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Moria Joy Smoski

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
Box 102505 Med Ctr, Durham, NC 27710
2400 Pratt St, North Pavilion Room 6045, Durham, NC 27705

Overview


My research interests are focused on emotion regulation and reward processes in psychopathology, primarily in major depressive disorder.  I am interested in the translation of knowledge gleaned from cognitive neuroscience methods including functional neuroimaging to better understand and improve psychosocial interventions, including cognitive behavioral and mindfulness interventions.

Current Appointments & Affiliations


Associate Professor in Psychiatry and Behavioral Sciences · 2021 - Present Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology, Psychiatry & Behavioral Sciences
Associate Research Professor of Psychology and Neuroscience · 2019 - Present Psychology & Neuroscience, Trinity College of Arts & Sciences
Affiliate of the Center for Brain Imaging and Analysis · 2012 - Present Duke-UNC Brain Imaging and Analysis Center, Institutes and Centers

In the News


Published March 6, 2024
Using Mindfulness to Enhance Student Well-being

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Recent Publications


Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial.

Journal Article J Mood Anxiety Disord · September 2025 BACKGROUND: Anhedonia remains a difficult-to-treat symptom and has been associated with poor clinical course transdiagnostically. Here, we applied machine learning models to individualized neural patches derived from fMRI data during the Monetary Incentive ... Full text Link to item Cite

Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.

Journal Article Psychiatry Res Neuroimaging · December 2024 BACKGROUND: Emotional dysregulation is a serious and impairing mental health problem. We examined functional activity and connectivity of neural networks involved in emotional dysregulation at baseline and following a pilot neurostimulation-enhanced cognit ... Full text Link to item Cite

Evaluating state-based network dynamics in anhedonia.

Journal Article Neuroimage Rep · December 2024 Anhedonia is a transdiagnostic clinical syndrome associated with significant clinical impairment. In spite of this, a clear network-level characterization of anhedonia does not yet exist. The present study addressed this gap in the literature by taking a g ... Full text Link to item Cite
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Recent Grants


2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030

Duke/UNC ADAR Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Duke University Psychiatry Physician-Scientist Residency Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Mental Health · 2024 - 2029

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Education, Training & Certifications


Vanderbilt University · 2004 Ph.D.
Vanderbilt University · 1999 M.A.
Yale University · 1995 B.A.