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Moria Joy Smoski

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
Box 102505 Med Ctr, Durham, NC 27710
2400 Pratt St, North Pavilion Room 6045, Durham, NC 27705

Selected Publications


The effects of psychotherapy for anhedonia on subcortical brain volumes measured with ultra-high field MRI.

Journal Article J Affect Disord · May 28, 2024 BACKGROUND: Anhedonia is a transdiagnostic symptom often resistant to treatment. The identification of biomarkers sensitive to anhedonia treatment will aid in the evaluation of novel anhedonia interventions. METHODS: This is an exploratory analysis of chan ... Full text Link to item Cite

Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.

Journal Article J Affect Disord · October 15, 2023 BACKGROUND: Growing evidence indicates that anhedonia is a multifaceted construct. This study examined the possibility of identifying subgroups of people with anhedonia using multiple reward-related measures to provide greater understanding the Research Do ... Full text Link to item Cite

Identifying modifiable factors associated with psychological health in women experiencing infertility.

Journal Article J Health Psychol · October 2023 This study assessed the relationship between modifiable psychological variables and depression, anxiety, and posttraumatic growth in women experiencing infertility. U.S. women (N = 457) who identified as experiencing infertility completed standardized self ... Full text Link to item Cite

Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation.

Journal Article Psychiatry Res Neuroimaging · August 2023 BACKGROUND: Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA, reward circuitry functioning, ... Full text Link to item Cite

Parsing within & between-person dynamics of therapy homework completion and clinical symptoms in two cognitive behavioral treatments for adults with anhedonia.

Journal Article Behav Res Ther · July 2023 OBJECTIVE: Homework is a key theoretical component of cognitive-behavioral therapies, however, the effects of homework on clinical outcomes have largely been evaluated between-persons rather than within-persons. METHODS: The effects of homework completion ... Full text Link to item Cite

Longitudinal associations between perceived stress and anhedonia during psychotherapy.

Journal Article J Affect Disord · June 1, 2023 BACKGROUND: Chronic stress alters reward sensitivity and contributes to the emergence of anhedonia. In clinical samples, the perception of stress is a strong predictor of anhedonia. While there is substantial evidence demonstrating psychotherapy reduces pe ... Full text Link to item Cite

Emotion regulation difficulties link trait resilience and symptoms of depression and anxiety in psychiatric outpatients.

Journal Article Ann Clin Psychiatry · November 2022 BACKGROUND: Despite negative associations of trait resilience with depression and anxiety symptoms, the mechanisms by which resilience may buffer against these symptoms remain underexplored. This study investigated emotion regulation difficulties as a pote ... Full text Link to item Cite

Enhancing cognitive restructuring with concurrent fMRI-guided neurostimulation for emotional dysregulation-A randomized controlled trial.

Journal Article J Affect Disord · March 15, 2022 BACKGROUND: Transdiagnostic clinical emotional dysregulation is a key component of many mental health disorders and offers an avenue to address multiple disorders with one transdiagnostic treatment. In the current study, we pilot an intervention that combi ... Full text Link to item Cite

Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?

Journal Article J Health Psychol · November 2021 Although mindfulness-based stress reduction (MBSR) can improve health and well-being, less is known about factors that predict outcomes. This prospective observational study examined gender and baseline anxiety and sleep quality as predictors of change in ... Full text Link to item Cite

Neural signatures of saliency-mapping in anhedonia: A narrative review.

Journal Article Psychiatry Res · October 2021 Anhedonia is the loss of pleasure or motivation to engage in previously enjoyable activities, and is a transdiagnostic symptom associated with significant clinical impairment. Anhedonia is implicated in several different psychiatric disorders, presenting a ... Full text Link to item Cite

Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state functional connectivity: Interim results of a randomized trial✰.

Journal Article J Affect Disord · September 1, 2021 BACKGROUND: The neural mechanisms associated with anhedonia treatment response are poorly understood. Additionally, no study has investigated changes in resting-state functional connectivity (rsFC) accompanying psychosocial treatment for anhedonia. METHODS ... Full text Link to item Cite

Do interoceptive accuracy and interoceptive sensibility predict emotion regulation?

