Paul Anthony Dennis | Scholars@Duke

Paul Anthony Dennis
Associate Professor in Population Health Sciences

Developmental psychologist, statistician, and data scientist. Research focused on cardiovascular risk associated with psychiatric illness and trauma exposure, intraindivdiual variability in symptoms and affect, and the use of mobile apps and devices for health and behavior monitoring and interventions. Interest in longitudinal and repeated-measures analyses, mediation analyses, machine learning, and applications to administrative healthcare data.

Current Appointments & Affiliations

Associate Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2021

Contact Information

Box 3625, Durham, NC 27710
Box 3625, Durham, NC 27710
paul.dennis@duke.edu (919) 286-0411

Background
Education, Training, & Certifications
- Ph.D., North Carolina State University 2012
Previous Appointments & Affiliations
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2021
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2019 - 2020
- Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2015 - 2019
- Medical Instructor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2014 - 2015
Academic Positions Outside Duke
- Faculty Statistician, Durham Veterans Affairs Medical Center. 2021 - 2029
Research
Selected Grants
- Cost Effectiveness of Combined Contingency Management and Cognitive Behavioral Therapy for Alcohol Use Disorder awarded by National Institutes of Health 2019 - 2024
- Impact of Reduced Cannabis Use on Functional Outcomes awarded by National Institutes of Health 2018 - 2023
- Neuromodulatory Treatments for Pain Management in Complex TBI using Mobile Technology awarded by Department of Defense 2017 - 2022
- Association of Posttraumatic Stress Disorder and Heart Disease in Women Veterans: Examining Risk Factors and Effects of Pharmacotherapy on Clinical Outcomes awarded by The Regents of the University of California 2018 - 2022
- Mobile contingency management for smoking cessation in returning US Veterans awarded by National Institutes of Health 2015 - 2020
- Pain Management using Mobile Technology in Veterans with PTSD and TBI awarded by National Institutes of Health 2014 - 2018
- Neural Markers and Rehabilitation of Executive Functioning in Veterans with TBI and PTSD awarded by University of North Carolina - Chapel Hill 2016 - 2017
- missing activity
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Senan, S., Özgüroğlu, M., Daniel, D., Villegas, A., Vicente, D., Murakami, S., … Antonia, S. J. (2022). Outcomes with durvalumab after chemoradiotherapy in stage IIIA-N2 non-small-cell lung cancer: an exploratory analysis from the PACIFIC trial. Esmo Open, 7(2), 100410. https://doi.org/10.1016/j.esmoop.2022.100410
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  - Van Voorhees, E. E., Dennis, P. A., Watkins, L. L., Patel, T. A., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2022). Ambulatory Heart Rate Variability Monitoring: Comparisons Between the Empatica E4 Wristband and Holter Electrocardiogram. Psychosom Med, 84(2), 210–214. https://doi.org/10.1097/PSY.0000000000001010
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  - Xu, Y., Towe, S. L., Causey, S. T., Dennis, P. A., & Meade, C. S. (2022). Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study. Exp Clin Psychopharmacol, 30(1), 39–50. https://doi.org/10.1037/pha0000423
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  - Pore, N., Wu, S., Standifer, N., Jure-Kunkel, M., de Los Reyes, M., Shrestha, Y., … Oberst, M. D. (2021). Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown. Cancer Discov, 11(11), 2828–2845. https://doi.org/10.1158/2159-8290.CD-20-1543
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  - Van Voorhees, E. E., Dillon, K. H., Wilson, S. M., Dennis, P. A., Neal, L. C., Medenblik, A. M., … Beckham, J. C. (2021). A Comparison of Group Anger Management Treatments for Combat Veterans With PTSD: Results From a Quasi-Experimental Trial. J Interpers Violence, 36(19–20), NP10276–NP10300. https://doi.org/10.1177/0886260519873335
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  - Ebrahimi, R., Lynch, K. E., Beckham, J. C., Dennis, P. A., Viernes, B., Tseng, C.-H., … Sumner, J. A. (2021). Association of Posttraumatic Stress Disorder and Incident Ischemic Heart Disease in Women Veterans. Jama Cardiol, 6(6), 642–651. https://doi.org/10.1001/jamacardio.2021.0227
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  - Christofferson, D. E., Dennis, P. A., Hertzberg, J. S., Beckham, J. C., Knoeppel, J., & Hamlett-Berry, K. (2021). Real-World Utilization and Outcomes of the Veterans Health Administration's Smoking Cessation Text Message Program. Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 23(6), 931–938. https://doi.org/10.1093/ntr/ntaa183
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  - Dillon, K. H., Glenn, J. J., Dennis, P. A., LoSavio, S. T., Cassiello-Robbins, C., Gromatsky, M. A., … Kimbrel, N. A. (2021). Anger precedes and predicts nonsuicidal self-injury in veterans: Findings from an ecological momentary assessment study. J Psychiatr Res, 135, 47–51. https://doi.org/10.1016/j.jpsychires.2021.01.011
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  - Elbogen, E. B., Alsobrooks, A., Battles, S., Molloy, K., Dennis, P. A., Beckham, J. C., … Russoniello, C. (2021). Mobile Neurofeedback for Pain Management in Veterans with TBI and PTSD. Pain Med, 22(2), 329–337. https://doi.org/10.1093/pm/pnz269
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  - Kawabata, S., Connis, N., Gills, J. J., Hann, C. L., & Dennis, P. A. (2021). Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors. Anticancer Res, 41(1), 91–99. https://doi.org/10.21873/anticanres.14754
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  - Lopiccolo, J., Kawabata, S., Gills, J. J., & Dennis, P. A. (2021). Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors. In Vivo, 35(1), 141–145. https://doi.org/10.21873/invivo.12241
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  - Ouwens, M., Darilay, A., Zhang, Y., Mukhopadhyay, P., Mann, H., Ryan, J., & Dennis, P. A. (2021). Assessing the Influence of Subsequent Immunotherapy on Overall Survival in Patients with Unresectable Stage III Non–Small Cell Lung Cancer from the PACIFIC Study. Current Therapeutic Research Clinical and Experimental, 95. https://doi.org/10.1016/j.curtheres.2021.100640
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  - Sumner, J. A., Lynch, K. E., Viernes, B., Beckham, J. C., Coronado, G., Dennis, P. A., … Ebrahimi, R. (2021). Military Sexual Trauma and Adverse Mental and Physical Health and Clinical Comorbidity in Women Veterans. Womens Health Issues, 31(6), 586–595. https://doi.org/10.1016/j.whi.2021.07.004
