Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Catholic University (Italy) 1986
• 

  Previous Appointments & Affiliations

  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology, Psychiatry & Behavioral Sciences 2020
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2019 - 2020
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2014 - 2019
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2006 - 2014
  • Associate Clinical Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005 - 2006
  • Associate Research Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005
  • Clinical Associate in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2004 - 2005
• Research
• 

  Selected Grants

  • Neurobehavioral mechanisms linking childhood adversity to increased risk for smoking awarded by National Institutes of Health 2022 - 2027
  • Randomized Controlled Trial of a Novel Smoking Cessation Application Tailored to Individuals with Serious Mental Illness awarded by National Institutes of Health 2020 - 2024
  • INDV-6000-400: A Randomised, Double-Blind Study Comparing 2 Maintenance Dosing Regimens of Buprenorphine Extended-Release Subcutaneous Injection (RBP-6000) in Treatment-Seeking Adult Participants with Opioid Use Disorder and High-risk Opioid Use awarded by INDIVIOR 2022 - 2024
  • Using Very Low Nicotine Content Cigarettes as a Strategy to Disrupt the Pain-Smoking Reinforcement Cycle awarded by National Institutes of Health 2021 - 2023
  • The impact of chronic pain on buprenorphine treatment utilization and retention among patients with opioid use disorder. awarded by National Institutes of Health 2020 - 2023
  • Impact of new standards for tobacco products among dual e-cigarette/combusted cigarette users awarded by National Institutes of Health 2019 - 2023
  • Mid Southern Primary Care Networks Node awarded by National Institutes of Health 2015 - 2023
  • Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace awarded by University of Minnesota 2018 - 2023
  • Early-phase Studies of a Tailored Evidence-Based Smoking Cessation mHealth App for Persons Living with HIV awarded by National Institutes of Health 2019 - 2022
  • A pilot study to permit opioid treatment program physicians to prescribe methadone through community pharmacies for their stable methadone patients awarded by Friends Research Institute 2019 - 2022
  • Substance Abuse/Treatment Gaps in Asians, Pacific Islanders & Multiple-race Individuals awarded by National Institutes of Health 2013 - 2021
  • Alkermes ALK6428-A302 awarded by Alkermes, plc 2017 - 2020
  • Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers awarded by National Institutes of Health 2016 - 2020
  • A Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of Naltrexone for Use in Conjunction with Buprenorphine in Adults with Opioid Use Disorder Prior to First Dose of VIVITROL. awarded by Alkermes, plc 2016 - 2019
  • Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers awarded by National Institutes of Health 2015 - 2019
  • A feasibility study for testing the effects of extended-release naltrexone (Vivitrol) on recidivism and other participant outcomes in drug court settings awarded by Laura and John Arnold Foundation 2016 - 2019
  • RCT of an Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Abuse awarded by National Institutes of Health 2013 - 2019
  • Retrospective Evaluation of Zubsolv Outcomes - A Longitudinal View (REZOLV) awarded by OREXO 2015 - 2018
  • Carolinas Comprehensive Substance Abuse Services Project awarded by Substance Abuse and Mental Health Services Administration 2012 - 2018
  • Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace awarded by University of Minnesota 2017
  • Project 2: Evaluating New Nicotine Standards for Cigarettes - Supplement awarded by University of Minnesota 2014 - 2017
  • Southern Consortium Node of the Clinical Trials Network awarded by Medical University of South Carolina 2013 - 2015
  • Carolina Alcohol and Drug Expansion Team (CADET) awarded by Department of Health and Human Services 2007 - 2013
  • 8/1/200Epidemiology of Non-Medical Prescription Analgesic Use awarded by National Institutes of Health 2007 - 2012
  • Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Use/Abuse awarded by National Institutes of Health 2008 - 2011
  • Place of Low-Dose Naltrexone in Opiate Detoxification awarded by National Institutes of Health 2004 - 2006
  • Serotonin and Cocaine Dependence awarded by National Institutes of Health 2003 - 2006
• 

  External Relationships

  • Adept
  • Clearview Health Partners
  • GroupH LTD
  • Guidepoint Global
  • Indivior PLC
  • clinilabs drug development corporation
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Mannelli, Paolo, Antoine B. Douaihy, Sarah C. Akerman, Anna Legedza, James Fratantonio, Abigail Zavod, and Maria A. Sullivan. “Characteristics and treatment preferences of individuals with opioid use disorder seeking to transition from buprenorphine to extended-release naltrexone in a residential setting.” Am J Addict 31, no. 2 (March 2022): 142–47. https://doi.org/10.1111/ajad.13264.
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    • Mannelli, Paolo. “New Pharmacological Targets for the Treatment of Excessive Alcohol use.” Curr Drug Res Rev 14, no. 3 (2022): 160–61. https://doi.org/10.2174/2589977514666220428125505.
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    • Mannelli, Paolo, Antoine B. Douaihy, Abigail Zavod, Anna Legedza, Sarah C. Akerman, and Maria A. Sullivan. “Patterns of withdrawal in patients with opioid use disorder (OUD) transitioning from untreated OUD or buprenorphine treatment to extended-release naltrexone.” Am J Drug Alcohol Abuse 47, no. 6 (November 2, 2021): 753–59. https://doi.org/10.1080/00952990.2021.1969659.
