Paul Anthony Dennis
Associate Professor in Population Health Sciences
Developmental psychologist, statistician, and data scientist. Research focused on cardiovascular risk associated with psychiatric illness and trauma exposure, intraindivdiual variability in symptoms and affect, and the use of mobile apps and devices for health and behavior monitoring and interventions. Interest in longitudinal and repeated-measures analyses, mediation analyses, machine learning, and applications to administrative healthcare data.
Current Appointments & Affiliations
- Associate Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2021
Contact Information
- Box 3625, Durham, NC 27710
- Box 3625, Durham, NC 27710
-
paul.dennis@duke.edu
(919) 286-0411
- Background
-
Education, Training, & Certifications
- Ph.D., North Carolina State University 2012
-
Previous Appointments & Affiliations
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2021
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2019 - 2020
- Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2015 - 2019
- Medical Instructor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2014 - 2015
-
Academic Positions Outside Duke
- Faculty Statistician, Durham Veterans Affairs Medical Center. 2021 - 2029
- Research
-
Selected Grants
- Cost Effectiveness of Combined Contingency Management and Cognitive Behavioral Therapy for Alcohol Use Disorder awarded by National Institutes of Health 2019 - 2024
- Impact of Reduced Cannabis Use on Functional Outcomes awarded by National Institutes of Health 2018 - 2023
- Neuromodulatory Treatments for Pain Management in Complex TBI using Mobile Technology awarded by Department of Defense 2017 - 2022
- Association of Posttraumatic Stress Disorder and Heart Disease in Women Veterans: Examining Risk Factors and Effects of Pharmacotherapy on Clinical Outcomes awarded by The Regents of the University of California 2018 - 2022
- Mobile contingency management for smoking cessation in returning US Veterans awarded by National Institutes of Health 2015 - 2020
- Pain Management using Mobile Technology in Veterans with PTSD and TBI awarded by National Institutes of Health 2014 - 2018
- Neural Markers and Rehabilitation of Executive Functioning in Veterans with TBI and PTSD awarded by University of North Carolina - Chapel Hill 2016 - 2017
- missing activity
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Senan, S., Özgüroğlu, M., Daniel, D., Villegas, A., Vicente, D., Murakami, S., … Antonia, S. J. (2022). Outcomes with durvalumab after chemoradiotherapy in stage IIIA-N2 non-small-cell lung cancer: an exploratory analysis from the PACIFIC trial. Esmo Open, 7(2), 100410. https://doi.org/10.1016/j.esmoop.2022.100410Full Text Link to Item
-
Van Voorhees, E. E., Dennis, P. A., Watkins, L. L., Patel, T. A., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2022). Ambulatory Heart Rate Variability Monitoring: Comparisons Between the Empatica E4 Wristband and Holter Electrocardiogram. Psychosom Med, 84(2), 210–214. https://doi.org/10.1097/PSY.0000000000001010Full Text Link to Item
-
Xu, Y., Towe, S. L., Causey, S. T., Dennis, P. A., & Meade, C. S. (2022). Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study. Exp Clin Psychopharmacol, 30(1), 39–50. https://doi.org/10.1037/pha0000423Full Text Link to Item
-
Pore, N., Wu, S., Standifer, N., Jure-Kunkel, M., de Los Reyes, M., Shrestha, Y., … Oberst, M. D. (2021). Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown. Cancer Discov, 11(11), 2828–2845. https://doi.org/10.1158/2159-8290.CD-20-1543Full Text Link to Item
-
Van Voorhees, E. E., Dillon, K. H., Wilson, S. M., Dennis, P. A., Neal, L. C., Medenblik, A. M., … Beckham, J. C. (2021). A Comparison of Group Anger Management Treatments for Combat Veterans With PTSD: Results From a Quasi-Experimental Trial. J Interpers Violence, 36(19–20), NP10276–NP10300. https://doi.org/10.1177/0886260519873335Full Text Link to Item
-
Ebrahimi, R., Lynch, K. E., Beckham, J. C., Dennis, P. A., Viernes, B., Tseng, C.-H., … Sumner, J. A. (2021). Association of Posttraumatic Stress Disorder and Incident Ischemic Heart Disease in Women Veterans. Jama Cardiol, 6(6), 642–651. https://doi.org/10.1001/jamacardio.2021.0227Full Text Link to Item
-
Christofferson, D. E., Dennis, P. A., Hertzberg, J. S., Beckham, J. C., Knoeppel, J., & Hamlett-Berry, K. (2021). Real-World Utilization and Outcomes of the Veterans Health Administration's Smoking Cessation Text Message Program. Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 23(6), 931–938. https://doi.org/10.1093/ntr/ntaa183Full Text
-
Dillon, K. H., Glenn, J. J., Dennis, P. A., LoSavio, S. T., Cassiello-Robbins, C., Gromatsky, M. A., … Kimbrel, N. A. (2021). Anger precedes and predicts nonsuicidal self-injury in veterans: Findings from an ecological momentary assessment study. J Psychiatr Res, 135, 47–51. https://doi.org/10.1016/j.jpsychires.2021.01.011Full Text Link to Item
-
Elbogen, E. B., Alsobrooks, A., Battles, S., Molloy, K., Dennis, P. A., Beckham, J. C., … Russoniello, C. (2021). Mobile Neurofeedback for Pain Management in Veterans with TBI and PTSD. Pain Med, 22(2), 329–337. https://doi.org/10.1093/pm/pnz269Full Text Link to Item
-
