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Nicholas Bandarenko III

Nicholas Bandarenko III

Associate Professor of Pathology
Pathology
nick.b@duke.edu
Duke Box 3712, Durham, NC 27708
Rm. 1720 Duke North, Box 3712, Med. Ctr., Durham, NC 27710

Selected Publications

Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial.

Journal Article Crit Care Med · July 1, 2021 OBJECTIVES: Four peer-reviewed publications have reported results from randomized controlled trials of convalescent plasma for coronavirus disease 2019 infection; none were conducted in the United States nor used standard plasma as a comparator. To determi ... Full text Link to item Cite

Pediatric Transfusion A Handbook

Book · November 2020 In addition, "ABC-PICU," which examined the age of red cells on outcomes in critically ill children, is discussed in this edition. The latest information on the use of pathogen-inactivated blood products is also included"-- ... Cite

Management of Blood Product Market Withdrawals - A Single Institution's Process and Experience.

Journal Article Ann Clin Lab Sci · July 2020 OBJECTIVE: While lookback investigations follow specific Food and Drug Administration (FDA) requirements, the management of blood product market withdrawals from suppliers varies widely. Follow-up data are limited, prompting this analysis of the types and ... Link to item Cite

Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

Journal Article JAMA · December 10, 2019 IMPORTANCE: The clinical consequences of red blood cell storage age for critically ill pediatric patients have not been examined in a large, randomized clinical trial. OBJECTIVE: To determine if the transfusion of fresh red blood cells (stored ≤7 days) red ... Full text Link to item Cite

Therapeutic Apheresis Handbook

Book · 2019 ' This handbook covers only therapeutic apheresis procedures"-- ... Cite

A randomized controlled pilot study of VO2 max testing: a potential model for measuring relative in vivo efficacy of different red blood cell products.

Journal Article Transfusion · March 2017 BACKGROUND: Randomized trials, for example, RECESS, comparing "young" (median, 7-day) versus "middle-aged" (median, 28-day) red blood cells (RBCs), showed no difference in outcome. These data are important; however, they do not inform us about the safety a ... Full text Link to item Cite

No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery.

Journal Article Transfusion · July 2016 BACKGROUND: Recent animal studies suggest that transfusion of plasma from young donors reverses age-related neurologic and cardiac changes in older recipients. Associations between age of blood product donors and corresponding outcomes in recipients have n ... Full text Link to item Cite

Randomized study of washing 40- to 42-day-stored red blood cells.

Journal Article Transfusion · October 2014 BACKGROUND: Pretransfusion washing of red blood cells (RBCs) stored for a longer duration may have theoretical advantages but few data exist to support this practice. In many hospital settings, use of a point-of-care cell washer could conceivably be used t ... Full text Link to item Cite

Thrombotic thrombocytopenic purpura: 2012 American Society for Apheresis (ASFA) consensus conference on classification, diagnosis, management, and future research.

Journal Article J Clin Apher · June 2014 The American Society for Apheresis (ASFA) conducted a 1 day consensus conference on Thrombotic Thrombocytopenic Purpura (TTP) during its annual meeting in Atlanta, GA, on April 10, 2012. The authors of this article, a subcommittee of ASFA's Clinical Applic ... Full text Link to item Cite

Feeding practices and other risk factors for developing transfusion-associated necrotizing enterocolitis.

Journal Article Early Hum Dev · May 2014 AIMS: The objective of this study is to determine the incidence of and risk factors for necrotizing enterocolitis (NEC) and transfusion-associated NEC (TANEC) in very-low-birth-weight (VLBW) infants pre/post implementation of a peri-transfusion feeding pro ... Full text Link to item Cite

Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion.

Journal Article Transfusion · May 2014 BACKGROUND: Intraoperative autologous platelet (PLT) collection as part of a multimodal blood conservation program carries a Class IIa recommendation from the Societies of Thoracic Surgeons and Cardiovascular Anesthesiologists, but achieving a suitable PLT ... Full text Link to item Cite

Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers.

Journal Article Transfusion · November 2012 BACKGROUND: Stored red blood cells (RBCs) accumulate biochemical and biophysical changes. Maximum storage duration is based on acceptable in vitro characteristics and 24-hour survival, but not RBC function. Relatively little is known about the impact of RB ... Full text Link to item Cite

Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR).

Journal Article Semin Thromb Hemost · November 2012 Thienopyridine-derivatives (ticlopidine, clopidogrel, and prasugrel) are the primary antiplatelet agents. Thrombotic thrombocytopenic purpura (TTP) is a rare drug-associated syndrome, with the thienopyridines being the most common drugs implicated in this ... Full text Link to item Cite

Carboxyhemoglobinemia in a pediatric cardiopulmonary bypass patient derived from a contaminated unit of allogenic blood.

