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Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study.

Publication ,  Journal Article
Addicott, MA; Baranger, DAA; Kozink, RV; Smoski, MJ; Dichter, GS; McClernon, FJ
Published in: Psychopharmacology (Berl)
January 2012

RATIONALE: Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS: The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminarily investigated by scanning adult smokers (n = 13) following 24 h of smoking abstinence and in a smoking-satiated condition. During fMRI scanning, participants completed the wheel of fortune task (Ernst et al. in Neuropsychologia 42:1585-1597, 2004), a decision-making task with probabilistic monetary outcomes. Brain activation was modeled during selection of options, anticipation of outcomes, and outcome feedback. RESULTS: During choice selection, reaction times were slower, and there was greater neural activation in the postcentral gyrus, insula, and frontal and parietal cortices in the abstinent condition compared to the satiated condition. During reward anticipation, greater activation was observed in the frontal pole, insula, and paracingulate cortex in the abstinent condition compared to the satiated condition. Greater activation was also shown in the precentral gyrus and putamen in the satiated condition compared to the abstinent condition. During the outcome phase, rewards (compared to no rewards) resulted in significant activation in the paracingulate cortex in the satiated condition compared to the abstinent condition. CONCLUSIONS: The results of this preliminary study suggest that smoking withdrawal results in greater recruitment of insular, frontal, and parietal cortical areas during probabilistic decision making.

Duke Scholars

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

January 2012

Volume

219

Issue

2

Start / End Page

563 / 573

Location

Germany

Related Subject Headings

  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Reward
  • Reaction Time
  • Psychomotor Performance
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
 

Citation

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Addicott, M. A., Baranger, D. A. A., Kozink, R. V., Smoski, M. J., Dichter, G. S., & McClernon, F. J. (2012). Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. Psychopharmacology (Berl), 219(2), 563–573. https://doi.org/10.1007/s00213-011-2404-3
Addicott, Merideth A., David A. A. Baranger, Rachel V. Kozink, Moria J. Smoski, Gabriel S. Dichter, and F Joseph McClernon. “Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study.Psychopharmacology (Berl) 219, no. 2 (January 2012): 563–73. https://doi.org/10.1007/s00213-011-2404-3.
Addicott MA, Baranger DAA, Kozink RV, Smoski MJ, Dichter GS, McClernon FJ. Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. Psychopharmacology (Berl). 2012 Jan;219(2):563–73.
Addicott, Merideth A., et al. “Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study.Psychopharmacology (Berl), vol. 219, no. 2, Jan. 2012, pp. 563–73. Pubmed, doi:10.1007/s00213-011-2404-3.
Addicott MA, Baranger DAA, Kozink RV, Smoski MJ, Dichter GS, McClernon FJ. Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. Psychopharmacology (Berl). 2012 Jan;219(2):563–573.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

January 2012

Volume

219

Issue

2

Start / End Page

563 / 573

Location

Germany

Related Subject Headings

  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Reward
  • Reaction Time
  • Psychomotor Performance
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans