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Moses Sekaran

Assistant Professor in Surgery
Surgery, Surgical Sciences
DUMC Box 104777, Durham, NC 27708
300 N. Duke Street, Room 47-102, Durham, NC 27701

Current Appointments & Affiliations


Assistant Professor in Surgery · 2021 - Present Surgery, Surgical Sciences, Surgery

Recent Publications


SARS-CoV-2 antibody-dependent enhancement of infection depends on antibody binding to both ACE2 and Fc receptors.

Journal Article JCI Insight · February 23, 2026 Antibody-dependent enhancement (ADE) of infection is a well-described phenomenon for several viruses, including dengue, Ebola, respiratory syncytial virus, and HIV. ADE occurs when virus-antibody complexes engage Fc receptors (FcRs) and virus-specific rece ... Full text Link to item Cite

A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein.

Journal Article Cell Rep · April 22, 2025 The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine refer ... Full text Link to item Cite

GeM-LR: Discovering predictive biomarkers for small datasets in vaccine studies.

Journal Article PLoS Comput Biol · November 2024 Despite significant progress in vaccine research, the level of protection provided by vaccination can vary significantly across individuals. As a result, understanding immunologic variation across individuals in response to vaccination is important for dev ... Full text Link to item Cite
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Recent Grants


Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology

ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029

HVTN Lab Center: B Cell Supplement

ResearchInvestigator · Awarded by Fred Hutchinson Cancer Center · 2023 - 2027

BNT165-02

ResearchInvestigator · Awarded by BioNTech SE · 2025 - 2027

View All Grants

Education


Jadavpur University (India) · 2000 Ph.D.
Bharathidasan University (India) · 1994 M.S.
Bharathidasan University (India) · 1992 B.S.