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  - Glenn, J. J., Dillon, K. H., Dennis, P. A., Patel, T. A., Mann, A. J., Calhoun, P. S., … Elbogen, E. B. (2020). Post-traumatic symptom severity mediates the association between combat exposure and suicidal ideation in veterans. Suicide Life Threat Behav, 50(6), 1167–1172. https://doi.org/10.1111/sltb.12678
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  - Ye, J., Ji, X., Dennis, P. A., Abdullah, H., & Mukhopadhyay, P. (2020). Relationship Between Progression-Free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune Checkpoint Blockade: A Meta-Analysis. Clin Pharmacol Ther, 108(6), 1274–1288. https://doi.org/10.1002/cpt.1956
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  - Zhang, Q., Luo, J., Wu, S., Si, H., Gao, C., Xu, W., … Hellmann, M. D. (2020). Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade. Cancer Discov, 10(12), 1842–1853. https://doi.org/10.1158/2159-8290.CD-20-0047
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  - Gopalakrishnan, V., Sellman, B. R., Cohen, T. S., & Dennis, P. A. (2020). Antibiotics and Immunotherapy: Too Much of Anything is Bad!. Eur Urol, 78(4), 544–545. https://doi.org/10.1016/j.eururo.2020.07.027
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  - Garassino, M. C., Cho, B.-C., Kim, J.-H., Mazières, J., Vansteenkiste, J., Lena, H., … Rizvi, N. A. (2020). Final overall survival and safety update for durvalumab in third- or later-line advanced NSCLC: The phase II ATLANTIC study. Lung Cancer, 147, 137–142. https://doi.org/10.1016/j.lungcan.2020.06.032
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  - Datta, S. K., Dennis, P. A., & Davis, J. M. (2020). Health benefits and economic advantages associated with increased utilization of a smoking cessation program. J Comp Eff Res, 9(11), 817–828. https://doi.org/10.2217/cer-2020-0005
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  - Davis, J. M., Thomas, L. C., Dirkes, J. E., Datta, S. K., & Dennis, P. A. (2020). Comparison of referral methods into a smoking cessation program. J Comp Eff Res, 9(11), 807–815. https://doi.org/10.2217/cer-2020-0004
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  - Gopalakrishnan, V., Weiner, B., Ford, C. B., Sellman, B. R., Hammond, S. A., Freeman, D. J., … Henn, M. R. (2020). Intervention strategies for microbial therapeutics in cancer immunotherapy. Immuno Oncology and Technology, 6, 9–17. https://doi.org/10.1016/j.iotech.2020.05.001
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  - Dillon, K. H., Van Voorhees, E. E., Dennis, P. A., Glenn, J. J., Wilks, C. R., Morland, L. A., … Elbogen, E. B. (2020). Anger mediates the relationship between posttraumatic stress disorder and suicidal ideation in veterans. J Affect Disord, 269, 117–124. https://doi.org/10.1016/j.jad.2020.03.053
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  - Juergens, R. A., Hao, D., Ellis, P. M., Tu, D., Mates, M., Kollmannsberger, C., … Laurie, S. A. (2020). A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226. Lung Cancer, 143, 1–11. https://doi.org/10.1016/j.lungcan.2020.02.016
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  - Komiya, T., Blumenthal, G. M., DeChowdhury, R., Fioravanti, S., Ballas, M. S., Morris, J., … Dennis, P. A. (2019). A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN. Oncologist, 24(12), 1510-e1265. https://doi.org/10.1634/theoncologist.2019-0514
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  - Norberg, M. M., Newins, A. R., Crone, C., Ham, L. S., Henry, A., Mills, L., & Dennis, P. A. (2019). Why are caffeinated alcoholic beverages especially risky? Addict Behav, 98, 106062. https://doi.org/10.1016/j.addbeh.2019.106062
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  - Sridhar, S., Paz-Ares, L., Liu, H., Shen, K., Morehouse, C., Rizvi, N., … Ranade, K. (2019). Prognostic Significance of Liver Metastasis in Durvalumab-Treated Lung Cancer Patients. Clin Lung Cancer, 20(6), e601–e608. https://doi.org/10.1016/j.cllc.2019.06.020
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  - Dennis, P. A., Neal, J. M., Travis, E., Watkins, L. L., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2019). Negative Affect-Related Autonomic Arousal Mediates the Association between Baroreflex Dysfunction and Insulin Resistance in Non-Diabetic Young Adults. J Psychophysiol, 33(4), 243–253. https://doi.org/10.1027/0269-8803/a000226
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  - Boothman, A.-M., Scott, M., Ratcliffe, M., Whiteley, J., Dennis, P. A., Wadsworth, C., … Walker, J. (2019). Impact of Patient Characteristics, Prior Therapy, and Sample Type on Tumor Cell Programmed Cell Death Ligand 1 Expression in Patients with Advanced NSCLC Screened for the ATLANTIC Study. J Thorac Oncol, 14(8), 1390–1399. https://doi.org/10.1016/j.jtho.2019.04.025
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  - Erwin, M. C., Dennis, P. A., Coughlin, L. N., Calhoun, P. S., & Beckham, J. C. (2019). Examining the relationship between negative affect and posttraumatic stress disorder symptoms among smokers using ecological momentary assessment. J Affect Disord, 253, 285–291. https://doi.org/10.1016/j.jad.2019.04.035
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  - Dennis, P. A., Thomas, S. N., Husain, M. M., & Dennis, N. M. (2019). Racial Disparities in the Administration of ECT in Texas, 1998-2013. J Ect, 35(2), 103–105. https://doi.org/10.1097/YCT.0000000000000555
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  - Gutierrez, E., Cahatol, I., Bailey, C. A. R., Lafargue, A., Zhang, N., Song, Y., … Zhang, C. (2019). Regulation of RhoB gene expression during tumorigenesis and aging process and its potential applications in these processes. Cancers, 11(6). https://doi.org/10.3390/cancers11060818
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  - Komiya, T., Memmott, R. M., Blumenthal, G. M., Bernstein, W., Ballas, M. S., De Chowdhury, R., … Dennis, P. A. (2019). A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer. Translational Lung Cancer Research, 8(3), 247–257. https://doi.org/10.21037/tlcr.2019.04.19
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  - Cunningham, K. C., Grossmann, J. L., Seay, K. B., Dennis, P. A., Clancy, C. P., Hertzberg, M. A., … Kimbrel, N. A. (2019). Nonsuicidal Self-Injury and Borderline Personality Features as Risk Factors for Suicidal Ideation Among Male Veterans With Posttraumatic Stress Disorder. J Trauma Stress, 32(1), 141–147. https://doi.org/10.1002/jts.22369
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  - Cunningham, K. C., LoSavio, S. T., Dennis, P. A., Farmer, C., Clancy, C. P., Hertzberg, M. A., … Beckham, J. C. (2019). Shame as a mediator between posttraumatic stress disorder symptoms and suicidal ideation among veterans. J Affect Disord, 243, 216–219. https://doi.org/10.1016/j.jad.2018.09.040
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  - Dedert, E. A., Dennis, P. A., Cunningham, K. C., Ulmer, C. S., Calhoun, P. S., Kimbrel, N., … Beckham, J. C. (2019). Roles of Guilt Cognitions in Trauma-Related Sleep Disturbance in Military Veterans With Posttraumatic Stress Disorder. Behav Sleep Med, 17(5), 595–604. https://doi.org/10.1080/15402002.2018.1435544
