Scholars@Duke
Paolo Mannelli

Paolo Mannelli

Professor of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
paolo.mannelli@duke.edu
Box 3074 Med Ctr, Durham, NC 27710
2213 Elba Street, Suite 156, Durham, NC 27705

Selected Publications

Pharmacy-based preventive services for opioid use disorder: a survey of U.S. pharmacists.

Journal Article Addict Sci Clin Pract · December 2, 2024 BACKGROUND: Pharmacists play a key role in combating the opioid-related overdose epidemic in the United States (US), but little is known about their experience and willingness to deliver preventive services for opioid use disorder (OUD). AIMS: This study s ... Full text Open Access Link to item Cite

Pharmacy-based methadone treatment in the US: views of pharmacists and opioid treatment program staff.

Journal Article Subst Abuse Treat Prev Policy · September 11, 2023 BACKGROUND: The US federal regulations allow pharmacy administration and dispensing of methadone for opioid use disorder (PADMOUD) to increase the capability of opioid treatment programs (OTPs) in providing methadone maintenance treatment (MMT) for opioid ... Full text Open Access Link to item Cite

Patient perspectives on community pharmacy administered and dispensing of methadone treatment for opioid use disorder: a qualitative study in the U.S.

Journal Article Addict Sci Clin Pract · August 2, 2023 BACKGROUND: Pharmacy administration and dispensing of methadone treatment for opioid use disorder (PADMOUD) may address inadequate capability of opioid treatment programs (OTPs) in the US by expanding access to methadone at community pharmacies nationally. ... Full text Open Access Link to item Cite

Association of chronic non-cancer pain status and buprenorphine treatment retention among individuals with opioid use disorder: Results from electronic health record data.

Journal Article Drug Alcohol Depend Rep · June 2022 BACKGROUND: Although chronic non-cancer pain (CNCP) is common among individuals with opioid use disorder (OUD), its impact on buprenorphine treatment retention is unclear. The goal of this study was to use electronic health record (EHR) data to examine the ... Full text Open Access Link to item Cite

Characteristics and treatment preferences of individuals with opioid use disorder seeking to transition from buprenorphine to extended-release naltrexone in a residential setting.

Journal Article Am J Addict · March 2022 BACKGROUND AND OBJECTIVES: Treatment for individuals receiving medication for opioid use disorder (MOUD) should follow an informed patient-centered approach. To better support patient autonomy in the decision-making process, clinicians should be aware of p ... Full text Link to item Cite

Patterns of withdrawal in patients with opioid use disorder (OUD) transitioning from untreated OUD or buprenorphine treatment to extended-release naltrexone.

Journal Article Am J Drug Alcohol Abuse · November 2, 2021 BACKGROUND: Pharmacologic treatment is recommended for many individuals with opioid use disorder (OUD). For patients who select opioid antagonist treatment, effective management of opioid withdrawal symptoms during transition to antagonist treatment requir ... Full text Link to item Cite

Buprenorphine physician-pharmacist collaboration in the management of patients with opioid use disorder: results from a multisite study of the National Drug Abuse Treatment Clinical Trials Network.

Journal Article Addiction · July 2021 BACKGROUND AND AIMS: Physician and pharmacist collaboration may help address the shortage of buprenorphine-waivered physicians and improve care for patients with opioid use disorder (OUD). This study investigated the feasibility and acceptability of a new ... Full text Open Access Link to item Cite

Heroin Use in Older Adults: A Treatment Challenge.

Journal Article Am J Geriatr Psychiatry · May 2021 Full text Link to item Cite

Review of Popularity and Quality Standards of Opioid-Related Smartphone Apps.

Journal Article Curr Addict Rep · December 2020 PURPOSE OF REVIEW: Opioid misuse, addiction, and related harm is a global crisis that affects public health and social and economic welfare. Many of the strategies being used to combat the opioid crisis could benefit from improved access and dissemination, ... Full text Link to item Cite

Pilot Randomized Controlled Trial of a Novel Smoking Cessation App Designed for Individuals With Co-Occurring Tobacco Use Disorder and Serious Mental Illness.

Journal Article Nicotine Tob Res · August 24, 2020 INTRODUCTION: High rates of tobacco use among people with serious mental illness (SMI), along with their unique needs, suggest the importance of developing tailored smoking cessation interventions for this group. Previous early-phase work empirically valid ... Full text Link to item Cite

Transition of Patients with Opioid Use Disorder from Buprenorphine to Extended-Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens.