Journal Article Psychol Res · July 2021 INTRODUCTION: Interoception refers to awareness, interpretation, and integration of sensations in the body. While interoceptive accuracy has long been regarded as a core component of emotional experience, less is known about the relationship of interocepti ... Full text Link to item Cite

Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).

Journal Article Neuropsychopharmacology · September 2020 Anhedonia remains a major clinical issue for which there is few effective interventions. Untreated or poorly controlled anhedonia has been linked to worse disease course and increased suicidal behavior across disorders. Taking a proof-of-mechanism approach ... Full text Link to item Cite

A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

Journal Article Nat Med · May 2020 The National Institute of Mental Health (NIMH) 'fast-fail' approach seeks to improve too-often-misleading early-phase drug development methods by incorporating biomarker-based proof-of-mechanism (POM) testing in phase 2a. This first comprehensive applicati ... Full text Link to item Cite

Reward Network Modulation as a Mechanism of Change in Behavioral Activation.

Journal Article Behav Modif · March 2020 Behavioral Activation (BA) is a contemporary third-wave psychosocial treatment approach that emphasizes helping individuals become more active in ways that are meaningful to them as a means of improving mood and quality of life. BA has been designated as a ... Full text Link to item Cite

Psychosocial Correlates of Jordanian Adolescents' Help-Seeking Intentions for Depression: Findings From a Nationally Representative School Survey.

Journal Article J Sch Nurs · April 2019 Little is known about help-seeking for depression among Jordanian adolescents who are a vulnerable population with high rates of depressive symptoms and few mental health services. The purpose of this study was to (1) explore Jordanian adolescents' helpsee ... Full text Link to item Cite

Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression.

Journal Article J Affect Disord · January 15, 2019 BACKGROUND: Neurobiological predictors of antidepressant response may help guide treatment selection and improve response rates to available treatments for major depressive disorder (MDD). Behavioral activation therapy for depression (BATD) is an evidence- ... Full text Link to item Cite

Do beliefs about depression etiologies influence the type and severity of depression stigma? The case of Arab adolescents.

Journal Article Perspect Psychiatr Care · October 2018 PURPOSE: Research has documented that holding certain etiological beliefs about depression can determine the level of stigma experienced by individuals with depression. To date, no studies have yet examined this relationship among adolescents. Using a samp ... Full text Link to item Cite

The effects of psychotherapy for anhedonia on subcortical brain volumes measured with ultra-high field MRI.

Journal Article J Affect Disord · May 28, 2024 BACKGROUND: Anhedonia is a transdiagnostic symptom often resistant to treatment. The identification of biomarkers sensitive to anhedonia treatment will aid in the evaluation of novel anhedonia interventions. METHODS: This is an exploratory analysis of chan ... Full text Link to item Cite

Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.

Journal Article J Affect Disord · October 15, 2023 BACKGROUND: Growing evidence indicates that anhedonia is a multifaceted construct. This study examined the possibility of identifying subgroups of people with anhedonia using multiple reward-related measures to provide greater understanding the Research Do ... Full text Link to item Cite

Identifying modifiable factors associated with psychological health in women experiencing infertility.

Journal Article J Health Psychol · October 2023 This study assessed the relationship between modifiable psychological variables and depression, anxiety, and posttraumatic growth in women experiencing infertility. U.S. women (N = 457) who identified as experiencing infertility completed standardized self ... Full text Link to item Cite

Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation.

Journal Article Psychiatry Res Neuroimaging · August 2023 BACKGROUND: Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA, reward circuitry functioning, ... Full text Link to item Cite

Parsing within & between-person dynamics of therapy homework completion and clinical symptoms in two cognitive behavioral treatments for adults with anhedonia.