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    • Wu, Li-Tzy, William S. John, Udi E. Ghitza, Aimee Wahle, Abigail G. Matthews, Mitra Lewis, Brett Hart, et al. “Buprenorphine physician-pharmacist collaboration in the management of patients with opioid use disorder: results from a multisite study of the National Drug Abuse Treatment Clinical Trials Network.” Addiction 116, no. 7 (July 2021): 1805–16. https://doi.org/10.1111/add.15353.
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    • Mannelli, Paolo. “Heroin Use in Older Adults: A Treatment Challenge.” Am J Geriatr Psychiatry 29, no. 5 (May 2021): 426–28. https://doi.org/10.1016/j.jagp.2021.02.039.
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    • Vilardaga, Roger, Javier Rizo, Paige E. Palenski, Paolo Mannelli, Jason A. Oliver, and Francis J. McClernon. “Erratum to: Pilot Randomized Controlled Trial of a Novel Smoking Cessation App Designed for Individuals With Co-Occurring Tobacco Dependence and Serious Mental Illness.” Nicotine Tob Res 23, no. 2 (January 22, 2021): 411. https://doi.org/10.1093/ntr/ntaa125.
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    • Vilardaga, Roger, Tykira Fisher, Paige E. Palenski, Viggy Kumaresan, Paolo Mannelli, Maggie M. Sweitzer, Francis Joseph McClernon, Matthew M. Engelhard, Patricia L. Sabo, and Kathleen A. Garrison. “Review of Popularity and Quality Standards of Opioid-Related Smartphone Apps.” Curr Addict Rep 7, no. 4 (December 2020): 486–96. https://doi.org/10.1007/s40429-020-00344-6.
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    • Vilardaga, Roger, Javier Rizo, Paige E. Palenski, Paolo Mannelli, Jason A. Oliver, and Francis J. Mcclernon. “Pilot Randomized Controlled Trial of a Novel Smoking Cessation App Designed for Individuals With Co-Occurring Tobacco Use Disorder and Serious Mental Illness.” Nicotine Tob Res 22, no. 9 (August 24, 2020): 1533–42. https://doi.org/10.1093/ntr/ntz202.
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    • Comer, Sandra D., Paolo Mannelli, Danesh Alam, Antoine Douaihy, Narinder Nangia, Sarah C. Akerman, Abigail Zavod, Bernard L. Silverman, and Maria A. Sullivan. “Transition of Patients with Opioid Use Disorder from Buprenorphine to Extended-Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens.” The American Journal on Addictions 29, no. 4 (July 2020): 313–22. https://doi.org/10.1111/ajad.13024.
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    • Proeschold-Bell, Rae Jean, Donna M. Evon, Jia Yao, Donna Niedzwiecki, Christina Makarushka, Kelly A. Keefe, Ashwin A. Patkar, et al. “A Randomized Controlled Trial of an Integrated Alcohol Reduction Intervention in Patients With Hepatitis C Infection.” Hepatology 71, no. 6 (June 2020): 1894–1909. https://doi.org/10.1002/hep.31058.
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    • Mannelli, Paolo, and Li-Tzy Wu. “Commentary on Winhusen et al. (2019): Substance use disorders, chronic diseases, and electronic health records-a paradigm for screening and intervention.” Addiction 114, no. 8 (August 2019): 1471–72. https://doi.org/10.1111/add.14659.
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    • Mannelli, Paolo, and Li-Tzy Wu. “Clinical epidemiology of substance use disorders: Understanding patterns, sharing knowledge, planning interventions.” Indian J Med Res 149, no. 4 (April 2019): 443–45. https://doi.org/10.4103/ijmr.IJMR_3_19.
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    • John, William S., He Zhu, Paolo Mannelli, Geetha A. Subramaniam, Robert P. Schwartz, Jennifer McNeely, and Li-Tzy Wu. “Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco.” Drug Alcohol Depend 194 (January 1, 2019): 468–75. https://doi.org/10.1016/j.drugalcdep.2018.11.011.
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    • Mannelli, Paolo, and Li-Tzy Wu. “Opioid use disorder deaths and the effects of medication therapy.” Am J Drug Alcohol Abuse 45, no. 3 (2019): 227–29. https://doi.org/10.1080/00952990.2019.1580289.
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    • Mannelli, Paolo, Marvin Swartz, and Li-Tzy Wu. “Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone.” Am J Addict 27, no. 6 (September 2018): 471–76. https://doi.org/10.1111/ajad.12763.
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    • Proeschold-Bell, Rae Jean, Donna M. Evon, Christina Makarushka, John B. Wong, Santanu K. Datta, Jia Yao, Ashwin A. Patkar, et al. “The Hepatitis C-Alcohol Reduction Treatment (Hep ART) intervention: Study protocol of a multi-center randomized controlled trial.” Contemp Clin Trials 72 (September 2018): 73–85. https://doi.org/10.1016/j.cct.2018.07.003.
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    • Bisaga, Adam, Paolo Mannelli, Miao Yu, Narinder Nangia, Christine E. Graham, D Andrew Tompkins, Thomas R. Kosten, Sarah C. Akerman, Bernard L. Silverman, and Maria A. Sullivan. “Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial.” Drug Alcohol Depend 187 (June 1, 2018): 171–78. https://doi.org/10.1016/j.drugalcdep.2018.02.023.
