Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 2016
• Research
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  Selected Grants

  • ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas awarded by National Institutes of Health 2022 - 2027
  • Reviving cancer immune surveillance with CD4 T cell help awarded by National Institutes of Health 2022 - 2025
  • Reviving cancer immune surveillance with CD4 T cell help awarded by National Institutes of Health 2021 - 2023
  • Innate Antiviral Signals for Cancer Immunotherapy awarded by National Institutes of Health 2018 - 2023
  • Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma? awarded by National Institutes of Health 2019 - 2022
  • Cancer Immunotherapy Through Intratumoral Activation of Recall Responses awarded by National Institutes of Health 2018 - 2021
  • Cancer Immunotherapy Through Intratumoral Activation of Recall Responses awarded by National Cancer Center 2017 - 2019
  • Oncolytic Virotherapy of Meningeal Cancer awarded by National Institutes of Health 2009 - 2015
• 

  External Relationships

  • Istari Oncology
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Dobrikov, Mikhail I., Elena Y. Dobrikova, Zachary P. McKay, Jonathan P. Kastan, Michael C. Brown, and Matthias Gromeier. “PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.” Mbio 13, no. 3 (June 28, 2022): e0085422. https://doi.org/10.1128/mbio.00854-22.
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    • Sarver, Melissa, Michael C. Brown, Kristen E. Rhodin, April K. S. Salama, and Georgia M. Beasley. “Predictive factors of neoadjuvant immune checkpoint blockade in melanoma.” Hum Vaccin Immunother 18, no. 3 (May 31, 2022): 1943987. https://doi.org/10.1080/21645515.2021.1943987.
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    • Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.
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    • Brown, Michael C., David M. Ashley, and Mustafa Khasraw. “Low tumor mutational burden and immunotherapy in gliomas.” Trends Cancer 8, no. 5 (May 2022): 345–46. https://doi.org/10.1016/j.trecan.2022.01.006.
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    • Brown, Michael. “Engaging Pattern Recognition Receptors in Solid Tumors to Generate Systemic Antitumor Immunity.” Cancer Treat Res 183 (2022): 91–129. https://doi.org/10.1007/978-3-030-96376-7_3.
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    • Kastan, Jonathan P., Martine W. Tremblay, Michael C. Brown, Joseph D. Trimarco, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.” Mbio 12, no. 2 (April 13, 2021). https://doi.org/10.1128/mBio.00116-21.
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    • Brown, Michael C., Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, et al. “Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.” Nat Commun 12, no. 1 (March 25, 2021): 1858. https://doi.org/10.1038/s41467-021-22088-1.
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    • McKay, Zachary P., Michael C. Brown, and Matthias Gromeier. “Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.” J Immunol 206, no. 6 (March 15, 2021): 1385–94. https://doi.org/10.4049/jimmunol.2000792.
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    • Gromeier, Matthias, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.” Nat Commun 12, no. 1 (January 13, 2021): 352. https://doi.org/10.1038/s41467-020-20469-6.
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    • Mosaheb, Mubeen M., Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Harnessing virus tropism for dendritic cells for vaccine design.” Curr Opin Virol 44 (October 2020): 73–80. https://doi.org/10.1016/j.coviro.2020.07.012.
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    • Mosaheb, Mubeen M., Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, and Matthias Gromeier. “Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.” Nat Commun 11, no. 1 (January 27, 2020): 524. https://doi.org/10.1038/s41467-019-13939-z.
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    • Puza, Charles J., Elizabeth Schell Bressler, Alicia M. Terando, John Harrison Howard, Michael C. Brown, Brent Hanks, April K. S. Salama, and Georgia M. Beasley. “The Emerging Role of Surgery for Patients With Advanced Melanoma Treated With Immunotherapy.” J Surg Res 236 (April 2019): 209–15. https://doi.org/10.1016/j.jss.2018.11.045.
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    • Walton, Ross W., Michael C. Brown, Matthew T. Sacco, and Matthias Gromeier. “Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.” J Virol 92, no. 19 (October 1, 2018). https://doi.org/10.1128/JVI.00879-18.
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    • Thompson, Eric M., Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael D. Taylor, Roger McLendon, Jennifer Sanks, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.” J Neuropathol Exp Neurol 77, no. 8 (August 1, 2018): 696–702. https://doi.org/10.1093/jnen/nly045.
