Overview
Nikki L. B. Freeman, PhD, joined the Department of Biostatistics and Bioinformatics and the Duke Clinical Research Institute in 2024. Her work focuses on building better, translatable, actionable methods and evidence for health and health care using statistical precision medicine framework. Her technical expertise is in dynamic treatment regimes, (Bayesian) machine learning, Bayesian analysis, topic modeling, clinical trial design including sequential multiple assignment randomized trials (SMARTs), and systematic review and meta-analysis. Her collaborative projects span topics in health services research, global maternal-fetal health, diabetes, and vascular disease.
Current Appointments & Affiliations
Assistant Professor of Biostatistics & Bioinformatics
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2024 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Member in the Duke Clinical Research Institute
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2024 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Design characteristics of sequential multiple assignment randomised trials (SMARTs) for human health: a scoping review of studies between 2009 and 2024.
Journal Article BMJ Open · December 30, 2025 OBJECTIVE: To characterise the reporting practices of sequential multiple assignment randomised trials (SMARTs) in human health research. DESIGN: Scoping review of protocol and primary analysis papers describing SMARTs published between January 2009 and Fe ... Full text Link to item CiteAbstract 4354732: Longitudinal LDL-C Control Among Patients With ASCVD and Elevated Baseline LDL-C: Insights From the cvMOBIUS-2 Registry
Conference Circulation · November 4, 2025 Background: Prior cross-sectional studies have documented poor low-density lipoprotein cholesterol (LDL-C) control in patients with atherosclerotic cardiovascular disease (ASCVD); howe ... Full text CiteAnatomic profile of arterial occlusive disease in the BEST-CLI trial.
Journal Article J Vasc Surg · November 2025 OBJECTIVE: The results of BEST-CLI trial indicated that, when eligible for both open surgical or endovascular therapy, a single-segment great saphenous vein bypass is the superior revascularization strategy for patients with chronic limb-threatening ischem ... Full text Link to item CiteRecent Grants
Fusing rapid-cycle testing and adaptive trial designs: A scientific pipeline to translate and individualize evidence-based psychosocial and behavioral interventions in routine type 1 diabetes care
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2024 - 2027Tailored treatment strategies for patients with chronic limb threatening ischemia
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2025 - 2026View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2023
Ph.D.