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Charles Michael Cotten

Professor of Pediatrics
Pediatrics, Neonatology
Box 102509 DUMC, Durham, NC 27710
2400 Pratt Street, 8th Floor, Durham, NC 27710
Office hours Available to be scheduled. Most weekdays 8 AM - 5 PM  

Research Interests


Neuroprotection with cell-based therapies; Clinical trials and practice variations in Neonatology; Innovative technologies for newborn medicine; Applied genomics in newborn medicine, optimizing mother's own milk for infants in the NICU

Selected Grants


Neonatal Platelet Transfusion Threshold (NeoPlaTT)

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2024 - 2031

Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchCollaborating Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2030

Milrinone for Prevention of Post-ligation Cardiac Syndrome (MIDAS) Trial

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2024 - 2029

Duke Women's Reproductive Health Research Scholars

Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2020 - 2025

Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)

ResearchPrincipal Investigator · Awarded by Boston Children's Hospital · 2022 - 2025

The Hydrocortisone for BPD Respiratory and Developmental Outcomes Study (HYBRiD Outcomes Study)

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2017 - 2025

TOP Trial

ResearchPrincipal Investigator · Awarded by Research Triangle Institute · 2012 - 2025

RTI NRN Capitation

ResearchPrincipal Investigator · Awarded by Research Triangle Institute · 2011 - 2025

Unified Program for Therapeutics in Children

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2019 - 2024

The Transfusion of Prematures Early School Age Follow-Up (TOP 5)

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2018 - 2023

Early Check: A Collaborative Innovation to Facilitate Pre-Symptomatic Clinical Trials in Newborns

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2016 - 2022

Darbepoetin Trial to Improve Red Cell Mass and Neuroprotectoin in Preterms (Darbe)

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2017 - 2022

Multiplex Platform for Point-of-Care Newborn Screening of Hyperbilirubinemia

ResearchPrincipal Investigator · Awarded by Baebies, Inc · 2019 - 2021

Expanding thyroid testing in high risk newborns: total T3, free T4, TSH and TRAB

ResearchCo Investigator · Awarded by Baebies, Inc · 2018 - 2021

Early Check: A Collaborative Innovation to Facilitate Pre-Symptomatic Clinical Trials in Newborns

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2020 - 2021

Comprehensive, Near Patient Assessment of Severe Hypoglycemia in Newborns Using Low Blood Volume (Phase II)

ResearchPrincipal Investigator · Awarded by Baebies, Inc · 2017 - 2021

A Low Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions Phase II

ResearchPrincipal Investigator · Awarded by Baebies, Inc · 2018 - 2021

Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation

Clinical TrialCo Investigator · Awarded by Robertson Foundation · 2015 - 2021

Near Patient Acute Kidney Injury Biomarker Analysis in Critically Ill Neonates- Phase II

ResearchPrincipal Investigator · Awarded by Baebies, Inc · 2018 - 2019

Growth Failure in Extremely Preterm Infants: Microbiomic and Metabolomic Analysis

ResearchCollaborator · Awarded by Gerber Foundation · 2014 - 2018

A rapid, ultrasensitive system for recurrent thyroid testing in high risk newborns

ResearchCo Investigator · Awarded by Baebies, Inc · 2017 - 2018

Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2018

A Secondary Study to the Transfusion of Prematures (TOP) Study

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2015 - 2018

Linking Safety Practices to Adverse Events and Outcomes in Hospitalized Infants

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2018

MICROBIAL SUCCESSION AND ADAPTIVE IMMUNE RESPONSES IN THE PREMATURE INFANT

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2017

PTN TO#25: Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2017

PK of Sildenafil in Premature Infants

Clinical TrialPrincipal Investigator · Awarded by Duke Clinical Research Institute · 2013 - 2017

Prospective Observational Study of Respiratory Support Provided to Premature Infants at Risk for Respiratory Distress Syndrome

Clinical TrialPrincipal Investigator · Awarded by Discovery Laboratories, Inc. · 2015 - 2017

Phase II Stannosoporfin

Clinical TrialPrincipal Investigator · Awarded by InfaCare Pharmaceutical Corporation · 2013 - 2016

Temperature Monitoring with InnerSense Esophageal Temperature Probe

Clinical TrialPhysician · Awarded by Philips Electronics North America Corp · 2014 - 2016

The Duke Multidisciplinary Training Program in Pediatric Lung Disease

Inst. Training Prgm or CMEFaculty Member · Awarded by National Institutes of Health · 2010 - 2016

PTN TO 13: PK of Antistaphylococcal Antibiotics in Infants

Clinical TrialPrincipal Investigator · Awarded by Duke Clinical Research Institute · 2012 - 2016

48-52 Month Follow Up Stannsoporfin 64,185-204

Clinical TrialPrincipal Investigator · Awarded by InfaCare Pharmaceutical Corporation · 2014 - 2016

PTN Task Order #5: Safety and Efficacy of High-Dose Acyclovir in Infants with HSV

Clinical TrialPrincipal Investigator · Awarded by National Institute for Child Health & Human Develo · 2014 - 2015

Multidisciplinary Neonatal Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2015

Data Coordinating Center for the Prematurity and Respiratory Outcomes Program

ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2012 - 2015

Multiplex platform for point of care newborn screening of hyperbilirubinemia

Clinical TrialPrincipal Investigator · Awarded by Advanced Liquid Logic · 2013 - 2014

Accelerating Adoption of Comparative Effectiveness Research in Premature Infants

ResearchCo Investigator · Awarded by Department of Health and Human Services · 2010 - 2013

Best Pharmaceutical for Children Act (BPCA): Use of Meropenem in Infants

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2007 - 2010

External Relationships


  • CryoCell International
  • FELIQS Corporation
  • Origin Biosciences
  • ReAlta Life Sciences

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.