Nick Brazeau

Journal Article Malaria journal · January 2024 BackgroundThough Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human health concern in central Africa given the high prevalence of the human Duffy-negative phenotype t ... Full text Cite

Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar

Preprint · November 17, 2023 Full text Cite

Alternative epidemic indicators for COVID-19 in three settings with incomplete death registration systems.

Journal Article Science advances · June 2023 Not all COVID-19 deaths are officially reported, and particularly in low-income and humanitarian settings, the magnitude of reporting gaps remains sparsely characterized. Alternative data sources, including burial site worker reports, satellite imagery of ... Full text Cite

Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context.

Journal Article Nature communications · June 2023 Reported COVID-19 cases and associated mortality remain low in many sub-Saharan countries relative to global averages, but true impact is difficult to estimate given limitations around surveillance and mortality registration. In Lusaka, Zambia, burial regi ... Full text Cite

Alternative epidemic indicators for COVID-19: a model-based assessment of COVID-19 mortality ascertainment in three settings with incomplete death registration systems

Preprint · 2023 Full text Cite

Reassessing Reported Deaths and Estimated Infection Attack Rate during the First 6 Months of the COVID-19 Epidemic, Delhi, India.

Journal Article Emerging infectious diseases · April 2022 India reported >10 million coronavirus disease (COVID-19) cases and 149,000 deaths in 2020. To reassess reported deaths and estimate incidence rates during the first 6 months of the epidemic, we used a severe acute respiratory syndrome coronavirus 2 transm ... Full text Cite

Genomic insights intoPlasmodium vivaxpopulation structure and diversity in central Africa

Preprint · 2022 Full text Cite

Estimating the COVID-19 infection fatality ratio accounting for seroreversion using statistical modelling.

Journal Article Communications medicine · January 2022 BackgroundThe infection fatality ratio (IFR) is a key statistic for estimating the burden of coronavirus disease 2019 (COVID-19) and has been continuously debated throughout the COVID-19 pandemic. The age-specific IFR can be quantified using antib ... Full text Cite

Household Prevalence of Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale in the Democratic Republic of the Congo, 2013-2014.

Journal Article Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · December 2021 In a cross-sectional molecular study in the Democratic Republic of the Congo, 78% of households had ≥1 member infected with Plasmodium falciparum, Plasmodium vivax, and/or Plasmodium ovale spp.; 47% of children and 33% of adults tested positive for ≥1 spec ... Full text Cite

The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo.

Journal Article Nature communications · July 2021 Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have been performed. To ... Full text Cite

Modelling intensive care unit capacity under different epidemiological scenarios of the COVID-19 pandemic in three Western European countries.

Journal Article International journal of epidemiology · July 2021 BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has placed enormous strain on intensive care units (ICUs) in Europe. Ensuring access to care, irrespective of COVID-19 status, in winter 2020-2021 is essential.MethodsAn integrate ... Full text Cite

Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout.

Journal Article BMC medicine · June 2021 BackgroundAs in many countries, quantifying COVID-19 spread in Indonesia remains challenging due to testing limitations. In Java, non-pharmaceutical interventions (NPIs) were implemented throughout 2020. However, as a vaccination campaign launches ... Full text Cite

The Burden of Malaria in the Democratic Republic of the Congo.

Journal Article The Journal of infectious diseases · June 2021 Despite evidence that older children and adolescents bear the highest burden of malaria, large malaria surveys focus on younger children. We used polymerase chain reaction data from the 2013-2014 Demographic and Health Survey in the Democratic Republic of ... Full text Cite

Within-country age-based prioritisation, global allocation, and public health impact of a vaccine against SARS-CoV-2: A mathematical modelling analysis.

Journal Article Vaccine · May 2021 The worldwide endeavour to develop safe and effective COVID-19 vaccines has been extraordinary, and vaccination is now underway in many countries. However, the doses available in 2021 are likely to be limited. We extend a mathematical model of SARS-CoV-2 t ... Full text Cite

Leveraging community mortality indicators to infer COVID-19 mortality and transmission dynamics in Damascus, Syria.

Journal Article Nature communications · April 2021 The COVID-19 pandemic has resulted in substantial mortality worldwide. However, to date, countries in the Middle East and Africa have reported considerably lower mortality rates than in Europe and the Americas. Motivated by reports of an overwhelmed health ... Full text Cite

Plasmodium interspecies interactions during a period of increasing prevalence of Plasmodium ovale in symptomatic individuals seeking treatment: an observational study.