Journal Article Behav Res Ther · July 2023 OBJECTIVE: Homework is a key theoretical component of cognitive-behavioral therapies, however, the effects of homework on clinical outcomes have largely been evaluated between-persons rather than within-persons. METHODS: The effects of homework completion ... Full text Link to item Cite

Longitudinal associations between perceived stress and anhedonia during psychotherapy.

Journal Article J Affect Disord · June 1, 2023 BACKGROUND: Chronic stress alters reward sensitivity and contributes to the emergence of anhedonia. In clinical samples, the perception of stress is a strong predictor of anhedonia. While there is substantial evidence demonstrating psychotherapy reduces pe ... Full text Link to item Cite

Emotion regulation difficulties link trait resilience and symptoms of depression and anxiety in psychiatric outpatients.

Journal Article Ann Clin Psychiatry · November 2022 BACKGROUND: Despite negative associations of trait resilience with depression and anxiety symptoms, the mechanisms by which resilience may buffer against these symptoms remain underexplored. This study investigated emotion regulation difficulties as a pote ... Full text Link to item Cite

Enhancing cognitive restructuring with concurrent fMRI-guided neurostimulation for emotional dysregulation-A randomized controlled trial.

Journal Article J Affect Disord · March 15, 2022 BACKGROUND: Transdiagnostic clinical emotional dysregulation is a key component of many mental health disorders and offers an avenue to address multiple disorders with one transdiagnostic treatment. In the current study, we pilot an intervention that combi ... Full text Link to item Cite

Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?

Journal Article J Health Psychol · November 2021 Although mindfulness-based stress reduction (MBSR) can improve health and well-being, less is known about factors that predict outcomes. This prospective observational study examined gender and baseline anxiety and sleep quality as predictors of change in ... Full text Link to item Cite

Neural signatures of saliency-mapping in anhedonia: A narrative review.

Journal Article Psychiatry Res · October 2021 Anhedonia is the loss of pleasure or motivation to engage in previously enjoyable activities, and is a transdiagnostic symptom associated with significant clinical impairment. Anhedonia is implicated in several different psychiatric disorders, presenting a ... Full text Link to item Cite

Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state functional connectivity: Interim results of a randomized trial✰.

Journal Article J Affect Disord · September 1, 2021 BACKGROUND: The neural mechanisms associated with anhedonia treatment response are poorly understood. Additionally, no study has investigated changes in resting-state functional connectivity (rsFC) accompanying psychosocial treatment for anhedonia. METHODS ... Full text Link to item Cite

Do interoceptive accuracy and interoceptive sensibility predict emotion regulation?

Journal Article Psychol Res · July 2021 INTRODUCTION: Interoception refers to awareness, interpretation, and integration of sensations in the body. While interoceptive accuracy has long been regarded as a core component of emotional experience, less is known about the relationship of interocepti ... Full text Link to item Cite

Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).

Journal Article Neuropsychopharmacology · September 2020 Anhedonia remains a major clinical issue for which there is few effective interventions. Untreated or poorly controlled anhedonia has been linked to worse disease course and increased suicidal behavior across disorders. Taking a proof-of-mechanism approach ... Full text Link to item Cite

A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

Journal Article Nat Med · May 2020 The National Institute of Mental Health (NIMH) 'fast-fail' approach seeks to improve too-often-misleading early-phase drug development methods by incorporating biomarker-based proof-of-mechanism (POM) testing in phase 2a. This first comprehensive applicati ... Full text Link to item Cite

Reward Network Modulation as a Mechanism of Change in Behavioral Activation.

Journal Article Behav Modif · March 2020 Behavioral Activation (BA) is a contemporary third-wave psychosocial treatment approach that emphasizes helping individuals become more active in ways that are meaningful to them as a means of improving mood and quality of life. BA has been designated as a ... Full text Link to item Cite

Psychosocial Correlates of Jordanian Adolescents' Help-Seeking Intentions for Depression: Findings From a Nationally Representative School Survey.