Journal Article The American journal on addictions · July 2020 Background and objectiveWhen patients seek to discontinue buprenorphine (BUP) treatment, monthly injectable extended-release naltrexone (XR-NTX) may help them avoid relapse. The efficacy of low ascending doses of oral NTX vs placebo for patients t ... Full text Cite

A Randomized Controlled Trial of an Integrated Alcohol Reduction Intervention in Patients With Hepatitis C Infection.

Journal Article Hepatology · June 2020 BACKGROUND AND AIMS: Hepatitis C virus (HCV) and alcohol use are patient risk factors for accelerated fibrosis progression, yet few randomized controlled trials have tested clinic-based alcohol interventions. APPROACH AND RESULTS: A total of 181 patients w ... Full text Link to item Cite

Commentary on Winhusen et al. (2019): Substance use disorders, chronic diseases, and electronic health records-a paradigm for screening and intervention.

Journal Article Addiction · August 2019 The use of the electronic health record to study the relationship between substance use disorders, diabetes and hypertension has identified high-severity, high-cost conditions. Improving data quality and validation will enhance our ability to perform medic ... Full text Open Access Link to item Cite

Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco.

Journal Article Drug Alcohol Depend · January 1, 2019 BACKGROUND: Current data suggest that opioid misuse or opioid use disorder (OUD) may be over represented among tobacco users. However, this association remains understudied in primary care settings. A better understanding of the extent of heterogeneity in ... Full text Open Access Link to item Cite

The Hepatitis C-Alcohol Reduction Treatment (Hep ART) intervention: Study protocol of a multi-center randomized controlled trial.

Journal Article Contemp Clin Trials · September 2018 INTRODUCTION: Among patients with hepatitis C virus (HCV) infection, alcohol synergistically increases the risk of cirrhosis, hepatocellular carcinoma, and death. Randomized controlled trials of integrated models of HCV-alcohol treatment have been recommen ... Full text Link to item Cite

Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone.

Journal Article Am J Addict · September 2018 BACKGROUND AND OBJECTIVES: Long acting naltrexone has improved the therapy of opioid use disorder (OUD), and safe and effective withdrawal management during naltrexone induction may help advance treatment. Despite the uncertain role of opioid withdrawal in ... Full text Open Access Link to item Cite

Prevalence, patterns, and correlates of multiple substance use disorders among adult primary care patients.

Journal Article Drug and alcohol dependence · June 2018 BackgroundAddressing multiple substance use disorders (SUDs) in primary care-based screening and intervention may improve SUD treatment access, engagement, and outcomes. To inform such efforts, research is needed on the prevalence and patterns of ... Full text Open Access Cite

Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial.

Journal Article Drug Alcohol Depend · June 1, 2018 BACKGROUND: Injectable extended-release naltrexone (XR-NTX), approved to prevent relapse to opioid dependence, requires initial abstinence. This multisite outpatient clinical trial examined the efficacy and safety of low-dose oral naltrexone (NTX), combine ... Full text Link to item Cite

Substance use disorders and medical comorbidities among high-need, high-risk patients with diabetes.

Journal Article Drug Alcohol Depend · May 1, 2018 BACKGROUND: The majority of the U.S. healthcare resources are utilized by a small population characterized as high-risk, high-need persons with complex care needs (e.g., adults with multiple chronic conditions). Substance use disorders (SUDs) and mental he ... Full text Open Access Link to item Cite

Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies.

Journal Article Am J Addict · April 2018 BACKGROUND AND OBJECTIVES: Opioid use disorder (OUD) is a chronic condition with potentially severe health and social consequences. Many who develop moderate to severe OUD will repeatedly seek treatment or interact with medical care via emergency departmen ... Full text Link to item Cite

Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States.

Journal Article Drug Alcohol Depend · August 1, 2017 BACKGROUND: The increase in cannabis potency may have treatment implications for cannabis use disorder (CUD). Given the reported increase in prevalence of cannabis use among adults, there is a need to understand substance use treatment needs for CUD. METHO ... Full text Open Access Link to item Cite

Pharmacological and Integrated Treatments in Older Adults with Substance Use Disorders

Chapter · December 31, 2014 As the number of older adults aged ≥50years rise and requests of treatment for substance use disorders increase, there is an emerging need to identify efficient interventions. Research on pharmacological management of substance abuse among older individual ... Full text Cite

Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial.

