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Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder.

Publication ,  Journal Article
Richey, JA; Damiano, CR; Sabatino, A; Rittenberg, A; Petty, C; Bizzell, J; Voyvodic, J; Heller, AS; Coffman, MC; Smoski, M; Davidson, RJ; Dichter, GS
Published in: J Autism Dev Disord
November 2015
Published version (DOI) Link to item

Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD.

Duke Scholars

James T. Voyvodic
Author James T. Voyvodic Radiology
Marika C Coffman
Author Marika C Coffman Psychiatry, Child & Family Mental Health & Community Psychia ...
Moria Joy Smoski
Author Moria Joy Smoski Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...
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Published In

J Autism Dev Disord

DOI

10.1007/s10803-015-2359-z

EISSN

1573-3432

Publication Date

November 2015

Volume

45

Issue

11

Start / End Page

3409 / 3423

Location

United States

Related Subject Headings

  • Young Adult
  • Pupil
  • Prefrontal Cortex
  • Nucleus Accumbens
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Functional Neuroimaging
  • Female
  • Facial Expression
 

Citation

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Richey, J. A., Damiano, C. R., Sabatino, A., Rittenberg, A., Petty, C., Bizzell, J., … Dichter, G. S. (2015). Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder. J Autism Dev Disord, 45(11), 3409–3423. https://doi.org/10.1007/s10803-015-2359-z
Richey, J Anthony, Cara R. Damiano, Antoinette Sabatino, Alison Rittenberg, Chris Petty, Josh Bizzell, James Voyvodic, et al. “Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder.” J Autism Dev Disord 45, no. 11 (November 2015): 3409–23. https://doi.org/10.1007/s10803-015-2359-z.
Richey JA, Damiano CR, Sabatino A, Rittenberg A, Petty C, Bizzell J, et al. Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder. J Autism Dev Disord. 2015 Nov;45(11):3409–23.
Richey, J. Anthony, et al. “Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder.” J Autism Dev Disord, vol. 45, no. 11, Nov. 2015, pp. 3409–23. Pubmed, doi:10.1007/s10803-015-2359-z.
Richey JA, Damiano CR, Sabatino A, Rittenberg A, Petty C, Bizzell J, Voyvodic J, Heller AS, Coffman MC, Smoski M, Davidson RJ, Dichter GS. Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder. J Autism Dev Disord. 2015 Nov;45(11):3409–3423.
Journal cover image

Published In

J Autism Dev Disord

DOI

10.1007/s10803-015-2359-z

EISSN

1573-3432

Publication Date

November 2015

Volume

45

Issue

11

Start / End Page

3409 / 3423

Location

United States

Related Subject Headings

  • Young Adult
  • Pupil
  • Prefrontal Cortex
  • Nucleus Accumbens
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Functional Neuroimaging
  • Female
  • Facial Expression