Kawabata, S., Connis, N., Gills, J. J., Hann, C. L., & Dennis, P. A. (2021). Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors. Anticancer Res, 41(1), 91–99. https://doi.org/10.21873/anticanres.14754Full Text Link to Item
-
Lopiccolo, J., Kawabata, S., Gills, J. J., & Dennis, P. A. (2021). Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors. In Vivo, 35(1), 141–145. https://doi.org/10.21873/invivo.12241Full Text Link to Item
-
Ouwens, M., Darilay, A., Zhang, Y., Mukhopadhyay, P., Mann, H., Ryan, J., & Dennis, P. A. (2021). Assessing the Influence of Subsequent Immunotherapy on Overall Survival in Patients with Unresectable Stage III Non–Small Cell Lung Cancer from the PACIFIC Study. Current Therapeutic Research Clinical and Experimental, 95. https://doi.org/10.1016/j.curtheres.2021.100640Full Text
-
Sumner, J. A., Lynch, K. E., Viernes, B., Beckham, J. C., Coronado, G., Dennis, P. A., … Ebrahimi, R. (2021). Military Sexual Trauma and Adverse Mental and Physical Health and Clinical Comorbidity in Women Veterans. Womens Health Issues, 31(6), 586–595. https://doi.org/10.1016/j.whi.2021.07.004Full Text Link to Item
-
Glenn, J. J., Dillon, K. H., Dennis, P. A., Patel, T. A., Mann, A. J., Calhoun, P. S., … Elbogen, E. B. (2020). Post-traumatic symptom severity mediates the association between combat exposure and suicidal ideation in veterans. Suicide Life Threat Behav, 50(6), 1167–1172. https://doi.org/10.1111/sltb.12678Full Text Link to Item
-
Ye, J., Ji, X., Dennis, P. A., Abdullah, H., & Mukhopadhyay, P. (2020). Relationship Between Progression-Free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune Checkpoint Blockade: A Meta-Analysis. Clin Pharmacol Ther, 108(6), 1274–1288. https://doi.org/10.1002/cpt.1956Full Text Link to Item
-
Zhang, Q., Luo, J., Wu, S., Si, H., Gao, C., Xu, W., … Hellmann, M. D. (2020). Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade. Cancer Discov, 10(12), 1842–1853. https://doi.org/10.1158/2159-8290.CD-20-0047Full Text Link to Item
-
Gopalakrishnan, V., Sellman, B. R., Cohen, T. S., & Dennis, P. A. (2020). Antibiotics and Immunotherapy: Too Much of Anything is Bad!. Eur Urol, 78(4), 544–545. https://doi.org/10.1016/j.eururo.2020.07.027Full Text Link to Item
-
Garassino, M. C., Cho, B.-C., Kim, J.-H., Mazières, J., Vansteenkiste, J., Lena, H., … Rizvi, N. A. (2020). Final overall survival and safety update for durvalumab in third- or later-line advanced NSCLC: The phase II ATLANTIC study. Lung Cancer, 147, 137–142. https://doi.org/10.1016/j.lungcan.2020.06.032Full Text Link to Item
-
Datta, S. K., Dennis, P. A., & Davis, J. M. (2020). Health benefits and economic advantages associated with increased utilization of a smoking cessation program. J Comp Eff Res, 9(11), 817–828. https://doi.org/10.2217/cer-2020-0005Full Text Open Access Copy Link to Item
-
Davis, J. M., Thomas, L. C., Dirkes, J. E., Datta, S. K., & Dennis, P. A. (2020). Comparison of referral methods into a smoking cessation program. J Comp Eff Res, 9(11), 807–815. https://doi.org/10.2217/cer-2020-0004Full Text Open Access Copy Link to Item
-
Gopalakrishnan, V., Weiner, B., Ford, C. B., Sellman, B. R., Hammond, S. A., Freeman, D. J., … Henn, M. R. (2020). Intervention strategies for microbial therapeutics in cancer immunotherapy. Immuno Oncology and Technology, 6, 9–17. https://doi.org/10.1016/j.iotech.2020.05.001Full Text
-
Dillon, K. H., Van Voorhees, E. E., Dennis, P. A., Glenn, J. J., Wilks, C. R., Morland, L. A., … Elbogen, E. B. (2020). Anger mediates the relationship between posttraumatic stress disorder and suicidal ideation in veterans. J Affect Disord, 269, 117–124. https://doi.org/10.1016/j.jad.2020.03.053Full Text Link to Item
-
Juergens, R. A., Hao, D., Ellis, P. M., Tu, D., Mates, M., Kollmannsberger, C., … Laurie, S. A. (2020). A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226. Lung Cancer, 143, 1–11. https://doi.org/10.1016/j.lungcan.2020.02.016Full Text Link to Item
-
Komiya, T., Blumenthal, G. M., DeChowdhury, R., Fioravanti, S., Ballas, M. S., Morris, J., … Dennis, P. A. (2019). A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN. Oncologist, 24(12), 1510-e1265. https://doi.org/10.1634/theoncologist.2019-0514Full Text Link to Item
-
Norberg, M. M., Newins, A. R., Crone, C., Ham, L. S., Henry, A., Mills, L., & Dennis, P. A. (2019). Why are caffeinated alcoholic beverages especially risky? Addict Behav, 98, 106062. https://doi.org/10.1016/j.addbeh.2019.106062Full Text Link to Item
-
Sridhar, S., Paz-Ares, L., Liu, H., Shen, K., Morehouse, C., Rizvi, N., … Ranade, K. (2019). Prognostic Significance of Liver Metastasis in Durvalumab-Treated Lung Cancer Patients. Clin Lung Cancer, 20(6), e601–e608. https://doi.org/10.1016/j.cllc.2019.06.020Full Text Link to Item
-
Dennis, P. A., Neal, J. M., Travis, E., Watkins, L. L., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2019). Negative Affect-Related Autonomic Arousal Mediates the Association between Baroreflex Dysfunction and Insulin Resistance in Non-Diabetic Young Adults. J Psychophysiol, 33(4), 243–253. https://doi.org/10.1027/0269-8803/a000226Full Text Link to Item
-
Boothman, A.-M., Scott, M., Ratcliffe, M., Whiteley, J., Dennis, P. A., Wadsworth, C., … Walker, J. (2019). Impact of Patient Characteristics, Prior Therapy, and Sample Type on Tumor Cell Programmed Cell Death Ligand 1 Expression in Patients with Advanced NSCLC Screened for the ATLANTIC Study. J Thorac Oncol, 14(8), 1390–1399. https://doi.org/10.1016/j.jtho.2019.04.025Full Text Link to Item