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    • John, William S., He Zhu, Paolo Mannelli, Robert P. Schwartz, Geetha A. Subramaniam, and Li-Tzy Wu. “Prevalence, patterns, and correlates of multiple substance use disorders among adult primary care patients.” Drug Alcohol Depend 187 (June 1, 2018): 79–87. https://doi.org/10.1016/j.drugalcdep.2018.01.035.
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    • Wu, Li-Tzy, Udi E. Ghitza, He Zhu, Susan Spratt, Marvin Swartz, and Paolo Mannelli. “Substance use disorders and medical comorbidities among high-need, high-risk patients with diabetes.” Drug Alcohol Depend 186 (May 1, 2018): 86–93. https://doi.org/10.1016/j.drugalcdep.2018.01.008.
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    • Bisaga, Adam, Paolo Mannelli, Maria A. Sullivan, Suzanne K. Vosburg, Peggy Compton, George E. Woody, and Thomas R. Kosten. “Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies.” Am J Addict 27, no. 3 (April 2018): 177–87. https://doi.org/10.1111/ajad.12711.
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    • Wu, Li-Tzy, He Zhu, Paolo Mannelli, and Marvin S. Swartz. “Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States.” Drug Alcohol Depend 177 (August 1, 2017): 153–62. https://doi.org/10.1016/j.drugalcdep.2017.03.037.
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    • Wu, Li-Tzy, Udi E. Ghitza, Anne L. Burns, and Paolo Mannelli. “The opioid overdose epidemic: opportunities for pharmacists.” Subst Abuse Rehabil 8 (2017): 53–55. https://doi.org/10.2147/SAR.S144268.
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    • Mannelli, Paolo, and Li-Tzy Wu. “Family substance use screening: less to hide, more to gain.” Indian J Med Res 143, no. 6 (June 2016): 682–84. https://doi.org/10.4103/0971-5916.191920.
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    • Mannelli, Paolo, and Li-Tzy Wu. “Primary care for opioid use disorder.” Subst Abuse Rehabil 7 (2016): 107–9. https://doi.org/10.2147/SAR.S69715.
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    • Mannelli, Paolo, Li-Tzy Wu, Kathleen S. Peindl, Marvin S. Swartz, and George E. Woody. “Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial.” Drug Alcohol Depend 138 (May 1, 2014): 83–88. https://doi.org/10.1016/j.drugalcdep.2014.02.002.
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    • Wu, Li-Tzy, Kathleen T. Brady, Paolo Mannelli, Therese K. Killeen, and Therese K. NIDA AAPI Workgroup. “Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study.” J Psychiatr Res 50 (March 2014): 26–35. https://doi.org/10.1016/j.jpsychires.2013.11.010.
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    • Proeschold-Bell, R. J., S. Reif, B. Taylor, A. Patkar, P. Mannelli, J. Yao, and E. B. Quinlivan. “Substance Use Outcomes of an Integrated HIV-Substance Use Treatment Model Implemented by Social Workers and HIV Medical Providers.” Health and Social Work 41, no. 1 (February 24, 2014): e1–10. https://doi.org/10.1093/hsw/hlv088.
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    • Wu, Li-Tzy, Dan G. Blazer, Kenneth R. Gersing, Bruce Burchett, Marvin S. Swartz, Paolo Mannelli, and Paolo NIDA AAPI Workgroup. “Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.” J Psychiatr Res 47, no. 12 (December 2013): 1940–48. https://doi.org/10.1016/j.jpsychires.2013.08.022.
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    • Mannelli, Paolo, Li-Tzy Wu, Kathleen S. Peindl, and David A. Gorelick. “Smoking and opioid detoxification: behavioral changes and response to treatment.” Nicotine Tob Res 15, no. 10 (October 2013): 1705–13. https://doi.org/10.1093/ntr/ntt046.
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    • Mannelli, Paolo. “The burden of caring: drug users & their families.” Indian J Med Res 137, no. 4 (April 2013): 636–38.
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    • Wu, Li-Tzy, Marvin S. Swartz, Jeng-Jong Pan, Bruce Burchett, Paolo Mannelli, Chongming Yang, and Dan G. Blazer. “Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.” Gen Hosp Psychiatry 35, no. 1 (2013): 74–82. https://doi.org/10.1016/j.genhosppsych.2012.06.014.
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    • Wu, Li-Tzy, Marvin S. Swartz, Zunyou Wu, Paolo Mannelli, Chongming Yang, and Dan G. Blazer. “Alcohol and drug use disorders among adults in emergency department settings in the United States.” Ann Emerg Med 60, no. 2 (August 2012): 172-80.e5. https://doi.org/10.1016/j.annemergmed.2012.02.003.
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    • Lee, Tong H., Steven T. Szabo, J Corey Fowler, Paolo Mannelli, O Barry Mangum, Wayne F. Beyer, Ashwin Patkar, and William C. Wetsel. “Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.” Drug Alcohol Depend 124, no. 1–2 (July 1, 2012): 11–18. https://doi.org/10.1016/j.drugalcdep.2012.01.021.
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    • Mannelli, Paolo, Kathleen Peindl, Li-Tzy Wu, Ashwin A. Patkar, and David A. Gorelick. “The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal.” Am J Drug Alcohol Abuse 38, no. 3 (May 2012): 200–205. https://doi.org/10.3109/00952990.2011.644003.