Journal Article Drug Alcohol Depend · May 1, 2014 BACKGROUND: The approval of extended release injectable naltrexone (XR-NTX; Vivitrol(®)) has introduced a new option for treating opioid addiction, but studies are needed to identify its place within the spectrum of available therapies. The absence of phys ... Full text Open Access Link to item Cite

Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study.

Journal Article J Psychiatr Res · March 2014 The racial/ethnic composition of the US population is shifting, with the nonwhite population growing faster than whites. We examined cannabis use disorder (CUD) prevalences and correlates in seven racial/ethnic groups. We included cannabis use (CU) prevale ... Full text Open Access Link to item Cite

Substance Use Outcomes of an Integrated HIV-Substance Use Treatment Model Implemented by Social Workers and HIV Medical Providers

Journal Article Health and Social Work · February 24, 2014 Substance use is highly prevalent among people living with HIV (PLWH) and associated with poor health outcomes. Although understudied, integrating substance use and medical care for PLWH may decrease substance use. Using a quasi-experimental design, the au ... Full text Cite

Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.

Journal Article J Psychiatr Res · December 2013 Little is known about behavioral healthcare needs of Asian Americans (AAs), Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race people (MRs)-the fastest growing segments of the U.S. population. We examined substance use disorder (SUD) prevalences ... Full text Open Access Link to item Cite

Smoking and opioid detoxification: behavioral changes and response to treatment.

Journal Article Nicotine Tob Res · October 2013 INTRODUCTION: The relevance of tobacco use in opioid addiction (OA) has generated a demand for available and more effective interventions. Thus, further analysis of less explored nicotine-opioid clinical interactions is warranted. METHODS: A post-hoc analy ... Full text Open Access Link to item Cite

The burden of caring: drug users & their families.

Journal Article Indian J Med Res · April 2013 Link to item Cite

Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.

Journal Article Gen Hosp Psychiatry · 2013 OBJECTIVE: The objective was to identify a potential core set of brief screeners for the detection of individuals with a substance use disorder (SUD) in medical settings. METHOD: Data were from two multisite studies that evaluated stimulant use outcomes of ... Full text Open Access Link to item Cite

Alcohol and drug use disorders among adults in emergency department settings in the United States.

Journal Article Ann Emerg Med · August 2012 STUDY OBJECTIVE: Improving identification and treatment for substance use disorders is a national priority, but data about various drug use disorders encountered in emergency departments (EDs) are lacking. We examine past-year substance use and substance u ... Full text Open Access Link to item Cite

Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.

Journal Article Drug Alcohol Depend · July 1, 2012 Psychostimulant abuse continues to present legal, socioeconomic and medical challenges as a primary psychiatric disorder, and represents a significant comorbid factor in major psychiatric and medical illnesses. To date, monotherapeutic drug treatments have ... Full text Link to item Cite

The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal.

Journal Article Am J Drug Alcohol Abuse · May 2012 BACKGROUND: The management of withdrawal absorbs substantial clinical efforts in opioid dependence (OD). The real challenge lies in improving current pharmacotherapies. Although widely used, clonidine causes problematic adverse effects and does not allevia ... Full text Open Access Link to item Cite

An integrated alcohol abuse and medical treatment model for patients with hepatitis C.

Journal Article Dig Dis Sci · April 2012 BACKGROUND: Patients with chronic hepatitis C virus (HCV) infection have high rates of alcohol consumption, which is associated with progression of fibrosis and lower response rates to HCV treatment. AIMS: This prospective cohort study examined the feasibi ... Full text Open Access Link to item Cite

Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.

Journal Article Curr Drug Abuse Rev · March 2012 Constant refinement of opioid dependence (OD) therapies is a condition to promote treatment access and delivery. Among other applications, the partial opioid agonist buprenorphine has been studied to improve evidence-based interventions for the transfer of ... Full text Open Access Link to item Cite

Pharmacological enhancement of naltrexone treatment for opioid dependence: a review.

