Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Catholic University (Italy) 1986
• 

  Duke Appointment History

  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Addictions, Psychiatry & Behavioral Sciences 2006 - 2014
  • Associate Clinical Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2005 - 2006
  • Associate Research Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2005
  • Clinical Associate in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2004 - 2005
• Research
• 

  Selected Grants

  • Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace awarded by University of Minnesota 2018 - 2022
  • Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers awarded by National Institutes of Health 2015 - 2020
  • Mid Southern Primary Care Networks Node awarded by National Institutes of Health 2015 - 2020
  • Alkermes ALK6428-A302 awarded by Alkermes, plc 2017 - 2019
  • Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers awarded by National Institutes of Health 2016 - 2019
  • RCT of an Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Abuse awarded by National Institutes of Health 2013 - 2019
  • Substance Abuse & Treatment Gaps in Asians, Pacific Islanders & Multiple-race Individuals awarded by National Institutes of Health 2013 - 2019
  • ALK648-A301 - NXT-VIV awarded by Alkermes, plc 2016 - 2018
  • Retrospective Evaluation of Zubsolv Outcomes - A Longitudinal View (REZOLV) awarded by OREXO 2015 - 2018
  • Carolinas Comprehensive Substance Abuse Services Project awarded by Substance Abuse and Mental Health Services Administration 2012 - 2018
  • Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace awarded by University of Minnesota 2017
  • Project 2: Evaluating New Nicotine Standards for Cigarettes - Supplement awarded by University of Minnesota 2014 - 2017
  • Southern Consortium Node of the Clinical Trials Network awarded by Medical University of South Carolina 2013 - 2015
  • Carolina Alcohol and Drug Expansion Team (CADET) awarded by Department of Health and Human Services 2007 - 2013
  • Epidemiology of Non-Medical Prescription Analgesic Use awarded by National Institutes of Health 2007 - 2012
  • Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Use/Abuse awarded by National Institutes of Health 2008 - 2011
  • Place of Low-Dose Naltrexone in Opiate Detoxification awarded by National Institutes of Health 2004 - 2006
  • Serotonin and Cocaine Dependence awarded by National Institutes of Health 2003 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Mannelli, P, Wu, LT, and Brady, KT. "Pharmacological and Integrated Treatments in Older Adults with Substance Use Disorders." In Substance Use and Older People, 273-294. December 31, 2014.  Full Text

  • Conference Papers

    • Mannelli, P, Tompkins, DA, Akerman, S, Yu, M, Nangia, N, Graham, C, Sullivan, M, Kosten, T, and Bisaga, A. "Transition to Extended-release Naltrexone: Heroin Versus Prescription Opioid Users." : WILEY, June 1, 2018.  Link to Item
    • Sullivan, M, Mannelli, P, Yu, M, Nangia, N, Graham, C, Webster, I, Tompkins, DA, Kosten, T, Akerman, S, and Silverman, B. "Outpatient Transition to Extended-release Naltrexone in Patients With Opioid-use Disorder." : WILEY, June 1, 2018.  Link to Item
    • Patkar, AA, Masand, PS, Krulewicz, S, Mannelli, P, Peindl, K, Beebe, KL, and Jiang, W. "A randomized, controlled, trial of controlled release paroxetine in fibromyalgia." May 2007.  Full Text  Link to Item