Journal Article J Sch Nurs · April 2019 Little is known about help-seeking for depression among Jordanian adolescents who are a vulnerable population with high rates of depressive symptoms and few mental health services. The purpose of this study was to (1) explore Jordanian adolescents' helpsee ... Full text Link to item Cite

Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression.

Journal Article J Affect Disord · January 15, 2019 BACKGROUND: Neurobiological predictors of antidepressant response may help guide treatment selection and improve response rates to available treatments for major depressive disorder (MDD). Behavioral activation therapy for depression (BATD) is an evidence- ... Full text Link to item Cite

Do beliefs about depression etiologies influence the type and severity of depression stigma? The case of Arab adolescents.

Journal Article Perspect Psychiatr Care · October 2018 PURPOSE: Research has documented that holding certain etiological beliefs about depression can determine the level of stigma experienced by individuals with depression. To date, no studies have yet examined this relationship among adolescents. Using a samp ... Full text Link to item Cite

The prevalence of depressive symptoms among Arab adolescents: Findings from Jordan.

Journal Article Public Health Nurs · March 2018 BACKGROUND: The lack of research regarding the current profile of adolescent depression in the Arab countries in general, and Jordan in particular, makes it difficult to design, implement, and disseminate effective interventions to improve the prevention, ... Full text Link to item Cite

Cultivation of Well-Being Through Mind-Body Interventions

Conference The American Journal of Geriatric Psychiatry · March 2018 Full text Cite

Adolescent Depression in Jordan: Symptoms Profile, Gender Differences, and the Role of Social Context.

Journal Article J Psychosoc Nurs Ment Health Serv · February 1, 2018 The influence of gender and other individual and context characteristics on the prevalence and severity of depressive symptoms among Jordanian adolescents remains unclear. The aims of the current study were to: (a) characterize depressive symptoms profiles ... Full text Link to item Cite

Mindfulness Meditation Targets Transdiagnostic Symptoms Implicated in Stress-Related Disorders: Understanding Relationships between Changes in Mindfulness, Sleep Quality, and Physical Symptoms.

Journal Article Evid Based Complement Alternat Med · 2018 Mindfulness-Based Stress Reduction (MBSR) is an 8-week meditation program known to improve anxiety, depression, and psychological well-being. Other health-related effects, such as sleep quality, are less well established, as are the psychological processes ... Full text Open Access Link to item Cite

Personal and Perceived Depression Stigma among Arab Adolescents: Associations with Depression Severity and Personal Characteristics.

Journal Article Arch Psychiatr Nurs · October 2017 BACKGROUND: In Arab communities, the selection, utilization, and attitudes towards mental health services are substantially affected by existing mental illness stigma. However, little is known about how the stigma of depression manifests among Arab adolesc ... Full text Link to item Cite

Effects of mindfulness, reappraisal, and suppression on sad mood and cognitive resources.

Journal Article Behav Res Ther · April 2017 The present study investigated the relative effects of mindfulness, reappraisal and suppression in reducing sadness, and the extent to which implementation of these strategies affects cognitive resources in a laboratory context. A total of 171 Singaporean ... Full text Link to item Cite

Attenuation of Frontostriatal Connectivity During Reward Processing Predicts Response to Psychotherapy in Major Depressive Disorder.

Journal Article Neuropsychopharmacology · March 2017 There are few reliable predictors of response to antidepressant treatments. In the present investigation, we examined pretreatment functional brain connectivity during reward processing as a potential predictor of response to Behavioral Activation Treatmen ... Full text Link to item Cite

Mindfulness Training for Emotional and Cognitive Health in Late Life

Journal Article Current Behavioral Neuroscience Reports · December 1, 2016 Purpose of Review: There is a growing interest in psychosocial interventions that can enhance emotional and cognitive health in older adults, both to treat psychopathology and/or cognitive decline and to prolong optimum functioning in healthy individuals. ... Full text Cite

Sustained anterior cingulate cortex activation during reward processing predicts response to psychotherapy in major depressive disorder.