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    • Bryant, Jeffrey D., Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang, and Matthias Gromeier. “Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.” Mol Cell Biol 38, no. 11 (June 1, 2018). https://doi.org/10.1128/MCB.00647-17.
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    • Evans, Myron K., Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, et al. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.” Cancer Res 78, no. 7 (April 1, 2018): 1726–38. https://doi.org/10.1158/0008-5472.CAN-17-1667.
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    • Brown, Michael C., Eda K. Holl, David Boczkowski, Elena Dobrikova, Mubeen Mosaheb, Vidya Chandramohan, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.” Sci Transl Med 9, no. 408 (September 20, 2017). https://doi.org/10.1126/scitranslmed.aan4220.
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    • Brown, Michael C., and Matthias Gromeier. “MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.” Cell Rep 18, no. 6 (February 7, 2017): 1444–57. https://doi.org/10.1016/j.celrep.2017.01.023.
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    • Brown, Michael C., and Matthias Gromeier. “MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.” Mol Cell Oncol 4, no. 3 (2017): e1306010. https://doi.org/10.1080/23723556.2017.1306010.
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    • Holl, Eda K., Michael C. Brown, David Boczkowski, Megan A. McNamara, Daniel J. George, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.” Oncotarget 7, no. 48 (November 29, 2016): 79828–41. https://doi.org/10.18632/oncotarget.12975.
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    • Brown, Michael C., and Matthias Gromeier. “Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.” Curr Opin Virol 13 (August 2015): 81–85. https://doi.org/10.1016/j.coviro.2015.05.007.
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    • Brown, Michael C., and Matthias Gromeier. “Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus.” Discov Med 19, no. 106 (May 2015): 359–65.
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    • Reynolds, John, Gloria A. Preston, Barrak M. Pressler, Peter Hewins, Michael Brown, Aleeza Roth, Elizabeth Alderman, et al. “Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by 'autoantigen complementarity'.” J Autoimmun 59 (May 2015): 8–18. https://doi.org/10.1016/j.jaut.2015.01.003.
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    • Brown, Michael C., Elena Y. Dobrikova, Mikhail I. Dobrikov, Ross W. Walton, Sarah L. Gemberling, Smita K. Nair, Annick Desjardins, et al. “Oncolytic polio virotherapy of cancer.” Cancer 120, no. 21 (November 1, 2014): 3277–86. https://doi.org/10.1002/cncr.28862.
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    • Brown, Michael C., Jeffrey D. Bryant, Elena Y. Dobrikova, Mayya Shveygert, Shelton S. Bradrick, Vidyalakshmi Chandramohan, Darell D. Bigner, and Matthias Gromeier. “Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.” J Virol 88, no. 22 (November 2014): 13135–48. https://doi.org/10.1128/JVI.01883-14.
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    • Brown, Michael C., Mikhail I. Dobrikov, and Matthias Gromeier. “Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.” J Virol 88, no. 22 (November 2014): 13149–60. https://doi.org/10.1128/JVI.01884-14.
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    • Inoue, Makoto, Tomohiro Arikawa, Yu-Hsun Chen, Yasuhiro Moriwaki, Michael Price, Michael Brown, John R. Perfect, and Mari L. Shinohara. “T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.” Proc Natl Acad Sci U S A 111, no. 14 (April 8, 2014): 5295–5300. https://doi.org/10.1073/pnas.1321427111.
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    • Dobrikov, Mikhail I., Mayya Shveygert, Michael C. Brown, and Matthias Gromeier. “Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.” Mol Cell Biol 34, no. 3 (February 2014): 439–51. https://doi.org/10.1128/MCB.01046-13.
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    • Roth, Aleeza J., Michael C. Brown, Rex Neal Smith, Anshul K. Badhwar, Oscar Parente, Hyun chul Chung, Donna O’Dell Bunch, et al. “Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis.” J Am Soc Nephrol 23, no. 3 (March 2012): 545–55. https://doi.org/10.1681/ASN.2011030273.
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  • Preprints

    • Brown, Michael, Zachary McKay, Yuanfan Yang, Georgia Beasley, David Ashley, Darell Bigner, Smita Nair, and Matthias Gromeier. “Intratumoral Recall of Childhood Vaccine-Specific CD4⁺ T cells Coordinates Type I and II Antitumor Immunity.” BioRxiv, 2022. https://doi.org/10.1101/2022.03.14.484260.
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    • Yang, Yuanfan, Michael Brown, Gao Zhang, Kevin Stevenson, Malte Mohme, Reb Kornahrens, Darell Bigner, David Ashley, Giselle López, and Matthias Gromeier. “Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation.” BioRxiv, 2022. https://doi.org/10.1101/2022.04.19.488771.
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