-
Erwin, M. C., Dennis, P. A., Coughlin, L. N., Calhoun, P. S., & Beckham, J. C. (2019). Examining the relationship between negative affect and posttraumatic stress disorder symptoms among smokers using ecological momentary assessment. J Affect Disord, 253, 285–291. https://doi.org/10.1016/j.jad.2019.04.035Full Text Link to Item
-
Dennis, P. A., Thomas, S. N., Husain, M. M., & Dennis, N. M. (2019). Racial Disparities in the Administration of ECT in Texas, 1998-2013. J Ect, 35(2), 103–105. https://doi.org/10.1097/YCT.0000000000000555Full Text Link to Item
-
Gutierrez, E., Cahatol, I., Bailey, C. A. R., Lafargue, A., Zhang, N., Song, Y., … Zhang, C. (2019). Regulation of RhoB gene expression during tumorigenesis and aging process and its potential applications in these processes. Cancers, 11(6). https://doi.org/10.3390/cancers11060818Full Text
-
Komiya, T., Memmott, R. M., Blumenthal, G. M., Bernstein, W., Ballas, M. S., De Chowdhury, R., … Dennis, P. A. (2019). A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer. Translational Lung Cancer Research, 8(3), 247–257. https://doi.org/10.21037/tlcr.2019.04.19Full Text
-
Cunningham, K. C., Grossmann, J. L., Seay, K. B., Dennis, P. A., Clancy, C. P., Hertzberg, M. A., … Kimbrel, N. A. (2019). Nonsuicidal Self-Injury and Borderline Personality Features as Risk Factors for Suicidal Ideation Among Male Veterans With Posttraumatic Stress Disorder. J Trauma Stress, 32(1), 141–147. https://doi.org/10.1002/jts.22369Full Text Link to Item
-
Cunningham, K. C., LoSavio, S. T., Dennis, P. A., Farmer, C., Clancy, C. P., Hertzberg, M. A., … Beckham, J. C. (2019). Shame as a mediator between posttraumatic stress disorder symptoms and suicidal ideation among veterans. J Affect Disord, 243, 216–219. https://doi.org/10.1016/j.jad.2018.09.040Full Text Link to Item
-
Dedert, E. A., Dennis, P. A., Cunningham, K. C., Ulmer, C. S., Calhoun, P. S., Kimbrel, N., … Beckham, J. C. (2019). Roles of Guilt Cognitions in Trauma-Related Sleep Disturbance in Military Veterans With Posttraumatic Stress Disorder. Behav Sleep Med, 17(5), 595–604. https://doi.org/10.1080/15402002.2018.1435544Full Text Link to Item
-
Dedert, E. A., Resick, P. A., Dennis, P. A., Wilson, S. M., Moore, S. D., & Beckham, J. C. (2019). Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment. J Addict Med, 13(4), 322–330. https://doi.org/10.1097/ADM.0000000000000502Full Text Link to Item
-
Elbogen, E. B., Dennis, P. A., Van Voorhees, E. E., Blakey, S. M., Johnson, J. L., Johnson, S. C., … Belger, A. (2019). Cognitive Rehabilitation With Mobile Technology and Social Support for Veterans With TBI and PTSD: A Randomized Clinical Trial. J Head Trauma Rehabil, 34(1), 1–10. https://doi.org/10.1097/HTR.0000000000000435Full Text Link to Item
-
Raja, R., Kuziora, M., Brohawn, P. Z., Higgs, B. W., Gupta, A., Dennis, P. A., & Ranade, K. (2018). Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab. Clin Cancer Res, 24(24), 6212–6222. https://doi.org/10.1158/1078-0432.CCR-18-0386Full Text Link to Item
-
Antonia, S. J., Villegas, A., Daniel, D., Vicente, D., Murakami, S., Hui, R., … PACIFIC Investigators, . (2018). Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med, 379(24), 2342–2350. https://doi.org/10.1056/NEJMoa1809697Full Text Link to Item
-
Ulmer, C. S., Hall, M. H., Dennis, P. A., Beckham, J. C., & Germain, A. (2018). Posttraumatic stress disorder diagnosis is associated with reduced parasympathetic activity during sleep in US veterans and military service members of the Iraq and Afghanistan wars. Sleep, 41(12). https://doi.org/10.1093/sleep/zsy174Full Text Link to Item
-
Calhoun, P. S., Schry, A. R., Dennis, P. A., Wagner, H. R., Kimbrel, N. A., Bastian, L. A., … Straits-Tröster, K. (2018). The Association Between Military Sexual Trauma and Use of VA and Non-VA Health Care Services Among Female Veterans With Military Service in Iraq or Afghanistan. J Interpers Violence, 33(15), 2439–2464. https://doi.org/10.1177/0886260515625909Full Text Link to Item
-
Baverel, P. G., Dubois, V. F. S., Jin, C. Y., Zheng, Y., Song, X., Jin, X., … Narwal, R. (2018). Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status. Clin Pharmacol Ther, 103(4), 631–642. https://doi.org/10.1002/cpt.982Full Text Link to Item
-
Garassino, M. C., Cho, B.-C., Kim, J.-H., Mazières, J., Vansteenkiste, J., Lena, H., … ATLANTIC Investigators, . (2018). Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study. Lancet Oncol, 19(4), 521–536. https://doi.org/10.1016/S1470-2045(18)30144-XFull Text Link to Item
-
Van Voorhees, E. E., Dennis, P. A., Elbogen, E. B., Fuemmeler, B., Neal, L. C., Calhoun, P. S., & Beckham, J. C. (2018). Characterizing anger-related affect in individuals with posttraumatic stress disorder using ecological momentary assessment. Psychiatry Res, 261, 274–280. https://doi.org/10.1016/j.psychres.2017.12.080Full Text Link to Item
-
Hicks, T. A., Wilson, S. M., Thomas, S. P., Dennis, P. A., Neal, J. M., & Calhoun, P. S. (2018). Low Income as a Multiplicative Risk Factor for Oral Pain and Dental Problems Among U.S. Veteran Smokers. Int J Behav Med, 25(1), 67–73. https://doi.org/10.1007/s12529-017-9660-5Full Text Link to Item
-