Journal Article Subst Abuse Rehabil · June 2011 PURPOSE: Opioid dependence (OD) is a serious and growing clinical condition with increasing social costs that requires expanding treatment beyond opioid agonist substitution. The opioid antagonist naltrexone has displayed a remarkable association of theore ... Full text Open Access Link to item Cite

Problem drinking and low-dose naltrexone-assisted opioid detoxification.

Journal Article J Stud Alcohol Drugs · May 2011 OBJECTIVE: The influence of alcohol use on opioid dependence is a major problem that warrants a search for more effective treatment strategies. The addition of very-low-dose naltrexone (VLNTX) to methadone taper was recently associated with reduced withdra ... Full text Open Access Link to item Cite

Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

Journal Article Subst Abuse Rehabil · May 2011 OBJECTIVES: To examine patterns of onset and abuse/dependence episodes of prescription opioid (PO) and heroin use disorders in a national sample of adults, and to explore differences by gender and substance abuse treatment status. METHODS: Analyses of data ... Full text Open Access Link to item Cite

Agonist-antagonist combinations in opioid dependence: a translational approach.

Journal Article Dipend Patologiche · 2010 The potential therapeutic benefits of co-administering opiate agonist and antagonist agents remain largely to be investigated. This paper focuses on the mechanisms of very low doses of naltrexone that help modulate the effects of methadone withdrawal and r ... Link to item Cite

Opioid use affects antioxidant activity and purine metabolism: preliminary results.

Journal Article Hum Psychopharmacol · December 2009 OBJECTIVE: More must be learned about metabolic and biochemical alterations that contribute to the development and expression of drug dependence. Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant ... Full text Link to item Cite

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study.

Journal Article Psychopharmacology (Berl) · October 2009 BACKGROUND: Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets. OBJECTIVE: We examined the differences in metabolites related to the tyrosine, tryptophan, purine, an ... Full text Link to item Cite

History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · August 31, 2009 BACKGROUND: Despite of a high comorbidity of depressive and/or anxiety disorders with fibromyalgia, information on the clinical implications of this comorbidity is limited but antidepressants are commonly prescribed to treat fibromyalgia in clinical practi ... Full text Link to item Cite

The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention.

Journal Article Addict Behav · August 2009 AIM: In light of the resurgence in MDMA use and its association with polysubstance use, we investigated the 12-month prevalence of substance use disorders (SUDs) among adult MDMA users to determine whether they are at risk of other drug-related problems th ... Full text Open Access Link to item Cite

Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial.

Journal Article Addict Biol · April 2009 Although current treatments for opioid detoxification are not always effective, medical detoxification remains a required step before long-term interventions. The use of opioid antagonist medications to improve detoxification has produced inconsistent resu ... Full text Open Access Link to item Cite

Childhood abuse and treatment response in patients with irritable bowel syndrome: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.

Journal Article J Clin Pharm Ther · February 2009 OBJECTIVE: Although irritable bowel syndrome (IBS) is frequently comorbid with childhood trauma, information on the clinical implications of this comorbidity is limited. We investigated whether a history of abuse was associated with response to treatment i ... Full text Link to item Cite

Early outcomes following low dose naltrexone enhancement of opioid detoxification.

Journal Article Am J Addict · 2009 Although withdrawal severity and treatment completion are the initial focus of opioid detoxification, post-detoxification outcome better defines effective interventions. Very low dose naltrexone (VLNTX) in addition to methadone taper was recently associate ... Full text Open Access Link to item Cite

Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial.

Journal Article Clin Neuropharmacol · 2009 There are limited data to indicate effective treatment strategies for antidepressant-related sexual dysfunction, in particular for patients with treatment-resistant major depression. We subanalyzed our published data whether augmentation with methylphenida ... Full text Link to item Cite

History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.

Journal Article World J Biol Psychiatry · 2009 OBJECTIVES: We conducted a post-hoc analysis to determine whether a history of physical or sexual abuse was associated with response to treatment in a double-blind, randomized, placebo-controlled trial of paroxetine controlled release (CR) in fibromyalgia. ... Full text Link to item Cite

A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome.

Journal Article Psychosomatics · 2009 BACKGROUND: Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace. OBJECTIV ... Full text Link to item Cite

Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.

Journal Article J Psychiatr Res · October 2008 BACKGROUND: Preclinical evidence indicates that exposure to cocaine influences the activity of the serotonin transporter (5-HTT) as well as several 5-HT receptor subtypes. However, little is known about the relationship between the 5-HTT and 5-HT receptors ... Full text Link to item Cite

Prescription pain reliever abuse and dependence among adolescents: a nationally representative study.