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    • Proeschold-Bell, Rae Jean, Ashwin A. Patkar, Susanna Naggie, Lesleyjill Coward, Paolo Mannelli, Jia Yao, Patricia Bixby, and Andrew J. Muir. “An integrated alcohol abuse and medical treatment model for patients with hepatitis C.” Dig Dis Sci 57, no. 4 (April 2012): 1083–91. https://doi.org/10.1007/s10620-011-1976-4.
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    • Mannelli, Paolo, Kathleen S. Peindl, Tong Lee, Kamal S. Bhatia, and Li-Tzy Wu. “Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.” Curr Drug Abuse Rev 5, no. 1 (March 2012): 52–63. https://doi.org/10.2174/1874473711205010052.
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    • Mannelli, Paolo. “Once-monthly extended-release naltrexone injections improve opioid abstinence over 24 weeks compared with placebo.” Evid Based Ment Health 14, no. 4 (November 2011): 106. https://doi.org/10.1136/ebmh.2011.100153.
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    • Mannelli, Paolo, Kathleen S. Peindl, and Li-Tzy Wu. “Pharmacological enhancement of naltrexone treatment for opioid dependence: a review.” Subst Abuse Rehabil 2011, no. 2 (June 2011): 113–23. https://doi.org/10.2147/SAR.S15853.
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    • Mannelli, Paolo, Kathleen Peindl, Ashwin A. Patkar, Li-Tzy Wu, Haresh M. Tharwani, and David A. Gorelick. “Problem drinking and low-dose naltrexone-assisted opioid detoxification.” J Stud Alcohol Drugs 72, no. 3 (May 2011): 507–13. https://doi.org/10.15288/jsad.2011.72.507.
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    • Wu, Li-Tzy, George E. Woody, Chongming Yang, Paolo Mannelli, and Dan G. Blazer. “Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions.” Subst Abuse Rehabil 2011, no. 2 (May 2011): 77–88. https://doi.org/10.2147/SAR.S18969.
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    • Mannelli, Paolo, Kathi Peindl, Ashwin A. Patkar, Li-Tzy Wu, Chi-Un Pae, and David A. Gorelick. “Reduced cannabis use after low-dose naltrexone addition to opioid detoxification.” J Clin Psychopharmacol 30, no. 4 (August 2010): 476–78. https://doi.org/10.1097/JCP.0b013e3181e5c168.
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    • Mannelli, P. “Agonist-antagonist combinations in opioid dependence: a translational approach.” Dipend Patologiche 5, no. 1 (2010): 17–24.
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    • Mannelli, Paolo, Ashwin Patkar, Steve Rozen, Wayne Matson, Ranga Krishnan, and Rima Kaddurah-Daouk. “Opioid use affects antioxidant activity and purine metabolism: preliminary results.” Hum Psychopharmacol 24, no. 8 (December 2009): 666–75. https://doi.org/10.1002/hup.1068.
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    • Patkar, Ashwin A., Steve Rozen, Paolo Mannelli, Wayne Matson, Chi-Un Pae, K Ranga Krishnan, and Rima Kaddurah-Daouk. “Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study.” Psychopharmacology (Berl) 206, no. 3 (October 2009): 479–89. https://doi.org/10.1007/s00213-009-1625-1.
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    • Pae, Chi-Un, Prakash S. Masand, David M. Marks, Stan Krulewicz, Kathleen Peindl, Paolo Mannelli, and Ashwin A. Patkar. “History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia.” Prog Neuropsychopharmacol Biol Psychiatry 33, no. 6 (August 31, 2009): 996–1002. https://doi.org/10.1016/j.pnpbp.2009.05.005.
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    • Wu, Li-Tzy, Andy C. Parrott, Christopher L. Ringwalt, Ashwin A. Patkar, Paolo Mannelli, and Dan G. Blazer. “The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention.” Addict Behav 34, no. 8 (August 2009): 654–61. https://doi.org/10.1016/j.addbeh.2009.03.029.
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    • Mannelli, Paolo, Ashwin A. Patkar, Kathi Peindl, David A. Gorelick, Li-Tzy Wu, and Edward Gottheil. “Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial.” Addict Biol 14, no. 2 (April 2009): 204–13. https://doi.org/10.1111/j.1369-1600.2008.00119.x.
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    • Han, C., P. S. Masand, S. Krulewicz, K. Peindl, P. Mannelli, I. M. Varia, C. -. U. Pae, and A. A. Patkar. “Childhood abuse and treatment response in patients with irritable bowel syndrome: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.” J Clin Pharm Ther 34, no. 1 (February 2009): 79–88. https://doi.org/10.1111/j.1365-2710.2008.00975.x.
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    • Pae, Chi-Un, Prakash S. Masand, David M. Marks, Stan Krulewicz, Changsu Han, Kathleen Peindl, Paolo Mannelli, and Ashwin A. Patkar. “History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.” World J Biol Psychiatry 10, no. 4 Pt 2 (2009): 435–41. https://doi.org/10.1080/15622970902789155.
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    • Mannelli, Paolo, Ashwin A. Patkar, Kathleen Peindl, Edward Gottheil, Li-Tzy Wu, and David A. Gorelick. “Early outcomes following low dose naltrexone enhancement of opioid detoxification.” Am J Addict 18, no. 2 (2009): 109–16. https://doi.org/10.1080/10550490902772785.
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    • Masand, Prakash S., Chi-Un Pae, Stan Krulewicz, Kathleen Peindl, Paolo Mannelli, Indu M. Varia, and Ashwin A. Patkar. “A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome.” Psychosomatics 50, no. 1 (2009): 78–86. https://doi.org/10.1176/appi.psy.50.1.78.