Dedert, E. A., Dennis, P. A., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2018). A Randomized Clinical Trial of Nicotine Preloading for Smoking Cessation in People with Posttraumatic Stress Disorder. J Dual Diagn, 14(3), 148–157. https://doi.org/10.1080/15504263.2018.1468947Full Text Link to Item
-
Calhoun, P. S., Wilson, S. M., Hertzberg, J. S., Kirby, A. C., McDonald, S. D., Dennis, P. A., … Beckham, J. C. (2017). Validation of Veterans Affairs Electronic Medical Record Smoking Data Among Iraq- and Afghanistan-Era Veterans. J Gen Intern Med, 32(11), 1228–1234. https://doi.org/10.1007/s11606-017-4144-5Full Text Link to Item
-
Cunningham, K. C., Farmer, C., LoSavio, S. T., Dennis, P. A., Clancy, C. P., Hertzberg, M. A., … Beckham, J. C. (2017). A model comparison approach to trauma-related guilt as a mediator of the relationship between PTSD symptoms and suicidal ideation among veterans. J Affect Disord, 221, 227–231. https://doi.org/10.1016/j.jad.2017.06.046Full Text Link to Item
-
Osoegawa, A., Gills, J. J., Kawabata, S., & Dennis, P. A. (2017). Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. Oncotarget, 8(50), 87044–87053. https://doi.org/10.18632/oncotarget.19667Full Text
-
Vinesett, A. L., Whaley, R. R., Woods-Giscombe, C., Dennis, P., Johnson, M., Li, Y., … Wilson, K. H. (2017). Modified African Ngoma Healing Ceremony for Stress Reduction: A Pilot Study. J Altern Complement Med, 23(10), 800–804. https://doi.org/10.1089/acm.2016.0410Full Text Link to Item
-
Green, K. T., Wilson, S. M., Dennis, P. A., Runnals, J. J., Williams, R. A., Bastian, L. A., … Calhoun, P. S. (2017). Cigarette Smoking and Musculoskeletal Pain Severity Among Male and Female Afghanistan/Iraq Era Veterans. Pain Med, 18(9), 1795–1804. https://doi.org/10.1093/pm/pnw339Full Text Link to Item
-
Wilson, S. M., Pacek, L. R., Dennis, P. A., Bastian, L. A., Beckham, J. C., & Calhoun, P. S. (2017). Veterans Living with HIV: A High-Risk Group for Cigarette Smoking. Aids Behav, 21(7), 1950–1955. https://doi.org/10.1007/s10461-017-1717-6Full Text Link to Item
-
Dennis, P. A., Kimbrel, N. A., Sherwood, A., Calhoun, P. S., Watkins, L. L., Dennis, M. F., & Beckham, J. C. (2017). Trauma and Autonomic Dysregulation: Episodic-Versus Systemic-Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder. Psychosom Med, 79(5), 496–505. https://doi.org/10.1097/PSY.0000000000000438Full Text Link to Item
-
Dennis, N. M., Dennis, P. A., Shafer, A., Weiner, R. D., & Husain, M. M. (2017). Electroconvulsive Therapy and All-Cause Mortality in Texas, 1998-2013. J Ect, 33(1), 22–25. https://doi.org/10.1097/YCT.0000000000000340Full Text Link to Item
-
Dennis, P. A., Dennis, N. M., Van Voorhees, E. E., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2017). Moral transgression during the Vietnam War: a path analysis of the psychological impact of veterans' involvement in wartime atrocities. Anxiety Stress Coping, 30(2), 188–201. https://doi.org/10.1080/10615806.2016.1230669Full Text Link to Item
-
Wilson, S. M., Krenek, M., Dennis, P. A., Yard, S. S., Browne, K. C., & Simpson, T. L. (2017). Daily associations between PTSD, drinking, and self-appraised alcohol-related problems. Psychol Addict Behav, 31(1), 27–35. https://doi.org/10.1037/adb0000238Full Text Link to Item
-
Dennis, P. A., Kimbrel, N. A., Sherwood, A., Calhoun, P. S., Watkins, L. L., Dennis, M. F., & Beckham, J. C. (2016). Trauma and Autonomic Dysregulation: Episodic - Versus Systemic - Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder. Psychosom Med. https://doi.org/10.1097/PSY.0000000000000438Full Text Link to Item
-
Christofferson, D. E., Hertzberg, J. S., Beckham, J. C., Dennis, P. A., & Hamlett-Berry, K. (2016). Engagement and abstinence among users of a smoking cessation text message program for veterans. Addict Behav, 62, 47–53. https://doi.org/10.1016/j.addbeh.2016.06.016Full Text Link to Item
-
Dennis, P. A., & Hess, T. M. (2016). Aging-related gains and losses associated with word production in connected speech. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 23(6), 638–650. https://doi.org/10.1080/13825585.2016.1158233Full Text Link to Item
-
Rissling, M. B., Dennis, P. A., Watkins, L. L., Calhoun, P. S., Dennis, M. F., Beckham, J. C., … Ulmer, C. S. (2016). Circadian Contrasts in Heart Rate Variability Associated With Posttraumatic Stress Disorder Symptoms in a Young Adult Cohort. J Trauma Stress, 29(5), 415–421. https://doi.org/10.1002/jts.22125Full Text Link to Item
-
Dedert, E. A., Hicks, T. A., Dennis, P. A., Calhoun, P. S., & Beckham, J. C. (2016). Roles of inter-individual differences and intra-individual acute elevations in early smoking lapse in people with posttraumatic stress disorder. Addict Behav, 60, 171–176. https://doi.org/10.1016/j.addbeh.2016.04.007Full Text Link to Item
-
Dennis, P. A., Dedert, E. A., Van Voorhees, E. E., Watkins, L. L., Hayano, J., Calhoun, P. S., … Beckham, J. C. (2016). Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability. Psychosom Med, 78(7), 805–809. https://doi.org/10.1097/PSY.0000000000000326Full Text Link to Item
-
Elbogen, E. B., Dennis, P. A., & Johnson, S. C. (2016). Beyond mental illness: Targeting stronger and more direct pathways to violence. Clinical Psychological Science, 4(5), 747–759. https://doi.org/10.1177/2167702615619363Full Text
-