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  - Dedert, E. A., Resick, P. A., Dennis, P. A., Wilson, S. M., Moore, S. D., & Beckham, J. C. (2019). Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment. J Addict Med, 13(4), 322–330. https://doi.org/10.1097/ADM.0000000000000502
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  - Elbogen, E. B., Dennis, P. A., Van Voorhees, E. E., Blakey, S. M., Johnson, J. L., Johnson, S. C., … Belger, A. (2019). Cognitive Rehabilitation With Mobile Technology and Social Support for Veterans With TBI and PTSD: A Randomized Clinical Trial. J Head Trauma Rehabil, 34(1), 1–10. https://doi.org/10.1097/HTR.0000000000000435
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  - Raja, R., Kuziora, M., Brohawn, P. Z., Higgs, B. W., Gupta, A., Dennis, P. A., & Ranade, K. (2018). Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab. Clin Cancer Res, 24(24), 6212–6222. https://doi.org/10.1158/1078-0432.CCR-18-0386
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  - Antonia, S. J., Villegas, A., Daniel, D., Vicente, D., Murakami, S., Hui, R., … PACIFIC Investigators, . (2018). Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med, 379(24), 2342–2350. https://doi.org/10.1056/NEJMoa1809697
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  - Ulmer, C. S., Hall, M. H., Dennis, P. A., Beckham, J. C., & Germain, A. (2018). Posttraumatic stress disorder diagnosis is associated with reduced parasympathetic activity during sleep in US veterans and military service members of the Iraq and Afghanistan wars. Sleep, 41(12). https://doi.org/10.1093/sleep/zsy174
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  - Calhoun, P. S., Schry, A. R., Dennis, P. A., Wagner, H. R., Kimbrel, N. A., Bastian, L. A., … Straits-Tröster, K. (2018). The Association Between Military Sexual Trauma and Use of VA and Non-VA Health Care Services Among Female Veterans With Military Service in Iraq or Afghanistan. J Interpers Violence, 33(15), 2439–2464. https://doi.org/10.1177/0886260515625909
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  - Baverel, P. G., Dubois, V. F. S., Jin, C. Y., Zheng, Y., Song, X., Jin, X., … Narwal, R. (2018). Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status. Clin Pharmacol Ther, 103(4), 631–642. https://doi.org/10.1002/cpt.982
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  - Garassino, M. C., Cho, B.-C., Kim, J.-H., Mazières, J., Vansteenkiste, J., Lena, H., … ATLANTIC Investigators, . (2018). Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study. Lancet Oncol, 19(4), 521–536. https://doi.org/10.1016/S1470-2045(18)30144-X
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  - Van Voorhees, E. E., Dennis, P. A., Elbogen, E. B., Fuemmeler, B., Neal, L. C., Calhoun, P. S., & Beckham, J. C. (2018). Characterizing anger-related affect in individuals with posttraumatic stress disorder using ecological momentary assessment. Psychiatry Res, 261, 274–280. https://doi.org/10.1016/j.psychres.2017.12.080
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  - Hicks, T. A., Wilson, S. M., Thomas, S. P., Dennis, P. A., Neal, J. M., & Calhoun, P. S. (2018). Low Income as a Multiplicative Risk Factor for Oral Pain and Dental Problems Among U.S. Veteran Smokers. Int J Behav Med, 25(1), 67–73. https://doi.org/10.1007/s12529-017-9660-5
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  - Dedert, E. A., Dennis, P. A., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2018). A Randomized Clinical Trial of Nicotine Preloading for Smoking Cessation in People with Posttraumatic Stress Disorder. J Dual Diagn, 14(3), 148–157. https://doi.org/10.1080/15504263.2018.1468947
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  - Calhoun, P. S., Wilson, S. M., Hertzberg, J. S., Kirby, A. C., McDonald, S. D., Dennis, P. A., … Beckham, J. C. (2017). Validation of Veterans Affairs Electronic Medical Record Smoking Data Among Iraq- and Afghanistan-Era Veterans. J Gen Intern Med, 32(11), 1228–1234. https://doi.org/10.1007/s11606-017-4144-5
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  - Cunningham, K. C., Farmer, C., LoSavio, S. T., Dennis, P. A., Clancy, C. P., Hertzberg, M. A., … Beckham, J. C. (2017). A model comparison approach to trauma-related guilt as a mediator of the relationship between PTSD symptoms and suicidal ideation among veterans. J Affect Disord, 221, 227–231. https://doi.org/10.1016/j.jad.2017.06.046
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  - Osoegawa, A., Gills, J. J., Kawabata, S., & Dennis, P. A. (2017). Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. Oncotarget, 8(50), 87044–87053. https://doi.org/10.18632/oncotarget.19667
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  - Vinesett, A. L., Whaley, R. R., Woods-Giscombe, C., Dennis, P., Johnson, M., Li, Y., … Wilson, K. H. (2017). Modified African Ngoma Healing Ceremony for Stress Reduction: A Pilot Study. J Altern Complement Med, 23(10), 800–804. https://doi.org/10.1089/acm.2016.0410
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  - Green, K. T., Wilson, S. M., Dennis, P. A., Runnals, J. J., Williams, R. A., Bastian, L. A., … Calhoun, P. S. (2017). Cigarette Smoking and Musculoskeletal Pain Severity Among Male and Female Afghanistan/Iraq Era Veterans. Pain Med, 18(9), 1795–1804. https://doi.org/10.1093/pm/pnw339
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  - Wilson, S. M., Pacek, L. R., Dennis, P. A., Bastian, L. A., Beckham, J. C., & Calhoun, P. S. (2017). Veterans Living with HIV: A High-Risk Group for Cigarette Smoking. Aids Behav, 21(7), 1950–1955. https://doi.org/10.1007/s10461-017-1717-6
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  - Dennis, P. A., Kimbrel, N. A., Sherwood, A., Calhoun, P. S., Watkins, L. L., Dennis, M. F., & Beckham, J. C. (2017). Trauma and Autonomic Dysregulation: Episodic-Versus Systemic-Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder. Psychosom Med, 79(5), 496–505. https://doi.org/10.1097/PSY.0000000000000438
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  - Dennis, N. M., Dennis, P. A., Shafer, A., Weiner, R. D., & Husain, M. M. (2017). Electroconvulsive Therapy and All-Cause Mortality in Texas, 1998-2013. J Ect, 33(1), 22–25. https://doi.org/10.1097/YCT.0000000000000340
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  - Dennis, P. A., Dennis, N. M., Van Voorhees, E. E., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2017). Moral transgression during the Vietnam War: a path analysis of the psychological impact of veterans' involvement in wartime atrocities. Anxiety Stress Coping, 30(2), 188–201. https://doi.org/10.1080/10615806.2016.1230669