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    • Pae, Chi-Un, David M. Marks, Prakash S. Masand, Kathleen Peindl, Christa Hooper-Wood, Changsu Han, Paolo Mannelli, Patrick Ciccone, and Ashwin A. Patkar. “Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial.” Clin Neuropharmacol 32, no. 2 (2009): 85–88. https://doi.org/10.1097/WNF.0b013e31817e559b.
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    • Patkar, Ashwin A., Paolo Mannelli, Kathleen Peindl, Kevin P. Hill, Li-Tzy Wu, Tong Lee, and Cynthia Kuhn. “Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.” J Psychiatr Res 42, no. 14 (October 2008): 1213–19. https://doi.org/10.1016/j.jpsychires.2008.01.008.
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    • Wu, Li-Tzy, Christopher L. Ringwalt, Paolo Mannelli, and Ashwin A. Patkar. “Prescription pain reliever abuse and dependence among adolescents: a nationally representative study.” J Am Acad Child Adolesc Psychiatry 47, no. 9 (September 2008): 1020–29. https://doi.org/10.1097/CHI.0b013e31817eed4d.
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    • Pae, C. U., P. S. Masand, K. Peindl, C. Hooper-Wood, C. Han, P. Mannelli, P. Ciccone, and A. A. Patkar. “Reply to Dr Ng's comments on "A Randomized, Double-Blind, Placebo-Controlled Trial of Augmentation with An Extended Release Formulation of Methylphenidate in Outpatients with Treatment-Resistant Depression" [11].” Journal of Clinical Psychopharmacology 28, no. 1 (February 1, 2008): 117–18. https://doi.org/10.1097/jcp.0b013e3181629990.
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    • Pae, Chi-Un, Prakash S. Masand, Kathleen Peindl, Paolo Mannelli, Changsu Han, David M. Marks, and Ashwin A. Patkar. “An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features.” Prim Care Companion J Clin Psychiatry 10, no. 3 (2008): 205–10. https://doi.org/10.4088/pcc.v10n0305.
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    • Wu, Li-Tzy, Christopher L. Ringwalt, Paolo Mannelli, and Ashwin A. Patkar. “Hallucinogen use disorders among adult users of MDMA and other hallucinogens.” Am J Addict 17, no. 5 (2008): 354–63. https://doi.org/10.1080/10550490802269064.
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    • Peindl, Kathleen S., Prakash Masand, Paolo Mannelli, Meera Narasimhan, and Ashwin Patkar. “Polypharmacy in pregnant women with major psychiatric illness: a pilot study.” J Psychiatr Pract 13, no. 6 (November 2007): 385–92. https://doi.org/10.1097/01.pra.0000300124.83945.b8.
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    • Mannelli, Paolo, Kathleen Peindl, Prakash S. Masand, and Ashwin A. Patkar. “Long-acting injectable naltrexone for the treatment of alcohol dependence.” Expert Rev Neurother 7, no. 10 (October 2007): 1265–77. https://doi.org/10.1586/14737175.7.10.1265.
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    • Mannelli, Paolo, Ashwin A. Patkar, Kathleen Peindl, Heather W. Murray, Li-Tzy Wu, and Robert Hubbard. “Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence.” J Clin Psychopharmacol 27, no. 5 (October 2007): 468–74. https://doi.org/10.1097/jcp.0b013e31814e5e9d.
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    • Davidson, Colin, Rupa Gopalan, Cassandra Ahn, Qiang Chen, Paolo Mannelli, Ashwin A. Patkar, G Daniel Weese, Tong H. Lee, and Everett H. Ellinwood. “Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal.” Eur J Pharmacol 565, no. 1–3 (June 22, 2007): 113–18. https://doi.org/10.1016/j.ejphar.2007.02.056.
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    • Mannelli, Paolo, and Chi Un Pae. “Medical comorbidity and alcohol dependence.” Curr Psychiatry Rep 9, no. 3 (June 2007): 217–24. https://doi.org/10.1007/s11920-007-0022-x.
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    • Tharwani, Haresh M., Pavan Yerramsetty, Paolo Mannelli, Ashwin Patkar, and Prakash Masand. “Recent advances in poststroke depression.” Curr Psychiatry Rep 9, no. 3 (June 2007): 225–31. https://doi.org/10.1007/s11920-007-0023-9.
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    • Patkar, Ashwin A., Prakash S. Masand, Stan Krulewicz, Paolo Mannelli, Kathleen Peindl, Katherine L. Beebe, and Wei Jiang. “A randomized, controlled, trial of controlled release paroxetine in fibromyalgia.” Am J Med 120, no. 5 (May 2007): 448–54. https://doi.org/10.1016/j.amjmed.2006.06.006.
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    • Peindl, Kathleen S., Paolo Mannelli, Li-Tzy Wu, and Ashwin A. Patkar. “Trends in nonheroin opioid abuse admissions: 1992-2004.” J Opioid Manag 3, no. 4 (2007): 215–23. https://doi.org/10.5055/jom.2007.0007.
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    • Patkar, Ashwin A., Prakash S. Masand, Chi-Un Pae, Kathleen Peindl, Christa Hooper-Wood, Paolo Mannelli, and Patrick Ciccone. “A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression.” J Clin Psychopharmacol 26, no. 6 (December 2006): 653–56. https://doi.org/10.1097/01.jcp.0000246212.03530.fd.
