Scholars@Duke
Nolan Bick

Current Appointments & Affiliations

Recent Publications

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis.

Journal Article Nature communications · December 2025 Cuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as an ... Full text Cite

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO.

Journal Article Nature · February 2025 Cancer genome alterations often lead to vulnerabilities that can be used to selectively target cancer cells. Various inhibitors of such synthetic lethal targets have been approved by the FDA or are in clinical trials, highlighting the potential of this app ... Full text Cite
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