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Nancy Crego

Assistant Professor in the School of Nursing
School of Nursing
307 Trent Drive, Pearson 3118, Durham, NC 27710

Research Interests


Eliminating health inequities, specifically in the care of people diagnosed with sickle cell disease and their families

Selected Grants


REAL (Registry Expansion Analysis to Learn) Answers

ResearchPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2023 - 2028

Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina

ResearchCo Investigator · Awarded by Agency for Healthcare Research and Quality · 2016 - 2021

Fellowships, Gifts, and Supported Research


Factors Influencing Safety in Sedated Children · 2008 - 2009 Principal Investigator · National Institute of Nursing Research · $27,763.00 To explore sedation related adverse events associated with registered nurse and/or physician providers.
PRIDE-Functional and Translational Genomics of Blood Disorders · 2019 - 2020 PRIDE Career Development Awardee · National Heart Lung and Blood Institute · $435,066.00 The purpose of the PRIDE program at Augusta University is to mentor underrepresented junior faculty. PRIDE includes two consecutive summers of training on functional and translational genomics techniques, including didactic, laboratory and individual mentorship.
Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Primary Care and Emergency Departments in Central North Carolina · 2016 - 2022 Co-Investigator · National Heart Lung and Blood Institute · $4,606,153.00 Sickle cell disease is a complex illness associated with many acute and chronic complications which would benefit from co-management between primary care physicians, sickle cell experts, and emergency departments. We provided web based decision aids to providers, nurse care managers and patient/peer coaches to improve outcomes for individuals with sickle cell disease. We aim to improve patient outcomes as well as shift healthcare use from emergency departments and specialty care only, to primary and specialty care. We also conducted a community needs assessment and participated in the NHLBI registry associated with the project.
Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina · 2016 - 2022 Co-investigator and Site PI for No Cost Extension Year · Agency for Healthcare Research and Quality · $1,545,782.00 In 2014, the National Heart, Lung, and Blood Institute published evidence based guidelines for the treatment of sickle cell disease (SCD). In this project the team will disseminate a toolbox of decision support tools based upon the recommendations to primary care physicians and Emergency Department (ED) providers in North Carolina. A new model of care will be implemented that supports co-management between primary care and SCD specialists, with care coordination to include the ED.
Exploring predictors of fetal hemoglobin responsiveness to hydroxyurea in adults with sickle cell disease · 2019 - 2021 Primary Investigator · National Heart Lung and Blood Institute · $7,298.92 In this Small Research grant, an existing database of Sickle Cell Disease (SCD) patients will be used to better understand the relationship of Hemoglobin F (HBF) to Hydroxyurea (HU) in adults. This database includes genetic and laboratory data that will be used to develop predictive models of HBF response to HU adherence, laboratory values and patient characteristics.
Factors Influencing Safety in Sedated Children · 2008 - 2009 Principal Investigator · National Institute of Nursing Research · $27,763.00 To explore sedation related adverse events associated with registered nurse and/or physician providers.
PRIDE-Functional and Translational Genomics of Blood Disorders · 2019 - 2020 PRIDE Career Development Awardee · National Heart Lung and Blood Institute · $435,066.00 The purpose of the PRIDE program at Augusta University is to mentor underrepresented junior faculty. PRIDE includes two consecutive summers of training on functional and translational genomics techniques, including didactic, laboratory and individual mentorship.
Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Primary Care and Emergency Departments in Central North Carolina · 2016 - 2022 Co-Investigator · National Heart Lung and Blood Institute · $4,606,153.00 Sickle cell disease is a complex illness associated with many acute and chronic complications which would benefit from co-management between primary care physicians, sickle cell experts, and emergency departments. We provided web based decision aids to providers, nurse care managers and patient/peer coaches to improve outcomes for individuals with sickle cell disease. We aim to improve patient outcomes as well as shift healthcare use from emergency departments and specialty care only, to primary and specialty care. We also conducted a community needs assessment and participated in the NHLBI registry associated with the project.
Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina · 2016 - 2022 Co-investigator and Site PI for No Cost Extension Year · Agency for Healthcare Research and Quality · $1,545,782.00 In 2014, the National Heart, Lung, and Blood Institute published evidence based guidelines for the treatment of sickle cell disease (SCD). In this project the team will disseminate a toolbox of decision support tools based upon the recommendations to primary care physicians and Emergency Department (ED) providers in North Carolina. A new model of care will be implemented that supports co-management between primary care and SCD specialists, with care coordination to include the ED.
Exploring predictors of fetal hemoglobin responsiveness to hydroxyurea in adults with sickle cell disease · 2019 - 2021 Primary Investigator · National Heart Lung and Blood Institute · $7,298.92 In this Small Research grant, an existing database of Sickle Cell Disease (SCD) patients will be used to better understand the relationship of Hemoglobin F (HBF) to Hydroxyurea (HU) in adults. This database includes genetic and laboratory data that will be used to develop predictive models of HBF response to HU adherence, laboratory values and patient characteristics.
Cure Sickle Cell Data Strategy Consortium · 2022 - 2025 Site Primary Investigator · National Heart Lung and Blood Institute · $226,876.00 Sickle cell disease (SCD) is a complex medical illness associated with many acute and chronic complications with limited treatments. In this study we will continue collecting longitudinal data that will inform the natural history of SCD. We will evaluate the collection of standardized core data that can be combined across other SCD studies to form a Natural History Data Resource (NHDR) of de-identified data for use by qualified researchers. The study will also provide a cohort of well-characterized patients that may be used as contemporaneous controls for gene therapy or other clinical trials or comparative effectiveness studies. The study will allow us to conduct pilot studies that inform the collection of common data elements in SCD, including extraction of structured data from the electronic health record.