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  - Wilson, S. M., Krenek, M., Dennis, P. A., Yard, S. S., Browne, K. C., & Simpson, T. L. (2017). Daily associations between PTSD, drinking, and self-appraised alcohol-related problems. Psychol Addict Behav, 31(1), 27–35. https://doi.org/10.1037/adb0000238
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  - Dennis, P. A., Kimbrel, N. A., Sherwood, A., Calhoun, P. S., Watkins, L. L., Dennis, M. F., & Beckham, J. C. (2016). Trauma and Autonomic Dysregulation: Episodic - Versus Systemic - Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder. Psychosom Med. https://doi.org/10.1097/PSY.0000000000000438
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  - Christofferson, D. E., Hertzberg, J. S., Beckham, J. C., Dennis, P. A., & Hamlett-Berry, K. (2016). Engagement and abstinence among users of a smoking cessation text message program for veterans. Addict Behav, 62, 47–53. https://doi.org/10.1016/j.addbeh.2016.06.016
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  - Dennis, P. A., & Hess, T. M. (2016). Aging-related gains and losses associated with word production in connected speech. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 23(6), 638–650. https://doi.org/10.1080/13825585.2016.1158233
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  - Rissling, M. B., Dennis, P. A., Watkins, L. L., Calhoun, P. S., Dennis, M. F., Beckham, J. C., … Ulmer, C. S. (2016). Circadian Contrasts in Heart Rate Variability Associated With Posttraumatic Stress Disorder Symptoms in a Young Adult Cohort. J Trauma Stress, 29(5), 415–421. https://doi.org/10.1002/jts.22125
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  - Dedert, E. A., Hicks, T. A., Dennis, P. A., Calhoun, P. S., & Beckham, J. C. (2016). Roles of inter-individual differences and intra-individual acute elevations in early smoking lapse in people with posttraumatic stress disorder. Addict Behav, 60, 171–176. https://doi.org/10.1016/j.addbeh.2016.04.007
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  - Dennis, P. A., Dedert, E. A., Van Voorhees, E. E., Watkins, L. L., Hayano, J., Calhoun, P. S., … Beckham, J. C. (2016). Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability. Psychosom Med, 78(7), 805–809. https://doi.org/10.1097/PSY.0000000000000326
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  - Elbogen, E. B., Dennis, P. A., & Johnson, S. C. (2016). Beyond mental illness: Targeting stronger and more direct pathways to violence. Clinical Psychological Science, 4(5), 747–759. https://doi.org/10.1177/2167702615619363
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  - Dennis, P. A., Kimbrel, N. A., Dedert, E. A., Beckham, J. C., Dennis, M. F., & Calhoun, P. S. (2016). Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial. Addict Behav, 59, 24–29. https://doi.org/10.1016/j.addbeh.2016.03.004
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  - Calhoun, P. S., Schry, A. R., Wagner, H. R., Kimbrel, N. A., Dennis, P., McDonald, S. D., … Straits-Troster, K. (2016). The prevalence of binge drinking and receipt of provider drinking advice among US veterans with military service in Iraq or Afghanistan. Am J Drug Alcohol Abuse, 42(3), 269–278. https://doi.org/10.3109/00952990.2015.1051185
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  - Lozada, F. T., Halberstadt, A. G., Craig, A. B., Dennis, P. A., & Dunsmore, J. C. (2016). Parents’ Beliefs about Children’s Emotions and Parents’ Emotion-Related Conversations with Their Children. Journal of Child and Family Studies, 25(5), 1525–1538. https://doi.org/10.1007/s10826-015-0325-1
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  - Dennis, P. A., Weinberg, J. B., Calhoun, P. S., Watkins, L. L., Sherwood, A., Dennis, M. F., & Beckham, J. C. (2016). An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. J Psychosom Res, 83, 33–39. https://doi.org/10.1016/j.jpsychores.2016.02.008
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  - Green, K. T., Dennis, P. A., Neal, L. C., Hobkirk, A. L., Hicks, T. A., Watkins, L. L., … Beckham, J. C. (2016). Exploring the relationship between posttraumatic stress disorder symptoms and momentary heart rate variability. J Psychosom Res, 82, 31–34. https://doi.org/10.1016/j.jpsychores.2016.01.003
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  - Lastwika, K. J., Wilson, W., Li, Q. K., Norris, J., Xu, H., Ghazarian, S. R., … Dennis, P. A. (2016). Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res, 76(2), 227–238. https://doi.org/10.1158/0008-5472.CAN-14-3362
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  - Dedert, E. A., Resick, P. A., McFall, M. E., Dennis, P. A., Olsen, M., & Beckham, J. C. (2016). Pilot Cases of Combined Cognitive Processing Therapy and Smoking Cessation for Smokers With Posttraumatic Stress Disorder. Behav Ther, 47(1), 54–65. https://doi.org/10.1016/j.beth.2015.09.002
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  - Van Voorhees, E. E., Dennis, P. A., Neal, L. C., Hicks, T. A., Calhoun, P. S., Beckham, J. C., & Elbogen, E. B. (2016). Posttraumatic Stress Disorder, Hostile Cognitions, and Aggression in Iraq/Afghanistan Era Veterans. Psychiatry, 79(1), 70–84. https://doi.org/10.1080/00332747.2015.1123593
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  - Carpenter, V. L., Hertzberg, J. S., Kirby, A. C., Calhoun, P. S., Moore, S. D., Dennis, M. F., … Beckham, J. C. (2015). Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans. J Clin Psychiatry, 76(7), 959–964. https://doi.org/10.4088/JCP.14m09053
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  - Kawabata, S., Hollander, M. C., Munasinghe, J. P., Brinster, L. R., Mercado-Matos, J. R., Li, J., … Dennis, P. A. (2015). Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. Oncotarget, 6(13), 11357–11368. https://doi.org/10.18632/oncotarget.3605
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  - Oddone, A. E., Dennis, P. A., Calhoun, P. S., Watkins, L. L., Sherwood, A., Dedert, E. A., … Beckham, J. C. (2015). Orthostatic hypotension in young adults with and without posttraumatic stress disorder. Psychol Trauma, 7(3), 229–233. https://doi.org/10.1037/a0036716
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  - Kawabata, S., Heredia, A., Gills, J., Redfield, R. R., Dennis, P. A., & Bryant, J. (2015). Impact of HIV on lung tumorigenesis in an animal model. Aids, 29(5), 633–635. https://doi.org/10.1097/QAD.0000000000000588
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  - Malte, C. A., Dennis, P. A., Saxon, A. J., McFall, M., Carmody, T. P., Unger, W., & Beckham, J. C. (2015). Tobacco use trajectories among a large cohort of treated smokers with posttraumatic stress disorder. Addict Behav, 41, 238–246. https://doi.org/10.1016/j.addbeh.2014.10.034
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  - Gentes, E., Dennis, P. A., Kimbrel, N. A., Kirby, A. C., Hair, L. P., Beckham, J. C., & Calhoun, P. S. (2015). Latent Factor Structure of DSM-5 Posttraumatic Stress Disorder. Psychopathol Rev, 2(1), 17–29. https://doi.org/10.5127/pr.035914