Journal Article The Lancet. Microbe · April 2021 BackgroundThe epidemiology and severity of non-falciparum malaria in endemic settings has garnered little attention. We aimed to characterise the prevalence, interaction, clinical risk factors, and temporal trends of non-falciparum Plasmodium spec ... Full text Cite

Under the Radar: Epidemiology of Plasmodium ovale in the Democratic Republic of the Congo.

Journal Article The Journal of infectious diseases · March 2021 BackgroundPlasmodium ovale is an understudied malaria species prevalent throughout much of sub-Saharan Africa. Little is known about the distribution of ovale malaria and risk factors for infection in areas of high malaria endemicity.Methods Full text Cite

Selection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia.

Journal Article Antimicrobial agents and chemotherapy · February 2021 Atovaquone-proguanil remains effective against multidrug-resistant Plasmodium falciparum in Southeast Asia, but resistance is mediated by a single point mutation in cytochrome b (cytb) that can arise during treatment. Among 14 atovaquo ... Full text Cite

Reduction in mobility and COVID-19 transmission.

Journal Article Nature communications · February 2021 In response to the COVID-19 pandemic, countries have sought to control SARS-CoV-2 transmission by restricting population movement through social distancing interventions, thus reducing the number of contacts. Mobility data represent an important proxy meas ... Full text Cite

Database of epidemic trends and control measures during the first wave of COVID-19 in mainland China.

Journal Article International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · January 2021 ObjectivesIn this data collation study, we aimed to provide a comprehensive database describing the epidemic trends and responses during the first wave of coronavirus disease 2019 (COVID-19) throughout the main provinces in China.MethodsF ... Full text Cite

Reconstructing the COVID-19 epidemic in Delhi, India: infection attack rate and reporting of deaths

Preprint · 2021 Full text Cite

Within-country age-based prioritisation, global allocation, and public health impact of a vaccine against SARS-CoV-2: a mathematical modelling analysis

Preprint · 2021 Full text Cite

Quantifying the Dynamics of COVID-19 Burden and Impact of Interventions in Java, Indonesia

Preprint · 2021 Full text Cite

SARS-CoV-2 infection prevalence on repatriation flights from Wuhan City, China.

Journal Article Journal of travel medicine · December 2020 Full text Cite

State-level tracking of COVID-19 in the United States.

Journal Article Nature communications · December 2020 As of 1st June 2020, the US Centres for Disease Control and Prevention reported 104,232 confirmed or probable COVID-19-related deaths in the US. This was more than twice the number of deaths reported in the next most severely impacted country. We jointly m ... Full text Cite

Comparison of molecular testing strategies for COVID-19 control: a mathematical modelling study.

Journal Article The Lancet. Infectious diseases · December 2020 BackgroundWHO has called for increased testing in response to the COVID-19 pandemic, but countries have taken different approaches and the effectiveness of alternative strategies is unknown. We aimed to investigate the potential impact of differen ... Full text Cite

Response to COVID-19 in South Korea and implications for lifting stringent interventions.

Journal Article BMC medicine · October 2020 BackgroundAfter experiencing a sharp growth in COVID-19 cases early in the pandemic, South Korea rapidly controlled transmission while implementing less stringent national social distancing measures than countries in Europe and the USA. This has l ... Full text Cite

Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study.

Journal Article The Lancet. Global health · September 2020 BackgroundCOVID-19 has the potential to cause substantial disruptions to health services, due to cases overburdening the health system or response measures limiting usual programmatic activities. We aimed to quantify the extent to which disruption ... Full text Cite

The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries.

Journal Article Science (New York, N.Y.) · July 2020 The ongoing coronavirus disease 2019 (COVID-19) pandemic poses a severe threat to public health worldwide. We combine data on demography, contact patterns, disease severity, and health care capacity and quality to understand its impact and inform strategie ... Full text Cite

Spatial and epidemiological drivers of <i>Plasmodium falciparum</i> malaria among adults in the Democratic Republic of the Congo.

Journal Article BMJ global health · June 2020 BackgroundAdults are frequently infected with malaria and may serve as a reservoir for further transmission, yet we know relatively little about risk factors for adult infections. In this study, we assessed malaria risk factors among adults using ... Full text Cite

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.

Journal Article Nature communications · April 2020 The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationall ... Full text Cite

Anonymised and aggregated crowd level mobility data from mobile phones suggests that initial compliance with COVID-19 social distancing interventions was high and geographically consistent across the UK.

Journal Article Wellcome open research · January 2020 Background: Since early March 2020, the COVID-19 epidemic across the United Kingdom has led to a range of social distancing policies, which have resulted in reduced mobility across different regions. Crowd level data on mobile phone usage can be use ... Full text Cite