Journal Article J Am Acad Child Adolesc Psychiatry · September 2008 OBJECTIVE: We examined the prevalence, patterns, and correlates of adolescents' abuse, subthreshold dependence ("diagnostic orphans"), and dependence on prescription pain relievers (PPRs) such as opioids in a representative national sample (N = 36,992). ME ... Full text Open Access Link to item Cite

Hallucinogen use disorders among adult users of MDMA and other hallucinogens.

Journal Article Am J Addict · 2008 We investigated the prevalence, patterns, and correlates of past-year DSM-IV hallucinogen use disorders (HUDs) among past-year users of MDMA and other hallucinogens from a sample of Americans 18 or older (n = 37,227). Users were categorized as MDMA users a ... Full text Open Access Link to item Cite

An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features.

Journal Article Prim Care Companion J Clin Psychiatry · 2008 OBJECTIVES: Although selective serotonin reuptake inhibitors (SSRIs) have become the standard of care for the treatment of major depressive disorder (MDD), limited data exist to support their use in MDD with atypical features. The current study investigate ... Full text Link to item Cite

Polypharmacy in pregnant women with major psychiatric illness: a pilot study.

Journal Article J Psychiatr Pract · November 2007 OBJECTIVE: There is increasing concern about the use of multiple medications in populations with psychiatric illnesses. One large study reported that 99% of pregnant women had received a prescription for at least one medication during pregnancy, with a mea ... Full text Link to item Cite

Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence.

Journal Article J Clin Psychopharmacol · October 2007 BACKGROUND: The clinical use of naltrexone (NTX) in the treatment of opioid dependence has been limited because of poor compliance and inconsistent outcomes. In particular, the therapeutic benefit of extended treatment with NTX after opioid detoxification ... Full text Open Access Link to item Cite

Long-acting injectable naltrexone for the treatment of alcohol dependence.

Journal Article Expert Rev Neurother · October 2007 Combining pharmacotherapy with psychosocial and behavioral interventions has helped improve the treatment of alcohol dependence. However, the clinical use of effective medications, such as naltrexone, is limited by poor adherence to a daily oral regimen. R ... Full text Link to item Cite

Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal.

Journal Article Eur J Pharmacol · June 22, 2007 We have previously found the 5-HT3 receptor antagonist ondansetron to be useful in reducing cocaine self-administration and cocaine induced sensitization in rats when given during cocaine withdrawal. More recently we have found the combination of the dopam ... Full text Link to item Cite

Recent advances in poststroke depression.

Journal Article Curr Psychiatry Rep · June 2007 Depression is the most common psychiatric complication after stroke. Its prevalence varies from 20% to 80%, and it is underdiagnosed and undertreated. It has significant impact on rehabilitation, motor recovery, activities of daily living, social and inter ... Full text Link to item Cite

Medical comorbidity and alcohol dependence.

Journal Article Curr Psychiatry Rep · June 2007 Alcohol dependence (AD) and, more generally, alcohol use disorders (AUDs) predispose individuals to adverse consequences that extend beyond the expected damage from alcohol-direct toxicity. Research has shown that the relationship of alcohol use to health ... Full text Link to item Cite

A randomized, controlled, trial of controlled release paroxetine in fibromyalgia.

Journal Article Am J Med · May 2007 PURPOSE: We investigated the efficacy and tolerability of paroxetine controlled release, a selective serotonin reuptake inhibitor in fibromyalgia. METHODS: After excluding patients with current major depression and anxiety disorders, 116 subjects with fibr ... Full text Link to item Cite

Trends in nonheroin opioid abuse admissions: 1992-2004.

Journal Article J Opioid Manag · 2007 AIMS: This study examines trends for treatment admissions for nonheroin opioid abuse from 1992 to 2004. METHODS: Databases from the Substance Abuse Mental Health Services Administration (SAMHSA, U.S.A.): Treatment Episode Data Set (TEDS) were used to exami ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression.

Journal Article J Clin Psychopharmacol · December 2006 We examined the efficacy and tolerability of augmentation with an extended release formulation of methylphenidate (OROS MPH, Concerta) in patients with major depression who were nonresponders or partial responders to antidepressants. Sixty subjects with tr ... Full text Link to item Cite

Bupropion reinstates cocaine seeking behavior in rats

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2006 Link to item Cite

Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.