    • Gopalan, R, Ahn, C, Mannelli, P, Patkar, A, Weese, D, Lee, T, Ellinwood, E, and Davidson, C. "Bupropion reinstates cocaine seeking behavior in rats." 45th Annual Meeting of the American-College-of-Neuropsychopharmacolgy. Hollywood, FL. December 3, 2006 - December 7, 2006.: NATURE PUBLISHING GROUP, December 1, 2006.  Link to Item
    • Mannelli, P, Patkar, A, Kuhn, C, and Perera, P. "Sodium oxybate for the treatment of fibromyalgia: A double-blind, placebo-controlled trial." 45th Annual Meeting of the American-College-of-Neuropsychopharmacolgy. Hollywood, FL. December 3, 2006 - December 7, 2006.: NATURE PUBLISHING GROUP, December 1, 2006.  Link to Item
    • Masand, PS, Pae, C-U, Peindl, K, Hooper-Wood, C, Ciccone, PE, Mannelli, P, and Patkar, AA. "A randomized, double-blind, placebo-controlled, flexible-dose, trial of augmentation with OROS methylphenidate in Treatment Resistant Depression." July 2006.  Link to Item
    • Mannelli, P, Gottheil, E, Thornton, C, Weinstein, S, and Levine, M. "Continuing care versus revolving door following opiate detoxification." : HAWORTH PRESS INC, January 1, 2003.  Link to Item
    • Mannelli, P, and Gottheil, E. "Very low antagonist dosing in opiate detoxification." : HAWORTH PRESS INC, January 1, 2001.  Link to Item

  • Journal Articles

    • Mannelli, P, Swartz, M, and Wu, L-T. "Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone." The American Journal on Addictions 27, no. 6 (September 2018): 471-476.  Full Text
    • Proeschold-Bell, RJ, Evon, DM, Makarushka, C, Wong, JB, Datta, SK, Yao, J, Patkar, AA, Mannelli, P, Hodge, T, Naggie, S, Wilder, JM, Fried, MW, Niedzwiecki, D, and Muir, AJ. "The Hepatitis C-Alcohol Reduction Treatment (Hep ART) intervention: Study protocol of a multi-center randomized controlled trial." Contemporary Clinical Trials 72 (July 10, 2018): 73-85.  Full Text
    • Bisaga, A, Mannelli, P, Yu, M, Nangia, N, Graham, CE, Tompkins, DA, Kosten, TR, Akerman, SC, Silverman, BL, and Sullivan, MA. "Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial." Drug and Alcohol Dependence 187 (June 2018): 171-178.  Full Text
    • John, WS, Zhu, H, Mannelli, P, Schwartz, RP, Subramaniam, GA, and Wu, L-T. "Prevalence, patterns, and correlates of multiple substance use disorders among adult primary care patients." Drug and Alcohol Dependence 187 (June 2018): 79-87.  Full Text
    • Wu, L-T, Ghitza, UE, Zhu, H, Spratt, S, Swartz, M, and Mannelli, P. "Substance use disorders and medical comorbidities among high-need, high-risk patients with diabetes." Drug and Alcohol Dependence 186 (May 2018): 86-93.  Full Text
    • Bisaga, A, Mannelli, P, Sullivan, MA, Vosburg, SK, Compton, P, Woody, GE, and Kosten, TR. "Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies." The American journal on addictions 27, no. 3 (April 2018): 177-187. (Review)  Full Text
    • Wu, L-T, Zhu, H, Mannelli, P, and Swartz, MS. "Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States." Drug and Alcohol Dependence 177 (August 2017): 153-162.  Full Text
    • Wu, L-T, Ghitza, UE, Burns, AL, and Mannelli, P. "The opioid overdose epidemic: opportunities for pharmacists." Substance Abuse and Rehabilitation 8 (January 2017): 53-55.  Full Text  Open Access Copy
    • Mannelli, P, and Wu, L-T. "Family substance use screening: less to hide, more to gain." The Indian Journal of Medical Research 143, no. 6 (June 2016): 682-684.  Full Text  Open Access Copy