Dennis, P. A., Kimbrel, N. A., Dedert, E. A., Beckham, J. C., Dennis, M. F., & Calhoun, P. S. (2016). Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial. Addict Behav, 59, 24–29. https://doi.org/10.1016/j.addbeh.2016.03.004Full Text Link to Item
-
Calhoun, P. S., Schry, A. R., Wagner, H. R., Kimbrel, N. A., Dennis, P., McDonald, S. D., … Straits-Troster, K. (2016). The prevalence of binge drinking and receipt of provider drinking advice among US veterans with military service in Iraq or Afghanistan. Am J Drug Alcohol Abuse, 42(3), 269–278. https://doi.org/10.3109/00952990.2015.1051185Full Text Link to Item
-
Lozada, F. T., Halberstadt, A. G., Craig, A. B., Dennis, P. A., & Dunsmore, J. C. (2016). Parents’ Beliefs about Children’s Emotions and Parents’ Emotion-Related Conversations with Their Children. Journal of Child and Family Studies, 25(5), 1525–1538. https://doi.org/10.1007/s10826-015-0325-1Full Text
-
Dennis, P. A., Weinberg, J. B., Calhoun, P. S., Watkins, L. L., Sherwood, A., Dennis, M. F., & Beckham, J. C. (2016). An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. J Psychosom Res, 83, 33–39. https://doi.org/10.1016/j.jpsychores.2016.02.008Full Text Link to Item
-
Green, K. T., Dennis, P. A., Neal, L. C., Hobkirk, A. L., Hicks, T. A., Watkins, L. L., … Beckham, J. C. (2016). Exploring the relationship between posttraumatic stress disorder symptoms and momentary heart rate variability. J Psychosom Res, 82, 31–34. https://doi.org/10.1016/j.jpsychores.2016.01.003Full Text Link to Item
-
Lastwika, K. J., Wilson, W., Li, Q. K., Norris, J., Xu, H., Ghazarian, S. R., … Dennis, P. A. (2016). Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res, 76(2), 227–238. https://doi.org/10.1158/0008-5472.CAN-14-3362Full Text Link to Item
-
Dedert, E. A., Resick, P. A., McFall, M. E., Dennis, P. A., Olsen, M., & Beckham, J. C. (2016). Pilot Cases of Combined Cognitive Processing Therapy and Smoking Cessation for Smokers With Posttraumatic Stress Disorder. Behav Ther, 47(1), 54–65. https://doi.org/10.1016/j.beth.2015.09.002Full Text Link to Item
-
Van Voorhees, E. E., Dennis, P. A., Neal, L. C., Hicks, T. A., Calhoun, P. S., Beckham, J. C., & Elbogen, E. B. (2016). Posttraumatic Stress Disorder, Hostile Cognitions, and Aggression in Iraq/Afghanistan Era Veterans. Psychiatry, 79(1), 70–84. https://doi.org/10.1080/00332747.2015.1123593Full Text Link to Item
-
Carpenter, V. L., Hertzberg, J. S., Kirby, A. C., Calhoun, P. S., Moore, S. D., Dennis, M. F., … Beckham, J. C. (2015). Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans. J Clin Psychiatry, 76(7), 959–964. https://doi.org/10.4088/JCP.14m09053Full Text Link to Item
-
Kawabata, S., Hollander, M. C., Munasinghe, J. P., Brinster, L. R., Mercado-Matos, J. R., Li, J., … Dennis, P. A. (2015). Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. Oncotarget, 6(13), 11357–11368. https://doi.org/10.18632/oncotarget.3605Full Text Link to Item
-
Oddone, A. E., Dennis, P. A., Calhoun, P. S., Watkins, L. L., Sherwood, A., Dedert, E. A., … Beckham, J. C. (2015). Orthostatic hypotension in young adults with and without posttraumatic stress disorder. Psychol Trauma, 7(3), 229–233. https://doi.org/10.1037/a0036716Full Text Link to Item
-
Kawabata, S., Heredia, A., Gills, J., Redfield, R. R., Dennis, P. A., & Bryant, J. (2015). Impact of HIV on lung tumorigenesis in an animal model. Aids, 29(5), 633–635. https://doi.org/10.1097/QAD.0000000000000588Full Text Link to Item
-
Malte, C. A., Dennis, P. A., Saxon, A. J., McFall, M., Carmody, T. P., Unger, W., & Beckham, J. C. (2015). Tobacco use trajectories among a large cohort of treated smokers with posttraumatic stress disorder. Addict Behav, 41, 238–246. https://doi.org/10.1016/j.addbeh.2014.10.034Full Text Link to Item
-
Gentes, E., Dennis, P. A., Kimbrel, N. A., Kirby, A. C., Hair, L. P., Beckham, J. C., & Calhoun, P. S. (2015). Latent Factor Structure of DSM-5 Posttraumatic Stress Disorder. Psychopathol Rev, 2(1), 17–29. https://doi.org/10.5127/pr.035914Full Text Link to Item
-
Gentes, E. L., Dennis, P. A., Kimbrel, N. A., Rissling, M. B., Beckham, J. C., VA Mid-Atlantic MIRECC Workgroup, ., & Calhoun, P. S. (2014). DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis. J Psychiatr Res, 59, 60–67. https://doi.org/10.1016/j.jpsychires.2014.08.014Full Text Link to Item
-
Dennis, P. A., Watkins, L. L., Calhoun, P. S., Oddone, A., Sherwood, A., Dennis, M. F., … Beckham, J. C. (2014). Posttraumatic stress, heart rate variability, and the mediating role of behavioral health risks. Psychosom Med, 76(8), 629–637. https://doi.org/10.1097/PSY.0000000000000110Full Text Link to Item
-
Blumenthal, G. M., Gills, J. J., Ballas, M. S., Bernstein, W. B., Komiya, T., Dechowdhury, R., … Dennis, P. A. (2014). A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors. Oncotarget, 5(18), 8161–8172. https://doi.org/10.18632/oncotarget.2415Full Text Link to Item
-
Mitchell, J. T., Dennis, M. F., English, J. S., Dennis, P. A., Brightwood, A., Beckham, J. C., & Kollins, S. H. (2014). Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder. Subst Use Misuse, 49(11), 1446–1456. https://doi.org/10.3109/10826084.2014.912229Full Text Link to Item
-