Journal Article J Affect Disord · October 2016 BACKGROUND: The purpose of the present investigation was to evaluate whether pre-treatment neural activation in response to rewards is a predictor of clinical response to Behavioral Activation Therapy for Depression (BATD), an empirically validated psychot ... Full text Link to item Cite

Effects of brief mindful acceptance induction on implicit dysfunctional attitudes and concordance between implicit and explicit dysfunctional attitudes.

Journal Article Behav Res Ther · August 2016 Mindfulness-based interventions have been shown to be effective in alleviating depressive symptoms. While much work has examined the effects of mindfulness training on subjective symptoms and experiences, and less is known regarding whether mindfulness tra ... Full text Link to item Cite

Dynamic Resting-State Functional Connectivity in Major Depression.

Journal Article Neuropsychopharmacology · June 2016 Major depressive disorder (MDD) is characterized by abnormal resting-state functional connectivity (RSFC), especially in medial prefrontal cortical (MPFC) regions of the default network. However, prior research in MDD has not examined dynamic changes in fu ... Full text Link to item Cite

Effects of Mindful Acceptance and Reappraisal Training on Maladaptive Beliefs About Rumination

Journal Article Mindfulness · April 1, 2016 The present study examined the relative effects of mindful acceptance and reappraisal on metacognitive attitudes and beliefs in relation to rumination and negative experiences. A small but growing literature has compared the effects of these strategies on ... Full text Open Access Cite

Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder.

Journal Article J Autism Dev Disord · November 2015 Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits mo ... Full text Link to item Cite

Neural indicators of emotion regulation via acceptance vs reappraisal in remitted major depressive disorder.

Journal Article Soc Cogn Affect Neurosci · September 2015 Mood disorders are characterized by impaired emotion regulation abilities, reflected in alterations in frontolimbic brain functioning during regulation. However, little is known about differences in brain function when comparing regulatory strategies. Reap ... Full text Link to item Cite

Resting-state connectivity predictors of response to psychotherapy in major depressive disorder.

Journal Article Neuropsychopharmacology · June 2015 Despite the heterogeneous symptom presentation and complex etiology of major depressive disorder (MDD), functional neuroimaging studies have shown with remarkable consistency that dysfunction in mesocorticolimbic brain systems are central to the disorder. ... Full text Link to item Cite

Decreased symptoms of depression after mindfulness-based stress reduction: potential moderating effects of religiosity, spirituality, trait mindfulness, sex, and age.

Journal Article J Altern Complement Med · March 2015 OBJECTIVE: Mindfulness-based stress reduction (MBSR) is a secular meditation training program that reduces depressive symptoms. Little is known, however, about the degree to which a participant's spiritual and religious background, or other demographic cha ... Full text Link to item Cite

Effects of Mindfulness-Based Stress Reduction Across the Adult Lifespan

Conference The American Journal of Geriatric Psychiatry · March 2015 Full text Cite

A systematic review of relations between resting-state functional-MRI and treatment response in major depressive disorder.

Journal Article J Affect Disord · February 1, 2015 BACKGROUND: Resting-state functional magnetic resonance imaging (fMRI) is a promising predictor of treatment response in major depressive disorder (MDD). METHODS: A search for papers published in English was conducted using PubMed with the following words: ... Full text Link to item Cite

Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2014 OBJECTIVES: The present study compares the effectiveness of two strategies, reappraisal and distraction, in reducing negative affect in older adults induced by focusing on personally relevant negative events and stressors. PARTICIPANTS: 30 adults with majo ... Full text Link to item Cite

Emotion Regulation in Late-Life Depression: Neural Models to Treatment Strategies

Conference The American Journal of Geriatric Psychiatry · March 2014 Full text Cite

Reappraisal and mindfulness: a comparison of subjective effects and cognitive costs.

Journal Article Behav Res Ther · December 2013 The present study investigated the relative effects of mindfulness and reappraisal in reducing sad mood and whether trait mindfulness and habitual reappraisal moderated the effects. The study also compared the extent to which implementation of these strate ... Full text Link to item Cite

Clinical outcomes of older depressed patients with and without comorbid neuroticism.