    • Proeschold-Bell, RJ, Reif, S, Taylor, B, Patkar, A, Mannelli, P, Yao, J, and Quinlivan, EB. "Substance Use Outcomes of an Integrated HIV–Substance Use Treatment Model Implemented by Social Workers and HIV Medical Providers." Health & Social Work 41, no. 1 (February 2016): e1-e10.  Full Text
    • Mannelli, P, and Wu, L-T. "Primary care for opioid use disorder." Substance Abuse and Rehabilitation 7 (January 2016): 107-109.  Full Text  Open Access Copy
    • Mannelli, P, Wu, L-T, Peindl, KS, Swartz, MS, and Woody, GE. "Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial." Drug and Alcohol Dependence 138 (May 2014): 83-88.  Full Text
    • Mannelli, P, Wu, LT, Peindl, KS, Swartz, MS, and Woody, GE. "Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: A very low dose naltrexone and buprenorphine open label trial." Drug and Alcohol Dependence 138, no. 1 (May 1, 2014): 83-88.  Full Text
    • Wu, L-T, Brady, KT, Mannelli, P, Killeen, TK, and NIDA AAPI Workgroup, . "Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study." Journal of Psychiatric Research 50 (March 2014): 26-35.  Full Text
    • Wu, LT, Brady, KT, Mannelli, P, and Killeen, TK. "Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: A national study." Journal of Psychiatric Research 50, no. 1 (January 1, 2014): 26-35.  Full Text
    • Wu, L-T, Blazer, DG, Gersing, KR, Burchett, B, Swartz, MS, Mannelli, P, and NIDA AAPI Workgroup, . "Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people." J Psychiatr Res 47, no. 12 (December 2013): 1940-1948.  Full Text  Link to Item
    • Mannelli, P, Wu, L-T, Peindl, KS, and Gorelick, DA. "Smoking and opioid detoxification: behavioral changes and response to treatment." Nicotine & Tobacco Research 15, no. 10 (October 2013): 1705-1713.  Full Text
    • Mannelli, P. "The burden of caring: drug users & their families." Indian J Med Res 137, no. 4 (April 2013): 636-638.  Link to Item
    • Wu, L-T, Blazer, DG, Gersing, KR, Burchett, B, Swartz, MS, and Mannelli, P. "Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people." Journal of Psychiatric Research 47, no. 12 (2013): 1940-1948.  Full Text
    • Wu, L-T, Swartz, MS, Pan, J-J, Burchett, B, Mannelli, P, Yang, C, and Blazer, DG. "Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults." General Hospital Psychiatry 35, no. 1 (January 2013): 74-82.  Full Text
    • Wu, L-T, Swartz, MS, Pan, J-J, Burchett, B, Mannelli, P, Yang, C, and Blazer, DG. "Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults." General Hospital Psychiatry 35, no. 1 (2013): 74-82.  Full Text
    • Wu, L-T, Swartz, MS, Wu, Z, Mannelli, P, Yang, C, and Blazer, DG. "Alcohol and drug use disorders among adults in emergency department settings in the United States." Annals of Emergency Medicine 60, no. 2 (August 2012): 172-80.e5.  Full Text
    • Lee, TH, Szabo, ST, Fowler, JC, Mannelli, P, Mangum, OB, Beyer, WF, Patkar, A, and Wetsel, WC. "Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy." Drug Alcohol Depend 124, no. 1-2 (July 1, 2012): 11-18. (Review)  Full Text  Link to Item
    • Mannelli, P, Peindl, K, Wu, L-T, Patkar, AA, and Gorelick, DA. "The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal." The American Journal of Drug and Alcohol Abuse 38, no. 3 (May 2012): 200-205.  Full Text
    • Proeschold-Bell, RJ, Patkar, AA, Naggie, S, Coward, L, Mannelli, P, Yao, J, Bixby, P, and Muir, AJ. "An integrated alcohol abuse and medical treatment model for patients with hepatitis C." Dig Dis Sci 57, no. 4 (April 2012): 1083-1091.  Full Text  Open Access Copy  Link to Item