Green, K. T., Hayward, L. C., Williams, A. M., Dennis, P. A., Bryan, B. C., Taber, K. H., … Calhoun, P. S. (2014). Examining the factor structure of the Connor-Davidson Resilience Scale (CD-RISC) in a post-9/11 U.S. military veteran sample. Assessment, 21(4), 443–451. https://doi.org/10.1177/1073191114524014Full Text Open Access Copy Link to Item
-
Dennis, P. A., Ulmer, C. S., Calhoun, P. S., Sherwood, A., Watkins, L. L., Dennis, M. F., & Beckham, J. C. (2014). Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia. J Psychosom Res, 77(1), 45–50. https://doi.org/10.1016/j.jpsychores.2014.05.001Full Text Link to Item
-
Dogan, I., Kawabata, S., Bergbower, E., Gills, J. J., Ekmekci, A., Wilson, W., … Dennis, P. A. (2014). SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines. Lung Cancer, 85(1), 1–6. https://doi.org/10.1016/j.lungcan.2014.03.021Full Text Link to Item
-
Wilson, S. M., Dedert, E. A., Dennis, P. A., Dennis, M. F., Calhoun, P. S., Kirby, A. C., & Beckham, J. C. (2014). Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse? Addict Behav, 39(7), 1163–1167. https://doi.org/10.1016/j.addbeh.2014.03.016Full Text Link to Item
-
Kawabata, S., Mercado-Matos, J. R., Hollander, M. C., Donahue, D., Wilson, W., Regales, L., … Dennis, P. A. (2014). Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M. Cell Rep, 7(6), 1824–1832. https://doi.org/10.1016/j.celrep.2014.05.039Full Text Link to Item
-
Volz, A. R., Dennis, P. A., Dennis, M. F., Calhoun, P. S., Wilson, S. M., & Beckham, J. C. (2014). The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt. Nicotine Tob Res, 16(6), 872–875. https://doi.org/10.1093/ntr/ntt286Full Text Link to Item
-
Kalu, N. N., Desai, P. J., Shirley, C. M., Gibson, W., Dennis, P. A., & Ambinder, R. F. (2014). Nelfinavir inhibits maturation and export of herpes simplex virus 1. J Virol, 88(10), 5455–5461. https://doi.org/10.1128/JVI.03790-13Full Text Link to Item
-
Dedert, E. A., Dennis, P. A., Swinkels, C. M., Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2014). Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. Nicotine Tob Res, 16(4), 430–436. https://doi.org/10.1093/ntr/ntt167Full Text Link to Item
-
Shtivelman, E., Hensing, T., Simon, G. R., Dennis, P. A., Otterson, G. A., Bueno, R., & Salgia, R. (2014). Molecular pathways and therapeutic targets in lung cancer. Oncotarget, 5(6), 1392–1433. https://doi.org/10.18632/oncotarget.1891Full Text Link to Item
-
Kawabata, S., Chiang, C.-T., Tsurutani, J., Shiga, H., Arwood, M. L., Komiya, T., … Dennis, P. A. (2014). Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer. Oncotarget, 5(4), 1062–1070. https://doi.org/10.18632/oncotarget.1760Full Text Link to Item
-
Van Voorhees, E. E., Dennis, P. A., Elbogen, E. B., Clancy, C. P., Hertzberg, M. A., Beckham, J. C., & Calhoun, P. S. (2014). Personality assessment inventory internalizing and externalizing structure in veterans with posttraumatic stress disorder: associations with aggression. Aggress Behav, 40(6), 582–592. https://doi.org/10.1002/ab.21554Full Text Link to Item
-
Shuch, B., Ricketts, C. J., Vocke, C. D., Komiya, T., Middelton, L. A., Kauffman, E. C., … Linehan, W. M. (2013). Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer. J Urol, 190(6), 1990–1998. https://doi.org/10.1016/j.juro.2013.06.012Full Text Link to Item
-
Hertzberg, J. S., Carpenter, V. L., Kirby, A. C., Calhoun, P. S., Moore, S. D., Dennis, M. F., … Beckham, J. C. (2013). Mobile contingency management as an adjunctive smoking cessation treatment for smokers with posttraumatic stress disorder. Nicotine Tob Res, 15(11), 1934–1938. https://doi.org/10.1093/ntr/ntt060Full Text Link to Item
-
Hess, T. M., Popham, L. E., Dennis, P. A., & Emery, L. (2013). Information content moderates positivity and negativity biases in memory. Psychol Aging, 28(3), 853–863. https://doi.org/10.1037/a0031440Full Text Link to Item
-
Quinn, B. J., Kitagawa, H., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2013). Repositioning metformin for cancer prevention and treatment. Trends Endocrinol Metab, 24(9), 469–480. https://doi.org/10.1016/j.tem.2013.05.004Full Text Link to Item
-
Quinn, B. J., Dallos, M., Kitagawa, H., Kunnumakkara, A. B., Memmott, R. M., Hollander, M. C., … Dennis, P. A. (2013). Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling. Cancer Prevention Research, 6(8), 801–810. https://doi.org/10.1158/1940-6207.CAPR-13-0058-TFull Text
-
Thomas, A., Xi, L., Carter, C. A., Rajan, A., Khozin, S., Szabo, E., … Raffeld, M. (2013). Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations. Clin Lung Cancer, 14(4), 452–456. https://doi.org/10.1016/j.cllc.2013.01.005Full Text Link to Item
-
Kalin, A., Merideth, M. A., Regier, D. S., Blumenthal, G. M., Dennis, P. A., & Stratton, P. (2013). Management of reproductive health in Cowden syndrome complicated by endometrial polyps and breast cancer. Obstet Gynecol, 121(2 Pt 2 Suppl 1), 461–464.Link to Item
-
Dennis, P. A., & Halberstadt, A. G. (2013). Is believing seeing? The role of emotion-related beliefs in selective attention to affective cues. Cogn Emot, 27(1), 3–20. https://doi.org/10.1080/02699931.2012.680578Full Text Link to Item
-
Tzarum, N., Eisenberg-Domovich, Y., Gills, J. J., Dennis, P. A., & Livnah, O. (2012). Lipid molecules induce p38α activation via a novel molecular switch. J Mol Biol, 424(5), 339–353. https://doi.org/10.1016/j.jmb.2012.10.007Full Text Link to Item
-
