Current Appointments & Affiliations
Adjunct Associate Professor in the Department of Surgery
·
2022 - Present
Surgery, Surgical Sciences,
Surgery
Recent Publications
Clinical trials of self-replicating RNA-based cancer vaccines.
Journal Article Cancer Gene Ther · June 2023 Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens, utilize a number of different platforms for antigen delivery. Among these are messenger RNAs (mRNA), successfully deployed in some prophylactic SARS-CoV2 vaccines. T ... Full text Link to item CiteThe use of histotripsy as intratumoral immunotherapy beyond tissue ablation-the rationale for exploring the immune effects of histotripsy.
Journal Article Int J Hyperthermia · 2023 Mechanical high-intensity focused ultrasound (M-HIFU), which includes histotripsy, is a non-ionizing, non-thermal ablation technology that can be delivered by noninvasive methods. Because acoustic cavitation is the primary mechanism of tissue disruption, h ... Full text Link to item CiteUltrasound Enhanced Perfusion and Drug Penetration for Intratumoral Immunotherapy Using a Needle Ultrasound Transducer - a Phantom Study
Conference IEEE International Ultrasonics Symposium Ius · January 1, 2023 Intratumoral immunotherapy is a promising cancer treatment approach that can initiate durable anti-tumor responses and avoid potential off-target toxicities. However, direct intratumoral injection remains challenging owing to elevated solid stress and inte ... Full text CiteRecent Grants
Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory
ResearchCo Investigator · Awarded by Department of Defense · 2021 - 2026Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy
ResearchCo Investigator · Awarded by Department of Defense · 2012 - 2022Detection and Elimination of Oncogenic Signaling Networks in Pre-malignant and Malignant Cells with Magnetic Resonance Imaging
ResearchCo Investigator · Awarded by Department of Defense · 2012 - 2022View All Grants
Education, Training & Certifications
University of Tokyo (Japan) ·
1997
Ph.D.
University of Tokyo (Japan) ·
1986
M.D.