Journal Article Perfusion · July 2011 A 4.3 kg, three-month-old patient, diagnosed with a perimembranous ventricular septal defect, presented for cardiac surgery. Upon initiation of cardiopulmonary bypass (CPB), the patient developed carboxyhemoglobinemia (11.1%). Potential sources for the une ... Full text Link to item Cite

Blood Transfusion Therapy A Physician's Handbook

Book · 2011 New this edition: * Component discussion addresses two recently approved platelet products. * Expanded information on prothrombin complex concentrates. * Revamped discussion of massive transfusion. * Expanded information on anticoagulant ... ... Cite

The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery.

Journal Article J Thorac Cardiovasc Surg · December 2010 OBJECTIVE: Pulmonary dysfunction is common in transfused patients recovering from heart surgery. Plasma transfusion from female donors has been linked with rare catastrophic lung injury, but its relationship with outcome after cardiac surgery is poorly und ... Full text Link to item Cite

A clinical prediction tool to estimate the number of units of red blood cells needed in primary elective coronary artery bypass surgery.

Journal Article Transfusion · November 2010 Featured Publication BACKGROUND: Red blood cell (RBC) transfusion is common during cardiac surgical procedures. Empiric crossmatching, without attempting to estimate individual transfusion requirements is typical. We hypothesized that a clinical prediction tool could be develo ... Full text Link to item Cite

Platelet factor 4/heparin antibodies in blood bank donors.

Journal Article Am J Clin Pathol · November 2010 Platelet factor 4 (PF4)/heparin antibody, typically associated with heparin therapy, is reported in some heparin-naive people. Seroprevalence in the general population, however, remains unclear. We prospectively evaluated PF4/heparin antibody in approximat ... Full text Link to item Cite

Many, but not all, outcome studies support exclusion of female plasma from the blood supply.

Journal Article Expert Rev Hematol · October 2010 Featured Publication Transfusion-related acute lung injury (TRALI) has been identified as the most common cause of transfusion-related death. Although extensive literature supports restrictions on female-donor plasma to reduce antibody-mediated TRALI, only a few outcome studie ... Full text Link to item Cite

Guidelines on the use of therapeutic apheresis in clinical practice--evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis.

Journal Article J Clin Apher · 2010 Featured Publication The American Society for Apheresis (ASFA) Apheresis Applications Committee is charged with a review and categorization of indications for therapeutic apheresis. Beginning with the 2007 ASFA Special Issue (fourth edition), the subcommittee has incorporated ... Full text Link to item Cite

A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients.

Journal Article Transfusion · July 2009 Featured Publication BACKGROUND: Recent evidence demonstrates an association between duration of storage of red blood cells (RBC) and morbidity and mortality after cardiac surgery. We studied the feasibility of two different schemes for categorizing and randomizing age of RBC ... Full text Link to item Cite

Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008).

Journal Article Kidney Int Suppl · February 2009 Featured Publication Thrombotic thrombocytopenic purpura (TTP) is a fulminant disease characterized by platelet aggregates, thrombocytopenia, renal insufficiency, neurologic changes, and mechanical injury to erythrocytes. Most idiopathic cases of TTP are characterized by a def ... Full text Link to item Cite

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells.

Journal Article AIDS · June 19, 2008 OBJECTIVES: Valproic acid and intensified antiretroviral therapy may deplete resting CD4+ T-cell HIV infection. We tested the ability of valproic acid to deplete resting CD4+ T-cell infection in patients receiving standard antiretroviral therapy. METHODS: ... Full text Link to item Cite

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project.

Journal Article J Am Coll Cardiol · September 18, 2007 OBJECTIVES: We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP). BACKGROUND: The thienopyridine derivatives, ticlopidine and clopidogrel, are the 2 m ... Full text Link to item Cite

Category IV indications for therapeutic apheresis: ASFA fourth special issue.

Journal Article J Clin Apher · June 2007 The American Society for Apheresis (ASFA) Committee on Clinical Applications systematically and critically reviews published information on the use of therapeutic apheresis in clinical practice. On the basis of this review, selected diseases are assigned o ... Full text Link to item Cite

Guidelines on the use of therapeutic apheresis in clinical practice: evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis.

Journal Article J Clin Apher · June 2007 The American Society for Apheresis (ASFA) Apheresis Applications Committee is charged with a review and categorization of indications for therapeutic apheresis. This elaborate process had been undertaken every 7 years resulting in three prior publications ... Full text Link to item Cite

The new approach to assignment of ASFA categories--introduction to the fourth special issue: clinical applications of therapeutic apheresis.

Journal Article J Clin Apher · June 2007 The American Society for Apheresis (ASFA) Apheresis Applications Committee is responsible for a review and categorization of indications for therapeutic apheresis. The results of the review process were previously published in 1986, 1993, and 2000 as the A ... Full text Link to item Cite

Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an automated closed system.

