Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 2016
• Research
• 

  Selected Grants

  • ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas awarded by National Institutes of Health 2022 - 2027
  • Reviving cancer immune surveillance with CD4 T cell help awarded by National Institutes of Health 2022 - 2025
  • Reviving cancer immune surveillance with CD4 T cell help awarded by National Institutes of Health 2021 - 2023
  • Innate Antiviral Signals for Cancer Immunotherapy awarded by National Institutes of Health 2018 - 2023
  • Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma? awarded by National Institutes of Health 2019 - 2022
  • Cancer Immunotherapy Through Intratumoral Activation of Recall Responses awarded by National Institutes of Health 2018 - 2021
  • Cancer Immunotherapy Through Intratumoral Activation of Recall Responses awarded by National Cancer Center 2017 - 2019
  • Oncolytic Virotherapy of Meningeal Cancer awarded by National Institutes of Health 2009 - 2015
• 

  External Relationships

  • Istari Oncology
  • Menarini Ricerche S.p.A.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Brown, Michael C., Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, et al. “Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils.” J Immunother Cancer 11, no. 4 (April 2023). https://doi.org/10.1136/jitc-2022-006463.
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    • Li, Sean, Roger McLendon, Eric Sankey, Reb Kornahrens, Anne-Marie Lyne, Florence Marie Géraldine Cavalli, Zachary McKay, et al. “CD155 is a putative therapeutic target in medulloblastoma.” Clin Transl Oncol 25, no. 3 (March 2023): 696–705. https://doi.org/10.1007/s12094-022-02975-9.
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    • Beasley, Georgia M., Michael C. Brown, Norma E. Farrow, Karenia Landa, Rami N. Al-Rohil, Maria Angelica Selim, Aaron D. Therien, et al. “Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma.” J Immunother Cancer 10, no. 9 (September 2022). https://doi.org/10.1136/jitc-2022-005052.
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    • Dobrikov, Mikhail I., Elena Y. Dobrikova, Zachary P. McKay, Jonathan P. Kastan, Michael C. Brown, and Matthias Gromeier. “PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.” Mbio 13, no. 3 (June 28, 2022): e0085422. https://doi.org/10.1128/mbio.00854-22.
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    • Sarver, Melissa, Michael C. Brown, Kristen E. Rhodin, April K. S. Salama, and Georgia M. Beasley. “Predictive factors of neoadjuvant immune checkpoint blockade in melanoma.” Hum Vaccin Immunother 18, no. 3 (May 31, 2022): 1943987. https://doi.org/10.1080/21645515.2021.1943987.
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    • Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.
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    • Brown, Michael C., David M. Ashley, and Mustafa Khasraw. “Low tumor mutational burden and immunotherapy in gliomas.” Trends Cancer 8, no. 5 (May 2022): 345–46. https://doi.org/10.1016/j.trecan.2022.01.006.
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    • Brown, Michael. “Engaging Pattern Recognition Receptors in Solid Tumors to Generate Systemic Antitumor Immunity.” Cancer Treat Res 183 (2022): 91–129. https://doi.org/10.1007/978-3-030-96376-7_3.
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    • Kastan, Jonathan P., Martine W. Tremblay, Michael C. Brown, Joseph D. Trimarco, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.” Mbio 12, no. 2 (April 13, 2021). https://doi.org/10.1128/mBio.00116-21.
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    • Brown, Michael C., Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, et al. “Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.” Nat Commun 12, no. 1 (March 25, 2021): 1858. https://doi.org/10.1038/s41467-021-22088-1.
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    • McKay, Zachary P., Michael C. Brown, and Matthias Gromeier. “Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.” J Immunol 206, no. 6 (March 15, 2021): 1385–94. https://doi.org/10.4049/jimmunol.2000792.
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    • Gromeier, Matthias, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.” Nat Commun 12, no. 1 (January 13, 2021): 352. https://doi.org/10.1038/s41467-020-20469-6.
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    • Mosaheb, Mubeen M., Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Harnessing virus tropism for dendritic cells for vaccine design.” Curr Opin Virol 44 (October 2020): 73–80. https://doi.org/10.1016/j.coviro.2020.07.012.
