Scholars@Duke
Michael R. Odom

Michael R. Odom

Assistant Professor of Urology
Urology
michael.r.odom@duke.edu
304 Research Drive, Durham, NC 27705
304 Research Drive, Durham, NC 27705

Selected Publications

Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN II) Urinary Urgency Phenotyping Study: Methods and Baseline Urinary Symptoms by Age and Sex.

Journal Article Neurourol Urodyn · June 2025 AIMS: To present the methods and baseline findings from a prospective, longitudinal cohort study of treatment seeking adults with urinary urgency (URG) with or without urgency urinary incontinence (UUI). METHODS: Adults seeking treatment for URG and/or UUI ... Full text Link to item Cite

Expanded Physiological Testing of the Lower Urinary Tract in Asymptomatic Women and Those With Urgency Urinary Incontinence: Findings From the LURN-Organ Study.

Journal Article Neurourol Urodyn · June 2025 PURPOSE: To investigate sensory and motor function of the bladder and urethra in women with and without urgency urinary incontinence (UUI). MATERIALS AND METHODS: Treatment-seeking women with UUI and healthy, asymptomatic, nontreatment seeking controls enr ... Full text Link to item Cite

Lack of group-to-individual generalizability in people with lower urinary tract symptoms emphasizes the need for deep phenotyping and personalized treatments.

Journal Article J Clin Transl Sci · 2025 INTRODUCTION: Understanding how different symptoms co-occur and are correlated may provide insights into the pathophysiology of disease. The lack of group-to-individual generalizability of co-occurrence of symptoms was recently demonstrated by comparing in ... Full text Link to item Cite

Male Akita diabetic mice develop underactive bladder independent of NLRP3 that can be prevented with blood glucose control.

Journal Article Continence (Amst) · December 2024 AIM: Diabetic bladder dysfunction (DBD) is the most common diabetic complication. Patients present with overactive symptoms, underactive symptoms, or both. While strict glucose control may be expected to reverse DBD, prior studies have not been supportive. ... Full text Link to item Cite

Strict glucose control and elimination of NLRP3-induced inflammation prevents diabetic bladder dysfunction in the female Akita mouse model.

Journal Article Neurourol Urodyn · November 2024 PURPOSE: Diabetic bladder dysfunction (DBD) is the most common diabetic complication. Logically, regulation of blood glucose should reverse dysfunction, but the Epidemiology of Diabetes Interventions and Complications study found strict control ineffective ... Full text Link to item Cite

Preclinical Female Model of Urogenital Dysfunction and Pathophysiological Changes After Pelvic Radiation Therapy.

Journal Article Cureus · August 2024 Introduction Radiation therapy (RT) is the gold standard for many pelvic cancers and improves overall patient survival. However, pelvic RT is associated with increased sexual dysfunction and urinary incontinence. Although the side effects of pelvic RT are ... Full text Link to item Cite

Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation.

Journal Article Front Biosci (Landmark Ed) · April 18, 2024 BACKGROUND: Diabetic bladder dysfunction (DBD) is driven in part by inflammation which dysregulates prostaglandin release in the bladder. Precise inflammatory mechanisms responsible for such dysregulation have been elusive. Since prostaglandins impact blad ... Full text Link to item Cite

Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons.

Journal Article Am J Physiol Renal Physiol · July 1, 2023 Diabetic bladder dysfunction (DBD) is a prevalent diabetic complication that is recalcitrant to glucose control. Using the Akita mouse model (type 1) bred to be NLR family pyrin domain containing 3 (NLRP3)+/+ or NLRP3-/-, we have previously found that fema ... Full text Link to item Cite

(008) Chronic High Fat Diet Decreases Vaginal Smooth Muscle Tone but does not Affect Pelvic Floor Skeletal Muscle in Mice

Conference The Journal of Sexual Medicine · June 27, 2023 AbstractIntroductionPelvic organ prolapse (POP) is a disease that affects the physical and mental health of women, as well as their qu ... Full text Cite

Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders.