    • Mannelli, P, Peindl, KS, Lee, T, Bhatia, KS, and Wu, L-T. "Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives." Curr Drug Abuse Rev 5, no. 1 (March 2012): 52-63. (Review)  Link to Item
    • Mannelli, P. "Once-monthly extended-release naltrexone injections improve opioid abstinence over 24 weeks compared with placebo." Evid Based Ment Health 14, no. 4 (November 2011): 106-.  Full Text  Link to Item
    • Mannelli, P, Peindl, KS, and Wu, L-T. "Pharmacological enhancement of naltrexone treatment for opioid dependence: a review." Substance Abuse and Rehabilitation 2011, no. 2 (June 2011): 113-123.  Full Text  Open Access Copy
    • Mannelli, P, Peindl, K, Patkar, AA, Wu, L-T, Tharwani, HM, and Gorelick, DA. "Problem drinking and low-dose naltrexone-assisted opioid detoxification." J Stud Alcohol Drugs 72, no. 3 (May 2011): 507-513.  Link to Item
    • Wu, L-T, Woody, GE, Yang, C, Mannelli, P, and Blazer, DG. "Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions." Substance Abuse and Rehabilitation 2011, no. 2 (May 2011): 77-88.  Full Text  Open Access Copy
    • Mannelli, P, Peindl, K, Patkar, AA, Wu, L-T, Pae, C-U, and Gorelick, DA. "Reduced cannabis use after low-dose naltrexone addition to opioid detoxification." Journal of Clinical Psychopharmacology 30, no. 4 (August 2010): 476-478. (Letter)  Full Text
    • Mannelli, P. "Agonist-antagonist combinations in opioid dependence: a translational approach." Dipendenze Patologiche 5, no. 1 (January 2010): 17-24.
    • Mannelli, P, Patkar, A, Rozen, S, Matson, W, Krishnan, R, and Kaddurah-Daouk, R. "Opioid use affects antioxidant activity and purine metabolism: preliminary results." Hum Psychopharmacol 24, no. 8 (December 2009): 666-675.  Full Text  Link to Item
    • Patkar, AA, Rozen, S, Mannelli, P, Matson, W, Pae, C-U, Krishnan, KR, and Kaddurah-Daouk, R. "Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study." Psychopharmacology (Berl) 206, no. 3 (October 2009): 479-489.  Full Text  Link to Item
    • Pae, C-U, Masand, PS, Marks, DM, Krulewicz, S, Peindl, K, Mannelli, P, and Patkar, AA. "History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia." Prog Neuropsychopharmacol Biol Psychiatry 33, no. 6 (August 31, 2009): 996-1002.  Full Text  Link to Item
    • Wu, L-T, Parrott, AC, Ringwalt, CL, Patkar, AA, Mannelli, P, and Blazer, DG. "The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention." Addict Behav 34, no. 8 (August 2009): 654-661.  Full Text  Link to Item
    • Mannelli, P, Patkar, AA, Peindl, K, Gorelick, DA, Wu, L-T, and Gottheil, E. "Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial." Addiction Biology 14, no. 2 (April 2009): 204-213.  Full Text
    • Mannelli, P, Patkar, AA, Peindl, K, Gottheil, E, Wu, L-T, and Gorelick, DA. "Early outcomes following low dose naltrexone enhancement of opioid detoxification." The American Journal on Addictions 18, no. 2 (March 2009): 109-116.  Full Text
    • Pae, C-U, Marks, DM, Masand, PS, Peindl, K, Hooper-Wood, C, Han, C, Mannelli, P, Ciccone, P, and Patkar, AA. "Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial." Clin Neuropharmacol 32, no. 2 (March 2009): 85-88.  Full Text  Link to Item
    • Han, C, Masand, PS, Krulewicz, S, Peindl, K, Mannelli, P, Varia, IM, Pae, C-U, and Patkar, AA. "Childhood abuse and treatment response in patients with irritable bowel syndrome: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release." J Clin Pharm Ther 34, no. 1 (February 2009): 79-88.  Full Text  Link to Item