Journal Article Int Psychogeriatr · December 2013 BACKGROUND: Neuroticism is a psychological construct that includes tendency to exhibit negative affect (NA), having poor stress tolerance and being at risk for depression and anxiety disorders. The consequences of neuroticism in the elderly adults are unde ... Full text Link to item Cite

Remitted major depression is characterized by reduced prefrontal cortex reactivity to reward loss.

Journal Article J Affect Disord · November 2013 BACKGROUND: Major depression (MDD) is characterized by anhedonia. Although a growing body of literature has linked anhedonia in MDD to reduced frontostriatal activity during reward gains, relatively few studies have examined neural responsivity to loss, an ... Full text Link to item Cite

Neural mechanisms of cognitive reappraisal in remitted major depressive disorder.

Journal Article J Affect Disord · October 2013 BACKGROUND: Down-regulation of negative emotions by cognitive strategies relies on prefrontal cortical modulation of limbic brain regions, and impaired frontolimbic functioning during cognitive reappraisal has been observed in affective disorders. However, ... Full text Link to item Cite

Executive Function as a Moderator of Emotion Regulation in Late-Life Depression

Conference The American Journal of Geriatric Psychiatry · March 2013 Full text Cite

Behavioral activation as a treatment for depression theory, neurobiologic effects, and potential linkages to resilience

Chapter · January 1, 2013 Unipolar major depressive disorder (MDD) is a debilitating condition with a lifetime prevalence rate of 17% (Kessler et al., 1994). Recent epidemiological evidence indicates that MDD is the 4th leading cause of disease burden and the leading cause of disab ... Full text Cite

Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability.

Journal Article Soc Cogn Affect Neurosci · January 2013 Featured Publication Mindfulness-based interventions are effective for reducing depressive symptoms. However, the psychological and neural mechanisms are unclear. This study examined which facets of trait mindfulness offer protection against negative bias and rumination, which ... Full text Link to item Cite

Association of five-factor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults.

Journal Article Am J Geriatr Psychiatry · January 2013 OBJECTIVES: To assess the relationship of multiple domains and facets of the five-factor model of personality with presence, onset, and severity of late-life depression. DESIGN: Cross-sectional analysis of depression status, and age of onset. Retrospective ... Full text Link to item Cite

Loss of sustained activity in the ventromedial prefrontal cortex in response to repeated stress in individuals with early-life emotional abuse: implications for depression vulnerability.

Journal Article Front Psychol · 2013 Repeated psychosocial stress in early-life has significant impact on both behavior and neural function which, together, increase vulnerability to depression. However, neural mechanisms related to repeated stress remain unclear. We hypothesize that early-li ... Full text Link to item Cite

Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study.

Journal Article BMC Psychiatry · September 21, 2012 BACKGROUND: Studies of individuals who do not meet criteria for major depressive disorder (MDD) but with subclinical levels of depressive symptoms may aid in the identification of neurofunctional abnormalities that possibly precede and predict the developm ... Full text Link to item Cite

A Review of Theoretical and Empirical Perspectives on Marital Satisfaction and Bereavement Outcomes: Implications for Working with Older Adults

Journal Article Clinical Gerontologist · May 1, 2012 The later years of one's life can contain many losses, perhaps none as prominent as the loss of one's spouse. Bereavement can be a life-changing loss, but the nature of that change can range from despair and depression to personal growth and resiliency. On ... Full text Cite

Association of Five-Factor Model Personality Domains and Facets with Presence, Onset, and Treatment Outcomes of Major Depression in Older Adults.

Journal Article Am J Geriatr Psychiatry · March 15, 2012 Featured Publication OBJECTIVES:: To assess the relationship of multiple domains and facets of the five-factor model of personality with presence, onset, and severity of late-life depression. DESIGN:: Cross-sectional analysis of depression status, and age of onset. Retrospecti ... Full text Link to item Cite

Reward Optimization and Behavioral Activation Treatment for Late-Life Depression

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2012 Link to item Cite

Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes.