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    • Mannelli, Paolo, Ashwin A. Patkar, Kathleen Peindl, Haresh Tharwani, Raman Gopalakrishnan, Kevin P. Hill, and Wade H. Berrettini. “Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.” Psychiatry Res 144, no. 2–3 (November 15, 2006): 99–108. https://doi.org/10.1016/j.psychres.2006.01.012.
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    • Patkar, Ashwin A., Paolo Mannelli, Kevin P. Hill, Kathleen Peindl, Chi-Un Pae, and Tong H. Lee. “Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence.” Hum Psychopharmacol 21, no. 6 (August 2006): 367–75. https://doi.org/10.1002/hup.780.
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    • Patkar, Ashwin A., Paolo Mannelli, Kathleen Peindl, Kevin P. Hill, Raman Gopalakrishnan, and Wade H. Berrettini. “Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients.” Psychopharmacology (Berl) 185, no. 1 (March 2006): 123–32. https://doi.org/10.1007/s00213-005-0261-7.
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    • Van Bockstaele, E. J., C. Rudoy, P. Mannelli, V. Oropeza, and Y. Qian. “Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.” J Neurosci Res 83, no. 3 (February 15, 2006): 508–14. https://doi.org/10.1002/jnr.20738.
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    • Patkar, Ashwin A., Kathleen Peindl, Rajnish Mago, Paolo Mannelli, and Prakash S. Masand. “An open-label, rater-blinded, augmentation study of aripiprazole in treatment-resistant depression.” Prim Care Companion J Clin Psychiatry 8, no. 2 (2006): 82–87. https://doi.org/10.4088/pcc.v08n0205.
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    • Mannelli, Paolo, Edward Gottheil, and Elisabeth J. Van Bockstaele. “Antagonist treatment of opioid withdrawal translational low dose approach.” J Addict Dis 25, no. 2 (2006): 1–8. https://doi.org/10.1300/J069v25n02_01.
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    • Patkar, Ashwin A., Paolo Mannelli, Kathleen Peindl, Heather W. Murray, Bradley Meier, and Frank T. Leone. “Changes in tobacco smoking following treatment for cocaine dependence.” Am J Drug Alcohol Abuse 32, no. 2 (2006): 135–48. https://doi.org/10.1080/00952990500479209.
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    • Ray, Riju, Glenn A. Doyle, James J. Crowley, Russell J. Buono, David W. Oslin, Ashwin A. Patkar, Paolo Mannelli, Peter A. DeMaria, Charles P. O’Brien, and Wade H. Berrettini. “A functional prodynorphin promoter polymorphism and opioid dependence.” Psychiatr Genet 15, no. 4 (December 2005): 295–98. https://doi.org/10.1097/00041444-200512000-00013.
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    • Mannelli, Paolo, Ashwin A. Patkar, Heather W. Murray, Kenneth Certa, Kathleen Peindl, Marja Mattila-Evenden, and Wade H. Berrettini. “Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.” Addict Biol 10, no. 3 (September 2005): 261–68. https://doi.org/10.1080/13556210500235540.
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    • Smith, Rachel J., Glenn A. Doyle, Angela M. Han, James J. Crowley, David W. Oslin, Ashwin A. Patkar, Paolo Mannelli, Peter A. Demaria, Charles P. O’brien, and Wade H. Berrettini. “Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence.” Am J Med Genet B Neuropsychiatr Genet 133B, no. 1 (February 5, 2005): 105–9. https://doi.org/10.1002/ajmg.b.30105.
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    • Patkar, Ashwin A., Vikas Batra, Paolo Mannelli, Sarah Evers-Casey, Michael J. Vergare, and Frank T. Leone. “Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients.” Am J Addict 14, no. 1 (2005): 43–53. https://doi.org/10.1080/10550490590899844.
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    • Patkar, Ashwin A., Paolo Mannelli, Kenneth M. Certa, Kathleen Peindl, Heather Murray, Michael J. Vergare, and Wade H. Berrettini. “Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence.” Psychopharmacology (Berl) 176, no. 1 (October 2004): 74–81. https://doi.org/10.1007/s00213-004-1856-0.
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    • Mannelli, Paolo, Edward Gottheil, James F. Peoples, Veronica C. Oropeza, and Elisabeth J. Van Bockstaele. “Chronic very low dose naltrexone administration attenuates opioid withdrawal expression.” Biol Psychiatry 56, no. 4 (August 15, 2004): 261–68. https://doi.org/10.1016/j.biopsych.2004.05.013.
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    • Patkar, Ashwin A., Wade H. Berrettini, Paolo Mannelli, Raman Gopalakrishnan, Margret R. Hoehe, Louai Bilal, Stephen Weinstein, and Michael J. Vergare. “Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers.” Psychiatr Genet 14, no. 1 (March 2004): 25–32. https://doi.org/10.1097/00041444-200403000-00004.
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    • Patkar, Ashwin A., Charles C. Thornton, Paolo Mannelli, Kevin P. Hill, Edward Gottheil, Michael J. Vergare, and Stephen P. Weinstein. “Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patients.” J Addict Dis 23, no. 1 (2004): 93–109. https://doi.org/10.1300/J069v23n01_08.