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    • Mosaheb, Mubeen M., Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, and Matthias Gromeier. “Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.” Nat Commun 11, no. 1 (January 27, 2020): 524. https://doi.org/10.1038/s41467-019-13939-z.
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    • Puza, Charles J., Elizabeth Schell Bressler, Alicia M. Terando, John Harrison Howard, Michael C. Brown, Brent Hanks, April K. S. Salama, and Georgia M. Beasley. “The Emerging Role of Surgery for Patients With Advanced Melanoma Treated With Immunotherapy.” J Surg Res 236 (April 2019): 209–15. https://doi.org/10.1016/j.jss.2018.11.045.
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    • Walton, Ross W., Michael C. Brown, Matthew T. Sacco, and Matthias Gromeier. “Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.” J Virol 92, no. 19 (October 1, 2018). https://doi.org/10.1128/JVI.00879-18.
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    • Thompson, Eric M., Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael D. Taylor, Roger McLendon, Jennifer Sanks, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.” J Neuropathol Exp Neurol 77, no. 8 (August 1, 2018): 696–702. https://doi.org/10.1093/jnen/nly045.
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    • Bryant, Jeffrey D., Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang, and Matthias Gromeier. “Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.” Mol Cell Biol 38, no. 11 (June 1, 2018). https://doi.org/10.1128/MCB.00647-17.
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    • Evans, Myron K., Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, et al. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.” Cancer Res 78, no. 7 (April 1, 2018): 1726–38. https://doi.org/10.1158/0008-5472.CAN-17-1667.
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    • Brown, Michael C., Eda K. Holl, David Boczkowski, Elena Dobrikova, Mubeen Mosaheb, Vidya Chandramohan, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.” Sci Transl Med 9, no. 408 (September 20, 2017). https://doi.org/10.1126/scitranslmed.aan4220.
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    • Brown, Michael C., and Matthias Gromeier. “MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.” Cell Rep 18, no. 6 (February 7, 2017): 1444–57. https://doi.org/10.1016/j.celrep.2017.01.023.
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    • Brown, Michael C., and Matthias Gromeier. “MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.” Mol Cell Oncol 4, no. 3 (2017): e1306010. https://doi.org/10.1080/23723556.2017.1306010.
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    • Holl, Eda K., Michael C. Brown, David Boczkowski, Megan A. McNamara, Daniel J. George, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.” Oncotarget 7, no. 48 (November 29, 2016): 79828–41. https://doi.org/10.18632/oncotarget.12975.
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    • Brown, Michael C., Eda K. Holl, David Boczkowski, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Abstract A157: Oncolytic poliovirus mediated immune events.” Cancer Immunology Research 4, no. 1_Supplement (January 1, 2016): A157–A157. https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a157.
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    • Brown, Michael C., and Matthias Gromeier. “Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.” Curr Opin Virol 13 (August 2015): 81–85. https://doi.org/10.1016/j.coviro.2015.05.007.
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    • Brown, Michael C., and Matthias Gromeier. “Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus.” Discov Med 19, no. 106 (May 2015): 359–65.
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    • Reynolds, John, Gloria A. Preston, Barrak M. Pressler, Peter Hewins, Michael Brown, Aleeza Roth, Elizabeth Alderman, et al. “Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by 'autoantigen complementarity'.” J Autoimmun 59 (May 2015): 8–18. https://doi.org/10.1016/j.jaut.2015.01.003.
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    • Brown, Michael C., Elena Y. Dobrikova, Mikhail I. Dobrikov, Ross W. Walton, Sarah L. Gemberling, Smita K. Nair, Annick Desjardins, et al. “Oncolytic polio virotherapy of cancer.” Cancer 120, no. 21 (November 1, 2014): 3277–86. https://doi.org/10.1002/cncr.28862.
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    • Brown, Michael C., Jeffrey D. Bryant, Elena Y. Dobrikova, Mayya Shveygert, Shelton S. Bradrick, Vidyalakshmi Chandramohan, Darell D. Bigner, and Matthias Gromeier. “Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.” J Virol 88, no. 22 (November 2014): 13135–48. https://doi.org/10.1128/JVI.01883-14.
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    • Brown, Michael C., Mikhail I. Dobrikov, and Matthias Gromeier. “Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.” J Virol 88, no. 22 (November 2014): 13149–60. https://doi.org/10.1128/JVI.01884-14.
