Current Duke Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Scholarly Works
Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood.
Journal article J Proteome Res · July 3, 2026 It is increasingly recognized that the 'omic analysis of whole blood has applications for precision medicine and disease phenotyping. Despite this realization, whole blood is generally viewed as a challenging analytical matrix in comparison to plasma or se ... Full text Link to item CiteMass Spectrometry-Based Quantification of Proteins and Post-Translational Modifications in Dried Blood: Longitudinal Sampling of Patients With Sepsis in Tanzania.
Journal article Proteomics · December 3, 2025 The proteomic analysis of blood is routine for disease phenotyping and biomarker development. Blood is commonly separated into soluble and cellular fractions. However, this can introduce pre-analytical variability, and analysis of a single component (which ... Full text Link to item CiteA surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.
Journal article Sci Rep · October 23, 2025 Many cancers evade immunosurveillance by downregulating surface major histocompatibility class (MHC)-I. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes MHC-I degradation and is elevated in glioma. Evolocumab is a clinically approved PCSK9 in ... Full text Open Access Link to item CiteRecent Grants
Role of Protein S-Palmitoylation in TGFbeta Signaling and Fibrotic Lung Disease
ResearchAdvisor · Awarded by National Heart, Lung, and Blood Institute · 2025 - 2030The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment
ResearchCollaborator · Awarded by National Institute on Aging · 2024 - 2029Proteomic Biomarkers Predicting Osteoarthritis Onset and Progression
ResearchCollaborator · Awarded by Department of Defense · 2025 - 2027View All Grants
Education
Ohio State University ·
2000
Ph.D.