    • Masand, PS, Pae, C-U, Krulewicz, S, Peindl, K, Mannelli, P, Varia, IM, and Patkar, AA. "A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome." Psychosomatics 50, no. 1 (January 2009): 78-86.  Full Text  Link to Item
    • Pae, C-U, Masand, PS, Marks, DM, Krulewicz, S, Han, C, Peindl, K, Mannelli, P, and Patkar, AA. "History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release." World J Biol Psychiatry 10, no. 4 Pt 2 (2009): 435-441.  Full Text  Link to Item
    • Pae, C-U, Masand, PS, Marks, DM, Krulewicz, S, Han, C, Peindl, K, Mannelli, P, and Patkar, AA. "History of early abuse as a predictor of treatment response in patients with fibromyalgia: A post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release." WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 10, no. 4 (2009): 435-441.  Full Text  Link to Item
    • Patkar, AA, Mannelli, P, Peindl, K, Hill, KP, Wu, L-T, Lee, T, and Kuhn, C. "Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence." J Psychiatr Res 42, no. 14 (October 2008): 1213-1219.  Full Text  Link to Item
    • Wu, L-T, Ringwalt, CL, Mannelli, P, and Patkar, AA. "Hallucinogen use disorders among adult users of MDMA and other hallucinogens." The American Journal on Addictions 17, no. 5 (September 2008): 354-363.  Full Text
    • Wu, L-T, Ringwalt, CL, Mannelli, P, and Patkar, AA. "Prescription pain reliever abuse and dependence among adolescents: a nationally representative study." Journal of the American Academy of Child and Adolescent Psychiatry 47, no. 9 (September 2008): 1020-1029.  Full Text
    • Pae, C-U, Masand, PS, Peindl, K, Hooper-Wood, C, Han, C, Mannelli, P, Ciccone, P, and Patkar, AA. "Reply to Dr Ng's Comments on "A Randomized, Double-Blind, Placebo-Controlled Trial of Augmentation With An Extended Release Formulation of Methylphenidate in Outpatients With Treatment-Resistant Depression"." Journal of Clinical Psychopharmacology 28, no. 1 (February 2008): 117-118.  Full Text
    • Pae, C-U, Masand, PS, Peindl, K, Mannelli, P, Han, C, Marks, DM, and Patkar, AA. "An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features." Prim Care Companion J Clin Psychiatry 10, no. 3 (2008): 205-210.  Link to Item
    • Peindl, KS, Masand, P, Mannelli, P, Narasimhan, M, and Patkar, A. "Polypharmacy in pregnant women with major psychiatric illness: a pilot study." J Psychiatr Pract 13, no. 6 (November 2007): 385-392.  Full Text  Link to Item
    • Mannelli, P, Patkar, AA, Peindl, K, Murray, HW, Wu, L-T, and Hubbard, R. "Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence." J Clin Psychopharmacol 27, no. 5 (October 2007): 468-474.  Full Text  Link to Item
    • Mannelli, P, Peindl, K, Masand, PS, and Patkar, AA. "Long-acting injectable naltrexone for the treatment of alcohol dependence." Expert Rev Neurother 7, no. 10 (October 2007): 1265-1277. (Review)  Full Text  Link to Item
    • Peindl, KS, Mannelli, P, Wu, L-T, and Patkar, AA. "Trends in nonheroin opioid abuse admissions: 1992-2004." J Opioid Manag 3, no. 4 (July 2007): 215-223.  Link to Item
    • Davidson, C, Gopalan, R, Ahn, C, Chen, Q, Mannelli, P, Patkar, AA, Weese, GD, Lee, TH, and Ellinwood, EH. "Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal." Eur J Pharmacol 565, no. 1-3 (June 22, 2007): 113-118.  Full Text  Link to Item
    • Mannelli, P, and Pae, CU. "Medical comorbidity and alcohol dependence." Curr Psychiatry Rep 9, no. 3 (June 2007): 217-224. (Review)  Link to Item