Mai, P. L., Malkin, D., Garber, J. E., Schiffman, J. D., Weitzel, J. N., Strong, L. C., … Savage, S. A. (2012). Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium. Cancer Genet, 205(10), 479–487. https://doi.org/10.1016/j.cancergen.2012.06.008Full Text Link to Item
-
Kawabata, S., Gills, J. J., Mercado-Matos, J. R., Lopiccolo, J., Wilson, W., Hollander, M. C., & Dennis, P. A. (2012). Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. Cell Death Dis, 3(7), e353. https://doi.org/10.1038/cddis.2012.87Full Text Link to Item
-
Gills, J. J., Zhang, C., Abu-Asab, M. S., Castillo, S. S., Marceau, C., LoPiccolo, J., … Dennis, P. A. (2012). Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. Cell Death Dis, 3(7), e340. https://doi.org/10.1038/cddis.2012.72Full Text Link to Item
-
West, L., Vidwans, S. J., Campbell, N. P., Shrager, J., Simon, G. R., Bueno, R., … Salgia, R. (2012). A novel classification of lung cancer into molecular subtypes. Plos One, 7(2), e31906. https://doi.org/10.1371/journal.pone.0031906Full Text Link to Item
-
Maier, C. R., Hollander, M. C., Hobbs, E. A., Dogan, I., Linnoila, R. I., & Dennis, P. A. (2011). Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. Cancer Prev Res (Phila), 4(11), 1743–1751. https://doi.org/10.1158/1940-6207.CAPR-11-0365Full Text Link to Item
-
West, K. A., & Dennis, P. A. (2011). Starting with the ABCs: Akt in breast cancer. Mol Cancer Ther, 10(11), 2031. https://doi.org/10.1158/1535-7163.MCT-11-0712Full Text Link to Item
-
Hollander, M. C., Zhou, X., Maier, C. R., Patterson, A. D., Ding, X., & Dennis, P. A. (2011). A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. Carcinogenesis, 32(8), 1279–1284. https://doi.org/10.1093/carcin/bgr097Full Text Link to Item
-
Zhang, C., Elkahloun, A. G., Liao, H., Delaney, S., Saber, B., Morrow, B., … Dennis, P. A. (2011). Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells. Mol Cancer Ther, 10(7), 1137–1148. https://doi.org/10.1158/1535-7163.MCT-10-1028Full Text Link to Item
-
Hollander, M. C., Blumenthal, G. M., & Dennis, P. A. (2011). Erratum: PTEN loss in the continuum of common cancers, rare syndromes and mouse models (Nature Reviews Cancer (2011) 11 (289-301)). Nature Reviews Cancer, 11(6), 437. https://doi.org/10.1038/nrc3085Full Text
-
Hollander, M. C., Maier, C. R., Hobbs, E. A., Ashmore, A. R., Linnoila, R. I., & Dennis, P. A. (2011). Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Oncogene, 30(15), 1812–1821. https://doi.org/10.1038/onc.2010.556Full Text Link to Item
-
Hollander, M. C., Blumenthal, G. M., & Dennis, P. A. (2011). PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer, 11(4), 289–301. https://doi.org/10.1038/nrc3037Full Text Link to Item
-
Halberstadt, A. G., Dennis, P. A., & Hess, U. (2011). The Influence of Family Expressiveness, Individuals' Own Emotionality, and Self-Expressiveness on Perceptions of Others' Facial Expressions. Journal of Nonverbal Behavior, 35(1), 35–50. https://doi.org/10.1007/s10919-010-0099-5Full Text
-
Zhang, C., Elkahloun, A. G., Robertson, M., Gills, J. J., Tsurutani, J., Shih, J. H., … Dennis, P. A. (2011). Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance. Plos One, 6(8), e23849. https://doi.org/10.1371/journal.pone.0023849Full Text Link to Item
-
Memmott, R. M., Mercado, J. R., Maier, C. R., Kawabata, S., Fox, S. D., & Dennis, P. A. (2010). Metformin prevents tobacco carcinogen--induced lung tumorigenesis. Cancer Prev Res (Phila), 3(9), 1066–1076. https://doi.org/10.1158/1940-6207.CAPR-10-0055Full Text Link to Item
-
Memmott, R. M., & Dennis, P. A. (2010). The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res, 16(1), 4–10. https://doi.org/10.1158/1078-0432.CCR-09-0234Full Text Link to Item
-
Memmott, R. M., & Dennis, P. A. (2009). LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin. J Clin Oncol, 27(34), e226. https://doi.org/10.1200/JCO.2009.25.3963Full Text Link to Item
-
Memmott, R. M., & Dennis, P. A. (2009). Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal, 21(5), 656–664. https://doi.org/10.1016/j.cellsig.2009.01.004Full Text Link to Item
-
Wang, Y., Digiovanna, J. J., Stern, J. B., Hornyak, T. J., Raffeld, M., Khan, S. G., … Kraemer, K. H. (2009). Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas. Proc Natl Acad Sci U S A, 106(15), 6279–6284. https://doi.org/10.1073/pnas.0812401106Full Text Link to Item
-
Han, W., Gills, J. J., Memmott, R. M., Lam, S., & Dennis, P. A. (2009). The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. Cancer Prev Res (Phila), 2(4), 370–376. https://doi.org/10.1158/1940-6207.CAPR-08-0209Full Text Link to Item
-
Gills, J. J., & Dennis, P. A. (2009). Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep, 11(2), 102–110. https://doi.org/10.1007/s11912-009-0016-4Full Text Link to Item
-
Dennis, P. A. (2009). Rapamycin for chemoprevention of upper aerodigestive tract cancers. Cancer Prev Res (Phila), 2(1), 7–9. https://doi.org/10.1158/1940-6207.CAPR-08-0215Full Text Link to Item
-
Granville, C. A., Memmott, R. M., Balogh, A., Mariotti, J., Kawabata, S., Han, W., … Dennis, P. A. (2009). A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. Plos One, 4(3), e5061. https://doi.org/10.1371/journal.pone.0005061Full Text Link to Item
-