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    • Inoue, Makoto, Tomohiro Arikawa, Yu-Hsun Chen, Yasuhiro Moriwaki, Michael Price, Michael Brown, John R. Perfect, and Mari L. Shinohara. “T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.” Proc Natl Acad Sci U S A 111, no. 14 (April 8, 2014): 5295–5300. https://doi.org/10.1073/pnas.1321427111.
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    • Dobrikov, Mikhail I., Mayya Shveygert, Michael C. Brown, and Matthias Gromeier. “Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.” Mol Cell Biol 34, no. 3 (February 2014): 439–51. https://doi.org/10.1128/MCB.01046-13.
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    • Roth, Aleeza J., Michael C. Brown, Rex Neal Smith, Anshul K. Badhwar, Oscar Parente, Hyun chul Chung, Donna O’Dell Bunch, et al. “Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis.” J Am Soc Nephrol 23, no. 3 (March 2012): 545–55. https://doi.org/10.1681/ASN.2011030273.
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  • Conference Papers

    • Brown, Michael, Zachary McKay, Yuanfan Yang, Darell Bigner, Smita Nair, and Matthias Gromeier. “739 Intratumor childhood vaccine-specific CD4+ T cell recall helps antitumor CD8 T cells.” In Journal for Immunotherapy of Cancer, 9:A770–A770. BMJ, 2021. https://doi.org/10.1136/jitc-2021-sitc2021.739.
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    • Brown, Michael, Gao Zhang, Kevin Stevenson, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “TUMOR-INTRINSIC AND PERIPHERAL FEATURES ASSOCIATE WITH SURVIVAL AFTER POLIO VIROTHERAPY IN RECURRENT GBM.” In Neuro Oncology, 23:14–14, 2021.
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    • Kelly, Andrea True, Prakash Ambady, Michael Brown, Nicholas Butowski, Robert Cavaliere, William Curry, Annick Desjardins, et al. “LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.” In Cancer Research, Vol. 81, 2021.
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    • Low, Justin, Vidyalakshmi Chandramohan, Michelle Bowie, Michael Brown, Matthew Waitkus, Aaron Briley, Kevin Stevenson, et al. “STING IS SILENCED IN GBM BY PROMOTER METHYLATION THAT IS ESTABLISHED BY TISSUE OF ORIGIN.” In Neuro Oncology, 23:4–4, 2021.
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    • Yang, Yuanfan, Michael Brown, Kevin Stevenson, Giselle Lopez, Reb Kornahrens, Gao Zhang, and Matthias Gromeier. “POLIO VIROTHERAPY OF MURINE BRAIN TUMORS INDUCES MICROGLIA PROLIFERATION AND INFLAMMATION THAT IS POTENTIATED BY IMMUNE CHECKPOINT BLOCKADE.” In Neuro Oncology, 23:181–181, 2021.
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    • Frazier, Victoria N., Eda Holl, Michael Brown, David Boczkowski, Karenia Landa, Shelley Hwang, Matthias Gromeier, and Smita K. Nair. “Oncolytic poliovirus immunotherapy for breast cancer.” In Journal of Immunology, Vol. 204, 2020.
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    • Hariharan, Seethalakshmi, Michelle Bowie, Janell Hostettler, Kristen Roso, Yiping He, Martin A. Roskoski, Casey Charbonneau, et al. “INTERPLAY BETWEEN IDH1 AND ATRX MUTATIONS GOVERN INNATE IMMUNE RESPONSES IN GLIOMAS.” In Neuro Oncology, 22:108–108, 2020.
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    • Low, Justin, Michelle Bowie, Vidya Chandramohan, Rebecca Fuller, Andrea Muscat, Michael Brown, Seethalakshmi Hariharan, et al. “STING PROMOTER EPIGENETIC SILENCING IN GLIOBLASTOMA.” In Neuro Oncology, 22:73–73, 2020.
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    • Mosaheb, Mubeen, Daniel Landi, Elena Dobrikova, Michael Brown, Yuanfan Yang, Jana Cable, Hideho Okada, et al. “GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION.” In Neuro Oncology, 22:472–472, 2020.
