophosphamide for Refractory Acute Cellular Rejection After Lung Transplantation.

Journal Article Transplant Direct · May 2018 BACKGROUND: Acute cellular rejection (ACR) is a major risk factor for chronic lung allograft dysfunction after lung transplantation. Acute cellular rejection can persist or recur despite augmentation of immunosuppression by conventional methods. There are ... Full text Link to item Cite

IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.

Journal Article J Immunol · January 15, 2016 CMV remains an important opportunistic pathogen in solid organ and hematopoietic cell transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor(+)/recipient(-); D(+)R(-)) are at high risk for active CMV infection an ... Full text Link to item Cite

Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis.

Journal Article Viral Immunol · June 2015 Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in immunocompromised hosts, many of whom undergo significant periods of lymphopenia. However, the impact of lymphopenia and subsequent immune reconstitution on T cell responses and pul ... Full text Link to item Cite

Serial monitoring of exhaled nitric oxide in lung transplant recipients.

Journal Article J Heart Lung Transplant · April 2015 BACKGROUND: Exhaled nitric oxide (FeNO), a marker of airway inflammation, is often elevated in lung transplant recipients (LTxRs) with acute rejection or infection. Isolated measurements in the setting of bronchiolitis obliterans syndrome have been variabl ... Full text Link to item Cite

De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation.

Journal Article J Heart Lung Transplant · December 2014 BACKGROUND: The development of human leukocyte antigen (HLA) antibody responses has been associated with worse clinical outcomes, such as bronchiolitis obliterans syndrome (BOS) and death, in lung transplant recipients (LTRs). However, the role of donor-sp ... Full text Link to item Cite

T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control.

Journal Article J Immunol · December 1, 2014 CMV remains an important opportunistic pathogen in solid organ transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient-; D+R-) are at high-risk for active CMV infection and increased mortality, however ... Full text Link to item Cite

Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry.

Journal Article Methods Mol Biol · 2014 Cytotoxic T lymphocytes (CTLs) are important constituents of the adaptive immune system. Development of CTLs are particularly important for bacterial and viral infections, in addition to tumor surveillance. Measuring T cell immune function is important in ... Full text Link to item Cite

High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control.

Journal Article Am J Transplant · January 2013 The maintenance of CMV-specific T cell memory in lung transplant recipients (LTRs) is critical for host defense and allograft durability, particularly in donor(+) /recipient(-) (D(+) R(-) ) individuals who demonstrate increased mortality. We studied CD4(+) ... Full text Link to item Cite

Acute kidney injury increases mortality after lung transplantation.

Journal Article Ann Thorac Surg · July 2012 BACKGROUND: Acute kidney injury requiring renal replacement therapy (RRT) is associated with increased mortality after cardiac surgery. Studies examining the impact of RRT after lung transplantation (LTx) are limited. We evaluated risk factors and outcomes ... Full text Link to item Cite

ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements.

Journal Article J Heart Lung Transplant · November 2021 Patients with connective tissue disease (CTD) present unique surgical, perioperative, operative, and postoperative challenges related to the often underlying severe pulmonary hypertension and right ventricular dysfunction. The International Society for Hea ... Full text Link to item Cite

Conida in Post-Transplant Lung Biopsies and Associated Infections

Conference LABORATORY INVESTIGATION · March 1, 2020 Link to item Cite

Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.

Journal Article J Immunol · October 15, 2019 CMV remains an important opportunistic pathogen in high-risk lung transplant recipients. We characterized the phenotype and function of CD8+ T cells from acute/primary into chronic CMV infection in 23 (donor+/recipient-; D+R-) lung transplant recipients an ... Full text Link to item Cite

Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.

Journal Article Am J Respir Crit Care Med · February 1, 2019 RATIONALE: Cytomegalovirus (CMV)-related morbidities remain one of the most common complications after lung transplantation and have been linked to allograft dysfunction, but the factors that predict high risk for CMV complications and effective immunity a ... Full text Link to item Cite

Cyclophosphamide for Refractory Acute Cellular Rejection After Lung Transplantation.

Journal Article Transplant Direct · May 2018 BACKGROUND: Acute cellular rejection (ACR) is a major risk factor for chronic lung allograft dysfunction after lung transplantation. Acute cellular rejection can persist or recur despite augmentation of immunosuppression by conventional methods. There are ... Full text Link to item Cite

IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.

Journal Article J Immunol · January 15, 2016 CMV remains an important opportunistic pathogen in solid organ and hematopoietic cell transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor(+)/recipient(-); D(+)R(-)) are at high risk for active CMV infection an ... Full text Link to item Cite

Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis.

Journal Article Viral Immunol · June 2015 Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in immunocompromised hosts, many of whom undergo significant periods of lymphopenia. However, the impact of lymphopenia and subsequent immune reconstitution on T cell responses and pul ... Full text Link to item Cite

Serial monitoring of exhaled nitric oxide in lung transplant recipients.