Journal Article Transfusion · April 2007 Featured Publication BACKGROUND: Previously, cryopreserved red blood cell (RBC) units derived from CPD/AS-5 whole-blood (WB) collections have been limited to 24 hours postthaw storage (1-6 degrees C). STUDY DESIGN AND METHODS: Sixty-four leukoreduced (LR) and 54 nonleukoreduce ... Full text Link to item Cite

Update on multi-center clinical trials in the United States.

Journal Article Transfus Apher Sci · February 2007 This article reviews numerous multi-center clinical trials, either ongoing or in planning stages, which involve diverse clinical applications and emerging technologies in apheresis and transfusion medicine. The investigations summarized herein involve the ... Full text Link to item Cite

Patterns of platelet response in idiopathic TTP/HUS: frequency of declining platelet counts with plasma exchange and the recognition and significance of a pseudo refractory state.

Journal Article Ther Apher Dial · June 2006 Featured Publication For thrombotic thrombocytopenic purpura (TTP), daily plasma exchange (TPE) is typically discontinued when the platelet count normalizes (>150 x 10(9)/L). We observed a decline in platelet count during TPE and in patients who appeared pseudo-refractory beca ... Full text Link to item Cite

Transfusion practices for patients with sickle cell disease at a major academic medical center.

Journal Article Immunohematology · 2006 Featured Publication The University of North Carolina at Chapel Hill (UNC) is a tertiarycare, academic university hospital and a major referral center for patients across the state of North Carolina. This 700-bed, Level 1 trauma center transfuses more than 22,000 RBC units to ... Link to item Cite

Relapse of thrombotic thrombocytopenic purpura: is it a continuum of disease?

Journal Article Semin Thromb Hemost · December 2005 The recurrence of thrombotic thrombocytopenic purpura (TTP) in 20 to 50% of patients who survive their initial episode, is not only a challenge to manage clinically, but brings to light our lack of understanding of the underlying pathophysiology. Recurrenc ... Full text Link to item Cite

Cardiogenic shock complicates successful treatment of refractory thrombotic thrombocytopenia purpura with rituximab.

Journal Article Transfusion · September 2005 BACKGROUND: Treatment of thrombotic thrombo-cytopenia purpura (TTP) with daily therapeutic plasma exchange (TPE) may be accompanied by a variety of adjunctive interventions including most recently rituximab. Rituximab, a murine and human monoclonal antibod ... Full text Link to item Cite

Preliminary Findings from the Prospective Multicenter Surveillance, Epidemiology and Risk Factors for Thrombotic Thrombocytopenic Purpura (SERF-TTP) Study.

Conference Blood · November 16, 2004 AbstractBackground: Due to the rarity of TTP (approximately 4 cases per million), epidemiologic data and correlative laboratory samples from a prospectively identified incident cohort of TTP patients are nee ... Full text Cite

Are There Two Distinct Mechanistic Pathways That Explain the Varying Clinical Presentations, Laboratory Findings, and Outcomes of Thienopyridine-Associated Thrombotic Thrombocytopenic Purpura (TTP)?.

Conference Blood · November 16, 2004 AbstractIntroduction: The antiplatelet agents ticlopidine and clopidogrel are thienopyridine derivatives that are commonly used for secondary prevention of cerebrovascular events, prevention of coronary arte ... Full text Cite

Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspension in AS-3 using an automated closed system.

Journal Article Transfusion · November 2004 BACKGROUND: The utilization of cryopreserved red blood cell (RBC) units had been limited by a maximum postdeglycerolization storage of 24 hours at 1 to 6 degrees C until the recent development of a closed system for the glycerolization and deglycerolizatio ... Full text Link to item Cite

Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration.

Journal Article Stroke · February 2004 BACKGROUND AND PURPOSE: Since the 1999 identification of clopidogrel-associated thrombotic thrombocytopenic purpura (TTP) through independent active surveillance, subsequent cases have been identified by pharmaceutical suppliers of clopidogrel and the Food ... Full text Link to item Cite

Differentiating thrombotic microangiopathies induced by severe hypertension from anemia and thrombocytopenia seen in thrombotic thrombocytopenia purpura.

Journal Article J Clin Apher · 2004 Thrombotic microangiopathy (TMA) is a recognized complication of malignant hypertension (HTN). Such patients have blood pressures > or = 200/140 mmHg but the condition is defined by the presence of papilledema and is frequently complicated by acute renal f ... Full text Link to item Cite

A large university medical center delivery system for therapeutic apheresis services.

Journal Article Transfus Apher Sci · April 2003 The clinical applications of therapeutic apheresis (TA) encompass a broad spectrum. Diversity exists not only in the age and acuity of patients treated, but also in the range of therapeutic approaches and technology. Particularly over the past decade, ther ... Full text Link to item Cite

In vivo and in vitro characteristics of double units of RBCs collected by apheresis with a single in-line WBC-reduction filter.