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  - Gentes, E. L., Dennis, P. A., Kimbrel, N. A., Rissling, M. B., Beckham, J. C., VA Mid-Atlantic MIRECC Workgroup, ., & Calhoun, P. S. (2014). DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis. J Psychiatr Res, 59, 60–67. https://doi.org/10.1016/j.jpsychires.2014.08.014
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  - Dennis, P. A., Watkins, L. L., Calhoun, P. S., Oddone, A., Sherwood, A., Dennis, M. F., … Beckham, J. C. (2014). Posttraumatic stress, heart rate variability, and the mediating role of behavioral health risks. Psychosom Med, 76(8), 629–637. https://doi.org/10.1097/PSY.0000000000000110
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  - Blumenthal, G. M., Gills, J. J., Ballas, M. S., Bernstein, W. B., Komiya, T., Dechowdhury, R., … Dennis, P. A. (2014). A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors. Oncotarget, 5(18), 8161–8172. https://doi.org/10.18632/oncotarget.2415
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  - Mitchell, J. T., Dennis, M. F., English, J. S., Dennis, P. A., Brightwood, A., Beckham, J. C., & Kollins, S. H. (2014). Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder. Subst Use Misuse, 49(11), 1446–1456. https://doi.org/10.3109/10826084.2014.912229
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  - Green, K. T., Hayward, L. C., Williams, A. M., Dennis, P. A., Bryan, B. C., Taber, K. H., … Calhoun, P. S. (2014). Examining the factor structure of the Connor-Davidson Resilience Scale (CD-RISC) in a post-9/11 U.S. military veteran sample. Assessment, 21(4), 443–451. https://doi.org/10.1177/1073191114524014
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  - Dennis, P. A., Ulmer, C. S., Calhoun, P. S., Sherwood, A., Watkins, L. L., Dennis, M. F., & Beckham, J. C. (2014). Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia. J Psychosom Res, 77(1), 45–50. https://doi.org/10.1016/j.jpsychores.2014.05.001
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  - Dogan, I., Kawabata, S., Bergbower, E., Gills, J. J., Ekmekci, A., Wilson, W., … Dennis, P. A. (2014). SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines. Lung Cancer, 85(1), 1–6. https://doi.org/10.1016/j.lungcan.2014.03.021
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  - Wilson, S. M., Dedert, E. A., Dennis, P. A., Dennis, M. F., Calhoun, P. S., Kirby, A. C., & Beckham, J. C. (2014). Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse? Addict Behav, 39(7), 1163–1167. https://doi.org/10.1016/j.addbeh.2014.03.016
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  - Kawabata, S., Mercado-Matos, J. R., Hollander, M. C., Donahue, D., Wilson, W., Regales, L., … Dennis, P. A. (2014). Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M. Cell Rep, 7(6), 1824–1832. https://doi.org/10.1016/j.celrep.2014.05.039
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  - Volz, A. R., Dennis, P. A., Dennis, M. F., Calhoun, P. S., Wilson, S. M., & Beckham, J. C. (2014). The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt. Nicotine Tob Res, 16(6), 872–875. https://doi.org/10.1093/ntr/ntt286
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  - Kalu, N. N., Desai, P. J., Shirley, C. M., Gibson, W., Dennis, P. A., & Ambinder, R. F. (2014). Nelfinavir inhibits maturation and export of herpes simplex virus 1. J Virol, 88(10), 5455–5461. https://doi.org/10.1128/JVI.03790-13
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  - Dedert, E. A., Dennis, P. A., Swinkels, C. M., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2014). Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. Nicotine Tob Res, 16(4), 430–436. https://doi.org/10.1093/ntr/ntt167
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  - Shtivelman, E., Hensing, T., Simon, G. R., Dennis, P. A., Otterson, G. A., Bueno, R., & Salgia, R. (2014). Molecular pathways and therapeutic targets in lung cancer. Oncotarget, 5(6), 1392–1433. https://doi.org/10.18632/oncotarget.1891
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  - Kawabata, S., Chiang, C.-T., Tsurutani, J., Shiga, H., Arwood, M. L., Komiya, T., … Dennis, P. A. (2014). Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer. Oncotarget, 5(4), 1062–1070. https://doi.org/10.18632/oncotarget.1760
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  - Van Voorhees, E. E., Dennis, P. A., Elbogen, E. B., Clancy, C. P., Hertzberg, M. A., Beckham, J. C., & Calhoun, P. S. (2014). Personality assessment inventory internalizing and externalizing structure in veterans with posttraumatic stress disorder: associations with aggression. Aggress Behav, 40(6), 582–592. https://doi.org/10.1002/ab.21554
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  - Shuch, B., Ricketts, C. J., Vocke, C. D., Komiya, T., Middelton, L. A., Kauffman, E. C., … Linehan, W. M. (2013). Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer. J Urol, 190(6), 1990–1998. https://doi.org/10.1016/j.juro.2013.06.012
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  - Hertzberg, J. S., Carpenter, V. L., Kirby, A. C., Calhoun, P. S., Moore, S. D., Dennis, M. F., … Beckham, J. C. (2013). Mobile contingency management as an adjunctive smoking cessation treatment for smokers with posttraumatic stress disorder. Nicotine Tob Res, 15(11), 1934–1938. https://doi.org/10.1093/ntr/ntt060
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  - Hess, T. M., Popham, L. E., Dennis, P. A., & Emery, L. (2013). Information content moderates positivity and negativity biases in memory. Psychol Aging, 28(3), 853–863. https://doi.org/10.1037/a0031440
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  - Quinn, B. J., Kitagawa, H., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2013). Repositioning metformin for cancer prevention and treatment. Trends Endocrinol Metab, 24(9), 469–480. https://doi.org/10.1016/j.tem.2013.05.004
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  - Quinn, B. J., Dallos, M., Kitagawa, H., Kunnumakkara, A. B., Memmott, R. M., Hollander, M. C., … Dennis, P. A. (2013). Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling. Cancer Prevention Research, 6(8), 801–810. https://doi.org/10.1158/1940-6207.CAPR-13-0058-T
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  - Thomas, A., Xi, L., Carter, C. A., Rajan, A., Khozin, S., Szabo, E., … Raffeld, M. (2013). Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations. Clin Lung Cancer, 14(4), 452–456. https://doi.org/10.1016/j.cllc.2013.01.005
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  - Kalin, A., Merideth, M. A., Regier, D. S., Blumenthal, G. M., Dennis, P. A., & Stratton, P. (2013). Management of reproductive health in Cowden syndrome complicated by endometrial polyps and breast cancer. Obstet Gynecol, 121(2 Pt 2 Suppl 1), 461–464.