Journal Article Psychiatry Res · November 15, 2006 Serotonin (5-HT) function is altered in several psychiatric disorders, including cocaine dependence (CD), and its role in impulsive-aggressive behaviors has been widely studied. However, the relationship between psychopathological and behavioral dimensions ... Full text Link to item Cite

Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence.

Journal Article Hum Psychopharmacol · August 2006 RATIONALE: Serotonergic (5-HT) mechanisms appear to mediate central effects of cocaine. Therefore 5-HT disturbances could be associated with drug severity. OBJECTIVES: We investigated whether prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP), ... Full text Link to item Cite

Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients.

Journal Article Psychopharmacology (Berl) · March 2006 RATIONALE: Considerable evidence indicates that serotonergic (5-HT) mechanisms may mediate central effects of cocaine, and disinhibition and aggression. OBJECTIVE: We investigated whether prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP), a m ... Full text Link to item Cite

Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.

Journal Article J Neurosci Res · February 15, 2006 We previously described a decrease in withdrawal behaviors in opiate-dependent rats that were chronically treated with very low doses of naltrexone in their drinking water. Attenuated expression of withdrawal behaviors correlated with decreased c-Fos expre ... Full text Link to item Cite

Changes in tobacco smoking following treatment for cocaine dependence.

Journal Article Am J Drug Alcohol Abuse · 2006 Incorporation of smoking cessation into cocaine treatment programs remains a challenge. A major concern is that cocaine abusers may tend to substitute one drug for the other. If this is true, successful treatment of cocaine abuse should lead to an increase ... Full text Link to item Cite

Antagonist treatment of opioid withdrawal translational low dose approach.

Journal Article J Addict Dis · 2006 Although antagonist drugs are receiving increasing attention in the treatment of opioid withdrawal, the mechanisms of interaction of opiate agonists and antagonists remain largely to be investigated. We focused on the effects of very low quantities of opia ... Full text Link to item Cite

An open-label, rater-blinded, augmentation study of aripiprazole in treatment-resistant depression.

Journal Article Prim Care Companion J Clin Psychiatry · 2006 BACKGROUND: About 30% to 46% of patients with major depressive disorder (MDD) fail to fully respond to initial antidepressants. While treatment-resistant depression commonly refers to nonresponse or partial response to at least 2 adequate trials with antid ... Full text Link to item Cite

A functional prodynorphin promoter polymorphism and opioid dependence.

Journal Article Psychiatr Genet · December 2005 OBJECTIVES: The prodynorphin gene (PDYN) promoter has a repeat polymorphism that is functionally important in association with substance abuse. We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically ... Full text Link to item Cite

Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.

Journal Article Addict Biol · September 2005 The serotonin transporter (5-HTT) regulates serotonin transmission and modulates behavioral effects of drug of abuse. A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) yielding a short (S) and long (L) allele has been assoc ... Full text Link to item Cite

Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence.

Journal Article Am J Med Genet B Neuropsychiatr Genet · February 5, 2005 The mu-opioid receptor (MOR) mediates reward and dependence associated with opioids and other commonly abused substances. Variability in the MOR gene, OPRM1, may influence risk for opioid dependence. In this study, associations between two single nucleotid ... Full text Link to item Cite

Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients.

Journal Article Am J Addict · 2005 Despite the widespread use of tobacco and marijuana by cocaine abusers, it remains unclear whether combined tobacco and marijuana smoking is more harmful than tobacco smoking alone in cocaine abusers. We investigated the differences in medical symptoms rep ... Full text Link to item Cite

Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence.

Journal Article Psychopharmacology (Berl) · October 2004 RATIONALE: Alteration in serum prolactin (PRL) levels may reflect changes in central dopamine activity, which modulates the behavioral effects of cocaine. Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment ... Full text Link to item Cite

Chronic very low dose naltrexone administration attenuates opioid withdrawal expression.

Journal Article Biol Psychiatry · August 15, 2004 BACKGROUND: Different regimens of agonist and antagonist drugs have been used in opioid withdrawal management, with variable results. We examined whether administering extremely small quantities of opiate antagonists in the presence of opiate agonist drugs ... Full text Link to item Cite

Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers.