Journal Article J Heart Lung Transplant · April 2015 BACKGROUND: Exhaled nitric oxide (FeNO), a marker of airway inflammation, is often elevated in lung transplant recipients (LTxRs) with acute rejection or infection. Isolated measurements in the setting of bronchiolitis obliterans syndrome have been variabl ... Full text Link to item Cite

De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation.

Journal Article J Heart Lung Transplant · December 2014 BACKGROUND: The development of human leukocyte antigen (HLA) antibody responses has been associated with worse clinical outcomes, such as bronchiolitis obliterans syndrome (BOS) and death, in lung transplant recipients (LTRs). However, the role of donor-sp ... Full text Link to item Cite

T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control.

Journal Article J Immunol · December 1, 2014 CMV remains an important opportunistic pathogen in solid organ transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient-; D+R-) are at high-risk for active CMV infection and increased mortality, however ... Full text Link to item Cite

Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry.

Journal Article Methods Mol Biol · 2014 Cytotoxic T lymphocytes (CTLs) are important constituents of the adaptive immune system. Development of CTLs are particularly important for bacterial and viral infections, in addition to tumor surveillance. Measuring T cell immune function is important in ... Full text Link to item Cite

High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control.

Journal Article Am J Transplant · January 2013 The maintenance of CMV-specific T cell memory in lung transplant recipients (LTRs) is critical for host defense and allograft durability, particularly in donor(+) /recipient(-) (D(+) R(-) ) individuals who demonstrate increased mortality. We studied CD4(+) ... Full text Link to item Cite

Acute kidney injury increases mortality after lung transplantation.

Journal Article Ann Thorac Surg · July 2012 BACKGROUND: Acute kidney injury requiring renal replacement therapy (RRT) is associated with increased mortality after cardiac surgery. Studies examining the impact of RRT after lung transplantation (LTx) are limited. We evaluated risk factors and outcomes ... Full text Link to item Cite

Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients.

Journal Article J Infect Dis · December 1, 2011 BACKGROUND: Cytomegalovirus (CMV) remains an important pathogen in solid organ transplantation, particularly lung transplantation. Lung transplant recipients (LTRs) mismatched for CMV (donor positive/recipient negative [D(+)R(-)]) are at highest risk for a ... Full text Link to item Cite

Therapies for refractory hypoxemia in acute respiratory distress syndrome.

Journal Article JAMA · December 8, 2010 Acute respiratory distress syndrome (ARDS) is a common and severe form of acute lung injury, resulting from both direct (eg, pneumonia) and indirect (eg, sepsis) pulmonary insults. It is a common cause of admission to the intensive care unit due to hypoxem ... Full text Link to item Cite

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.

Journal Article J Clin Invest · October 2009 Acute lung injury (ALI) is characterized by rapid alveolar injury, inflammation, cytokine induction, and neutrophil accumulation. Although early events in the pathogenesis of ALI have been defined, the mechanisms underlying resolution are unknown. As a mod ... Full text Link to item Cite

Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness.

Journal Article J Virol · March 2009 To better understand the components of an effective immune response to human immunodeficiency virus (HIV), the CD8(+) T-cell responses to HIV, hepatitis C virus (HCV), and cytomegalovirus (CMV) were compared with regard to frequency, immunodominance, pheno ... Full text Link to item Cite

Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection.

Journal Article J Immunol · July 1, 2008 Acquisition of T cell responses during primary CMV infection in lung transplant recipients (LTRs) appear critical for host defense and allograft durability, with increased mortality in donor+/recipient- (D+R-) individuals. In 15 D+R- LTRs studied, acute pr ... Full text Link to item Cite

"Still" ill?

Journal Article Am J Med · June 2008 Full text Link to item Cite

Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity.

Journal Article J Immunol · January 1, 2008 Evaluation of T cell responses to tumor- and pathogen-derived peptides in preclinical models is necessary to define the characteristics of efficacious peptide vaccines. We show in this study that vaccination with insect cells infected with baculoviruses ex ... Full text Link to item Cite

Successful treatment of Trichosporon mucoides infection with fluconazole in a heart and kidney transplant recipient.

Journal Article Clin Infect Dis · February 15, 2003 Trichosporon species are an emerging cause of infection, particularly among transplant recipients. We report what we believe to be the first case of successful management of disseminated Trichosporon mucoides infection with orally administered fluconazole ... Full text Link to item Cite

Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma.

Journal Article Cancer Immunol Immunother · April 2000 Because they are difficult to treat, animal models of widespread, established metastatic cancer are rarely used to test novel immunotherapies. Two such mouse models are used in this report to demonstrate the therapeutic efficacy and to probe the mechanisms ... Full text Link to item Cite

Cell-based vaccines for the stimulation of immunity to metastatic cancers.

Journal Article Immunol Rev · August 1999 We are developing vaccines for inducing immunity to metastatic cancers. Although primary tumors are frequently cured by surgery, chemotherapy, or radiation therapy, metastatic lesions often do not respond to these treatments or proliferate after convention ... Full text Link to item Cite