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Nicoleta Economou-Zavlanos

Consultant, IT, Senior
School of Medicine
2424 Erwin Road, Room 9042, Durham, NC 27705

Selected Publications


A Clinician's Guide to Understanding Bias in Critical Clinical Prediction Models.

Journal Article Crit Care Clin · October 2024 This narrative review focuses on the role of clinical prediction models in supporting informed decision-making in critical care, emphasizing their 2 forms: traditional scores and artificial intelligence (AI)-based models. Acknowledging the potential for bo ... Full text Link to item Cite

Evaluating Factors Associated With Telehealth Appropriateness in Outpatient Rheumatoid Arthritis Encounters Using the Encounter Appropriateness Score for You (EASY).

Journal Article J Rheumatol · August 1, 2024 OBJECTIVE: Telehealth has been proposed as a safe and effective alternative to in-person care for rheumatoid arthritis (RA). The purpose of this study was to evaluate factors associated with telehealth appropriateness in outpatient RA encounters. METHODS: ... Full text Open Access Link to item Cite

Empowering nurses to champion Health equity & BE FAIR: Bias elimination for fair and responsible AI in healthcare.

Journal Article J Nurs Scholarsh · July 29, 2024 BACKGROUND: The concept of health equity by design encompasses a multifaceted approach that integrates actions aimed at eliminating biased, unjust, and correctable differences among groups of people as a fundamental element in the design of algorithms. As ... Full text Link to item Cite

BOLD: Blood-gas and Oximetry Linked Dataset.

Journal Article Sci Data · May 24, 2024 Pulse oximeters measure peripheral arterial oxygen saturation (SpO2) noninvasively, while the gold standard (SaO2) involves arterial blood gas measurement. There are known racial and ethnic disparities in their performance. BOLD is a dataset that aims to u ... Full text Link to item Cite

Use of artificial intelligence in critical care: opportunities and obstacles.

Journal Article Crit Care · April 8, 2024 BACKGROUND: Perhaps nowhere else in the healthcare system than in the intensive care unit environment are the challenges to create useful models with direct time-critical clinical applications more relevant and the obstacles to achieving those goals more m ... Full text Link to item Cite

Evaluating Provider Perceptions of Telehealth Utility in Outpatient Rheumatology Telehealth Encounters.

Journal Article J Clin Rheumatol · March 1, 2024 OBJECTIVE: This study aims to explore the factors associated with rheumatology providers' perceptions of telehealth utility in real-world telehealth encounters. METHODS: From September 14, 2020 to January 31, 2021, 6 providers at an academic medical center ... Full text Link to item Cite

Translating ethical and quality principles for the effective, safe and fair development, deployment and use of artificial intelligence technologies in healthcare.

Journal Article J Am Med Inform Assoc · February 16, 2024 OBJECTIVE: The complexity and rapid pace of development of algorithmic technologies pose challenges for their regulation and oversight in healthcare settings. We sought to improve our institution's approach to evaluation and governance of algorithmic techn ... Full text Link to item Cite

Implementing quality management systems to close the AI translation gap and facilitate safe, ethical, and effective health AI solutions.

Journal Article NPJ Digit Med · November 25, 2023 The integration of Quality Management System (QMS) principles into the life cycle of development, deployment, and utilization of machine learning (ML) and artificial intelligence (AI) technologies within healthcare settings holds the potential to close the ... Full text Link to item Cite

Facilitating Harmonization of Variables in Framingham, MESA, ARIC, and REGARDS Studies Through a Metadata Repository.

Journal Article Circ Cardiovasc Qual Outcomes · November 2023 BACKGROUND: High-quality research in cardiovascular prevention, as in other fields, requires inclusion of a broad range of data sets from different sources. Integrating and harmonizing different data sources are essential to increase generalizability, samp ... Full text Link to item Cite

BOLD: Blood-gas and Oximetry Linked Dataset - Open Source Research.

Journal Article medRxiv · October 3, 2023 Pulse oximeters measure peripheral arterial oxygen saturation (SpO 2 ) noninvasively, while the gold standard (SaO 2 ) involves arterial blood gas measurement. There are known racial and ethnic disparities in their performance. BOLD is a new comprehensive ... Full text Link to item Cite

Mitigating Racial And Ethnic Bias And Advancing Health Equity In Clinical Algorithms: A Scoping Review.

Journal Article Health Aff (Millwood) · October 2023 In August 2022 the Department of Health and Human Services (HHS) issued a notice of proposed rulemaking prohibiting covered entities, which include health care providers and health plans, from discriminating against individuals when using clinical algorith ... Full text Link to item Cite

Predictive Modeling to Identify Children With Complex Health Needs At Risk for Hospitalization.

Journal Article Hosp Pediatr · May 1, 2023 BACKGROUND: Identifying children at high risk with complex health needs (CCHN) who have intersecting medical and social needs is challenging. This study's objectives were to (1) develop and evaluate an electronic health record (EHR)-based clinical predicti ... Full text Link to item Cite

Telehealth Made EASY: Understanding Provider Perceptions of Telehealth Appropriateness in Outpatient Rheumatology Encounters.

Journal Article ACR Open Rheumatol · October 2022 OBJECTIVE: The purpose of this study was to evaluate a novel scoring system, the Encounter Appropriateness Score for You (EASY), to assess provider perceptions of telehealth appropriateness in rheumatology encounters. METHODS: The EASY scoring system promp ... Full text Open Access Link to item Cite

A framework for the oversight and local deployment of safe and high-quality prediction models.

Journal Article J Am Med Inform Assoc · August 16, 2022 Artificial intelligence/machine learning models are being rapidly developed and used in clinical practice. However, many models are deployed without a clear understanding of clinical or operational impact and frequently lack monitoring plans that can detec ... Full text Link to item Cite

Impact of the COVID-19 pandemic on patterns of outpatient cardiovascular care.

Journal Article Am Heart J · January 2021 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic brought about abrupt changes in the way health care is delivered, and the impact of transitioning outpatient clinic visits to telehealth visits on processes of care and outcomes is unclear. METHO ... Full text Link to item Cite

Enzymatic Basis of “Hybridity” in Thiomarinol Biosynthesis

Journal Article Angewandte Chemie International Edition · April 20, 2015 AbstractThiomarinol is a naturally occurring double‐headed antibiotic that is highly potent against methicillin‐resistant Staphylococcus aureus. Its structure comprises two antimicrobial subcomponents, pseudomonic acid anal ... Full text Cite

High-resolution crystal structure reveals molecular details of target recognition by bacitracin

Journal Article Proceedings of the National Academy of Sciences · August 27, 2013 Bacitracin is a metalloantibiotic agent that is widely used as a medicine and feed additive. It interferes with bacterial cell-wall biosynthesis by binding undecaprenyl-pyrophosphate, a lipid carrier that serves as a critical intermediate in cell w ... Full text Cite

Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach

Journal Article Acta Crystallographica Section D Biological Crystallography · April 1, 2013 Full text Cite

A Carrier Protein Strategy Yields the Structure of Dalbavancin

Journal Article Journal of the American Chemical Society · March 14, 2012 Full text Cite

A Unitary Anesthetic Binding Site at High Resolution

Journal Article Journal of Biological Chemistry · September 2009 Full text Cite