Journal Article Psychiatr Genet · March 2004 Alterations in the serotonin transporter (5-HTT) have been implicated in a variety of psychiatric disorders including cocaine dependence. A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) appears to influence the expression ... Full text Link to item Cite

The distribution of cocaine in mice differs by age and strain.

Journal Article Neurotoxicol Teratol · 2004 Few studies have examined the influence of the age and the strain of mouse on the pharmacokinetics of psychostimulants, or the role of pharmacokinetics in age-related differences in drug responses. The present study compared concentrations of cocaine, and ... Full text Link to item Cite

Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patients.

Journal Article J Addict Dis · 2004 We investigated whether pretreatment characteristics and measures of outcome differed for alcohol-, cocaine-, and multisubstance-dependent patients receiving outpatient substance abuse treatment. One hundred and forty substance dependent individuals (32 al ... Full text Link to item Cite

Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients.

Journal Article J Addict Dis · 2004 We investigated whether measures of impulsivity, aggression and sensation seeking differed between cocaine-dependent subjects and controls, and whether these measures were related to treatment-outcome for cocaine patients. Pre-treatment assessments of impu ... Full text Link to item Cite

Relationship of Aggression, Sensation Seeking, and Impulsivity, with Severity of Cocaine Use

Journal Article Addictive Disorders and their Treatment · December 16, 2003 We investigated whether pretreatment measures of sensation seeking, impulsivity, and aggression were related to severity of cocaine use. Assessments of sensation seeking (SSS), impulsivity (BIS), and aggression (BDHI) were obtained for 140 African-American ... Full text Cite

High- and low-structure treatments for substance dependence: role of learned helplessness.

Journal Article Am J Drug Alcohol Abuse · August 2003 We studied whether pretreatment levels of learned helplessness (LH) were related to outcomes for substance-dependent individuals receiving high-structure, behaviorally oriented (HSB) or low-structure, facilitative (LSF) treatment. The subjects were 120 sub ... Full text Link to item Cite

Use of very low-dose naltrexone during opiate detoxification.

Journal Article J Addict Dis · 2003 The use of antagonist drugs to reduce the duration of opiate detoxification severely enhances withdrawal symptoms. To investigate the feasibility of administering antagonists with opiates without intense withdrawal during detoxification, 5 methadone mainta ... Full text Link to item Cite

Continuing care versus revolving door following opiate detoxification

Conference JOURNAL OF ADDICTIVE DISEASES · January 1, 2003 Link to item Cite

Very low antagonist dosing in opiate detoxification

Conference JOURNAL OF ADDICTIVE DISEASES · January 1, 2001 Link to item Cite

Psychological discomfort and mental illness in patients with AIDS: implications for home care.

Journal Article AIDS Patient Care STDS · September 1999 A chart review study of 100 consecutive AIDS patients cared for by our Home Care (HC) unit was performed. The main characteristics of the sample were: M/F ratio = 3/1; mean age = 39.7 +/- 6.6; mode of transmission = 56% intravenous drug users (IVDU); Cente ... Full text Link to item Cite

Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone.

Journal Article Eur J Emerg Med · June 1999 We report the case of a 30-year-old male, heroin dependent, receiving methadone treatment, who, while staying at home, ingested 50 mg of naltrexone. He immediately developed serious withdrawal symptoms and was admitted to the hospital. In the emergency dep ... Full text Link to item Cite

Serendipitous rapid detoxification from opiates: the importance of time-dependent processes.

Journal Article Addiction · April 1999 Opiate detoxification procedures aim to reduce intensity and duration of withdrawal. Ultra-rapid opiate detoxification (UROD) methods attempt to obtain this goal by administering naltrexone under deep sedation or anaesthesia. We present a case study on acc ... Full text Link to item Cite

Adjuvant trazodone in the treatment of alcoholism: an open study.

Journal Article Alcohol Alcohol · 1998 Serotonergic drugs have been proven to be helpful to alcoholics in maintaining abstinence. In this open study, we report that the atypical antidepressant trazodone at low doses was able to significantly decrease craving for alcohol, depressive, and anxious ... Full text Link to item Cite

Effects of fluoxetine at antidepressant doses on short-term outcome of detoxified alcoholics.