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    • McCarthy, Lois E., Paolo Mannelli, Michelle Niculescu, Kevin Gingrich, Ellen M. Unterwald, and Michelle E. Ehrlich. “The distribution of cocaine in mice differs by age and strain.” Neurotoxicol Teratol 26, no. 6 (2004): 839–48. https://doi.org/10.1016/j.ntt.2004.07.004.
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    • Patkar, Ashwin A., Heather W. Murray, Paolo Mannelli, Edward Gottheil, Stephen P. Weinstein, and Michael J. Vergare. “Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients.” J Addict Dis 23, no. 2 (2004): 109–22. https://doi.org/10.1300/J069v23n02_08.
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    • Murray, H. W., A. A. Patkar, P. Mannelli, P. DeMaria, A. M. Desai, and M. J. Vergare. “Relationship of Aggression, Sensation Seeking, and Impulsivity, with Severity of Cocaine Use.” Addictive Disorders and Their Treatment 2, no. 4 (December 16, 2003): 113–21. https://doi.org/10.1097/00132576-200302040-00002.
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    • Thornton, Charles C., Ashwin A. Patkar, Heather W. Murray, Paolo Mannelli, Edward Gottheil, Michael J. Vergare, and Stephen P. Weinstein. “High- and low-structure treatments for substance dependence: role of learned helplessness.” Am J Drug Alcohol Abuse 29, no. 3 (August 2003): 567–84. https://doi.org/10.1081/ada-120023459.
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    • Mannelli, Paolo, Edward Gottheil, Antonio Buonanno, and Sergio De Risio. “Use of very low-dose naltrexone during opiate detoxification.” J Addict Dis 22, no. 2 (2003): 63–70. https://doi.org/10.1300/J069v22n02_05.
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    • Pozzi, G., C. Del Borgo, A. Del Forno, A. Genualdo, P. Mannelli, and M. Fantoni. “Psychological discomfort and mental illness in patients with AIDS: implications for home care.” Aids Patient Care Stds 13, no. 9 (September 1999): 555–64. https://doi.org/10.1089/apc.1999.13.555.
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    • De Giacomo, M., R. Gaspari, A. Stefanelli, A. Barelli, and P. Mannelli. “Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone.” Eur J Emerg Med 6, no. 2 (June 1999): 153–55. https://doi.org/10.1097/00063110-199906000-00013.
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    • Mannelli, P., S. De Risio, G. Pozzi, L. Janiri, and M. De Giacomo. “Serendipitous rapid detoxification from opiates: the importance of time-dependent processes.” Addiction 94, no. 4 (April 1999): 589–91. https://doi.org/10.1046/j.1360-0443.1999.94458913.x.
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    • Janiri, L., A. Hadjichristos, A. Buonanno, R. Rago, P. Mannelli, and S. de Risio. “Adjuvant trazodone in the treatment of alcoholism: an open study.” Alcohol Alcohol 33, no. 4 (1998): 362–65. https://doi.org/10.1093/oxfordjournals.alcalc.a008405.
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    • Janiri, L., G. Gobbi, P. Mannelli, G. Pozzi, A. Serretti, and E. Tempesta. “Effects of fluoxetine at antidepressant doses on short-term outcome of detoxified alcoholics.” Int Clin Psychopharmacol 11, no. 2 (June 1996): 109–17.
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    • Janiri, L., P. Mannelli, A. M. Persico, A. Serretti, and E. Tempesta. “Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine.” Drug Alcohol Depend 36, no. 2 (October 1994): 139–45. https://doi.org/10.1016/0376-8716(94)90096-5.
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    • Janiri, L., P. Mannelli, A. Serretti, and E. Tempesta. “Low-dose buprenorphine detoxification in long term methadone addicts.” Regulatory Peptides 53, no. SUPPL. 1 (February 21, 1994). https://doi.org/10.1016/0167-0115(94)90351-4.
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    • Mannelli, P., L. Janiri, M. C. Mizzoni, and E. Tempesta. “Sources of differentiation of cocaine withdrawal symptomatology.” European Neuropsychopharmacology 4, no. 3 (January 1, 1994): 400. https://doi.org/10.1016/0924-977X(94)90232-1.
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    • Mannelli, P., L. Janiri, E. Tempesta, and R. T. Jones. “Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine.” Br J Psychiatry Suppl, no. 21 (September 1993): 39–45.
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    • Bartoloni, C., L. Guidi, A. L. di Giovanni, L. Antico, F. Cursi, R. Pili, A. Tricerri, et al. “Psychological status, life and social conditions: A study in a population of institutionalized elderly people.” International Journal of Geriatric Psychiatry 8, no. 5 (January 1, 1993): 419–26. https://doi.org/10.1002/gps.930080509.
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    • Mannelli, P., L. Janiri, E. Tempesta, and R. T. Jones. “Prediction in drug abuse: Cocaine interactions with alcohol and buprenorphine.” British Journal of Psychiatry 163, no. SEPT. SUPPL. 21 (January 1, 1993): 39–45. https://doi.org/10.1192/s0007125000292489.
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    • Mannelli, P., S. Mazza, L. Janiri, and E. Tempesta. “Serotoninergic hypothesis on the drug mechanism of cocaine.” Bollettino Di Psichiatria Biologica 7, no. 3 (December 1, 1991): 56–59.
    • Janiri, L., A. Di Giovanni, A. Persico, E. Zeppetelli, P. Mannelli, L. Antico, and E. Tempesta. “Benzodiazepine use and dependency risk in geriatric inpatients.” Minerva Psichiatrica 32, no. 3 (October 28, 1991): 151–63.