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    • Yang, Yuanfan, Michael Brown, Matthias Gromeier, and Darell Bigner. “ONCOLYTIC POLIOVIRUS AS A PROBE FOR MECHANISMS OF IMMUNE RESISTANCE IN GLIOBLASTOMA.” In Neuro Oncology, 22:231–231, 2020.
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    • Bowie, Michelle, Seethalakshmi Hariharan, Janell Hostettler, Kristen Roso, Yiping He, Christopher Pirozzi, Martin Roskoski, et al. “ATRX MUTATIONS PREDICT RESPONSE TO INNATE BASED THERAPY IN GLIOMA.” In Neuro Oncology, 21:126–126. OXFORD UNIV PRESS INC, 2019.
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    • Gromeier, Matthias, Michael Brown, Nike Beuabier, Hai Yan, Yiping He, Gao Zhang, Annick Desjardins, et al. “TUMOR MUTATIONAL BURDEN PREDICTS RESPONSE TO ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN MALIGNANT GLIOMA PATIENTS: ASSESSMENT OF TRANSCRIPTIONAL AND IMMUNOLOGICAL CORRELATES.” In Neuro Oncology, 21:7–7. OXFORD UNIV PRESS INC, 2019.
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    • Gromeier, Matthias, Mubeen Mosaheb, Elena Dobrikova, Michael Brown, Darell Bigner, and David Ashley. “GENETICALLY STABLE POLIOVIRUS VECTOR PLATFORM FOR DIPG IMMUNOTHERAPY.” In Neuro Oncology, 21:93–93. OXFORD UNIV PRESS INC, 2019.
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    • Bowie, Michelle, David Ashley, Janell Hostettler, Michael Brown, Jeffrey Bryant, Darell Bigner, Matthias Gromeier, and Smita Nair. “DYSFUNCTIONAL STING PATHWAY SIGNALING COMPROMISES INNATE IMMUNITY IN GLIOBLASTOMA.” In Neuro Oncology, 20:127–28. OXFORD UNIV PRESS INC, 2018.
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    • Thompson, Eric, Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael Taylor, Roger McLendon, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “POLIOVIRUS RECEPTOR (CD155) EXPRESSION IN PEDIATRIC BRAIN TUMORS MEDIATES ONCOLYSIS OF MEDULLOBLASTOMA AND PLEOMORPHIC XANTHOASTROCYTOMA.” In Neuro Oncology, 20:213–213. OXFORD UNIV PRESS INC, 2018.
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    • Landa, Karenia, Eda Holl, Michael Brown, James Herndon, Lars Grimm, Jeremy Force, Darell Bigner, Shelley Hwang, Matthias Gromeier, and Smita Nair. “Abstract LB-302: Oncolytic poliovirus-mediated inflammation and immunity in breast cancer.” In Cancer Research, Vol. 78. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-lb-302.
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    • Force, Jeremy, Eda Holl, Michael Brown, Paul Kelly Marcom, Lars Grimm, David Boczkowski, Victoria Frazier, et al. “Recombinant oncolytic poliovirus combined with checkpoint blockade for breast cancer therapy.” In Journal of Clinical Oncology, 36:e12641–e12641. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e12641.
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    • Bryant, Jeffrey, Michael Brown, and Matthias Gromeier. “Chemotherapy enhances oncolytic recombinant poliovirus efficacy.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.
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    • Walton, Ross, Michael Brown, Eda Holl, David Boczkowski, Vidya Chandramohan, Smita Nair, and Matthias Gromeier. “PVSRIPO is an interferon-resistant, immunotherapeutic oncolytic virus.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.
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  • Preprints

    • Brown, Michael, Zachary McKay, Yuanfan Yang, Georgia Beasley, David Ashley, Darell Bigner, Smita Nair, and Matthias Gromeier. “Intratumor Childhood Vaccine-Specific CD4⁺T cell Recall Coordinates Antitumor CD8⁺T cells and Eosinophils.” BioRxiv, 2022. https://doi.org/10.1101/2022.03.14.484260.
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    • Yang, Yuanfan, Michael Brown, Gao Zhang, Kevin Stevenson, Malte Mohme, Reb Kornahrens, Darell Bigner, David Ashley, Giselle López, and Matthias Gromeier. “Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation.” BioRxiv, 2022. https://doi.org/10.1101/2022.04.19.488771.
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