Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.
Publication
, Journal Article
Mannelli, P; Janiri, L; De Marinis, M; Tempesta, E
Published in: Drug Alcohol Depend
October 1989
Lefetamine (SPA) combining amphetamine with opioid-like effects, a drug of wide abuse in Japan in the fifties, has now been introduced as such in Italy. In this study the drug was tested to verify its resemblance to opiates. Ten lefetamine abusers were hospitalized and then subjected to naloxone- and pentazocine-tests and detoxified. Moreover, lefetamine was administered to ten opiate addicts with an acute withdrawal syndrome and to ten methadone-treated addicts. The naloxone-test was positive and pentazocine could be substituted for lefetamine. Lefetamine was able to relieve opiate withdrawal and did not precipitate withdrawal symptoms in stabilized opiate addicts. It is concluded that lefetamine may act as an opioid partial agonist.
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Published In
Drug Alcohol Depend
DOI
ISSN
0376-8716
Publication Date
October 1989
Volume
24
Issue
2
Start / End Page
95 / 101
Location
Ireland
Related Subject Headings
- Substance-Related Disorders
- Substance Abuse
- Receptors, Opioid
- Randomized Controlled Trials as Topic
- Phenethylamines
- Methadone
- Humans
- Heroin Dependence
- Follow-Up Studies
- Clonidine
Citation
APA
Chicago
ICMJE
MLA
NLM
Mannelli, P., Janiri, L., De Marinis, M., & Tempesta, E. (1989). Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Drug Alcohol Depend, 24(2), 95–101. https://doi.org/10.1016/0376-8716(89)90071-9
Mannelli, P., L. Janiri, M. De Marinis, and E. Tempesta. “Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.” Drug Alcohol Depend 24, no. 2 (October 1989): 95–101. https://doi.org/10.1016/0376-8716(89)90071-9.
Mannelli P, Janiri L, De Marinis M, Tempesta E. Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Drug Alcohol Depend. 1989 Oct;24(2):95–101.
Mannelli, P., et al. “Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.” Drug Alcohol Depend, vol. 24, no. 2, Oct. 1989, pp. 95–101. Pubmed, doi:10.1016/0376-8716(89)90071-9.
Mannelli P, Janiri L, De Marinis M, Tempesta E. Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Drug Alcohol Depend. 1989 Oct;24(2):95–101.
Published In
Drug Alcohol Depend
DOI
ISSN
0376-8716
Publication Date
October 1989
Volume
24
Issue
2
Start / End Page
95 / 101
Location
Ireland
Related Subject Headings
- Substance-Related Disorders
- Substance Abuse
- Receptors, Opioid
- Randomized Controlled Trials as Topic
- Phenethylamines
- Methadone
- Humans
- Heroin Dependence
- Follow-Up Studies
- Clonidine