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  - Dennis, P. A., & Halberstadt, A. G. (2013). Is believing seeing? The role of emotion-related beliefs in selective attention to affective cues. Cogn Emot, 27(1), 3–20. https://doi.org/10.1080/02699931.2012.680578
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  - Tzarum, N., Eisenberg-Domovich, Y., Gills, J. J., Dennis, P. A., & Livnah, O. (2012). Lipid molecules induce p38α activation via a novel molecular switch. J Mol Biol, 424(5), 339–353. https://doi.org/10.1016/j.jmb.2012.10.007
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  - Mai, P. L., Malkin, D., Garber, J. E., Schiffman, J. D., Weitzel, J. N., Strong, L. C., … Savage, S. A. (2012). Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium. Cancer Genet, 205(10), 479–487. https://doi.org/10.1016/j.cancergen.2012.06.008
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  - Kawabata, S., Gills, J. J., Mercado-Matos, J. R., Lopiccolo, J., Wilson, W., Hollander, M. C., & Dennis, P. A. (2012). Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. Cell Death Dis, 3(7), e353. https://doi.org/10.1038/cddis.2012.87
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  - Gills, J. J., Zhang, C., Abu-Asab, M. S., Castillo, S. S., Marceau, C., LoPiccolo, J., … Dennis, P. A. (2012). Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. Cell Death Dis, 3(7), e340. https://doi.org/10.1038/cddis.2012.72
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  - West, L., Vidwans, S. J., Campbell, N. P., Shrager, J., Simon, G. R., Bueno, R., … Salgia, R. (2012). A novel classification of lung cancer into molecular subtypes. Plos One, 7(2), e31906. https://doi.org/10.1371/journal.pone.0031906
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  - Maier, C. R., Hollander, M. C., Hobbs, E. A., Dogan, I., Linnoila, R. I., & Dennis, P. A. (2011). Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. Cancer Prev Res (Phila), 4(11), 1743–1751. https://doi.org/10.1158/1940-6207.CAPR-11-0365
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  - West, K. A., & Dennis, P. A. (2011). Starting with the ABCs: Akt in breast cancer. Mol Cancer Ther, 10(11), 2031. https://doi.org/10.1158/1535-7163.MCT-11-0712
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  - Hollander, M. C., Zhou, X., Maier, C. R., Patterson, A. D., Ding, X., & Dennis, P. A. (2011). A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. Carcinogenesis, 32(8), 1279–1284. https://doi.org/10.1093/carcin/bgr097
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  - Zhang, C., Elkahloun, A. G., Liao, H., Delaney, S., Saber, B., Morrow, B., … Dennis, P. A. (2011). Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells. Mol Cancer Ther, 10(7), 1137–1148. https://doi.org/10.1158/1535-7163.MCT-10-1028
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  - Hollander, M. C., Blumenthal, G. M., & Dennis, P. A. (2011). Erratum: PTEN loss in the continuum of common cancers, rare syndromes and mouse models (Nature Reviews Cancer (2011) 11 (289-301)). Nature Reviews Cancer, 11(6), 437. https://doi.org/10.1038/nrc3085
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  - Hollander, M. C., Maier, C. R., Hobbs, E. A., Ashmore, A. R., Linnoila, R. I., & Dennis, P. A. (2011). Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Oncogene, 30(15), 1812–1821. https://doi.org/10.1038/onc.2010.556
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  - Hollander, M. C., Blumenthal, G. M., & Dennis, P. A. (2011). PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer, 11(4), 289–301. https://doi.org/10.1038/nrc3037
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  - Halberstadt, A. G., Dennis, P. A., & Hess, U. (2011). The Influence of Family Expressiveness, Individuals' Own Emotionality, and Self-Expressiveness on Perceptions of Others' Facial Expressions. Journal of Nonverbal Behavior, 35(1), 35–50. https://doi.org/10.1007/s10919-010-0099-5
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  - Zhang, C., Elkahloun, A. G., Robertson, M., Gills, J. J., Tsurutani, J., Shih, J. H., … Dennis, P. A. (2011). Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance. Plos One, 6(8), e23849. https://doi.org/10.1371/journal.pone.0023849
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  - Memmott, R. M., Mercado, J. R., Maier, C. R., Kawabata, S., Fox, S. D., & Dennis, P. A. (2010). Metformin prevents tobacco carcinogen--induced lung tumorigenesis. Cancer Prev Res (Phila), 3(9), 1066–1076. https://doi.org/10.1158/1940-6207.CAPR-10-0055
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  - Memmott, R. M., & Dennis, P. A. (2010). The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res, 16(1), 4–10. https://doi.org/10.1158/1078-0432.CCR-09-0234
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  - Memmott, R. M., & Dennis, P. A. (2009). LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin. J Clin Oncol, 27(34), e226. https://doi.org/10.1200/JCO.2009.25.3963
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  - Memmott, R. M., & Dennis, P. A. (2009). Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal, 21(5), 656–664. https://doi.org/10.1016/j.cellsig.2009.01.004
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  - Wang, Y., Digiovanna, J. J., Stern, J. B., Hornyak, T. J., Raffeld, M., Khan, S. G., … Kraemer, K. H. (2009). Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas. Proc Natl Acad Sci U S A, 106(15), 6279–6284. https://doi.org/10.1073/pnas.0812401106
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  - Han, W., Gills, J. J., Memmott, R. M., Lam, S., & Dennis, P. A. (2009). The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. Cancer Prev Res (Phila), 2(4), 370–376. https://doi.org/10.1158/1940-6207.CAPR-08-0209
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  - Gills, J. J., & Dennis, P. A. (2009). Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep, 11(2), 102–110. https://doi.org/10.1007/s11912-009-0016-4
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  - Dennis, P. A. (2009). Rapamycin for chemoprevention of upper aerodigestive tract cancers. Cancer Prev Res (Phila), 2(1), 7–9. https://doi.org/10.1158/1940-6207.CAPR-08-0215
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  - Granville, C. A., Memmott, R. M., Balogh, A., Mariotti, J., Kawabata, S., Han, W., … Dennis, P. A. (2009). A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. Plos One, 4(3), e5061. https://doi.org/10.1371/journal.pone.0005061
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  - Bernstein, W. B., & Dennis, P. A. (2008). Repositioning HIV protease inhibitors as cancer therapeutics. Current Opinion in Hiv and Aids, 3(6), 666–675. https://doi.org/10.1097/COH.0b013e328313915d
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  - Blumenthal, G. M., & Dennis, P. A. (2008). PTEN hamartoma tumor syndromes. Eur J Hum Genet, 16(11), 1289–1300. https://doi.org/10.1038/ejhg.2008.162