Journal Article J Affect Disord · February 2012 Featured Publication BACKGROUND: Although functional brain imaging has established that individuals with unipolar major depressive disorder (MDD) are characterized by frontostriatal dysfunction during reward processing, no research to date has examined the chronometry of neura ... Full text Link to item Cite

Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study.

Journal Article Psychopharmacology (Berl) · January 2012 RATIONALE: Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS: The effects of nicotine abstinence on brain function ... Full text Link to item Cite

Mechanisms of change in mindfulness-based stress reduction: Self-compassion and mindfulness as mediators of intervention outcomes

Journal Article Journal of Cognitive Psychotherapy · January 1, 2012 Research has demonstrated support for the efficacy of mindfulness-based stress reduction (MBSR) in alleviating psychological distress and symptoms. Less is known, however, about the mechanisms through which MBSR achieves its outcomes. This study examined m ... Full text Cite

Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards.

Journal Article Psychiatry Res · December 30, 2011 Featured Publication Anhedonia, the loss of interest or pleasure in normally rewarding activities, is a hallmark feature of unipolar Major Depressive Disorder (MDD). A growing body of literature has identified frontostriatal dysfunction during reward anticipation and outcomes ... Full text Link to item Cite

Changes in spirituality partly explain health-related quality of life outcomes after Mindfulness-Based Stress Reduction.

Journal Article J Behav Med · December 2011 Featured Publication Mindfulness-Based Stress Reduction is a secular behavioral medicine program that has roots in meditative spiritual practices. Thus, spirituality may partly explain Mindfulness-Based Stress Reduction outcomes. Participants (N = 279; M (SD) age = 45(12); 75% ... Full text Link to item Cite

Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study.

Journal Article Personal Disord · October 2011 The aim of this preliminary study was to examine whether individuals with avoidant personality disorder (APD) could be characterized by deficits in the classification of dynamically presented facial emotional expressions. Using a community sample of adults ... Full text Link to item Cite

Effects of mindfulness on psychological health: a review of empirical studies.

Journal Article Clin Psychol Rev · August 2011 Featured Publication Within the past few decades, there has been a surge of interest in the investigation of mindfulness as a psychological construct and as a form of clinical intervention. This article reviews the empirical literature on the effects of mindfulness on psycholo ... Full text Link to item Cite

Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder.

Journal Article Personal Disord · July 2011 Featured Publication Opiate dependence (OD) and borderline personality disorder (BPD), separately and together, are significant public health problems with poor treatment outcomes. BPD is associated with difficulties in emotion regulation, and brain-imaging studies in BPD indi ... Full text Link to item Cite

Functional Neuroimaging of Emotion Regulation in Late-Life Depression

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2011 Link to item Cite

The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation.

Journal Article J Affect Disord · October 2010 Featured Publication BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by impaired cognitive control in affective contexts, but the potential for psychotherapy to affect the neural correlates of these functions has not been evaluated. METHOD: Twelve adults ... Full text Link to item Cite

Unipolar depression does not moderate responses to the Sweet Taste Test.

Journal Article Depress Anxiety · September 2010 BACKGROUND: The Sweet Taste Test (STT) measures hedonic responses to sweet tastes and has been linked to both alcoholism and to a family history of alcoholism. However, STT response profiles in unipolar major depressive disorder (MDD), a disorder character ... Full text Link to item Cite

Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.

Journal Article Front Hum Neurosci · 2010 Featured Publication During times of emotional stress, individuals often engage in emotion regulation to reduce the experiential and physiological impact of negative emotions. Interestingly, emotion regulation strategies also influence memory encoding of the event. Cognitive r ... Full text Open Access Link to item Cite

The effects of psychotherapy on neural responses to rewards in major depression.