    • Tharwani, HM, Yerramsetty, P, Mannelli, P, Patkar, A, and Masand, P. "Recent advances in poststroke depression." Curr Psychiatry Rep 9, no. 3 (June 2007): 225-231. (Review)  Link to Item
    • Patkar, AA, Masand, PS, Krulewicz, S, Mannelli, P, Peindl, K, Beebe, KL, and Jiang, W. "A randomized, controlled, trial of controlled release paroxetine in fibromyalgia." Am J Med 120, no. 5 (May 2007): 448-454.  Full Text  Link to Item
    • Patkar, AA, Masand, PS, Pae, C-U, Peindl, K, Hooper-Wood, C, Mannelli, P, and Ciccone, P. "A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression." Journal of Clinical Psychopharmacology 26, no. 6 (December 2006): 653-656.  Full Text
    • Mannelli, P, Patkar, AA, Peindl, K, Tharwani, H, Gopalakrishnan, R, Hill, KP, and Berrettini, WH. "Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls." Psychiatry Res 144, no. 2-3 (November 15, 2006): 99-108.  Full Text  Link to Item
    • Patkar, AA, Mannelli, P, Hill, KP, Peindl, K, Pae, C-U, and Lee, TH. "Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence." Human Psychopharmacology 21, no. 6 (August 2006): 367-375.  Full Text
    • Patkar, AA, Mannelli, P, Peindl, K, Hill, KP, Gopalakrishnan, R, and Berrettini, WH. "Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients." Psychopharmacology 185, no. 1 (March 2006): 123-132.  Full Text
    • Van Bockstaele, EJ, Rudoy, C, Mannelli, P, Oropeza, V, and Qian, Y. "Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats." J Neurosci Res 83, no. 3 (February 15, 2006): 508-514.  Full Text  Link to Item
    • Mannelli, P, Gottheil, E, and Van Bockstaele, EJ. "Antagonist treatment of opioid withdrawal translational low dose approach." Journal of Addictive Diseases 25, no. 2 (January 2006): 1-8. (Review)  Full Text
    • Patkar, AA, Mannelli, P, Peindl, K, Murray, HW, Meier, B, and Leone, FT. "Changes in tobacco smoking following treatment for cocaine dependence." The American Journal of Drug and Alcohol Abuse 32, no. 2 (January 2006): 135-148.  Full Text
    • Patkar, AA, Peindl, K, Mago, R, Mannelli, P, and Masand, PS. "An open-label, rater-blinded, augmentation study of aripiprazole in treatment-resistant depression." Prim Care Companion J Clin Psychiatry 8, no. 2 (2006): 82-87.  Link to Item
    • Ray, R, Doyle, GA, Crowley, JJ, Buono, RJ, Oslin, DW, Patkar, AA, Mannelli, P, DeMaria, PA, O'Brien, CP, and Berrettini, WH. "A functional prodynorphin promoter polymorphism and opioid dependence." Psychiatr Genet 15, no. 4 (December 2005): 295-298.  Link to Item
    • Mannelli, P, Patkar, AA, Murray, HW, Certa, K, Peindl, K, Mattila-Evenden, M, and Berrettini, WH. "Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals." Addiction Biology 10, no. 3 (September 2005): 261-268.  Full Text
    • Smith, RJ, Doyle, GA, Han, AM, Crowley, JJ, Oslin, DW, Patkar, AA, Mannelli, P, Demaria, PA, O'brien, CP, and Berrettini, WH. "Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence." American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics 133B, no. 1 (February 2005): 105-109.  Full Text
    • Patkar, AA, Batra, V, Mannelli, P, Evers-Casey, S, Vergare, MJ, and Leone, FT. "Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients." Am J Addict 14, no. 1 (January 2005): 43-53.  Full Text  Link to Item
    • McCarthy, LE, Mannelli, P, Niculescu, M, Gingrich, K, Unterwald, EM, and Ehrlich, ME. "The distribution of cocaine in mice differs by age and strain." Neurotoxicol Teratol 26, no. 6 (November 2004): 839-848.  Full Text  Link to Item