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  - Hollander, M. C., Balogh, A. R., Liwanag, J., Han, W., Linnoila, R. I., Anver, M. R., & Dennis, P. A. (2008). Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice. Neoplasia, 10(8), 866–872. https://doi.org/10.1593/neo.08406
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  - Blumenthal, G. M., & Dennis, P. A. (2008). Germline PTEN mutations as a cause of early-onset endometrial cancer. J Clin Oncol, 26(13), 2234. https://doi.org/10.1200/JCO.2007.15.8949
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  - Memmott, R. M., Gills, J. J., Hollingshead, M., Powers, M. C., Chen, Z., Kemp, B., … Dennis, P. A. (2008). Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res, 68(2), 580–588. https://doi.org/10.1158/0008-5472.CAN-07-3091
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  - Gills, J. J., Lopiccolo, J., & Dennis, P. A. (2008). Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. Autophagy, 4(1), 107–109. https://doi.org/10.4161/auto.5224
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  - LoPiccolo, J., Blumenthal, G. M., Bernstein, W. B., & Dennis, P. A. (2008). Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat, 11(1–2), 32–50. https://doi.org/10.1016/j.drup.2007.11.003
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  - Gills, J. J., Castillo, S. S., Zhang, C., Petukhov, P. A., Memmott, R. M., Hollingshead, M., … Dennis, P. A. (2007). Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. J Biol Chem, 282(37), 27020–27029. https://doi.org/10.1074/jbc.M701108200
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  - Gills, J. J., Lopiccolo, J., Tsurutani, J., Shoemaker, R. H., Best, C. J. M., Abu-Asab, M. S., … Dennis, P. A. (2007). Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res, 13(17), 5183–5194. https://doi.org/10.1158/1078-0432.CCR-07-0161
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  - LoPiccolo, J., Granville, C. A., Gills, J. J., & Dennis, P. A. (2007). Targeting Akt in cancer therapy. Anticancer Drugs, 18(8), 861–874. https://doi.org/10.1097/CAD.0b013e3280cc2c6f
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  - Lopiccolo, J., Ballas, M. S., & Dennis, P. A. (2007). PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development. Crit Rev Oncol Hematol, 63(3), 203–214. https://doi.org/10.1016/j.critrevonc.2007.06.002
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  - Granville, C. A., Warfel, N., Tsurutani, J., Hollander, M. C., Robertson, M., Fox, S. D., … Dennis, P. A. (2007). Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors. Clin Cancer Res, 13(7), 2281–2289. https://doi.org/10.1158/1078-0432.CCR-06-2570
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  - Lipkowitz, S., & Dennis, P. A. (2007). PPARgamma agonists follow an unknown TRAIL in lung cancer. Cancer Biol Ther, 6(1), 107–109. https://doi.org/10.4161/cbt.6.1.3751
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  - Tsurutani, J., Steinberg, S. M., Ballas, M., Robertson, M., LoPiccolo, J., Soda, H., … Dennis, P. A. (2007). Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. Lung Cancer, 55(1), 115–121. https://doi.org/10.1016/j.lungcan.2006.09.026
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  - Warfel, N. A., Lepper, E. R., Zhang, C., Figg, W. D., & Dennis, P. A. (2006). Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res, 12(11 Pt 1), 3502–3509. https://doi.org/10.1158/1078-0432.CCR-05-1837
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  - Tsurutani, J., Ballas, M. S., & Dennis, P. A. (2006). Overestimating the influence of the 1999 WHO classification of lung tumors on survival in bronchioloalveloar carcinoma. J Clin Oncol, 24(12), 1963. https://doi.org/10.1200/JCO.2005.05.1318
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  - Gills, J. J., Holbeck, S., Hollingshead, M., Hewitt, S. M., Kozikowski, A. P., & Dennis, P. A. (2006). Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt. Mol Cancer Ther, 5(3), 713–722. https://doi.org/10.1158/1535-7163.MCT-05-0484
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  - Granville, C. A., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2006). Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway. Clin Cancer Res, 12(3 Pt 1), 679–689. https://doi.org/10.1158/1078-0432.CCR-05-1654
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  - O’Mahony, D., & Dennis, P. A. (2006). Using immunotherapy to target EGF in patients with NSCLC. Cancer Biol Ther, 5(2), 150–151. https://doi.org/10.4161/cbt.5.2.2557
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  - Tsurutani, J., Ballas, M., Steinberg, S. M., Egilsson, V., & Dennis, P. A. (2006). Gefitinib for refractory advanced non-small-cell lung cancer. Lancet, 367(9507), 300. https://doi.org/10.1016/S0140-6736(06)68064-1
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  - Tsurutani, J., Fukuoka, J., Tsurutani, H., Shih, J. H., Hewitt, S. M., Travis, W. D., … Dennis, P. A. (2006). Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J Clin Oncol, 24(2), 306–314. https://doi.org/10.1200/JCO.2005.02.4133
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  - Ballas, M. S., & Dennis, P. A. (2005). A slow disengagement from platinum-based chemotherapy for patients with advanced non-small cell lung cancer. Cancer Biol Ther, 4(12), 1316–1317. https://doi.org/10.4161/cbt.4.12.2488
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  - Tsurutani, J., West, K. A., Sayyah, J., Gills, J. J., & Dennis, P. A. (2005). Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. Cancer Res, 65(18), 8423–8432. https://doi.org/10.1158/0008-5472.CAN-05-0058
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  - Coxon, A., Rozenblum, E., Park, Y.-S., Joshi, N., Tsurutani, J., Dennis, P. A., … Kaye, F. J. (2005). Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res, 65(16), 7137–7144. https://doi.org/10.1158/0008-5472.CAN-05-1125
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  - Tsurutani, J., Castillo, S. S., Brognard, J., Granville, C. A., Zhang, C., Gills, J. J., … Dennis, P. A. (2005). Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis, 26(7), 1182–1195. https://doi.org/10.1093/carcin/bgi072
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  - Li, Z., Jaboin, J., Dennis, P. A., & Thiele, C. J. (2005). Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. Cancer Res, 65(6), 2070–2075. https://doi.org/10.1158/0008-5472.CAN-04-3606
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  - Fiala, E. S., Sohn, O. S., Wang, C.-X., Seibert, E., Tsurutani, J., Dennis, P. A., … Aliaga, C. (2005). Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E. Carcinogenesis, 26(3), 605–612. https://doi.org/10.1093/carcin/bgh341
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  - Granville, C. A., & Dennis, P. A. (2005). An overview of lung cancer genomics and proteomics. Am J Respir Cell Mol Biol, 32(3), 169–176. https://doi.org/10.1165/rcmb.F290
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  - Carón, R. W., Yacoub, A., Li, M., Zhu, X., Mitchell, C., Hong, Y., … Dent, P. (2005). Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther, 4(2), 257–270.