Journal Article Biol Psychiatry · November 1, 2009 Featured Publication BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by anomalous neurobiological responses to pleasant stimuli, a pattern that may be linked to symptoms of anhedonia. However, the potential for psychotherapy to normalize neurobiological r ... Full text Link to item Cite

fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder.

Journal Article J Affect Disord · November 2009 Featured Publication The purpose of the present investigation was to evaluate reward processing in unipolar major depressive disorder (MDD). Specifically, we investigated whether adults with MDD demonstrated hyporesponsivity in striatal brain regions and/or hyperresponsivity i ... Full text Link to item Cite

Affective context interferes with cognitive control in unipolar depression: an fMRI investigation.

Journal Article J Affect Disord · April 2009 Featured Publication BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by aberrant amygdala responses to sad stimuli and poor cognitive control, but the interactive effects of these impairments are poorly understood. AIM: To evaluate brain activation in MDD ... Full text Link to item Cite

Decision-making and risk aversion among depressive adults.

Journal Article J Behav Ther Exp Psychiatry · December 2008 Featured Publication Depression is associated with behavioral avoidance of potentially rewarding environmental contexts. The present study examined the performance of depressive individuals and controls on a neuropsychological measure of decision-making that favors risk avoida ... Full text Link to item Cite

Prefrontal mechanisms for executive control over emotional distraction are altered in major depression.

Journal Article Psychiatry Res · July 15, 2008 Featured Publication A dysfunction in the interaction between executive function and mood regulation has been proposed as the pathophysiology of depression. However, few studies have investigated the alteration in brain systems related to executive control over emotional distr ... Full text Link to item Cite

Dialectical behavior therapy: Efficacy, mechanisms, and application

Journal Article Psychiatric Times · February 1, 2008 Cite

Risk aversion among depressed older adults with obsessive compulsive personality disorder

Journal Article Cognitive Therapy and Research · April 1, 2007 Despite considerable research on depression in older adults, few studies have included individuals with personality disorders or have used laboratory tasks to examine behavioral correlates of depression among older adults. This study used the Bechara Gambl ... Full text Cite

Antiphonal laughter in developing friendships.

Journal Article Ann N Y Acad Sci · December 2003 Full text Link to item Cite

Visual recognition of biological motion is impaired in children with autism.

Journal Article Psychol Sci · March 2003 Autistic children and typically developing control children were tested on two visual tasks, one involving grouping of small line elements into a global figure and the other involving perception of human activity portrayed in point-light animations. Perfor ... Full text Link to item Cite

Antiphonal laughter between friends and strangers.

Journal Article Cogn Emot · March 2003 Drawing from an affect-induction model of laughter (Bachorowski & Owren, 2001; Owren & Bachorowski, 2002), we propose that "antiphonal" laughter--that is, laughter that occurs during or immediately after a social partner's laugh--is a behavioural manifesta ... Full text Link to item Cite

Infants of depressed mothers, although competent learners, fail to learn in response to their own mothers' infant-directed speech.

Journal Article Psychol Sci · May 2002 Depressed mothers use less of the exaggerated prosody that is typical of infant-directed (ID) speech than do nondepressed mothers. We investigated the consequences of this reduced perceptual salience in ID speech for infant learning. Infants of nondepresse ... Full text Link to item Cite

Role of Clinical Diagnosis and Medication Use in Effects of Maternal Depression on Infant-Directed Speech.

Journal Article Infancy : the official journal of the International Society on Infant Studies · October 2001 Infant-directed (ID) speech was recorded from mothers as they interacted with their 4- to 12-month-old infants. Hierarchical regression analyses revealed that two variables, age of the mother and mother's diagnosed depression, independently accounted for s ... Full text Cite

The acoustic features of human laughter.

Journal Article J Acoust Soc Am · September 2001 Remarkably little is known about the acoustic features of laughter. Here, acoustic outcomes are reported for 1024 naturally produced laugh bouts recorded from 97 young adults as they watched funny video clips. Analyses focused on temporal features, product ... Full text Link to item Cite