Scholars@Duke
Nolan Bick

Selected Publications

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis.

Journal Article Nature communications · December 2025 Cuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as an ... Full text Cite

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO.

Journal Article Nature · February 2025 Cancer genome alterations often lead to vulnerabilities that can be used to selectively target cancer cells. Various inhibitors of such synthetic lethal targets have been approved by the FDA or are in clinical trials, highlighting the potential of this app ... Full text Cite

Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency.

Journal Article The Journal of biological chemistry · December 2024 Protein lipoylation, a vital lysine post-translational modification, plays a crucial role in the function of key mitochondrial tricarboxylic acid cycle enzymatic complexes. In eukaryotes, lipoyl post-translational modification synthesis occurs exclusively ... Full text Cite

FDX1 regulates cellular protein lipoylation through direct binding to LIAS.

Journal Article The Journal of biological chemistry · September 2023 Ferredoxins are a family of iron-sulfur (Fe-S) cluster proteins that serve as essential electron donors in numerous cellular processes that are conserved through evolution. The promiscuous nature of ferredoxins as electron donors enables them to participat ... Full text Cite

A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.

Journal Article Cancer discovery · March 2023 Systematic identification of signaling pathways required for the fitness of cancer cells will facilitate the development of new cancer therapies. We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules ... Full text Cite

Systematic profiling of conditional degron tag technologies for target validation studies.

Journal Article Nature communications · September 2022 Conditional degron tags (CDTs) are a powerful tool for target validation that combines the kinetics and reversible action of pharmacological agents with the generalizability of genetic manipulation. However, successful design of a CDT fusion protein often ... Full text Cite

Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults.

Journal Article The Journal of clinical endocrinology and metabolism · August 2022 ContextDue to its rare incidence, molecular features of primary aldosteronism (PA) in young adults are largely unknown. Recently developed targeted mutational analysis identified aldosterone-driver somatic mutations in aldosterone-producing lesion ... Full text Cite

Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients.

Journal Article The Journal of clinical endocrinology and metabolism · November 2020 ContextResults of previous studies demonstrated clear racial differences in the prevalence of somatic mutations among patients with aldosterone-producing adenoma (APA). For instance, those in East Asian countries have a high prevalence of somatic ... Full text Cite

Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes.

Journal Article Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · November 2020 Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at many anatomic sites, the driving molecular alterations underlying their progression from precursor lesions are poorly understood, especially in the context of photodamage. T ... Full text Cite

Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.

Journal Article Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · August 2020 Lack of routine fresh or frozen tissue is a barrier to widespread transcriptomic analysis of adrenal cortical tumors and an impediment to translational research in endocrinology and endocrine oncology. Our group has previously pioneered the use of targeted ... Full text Cite

Multiclonality and Marked Branched Evolution of Low-Grade Endometrioid Endometrial Carcinoma.

Journal Article Molecular cancer research : MCR · March 2019 The molecular events driving low-grade endometrioid endometrial carcinoma (LGEC) development-like in many cancers-are incompletely understood. Hence, here we performed multiregion, comprehensive somatic molecular profiling of routinely processed formalin-f ... Full text Cite