    • Patkar, AA, Mannelli, P, Certa, KM, Peindl, K, Murray, H, Vergare, MJ, and Berrettini, WH. "Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence." Psychopharmacology 176, no. 1 (October 2004): 74-81.  Full Text
    • Mannelli, P, Gottheil, E, Peoples, JF, Oropeza, VC, and Van Bockstaele, EJ. "Chronic very low dose naltrexone administration attenuates opioid withdrawal expression." Biological Psychiatry 56, no. 4 (August 2004): 261-268.  Full Text
    • Patkar, AA, Berrettini, WH, Mannelli, P, Gopalakrishnan, R, Hoehe, MR, Bilal, L, Weinstein, S, and Vergare, MJ. "Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers." Psychiatric Genetics 14, no. 1 (March 2004): 25-32.  Full Text
    • Patkar, AA, Murray, HW, Mannelli, P, Gottheil, E, Weinstein, SP, and Vergare, MJ. "Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients." Journal of Addictive Diseases 23, no. 2 (January 2004): 109-122.  Full Text
    • Patkar, AA, Thornton, CC, Mannelli, P, Hill, KP, Gottheil, E, Vergare, MJ, and Weinstein, SP. "Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patients." Journal of Addictive Diseases 23, no. 1 (January 2004): 93-109.  Full Text
    • Thornton, CC, Patkar, AA, Murray, HW, Mannelli, P, Gottheil, E, Vergare, MJ, and Weinstein, SP. "High- and low-structure treatments for substance dependence: role of learned helplessness." Am J Drug Alcohol Abuse 29, no. 3 (August 2003): 567-584.  Link to Item
    • Mannelli, P, Gottheil, E, Buonanno, A, and De Risio, S. "Use of very low-dose naltrexone during opiate detoxification." J Addict Dis 22, no. 2 (2003): 63-70.  Full Text  Link to Item
    • Murray, HW, Patkar, AA, Mannelli, P, DeMaria, P, Desai, AM, and Vergare, MJ. "Relationship of Aggression, Sensation Seeking, and Impulsivity, with Severity of Cocaine Use." Addictive Disorders and their Treatment 2, no. 4 (2003): 113-121.  Full Text
    • Pozzi, G, Del Borgo, C, Del Forno, A, Genualdo, A, Mannelli, P, and Fantoni, M. "Psychological discomfort and mental illness in patients with AIDS: implications for home care." AIDS Patient Care STDS 13, no. 9 (September 1999): 555-564.  Full Text  Link to Item
    • De Giacomo, M, Gaspari, R, Stefanelli, A, Barelli, A, and Mannelli, P. "Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone." Eur J Emerg Med 6, no. 2 (June 1999): 153-155.  Link to Item
    • Mannelli, P, De Risio, S, Pozzi, G, Janiri, L, and De Giacomo, M. "Serendipitous rapid detoxification from opiates: the importance of time-dependent processes." Addiction (Abingdon, England) 94, no. 4 (April 1999): 589-591.  Full Text
    • Janiri, L, Hadjichristos, A, Buonanno, A, Rago, R, Mannelli, P, and de Risio, S. "Adjuvant trazodone in the treatment of alcoholism: an open study." Alcohol Alcohol 33, no. 4 (July 1998): 362-365.  Link to Item
    • Janiri, L, Gobbi, G, Mannelli, P, Pozzi, G, Serretti, A, and Tempesta, E. "Effects of fluoxetine at antidepressant doses on short-term outcome of detoxified alcoholics." Int Clin Psychopharmacol 11, no. 2 (June 1996): 109-117.  Link to Item
    • Janiri, L, Mannelli, P, Persico, AM, Serretti, A, and Tempesta, E. "Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine." Drug Alcohol Depend 36, no. 2 (October 1994): 139-145.  Link to Item
    • Janiri, L, Mannelli, P, Serretti, A, and Tempesta, E. "Low-dose buprenorphine detoxification in long term methadone addicts." Regulatory Peptides 53, no. SUPPL. 1 (1994): S289-S290.