    • Janiri, L., P. Mannelli, A. M. Persico, S. Diodato, and E. Tempesta. “Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects.” Drug Alcohol Depend 27, no. 2 (March 1991): 121–25. https://doi.org/10.1016/0376-8716(91)90030-3.
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    • Janiri, L., A. D. Giovanni, A. Persico, E. Zeppetelli, P. Mannelli, L. Antico, and E. Tempesta. “Benzodiazepine use and dependency risk in geriatric inpatients.” Minerva Psichiatrica 32, no. 3 (1991): 151–63.
    • Mannelli, P., S. Mazza, L. Janiri, and E. Tempesta. “Serotoninergic hypothesis on the drug mechanism of cocaine.” Bollettino Di Psichiatria Biologica 7, no. 3 (1991): 56–59.
    • Tempesta, E., L. Janiri, and P. Mannelli. “Patterns of cocaine abuse and indications for treatment.” European Neuropsychopharmacology 1, no. 3 (January 1, 1991): 259–61. https://doi.org/10.1016/0924-977X(91)90515-V.
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    • Janiri, L., A. Di Giovanni, A. Persico, E. Zeppetelli, P. Mannelli, L. Antico, and E. Tempesta. “[Benzodiazepines consumption and risk of dependence in institutionalized geriatric patients].” Minerva Psichiatr 32, no. 3 (1991): 151–63.
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    • Tempesta, E., L. Janiri, P. Mannelli, A. M. Persico, and S. Diodato. “Clinical reports on recent abuse of an antitussive.” Br J Addict 85, no. 6 (June 1990): 815–16. https://doi.org/10.1111/j.1360-0443.1990.tb01695.x.
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    • Mannelli, P., L. Janiri, M. De Marinis, and E. Tempesta. “Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.” Drug Alcohol Depend 24, no. 2 (October 1989): 95–101. https://doi.org/10.1016/0376-8716(89)90071-9.
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    • Janiri, L., P. Mannelli, C. Pirrongelli, M. Lo Monaco, and E. Tempesta. “Lephetamine abuse and dependence: clinical effects and withdrawal syndrome.” Br J Addict 84, no. 1 (January 1989): 89–95. https://doi.org/10.1111/j.1360-0443.1989.tb00555.x.
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  • Book Sections

    • Mannelli, P., L. T. Wu, and K. T. Brady. “Pharmacological and Integrated Treatments in Older Adults with Substance Use Disorders.” In Substance Use and Older People, 9781119975380:273–94, 2014. https://doi.org/10.1002/9781118430965.ch20.
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  • Conference Papers

    • Muir, Andrew Joseph, Jia Yao, Julius Wilder, Christina Makarushka, Kelly Keefe, James Henry Helzberg, Paolo Mannelli, et al. “The Alcohol Use Disorders Identification Test Screening in Patients with Hepatitis C.” In Hepatology, 68:908A-908A. WILEY, 2018.
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    • Mannelli, Paolo, D Andrew Tompkins, Sarah Akerman, Miao Yu, Narinder Nangia, Christine Graham, Maria Sullivan, Thomas Kosten, and Adam Bisaga. “Transition to Extended-release Naltrexone: Heroin Versus Prescription Opioid Users.” In American Journal on Addictions, 27:323–24. WILEY, 2018.
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    • Sullivan, Maria, Paolo Mannelli, Miao Yu, Narinder Nangia, Christine Graham, Irena Webster, D Andrew Tompkins, Thomas Kosten, Sarah Akerman, and Bernard Silverman. “Outpatient Transition to Extended-release Naltrexone in Patients With Opioid-use Disorder.” In American Journal on Addictions, 27:323–323. WILEY, 2018.
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    • Gopalan, Rupa, Cassie Ahn, Paolo Mannelli, Ashwin Patkar, Dan Weese, Tong Lee, Everett Ellinwood, and Colin Davidson. “Bupropion reinstates cocaine seeking behavior in rats.” In Neuropsychopharmacology, 31:S200–S200. NATURE PUBLISHING GROUP, 2006.
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    • Mannelli, Paolo, Ashwin Patkar, Cynthia Kuhn, and Philip Perera. “Sodium oxybate for the treatment of fibromyalgia: A double-blind, placebo-controlled trial.” In Neuropsychopharmacology, 31:S260–S260. NATURE PUBLISHING GROUP, 2006.
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    • Masand, P. S., C. -. U. Pae, K. Peindl, C. Hooper-Wood, P. E. Ciccone, P. Mannelli, and A. A. Patkar. “A randomized, double-blind, placebo-controlled, flexible-dose, trial of augmentation with OROS methylphenidate in Treatment Resistant Depression.” In International Journal of Neuropsychopharmacology, 9:S235–S235. CAMBRIDGE UNIV PRESS, 2006.
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    • Mannelli, P., E. Gottheil, C. Thornton, S. Weinstein, and M. Levine. “Continuing care versus revolving door following opiate detoxification.” In Journal of Addictive Diseases, 22:123–123. HAWORTH PRESS INC, 2003.
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    • Mannelli, P., and E. Gottheil. “Very low antagonist dosing in opiate detoxification.” In Journal of Addictive Diseases, 20:157–157. HAWORTH PRESS INC, 2001.
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