Journal Article Int J Mol Sci · February 1, 2023 Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population and recent prospective studies have confirmed this link. Break ... Full text Open Access Link to item Cite

Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity.

Journal Article Am J Physiol Renal Physiol · December 1, 2022 Approximately half of the patients with diabetes develop diabetic bladder dysfunction (DBD). The initiation and progression of DBD is largely attributed to inflammation due to dysregulated glucose and the production of toxic metabolites that activate the N ... Full text Link to item Cite

Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3.

Journal Article Life Sci · June 15, 2022 AIMS: Diabetic bladder dysfunction (DBD) is a prevalent diabetic complication thought to progress from overactive (OAB) to underactive (UAB) bladder. Previously we found OAB at 15 weeks in the Akita mouse, a genetic model of Type 1 diabetes. The first aim ... Full text Link to item Cite

023 Castration Mediated Schwann Cell Dedifferentiation Leads to Slower Nerve Conduction, Decreased Neuritogenesis, and Nitrergic Neuron Loss

Conference The Journal of Sexual Medicine · May 1, 2022 ABSTRACTIntroduction/ObjectivesLow levels of androgens due to androgen deprivation therapy for prostate cancer treatment or due to agi ... Full text Cite

High-fat diet induces obesity in adult mice but fails to develop pre-penile and penile vascular dysfunction.

Journal Article Int J Impot Res · April 2022 Obesity can lead to cardiovascular disease, diabetes, and erectile dysfunction (ED), which decreases overall quality of life. Mechanisms responsible for obesity-induced ED are unknown. Current mouse models of high-fat diet (HFD)-induced obesity yield confl ... Full text Link to item Cite

Specialized pro-resolution mediators in the bladder: Receptor expression and recovery of bladder function from cystitis.

Journal Article Exp Biol Med (Maywood) · April 2022 Inflammation is a central process in most benign bladder disorders, and its control is a delicate balance between initiating factors and resolving factors. While recent discoveries have shown a central role for the NLRP3 inflammasome in initiation, the res ... Full text Link to item Cite

Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction.

Journal Article Front Physiol · 2022 Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by 2050. This disease is characterized by devastating complications brought about high glucose and metabolic derangement. The most common of these complications is dia ... Full text Open Access Link to item Cite

Ex vivo Akt inhibition reverses castration induced internal pudendal artery and penile endothelial dysfunction.

Journal Article Life Sci · November 15, 2021 AIMS: Androgen deprivation therapy is a common prostate cancer treatment which causes men to have castrate levels of testosterone. Unfortunately, most testosterone deficient patients will suffer severe erectile dysfunction (ED) and have no effective ED tre ... Full text Link to item Cite

Dysfunctional voiding behavior and impaired muscle contractility in a rat model of detrusor underactivity.

Journal Article Neurourol Urodyn · November 2021 AIMS: Detrusor underactivity (DU) is an understudied health concern with inadequate clinical management. The pathophysiology of DU is unclear, and current therapies fail to improve symptoms. The current studies characterized voiding function and contractil ... Full text Link to item Cite

Impact of prostatic radiation therapy on bladder contractility and innervation.

Journal Article Neurourol Urodyn · August 2021 AIMS: To determine the effect of prostatic radiation therapy (RT) on bladder contractility and morphology, and axon, or neuron profiles within the detrusor and major pelvic ganglia (MPG) in male rats. METHODS: Male Sprague-Dawley rats (8 weeks) received a ... Full text Link to item Cite

Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth.

Journal Article J Sex Med · January 2019 BACKGROUND: Erectile dysfunction (ED) is common following radiation therapy (RT) for prostate cancer. Although the cause of RT-induced ED is unknown, damage to both the neuronal and vascular components supporting erections are often implicated. AIM: To det ... Full text Link to item Cite

Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries.

Journal Article J Sex Med · November 2017 BACKGROUND: The internal pudendal arteries (IPAs) supply blood to the penis and are highly susceptible to vascular remodeling in rodent models of diabetes, hypertension, aging, and chronic kidney disease, thus contributing to erectile dysfunction. Interest ... Full text Link to item Cite