    • Mannelli, P, Janiri, L, Mizzoni, MC, and Tempesta, E. "Sources of differentiation of cocaine withdrawal symptomatology." European Neuropsychopharmacology 4, no. 3 (1994): 400--.
    • Mannelli, P, Janiri, L, Tempesta, E, and Jones, RT. "Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine." The British Journal of Psychiatry. Supplement , no. 21 (September 1993): 39-45.
    • Bartoloni, C, Guidi, L, Giovanni, ALD, Antico, L, Cursi, F, Pili, R, Tricerri, A, Janiri, L, Mannelli, P, Pariante, C, Menini, E, Carbonin, P, and Gambassi, G. "Psychological status, life and social conditions: A study in a population of institutionalized elderly people." International Journal of Geriatric Psychiatry 8, no. 5 (1993): 419-426.  Full Text
    • Mannelli, P, Janiri, L, Tempesta, E, and Jones, RT. "Prediction in drug abuse: Cocaine interactions with alcohol and buprenorphine." British Journal of Psychiatry 163, no. SEPT. SUPPL. 21 (1993): 39-45.
    • Mannelli, P, Mazza, S, Janiri, L, and Tempesta, E. "Serotoninergic hypothesis on the drug mechanism of cocaine." Bollettino di Psichiatria Biologica 7, no. 3 (December 1, 1991): 56-59.
    • Janiri, L, Di Giovanni, A, Persico, A, Zeppetelli, E, Mannelli, P, Antico, L, and Tempesta, E. "Benzodiazepine use and dependency risk in geriatric inpatients." Minerva Psichiatrica 32, no. 3 (October 28, 1991): 151-163.
    • Janiri, L, Di Giovanni, A, Persico, A, Zeppetelli, E, Mannelli, P, Antico, L, and Tempesta, E. "[Benzodiazepines consumption and risk of dependence in institutionalized geriatric patients]." Minerva Psichiatrica 32, no. 3 (July 1991): 151-163.
    • Janiri, L, Mannelli, P, Persico, AM, Diodato, S, and Tempesta, E. "Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects." Drug Alcohol Depend 27, no. 2 (March 1991): 121-125.  Link to Item
    • Janiri, L, Giovanni, AD, Persico, A, Zeppetelli, E, Mannelli, P, Antico, L, and Tempesta, E. "Benzodiazepine use and dependency risk in geriatric inpatients." Minerva Psichiatrica 32, no. 3 (1991): 151-163.
    • Mannelli, P, Mazza, S, Janiri, L, and Tempesta, E. "Serotoninergic hypothesis on the drug mechanism of cocaine." Bollettino di Psichiatria Biologica 7, no. 3 (1991): 56-59.
    • Tempesta, E, Janiri, L, and Mannelli, P. "Patterns of cocaine abuse and indications for treatment." European Neuropsychopharmacology 1, no. 3 (1991): 259-261.
    • Tempesta, E, Janiri, L, Mannelli, P, Persico, AM, and Diodato, S. "Clinical reports on recent abuse of an antitussive." Br J Addict 85, no. 6 (June 1990): 815-816. (Letter)  Link to Item
    • Mannelli, P, Janiri, L, De Marinis, M, and Tempesta, E. "Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity." Drug Alcohol Depend 24, no. 2 (October 1989): 95-101.  Link to Item
    • Janiri, L, Mannelli, P, Pirrongelli, C, Lo Monaco, M, and Tempesta, E. "Lephetamine abuse and dependence: clinical effects and withdrawal syndrome." Br J Addict 84, no. 1 (January 1989): 89-95.  Link to Item

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