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Moses Sekaran

Assistant Professor in Surgery
Surgery, Surgical Sciences
DUMC Box 104777, Durham, NC 27708
300 N. Duke Street, Room 47-102, Durham, NC 27701

Current Appointments & Affiliations


Assistant Professor in Surgery · 2021 - Present Surgery, Surgical Sciences, Surgery

Recent Publications


Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants.

Journal Article Journal of virology · December 2023 ImportanceMultiple SARS-CoV-2 variants of concern have emerged and caused a significant number of infections and deaths worldwide. These variants of concern contain mutations that might significantly affect antigen-targeting by antibodies. It is t ... Full text Cite

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.

Journal Article Cell Rep · November 28, 2023 IGHV3-33-encoded antibodies are prevalent in the human humoral response against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 antibodies, cross-reactivity between PfCSP major repeat (NANP), minor (NVDP), and junctional (NPDP) mot ... Full text Link to item Cite

Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding.

Journal Article Anal Biochem · October 15, 2023 Surface plasmon resonance (SPR) is an extensively used technique to characterize antigen-antibody interactions. Affinity measurements by SPR typically involve testing the binding of antigen in solution to monoclonal antibodies (mAbs) immobilized on a chip ... Full text Link to item Cite
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Recent Grants


Nonhuman Primate Core-Option 6

ResearchInvestigator · Awarded by National Institutes of Health · 2025 - 2032

Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology

ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029

BNT165-02

ResearchInvestigator · Awarded by BioNTech SE · 2025 - 2028

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Education, Training & Certifications


Jadavpur University (India) · 2000 Ph.D.
Bharathidasan University (India) · 1994 M.S.
Bharathidasan University (India) · 1992 B.S.