Journal Article Transfusion · November 2001 BACKGROUND: A novel apheresis procedure for a blood separator (MCS+, Haemonetics) enables the collection of 2 WBC-reduced RBC units in a single donation by using one disposable set with one in-line WBC-reduction filter (RC2H, Pall Corp.). The objective of ... Full text Link to item Cite

Likelihood of D heterozygosity in Mestizo Mexicans and Mexican Americans.

Journal Article Immunohematology · 2001 Information on the gene frequencies of the Rh system in the Mexican or Mexican American population is currently not available in the medical literature, thus hindering management of pregnancies at risk for development of hemolytic disease of the newborn. D ... Link to item Cite

Incidence of allergic reactions with fresh frozen plasma or cryo-supernatant plasma in the treatment of thrombotic thrombocytopenic purpura.

Journal Article J Clin Apher · 2001 Plasma replacement for thrombotic thrombocytopenic purpura (TTP) is accomplished with various plasma products. This study sought to determine the incidence of allergic reactions with FFP or CPP as replacement in therapeutic plasma exchange (TPE). Forty-one ... Full text Link to item Cite

Apheresis and the thrombotic thrombocytopenic purpura syndrome: current advances in diagnosis, pathophysiology, and management.

Journal Article Ther Apher · February 1999 Endeavors to optimize the management of thrombotic thrombocytopenic purpura (TTP) syndrome and improve mortality and relapse rates are hindered by its poorly understood pathophysiology. Variability in the application of therapeutic plasma exchange (TPE), i ... Full text Link to item Cite

Lack of efficacy for conventional gamma irradiation of platelet concentrates to abrogate bacterial growth.

Journal Article Am J Clin Pathol · June 1998 The maximum storage time for platelet concentrates is 5 days, owing to the higher risk bacterial contamination with longer storage. The expiration date could potentially be extended if a rapid system to detect microbial contamination or a safe sterilizatio ... Full text Link to item Cite

Thrombotic thrombocytopenic purpura that is refractory to therapeutic plasma exchange in two patients with occult infection.

Journal Article Transfusion · May 1998 BACKGROUND: The etiology of thrombotic thrombocytopenic purpura (TTP) remains undetermined. TTP has been associated with a number of secondary causes including infections, drugs, menses, pregnancy, autoimmune diseases, and bone marrow transplantation. Rega ... Full text Link to item Cite

United States Thrombotic Thrombocytopenic Purpura Apheresis Study Group (US TTP ASG): multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange.

Journal Article J Clin Apher · 1998 Featured Publication Thrombotic thrombocytopenic purpura (TTP) remains enigmatic from the perspective of its etiology, pathophysiology, and treatment. Once recognized, the accepted standard of care for TTP is daily therapeutic plasma exchange (TPE). However, the diversity in T ... Full text Link to item Cite

Cellular source of serum lactate dehydrogenase elevation in patients with thrombotic thrombocytopenic purpura.

Journal Article J Clin Apher · 1998 Elevated serum lactate dehydrogenase (LDH) is a characteristic finding in patients with thrombotic thrombocytopenic purpura (TTP). It is widely accepted that total serum LDH principally rises due to the release of red blood cell LDH as a consequence of int ... Full text Link to item Cite

Alternatives to albumin: starch replacement for plasma exchange.

Journal Article J Clin Apher · 1997 Today, albumin, or a combination of saline and albumin, is used and widely accepted as a replacement for routine plasma exchange. However, decreased availability (due to market recalls secondary to Creutzfeld-Jacob or bacterial contamination risk) rising c ... Full text Link to item Cite

Apheresis. New opportunities.

Journal Article Clin Lab Med · December 1996 Recent advances in apheresis have emerged in a variety of clinical settings. Improvements in granulocyte and peripheral blood stem cell collection and mobilization, the changing role of intravenous gamma globulin, the importance of patient assessment and s ... Link to item Cite

Tissue transglutaminase expression in human breast cancer.

Journal Article Lab Invest · November 1996 Tissue transglutaminase (tTG) is postulated to play a role in apoptosis, cell adhesion, metastasis, and extracellular matrix (ECM) assembly. In this study, the distribution and expression of tissue transglutaminase was investigated in normal human mammary ... Link to item Cite

Overexpression of p53 and HER-2/neu proteins as prognostic markers in early stage breast cancer.

Journal Article Ann Surg · April 1994 OBJECTIVE: Overexpression of the p53 and HER-2/neu oncogenes are the two most common genetic abnormalities associated with breast cancer. Shorter survival time has been reported in patients with tumors with p53 or HER-2/neu. This report analyzes a retrospe ... Full text Link to item Cite