Journal Article Int Clin Psychopharmacol · June 1996 Compulsivity in alcohol-dependent patients is a frequent cause of early relapse in the post-detoxification period. The present study is a 2-month trial on detoxified alcoholics undergoing a double-blind placebo-controlled treatment with fluoxetine (20 mg/d ... Link to item Cite

Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine.

Journal Article Drug Alcohol Depend · October 1994 Thirty-nine methadone maintenance patients were included in a 9-day, double blind, randomized, inpatient detoxification trial. Methadone was tapered to 10 mg/day and then patients were assigned to one of these 3 protocols: clonidine (0.3-0.9 mg/day), lefet ... Full text Link to item Cite

Low-dose buprenorphine detoxification in long term methadone addicts

Journal Article Regulatory Peptides · February 21, 1994 Full text Cite

Sources of differentiation of cocaine withdrawal symptomatology

Journal Article European Neuropsychopharmacology · January 1, 1994 Full text Cite

Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine.

Journal Article Br J Psychiatry Suppl · September 1993 We describe the limitations on studying the interactions of drugs of abuse in humans. Two 'acute' studies were carried out. In the first study, the administration of alcohol/placebo with cocaine showed the possibility of identifying the euphoric effect of ... Link to item Cite

Prediction in drug abuse: Cocaine interactions with alcohol and buprenorphine

Journal Article British Journal of Psychiatry · January 1, 1993 We describe the limitations on studying the interactions of drugs of abuse in humans. Two 'acute' studies were carried out. In the first study, the administration of alcohol/placebo with cocaine showed the possibility of identifying the euphoric effect of ... Full text Cite

Psychological status, life and social conditions: A study in a population of institutionalized elderly people

Journal Article International Journal of Geriatric Psychiatry · January 1, 1993 The relationship between social and life conditions on the one hand and the presence of depression on the other was analysed in a population of institutionalized elderly subjects. The influence of health status on psychological condition and the presence o ... Full text Cite

Serotoninergic hypothesis on the drug mechanism of cocaine

Journal Article Bollettino di Psichiatria Biologica · December 1, 1991 Cite

Benzodiazepine use and dependency risk in geriatric inpatients

Journal Article Minerva Psichiatrica · October 28, 1991 The use of of psychoactive drugs in geriatric nursing homes has to be considered within the peculiar frame work of the elderly condition. The present study was aimed at verifying the prevalence and characteristics of prolonged benzodiazepine use (~ 1 month ... Cite

Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects.

Journal Article Drug Alcohol Depend · March 1991 Zipeprol is a non-opioid cough suppressor agent recently abused in Italy. Clinical reports from 30 street abusers show that the drug in high doses has a definite abuse liability and dependence potential. Many of its effects were identical to those induced ... Full text Link to item Cite

Patterns of cocaine abuse and indications for treatment

Journal Article European Neuropsychopharmacology · January 1, 1991 Full text Cite

Serotoninergic hypothesis on the drug mechanism of cocaine

Journal Article Bollettino di Psichiatria Biologica · 1991 Cite

Benzodiazepine use and dependency risk in geriatric inpatients

Journal Article Minerva Psichiatrica · 1991 The use of of psychoactive drugs in geriatric nursing homes has to be considered within the peculiar frame work of the elderly condition. The present study was aimed at verifying the prevalence and characteristics of prolonged benzodiazepine use (~ 1 month ... Cite

[Benzodiazepines consumption and risk of dependence in institutionalized geriatric patients].

Journal Article Minerva Psichiatr · 1991 The use of psychoactive drugs in geriatric nursing homes has to be considered within the peculiar frame work of the elderly condition. The present study was aimed at verifying the prevalence and characteristics of prolonged benzodiazepine use (greater than ... Link to item Cite

Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.

Journal Article Drug Alcohol Depend · October 1989 Lefetamine (SPA) combining amphetamine with opioid-like effects, a drug of wide abuse in Japan in the fifties, has now been introduced as such in Italy. In this study the drug was tested to verify its resemblance to opiates. Ten lefetamine abusers were hos ... Full text Link to item Cite

Lephetamine abuse and dependence: clinical effects and withdrawal syndrome.

Journal Article Br J Addict · January 1989 Lephetamine (L-SPA) is a compound with central analgesic and anti-inflammatory action, recently reported to be abused in Italy. In this study, cases of L-SPA abuse were recorded. The survey included 15 patients who were assessed for effects caused by using ... Full text Link to item Cite