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  - Tsurutani, J., & Dennis, P. A. (2004). Re: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst, 96(23), 1795. https://doi.org/10.1093/jnci/djh342
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  - Dennis, P. A. (2004). Disparities in cancer funding. Science, 305(5689), 1401–1402. https://doi.org/10.1126/science.305.5689.1401e
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  - Gills, J. J., & Dennis, P. A. (2004). The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. Expert Opin Investig Drugs, 13(7), 787–797. https://doi.org/10.1517/13543784.13.7.787
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  - Castillo, S. S., Brognard, J., Petukhov, P. A., Zhang, C., Tsurutani, J., Granville, C. A., … Dennis, P. A. (2004). Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. Cancer Res, 64(8), 2782–2792. https://doi.org/10.1158/0008-5472.can-03-1530
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  - Gills, J. J., Granville, C. A., & Dennis, P. A. (2004). Targeting aberrant signal transduction pathways in lung cancer. Cancer Biol Ther, 3(2), 147–155. https://doi.org/10.4161/cbt.3.2.612
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  - West, K. A., Linnoila, I. R., Belinsky, S. A., Harris, C. C., & Dennis, P. A. (2004). Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. Cancer Res, 64(2), 446–451. https://doi.org/10.1158/0008-5472.can-03-3241
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  - Lorenzo, P. S., & Dennis, P. A. (2003). Modulating protein kinase C (PKC) to increase the efficacy of chemotherapy: stepping into darkness. Drug Resist Updat, 6(6), 329–339. https://doi.org/10.1016/j.drup.2003.10.003
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  - Bianco, R., Shin, I., Ritter, C. A., Yakes, F. M., Basso, A., Rosen, N., … Arteaga, C. L. (2003). Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene, 22(18), 2812–2822. https://doi.org/10.1038/sj.onc.1206388
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  - Clark, A. S., West, K. A., Blumberg, P. M., & Dennis, P. A. (2003). Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. Cancer Res, 63(4), 780–786.
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  - Kozikowski, A. P., Sun, H., Brognard, J., & Dennis, P. A. (2003). Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J Am Chem Soc, 125(5), 1144–1145. https://doi.org/10.1021/ja0285159
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  - West, K. A., Brognard, J., Clark, A. S., Linnoila, I. R., Yang, X., Swain, S. M., … Dennis, P. A. (2003). Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest, 111(1), 81–90. https://doi.org/10.1172/JCI16147
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  - West, K. A., Castillo, S. S., & Dennis, P. A. (2002). Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat, 5(6), 234–248. https://doi.org/10.1016/s1368-7646(02)00120-6
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  - Brognard, J., & Dennis, P. A. (2002). Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. Cell Death Differ, 9(9), 893–904. https://doi.org/10.1038/sj.cdd.4401054
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  - Clark, A. S., West, K., Streicher, S., & Dennis, P. A. (2002). Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther, 1(9), 707–717.
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  - Cuello, M., Ettenberg, S. A., Clark, A. S., Keane, M. M., Posner, R. H., Nau, M. M., … Lipkowitz, S. (2001). Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res, 61(12), 4892–4900.
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  - Brognard, J., Clark, A. S., Ni, Y., & Dennis, P. A. (2001). Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res, 61(10), 3986–3997.
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  - Kastanos, E. K., Zajac-Kaye, M., Dennis, P. A., & Allegra, C. J. (2001). Downregulation of p21/WAF1 expression by thymidylate synthase. Biochemical and Biophysical Research Communications, 285(2), 195–200. https://doi.org/10.1006/bbrc.2001.5145
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  - Dennis, P. A., & Kastan, M. B. (1998). Cellular survival pathways and resistance to cancer therapy. Drug Resist Updat, 1(5), 301–309. https://doi.org/10.1016/s1368-7646(98)80046-0
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  - Kastan, M. B., Morgan, S. E., Siliciano, J., Kirsch, D., Dennis, P., & Canman, C. E. (1997). Cell cycle and cell death after DNA damaye. Faseb Journal, 11(9).
  - Dennis, P. A., & Rifkin, D. B. (1991). Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A, 88(2), 580–584. https://doi.org/10.1073/pnas.88.2.580
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  - Rifkin, D. B., Moscatelli, D., Bizik, J., Quarto, N., Blei, F., Dennis, P., … Mignatti, P. (1990). Growth factor control of extracellular proteolysis. Cell Differ Dev, 32(3), 313–318. https://doi.org/10.1016/0922-3371(90)90045-x
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  - Dennis, P. A., & Rifkin, D. B. (1990). Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. J Cell Physiol, 144(1), 84–98. https://doi.org/10.1002/jcp.1041440112
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  - Dennis, P. A., Saksela, O., Harpel, P., & Rifkin, D. B. (1989). Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor. J Biol Chem, 264(13), 7210–7216.
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- Book Sections
  - Granville, C. A., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2008). Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway. In Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (Vol. 2, pp. 966–996). https://doi.org/10.1002/9783527619665.ch38
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- Conference Papers
  - de Wit, M., Gray, J. E., Villegas, A., Daniel, D., Vicente, D., Murakami, S., … Reck, M. (2019). Three-year overall survival update from the PACIFIC trial. In Oncology Research and Treatment (Vol. 42, pp. 76–76).
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  - Van Voorhees, E., Dennis, P. A., Carter, L., Neal, L. C., Calhoun, P., Beckham, J., & Watkins, L. (2018). MEASURING HEART RATE VARIABILITY USING THE EMPATICA E4 WRISTBAND: RELIABILITY WITH HOLTER MONITOR. In Annals of Behavioral Medicine (Vol. 52, pp. S779–S779). OXFORD UNIV PRESS INC.
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  - Christofferson, D., Dennis, P. A., Hertzberg, J., Beckham, J. C., Hamlett-Berry, K., & Augustson, E. (2016). USE AND EFFECTS OF "KEYWORDS" COMPONENT DURING A SMOKING CESSATION TEXTING PROGRAM FOR VETERANS. In Annals of Behavioral Medicine (Vol. 50, pp. S333–S333). OXFORD UNIV PRESS INC.
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  - West, K. A., Linnoila, I. R., Brognard, J., Belinsky, S., Harris, C., & Dennis, P. A. (2004). Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo. In Chest (Vol. 125, pp. 101S-102S). United States. https://doi.org/10.1378/chest.125.5_suppl.101s
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