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Patricia Lynne Lugar

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
1821 Hillandale Rd, Suite 25A, Durham, NC 27705

Research Interests


Advancing the understanding of human immunodeficiency syndromes through genetic sequencing and the development of animal models. Ultimate aim to provide strategies for early surveillance of disease associated complications including the development of hematologic malignancies and novel therapeutics aimed at correcting the immune dysregulation

Selected Grants


R01: Genetic Origins of Adverse Outcomes in African Americans with Lymphoma

ResearchInvestigator · Awarded by National Institutes of Health · 2023 - 2028

HAE Outcome Study. An observational, non-interventional, study of patients with Hereditary Angioedema in the United States and Canada.

Clinical TrialPrincipal Investigator · Awarded by Takeda Pharmaceutical Company Limited · 2019 - 2024

Abatacept for the treatment of Common Variable Immunodeficiency with Interstitial Lung Disease (ABCVILD)- Fixed Price

Clinical TrialPrincipal Investigator · Awarded by Cincinnati Children's Hospital Medical Center · 2023 - 2023

R01: Genetic Origins of Adverse Outcomes in African Americans with Lymphoma

ResearchInvestigator · Awarded by National Institutes of Health · 2023 - 2028

HAE Outcome Study. An observational, non-interventional, study of patients with Hereditary Angioedema in the United States and Canada.

Clinical TrialPrincipal Investigator · Awarded by Takeda Pharmaceutical Company Limited · 2019 - 2024

Abatacept for the treatment of Common Variable Immunodeficiency with Interstitial Lung Disease (ABCVILD)- Fixed Price

Clinical TrialPrincipal Investigator · Awarded by Cincinnati Children's Hospital Medical Center · 2023 - 2023

Abatacept for the treatment of Common Variable Immunodeficiency with Interstitial Lung Disease (ABCVILD) - Cost Reimbursable

Clinical TrialPrincipal Investigator · Awarded by Cincinnati Children's Hospital Medical Center · 2021 - 2023

Understanding the context-dependent roles of mutations in lymphoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2021

Clinical indicators for early bone loss in Common Variable Immunodeficiency

ResearchPrincipal Investigator · Awarded by Immune Deficiency Foundation · 2019 - 2020

CSL Behring IgPro20_4004

Clinical TrialPrincipal Investigator · Awarded by CSL Behring LLC · 2017 - 2019

The HELP Study

Clinical TrialPrincipal Investigator · Awarded by Dyax Corporation · 2016 - 2017

The genetics of hepatosplenic T cell lymphoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2017

Clinical Oncology Research Career Development Program

ResearchResearch Candidate · Awarded by National Institutes of Health · 2009 - 2015

External Relationships


  • BioCryst Pharmaceuticals
  • Blueprint Medicines
  • Data Driven Bioscience
  • Grifols

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.