Bernstein, W. B., & Dennis, P. A. (2008). Repositioning HIV protease inhibitors as cancer therapeutics. Current Opinion in Hiv and Aids, 3(6), 666–675. https://doi.org/10.1097/COH.0b013e328313915dFull Text
-
Blumenthal, G. M., & Dennis, P. A. (2008). PTEN hamartoma tumor syndromes. Eur J Hum Genet, 16(11), 1289–1300. https://doi.org/10.1038/ejhg.2008.162Full Text Link to Item
-
Hollander, M. C., Balogh, A. R., Liwanag, J., Han, W., Linnoila, R. I., Anver, M. R., & Dennis, P. A. (2008). Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice. Neoplasia, 10(8), 866–872. https://doi.org/10.1593/neo.08406Full Text Link to Item
-
Blumenthal, G. M., & Dennis, P. A. (2008). Germline PTEN mutations as a cause of early-onset endometrial cancer. J Clin Oncol, 26(13), 2234. https://doi.org/10.1200/JCO.2007.15.8949Full Text Link to Item
-
Memmott, R. M., Gills, J. J., Hollingshead, M., Powers, M. C., Chen, Z., Kemp, B., … Dennis, P. A. (2008). Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res, 68(2), 580–588. https://doi.org/10.1158/0008-5472.CAN-07-3091Full Text Link to Item
-
Gills, J. J., Lopiccolo, J., & Dennis, P. A. (2008). Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. Autophagy, 4(1), 107–109. https://doi.org/10.4161/auto.5224Full Text Link to Item
-
LoPiccolo, J., Blumenthal, G. M., Bernstein, W. B., & Dennis, P. A. (2008). Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat, 11(1–2), 32–50. https://doi.org/10.1016/j.drup.2007.11.003Full Text Link to Item
-
Gills, J. J., Castillo, S. S., Zhang, C., Petukhov, P. A., Memmott, R. M., Hollingshead, M., … Dennis, P. A. (2007). Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. J Biol Chem, 282(37), 27020–27029. https://doi.org/10.1074/jbc.M701108200Full Text Link to Item
-
Gills, J. J., Lopiccolo, J., Tsurutani, J., Shoemaker, R. H., Best, C. J. M., Abu-Asab, M. S., … Dennis, P. A. (2007). Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res, 13(17), 5183–5194. https://doi.org/10.1158/1078-0432.CCR-07-0161Full Text Link to Item
-
LoPiccolo, J., Granville, C. A., Gills, J. J., & Dennis, P. A. (2007). Targeting Akt in cancer therapy. Anticancer Drugs, 18(8), 861–874. https://doi.org/10.1097/CAD.0b013e3280cc2c6fFull Text Link to Item
-
Lopiccolo, J., Ballas, M. S., & Dennis, P. A. (2007). PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development. Crit Rev Oncol Hematol, 63(3), 203–214. https://doi.org/10.1016/j.critrevonc.2007.06.002Full Text Link to Item
-
Granville, C. A., Warfel, N., Tsurutani, J., Hollander, M. C., Robertson, M., Fox, S. D., … Dennis, P. A. (2007). Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors. Clin Cancer Res, 13(7), 2281–2289. https://doi.org/10.1158/1078-0432.CCR-06-2570Full Text Link to Item
-
Lipkowitz, S., & Dennis, P. A. (2007). PPARgamma agonists follow an unknown TRAIL in lung cancer. Cancer Biol Ther, 6(1), 107–109. https://doi.org/10.4161/cbt.6.1.3751Full Text Link to Item
-
Tsurutani, J., Steinberg, S. M., Ballas, M., Robertson, M., LoPiccolo, J., Soda, H., … Dennis, P. A. (2007). Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. Lung Cancer, 55(1), 115–121. https://doi.org/10.1016/j.lungcan.2006.09.026Full Text Link to Item
-
Warfel, N. A., Lepper, E. R., Zhang, C., Figg, W. D., & Dennis, P. A. (2006). Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res, 12(11 Pt 1), 3502–3509. https://doi.org/10.1158/1078-0432.CCR-05-1837Full Text Link to Item
-
Tsurutani, J., Ballas, M. S., & Dennis, P. A. (2006). Overestimating the influence of the 1999 WHO classification of lung tumors on survival in bronchioloalveloar carcinoma. J Clin Oncol, 24(12), 1963. https://doi.org/10.1200/JCO.2005.05.1318Full Text Link to Item
-
Gills, J. J., Holbeck, S., Hollingshead, M., Hewitt, S. M., Kozikowski, A. P., & Dennis, P. A. (2006). Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt. Mol Cancer Ther, 5(3), 713–722. https://doi.org/10.1158/1535-7163.MCT-05-0484Full Text Link to Item
-
Granville, C. A., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2006). Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway. Clin Cancer Res, 12(3 Pt 1), 679–689. https://doi.org/10.1158/1078-0432.CCR-05-1654Full Text Link to Item
-
O’Mahony, D., & Dennis, P. A. (2006). Using immunotherapy to target EGF in patients with NSCLC. Cancer Biol Ther, 5(2), 150–151. https://doi.org/10.4161/cbt.5.2.2557Full Text Link to Item
-
Tsurutani, J., Ballas, M., Steinberg, S. M., Egilsson, V., & Dennis, P. A. (2006). Gefitinib for refractory advanced non-small-cell lung cancer. Lancet, 367(9507), 300. https://doi.org/10.1016/S0140-6736(06)68064-1Full Text Link to Item
-
Tsurutani, J., Fukuoka, J., Tsurutani, H., Shih, J. H., Hewitt, S. M., Travis, W. D., … Dennis, P. A. (2006). Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J Clin Oncol, 24(2), 306–314. https://doi.org/10.1200/JCO.2005.02.4133Full Text Link to Item
-
Ballas, M. S., & Dennis, P. A. (2005). A slow disengagement from platinum-based chemotherapy for patients with advanced non-small cell lung cancer. Cancer Biol Ther, 4(12), 1316–1317. https://doi.org/10.4161/cbt.4.12.2488Full Text Link to Item
-
Tsurutani, J., West, K. A., Sayyah, J., Gills, J. J., & Dennis, P. A. (2005). Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. Cancer Res, 65(18), 8423–8432. https://doi.org/10.1158/0008-5472.CAN-05-0058Full Text Link to Item
-
Coxon, A., Rozenblum, E., Park, Y.-S., Joshi, N., Tsurutani, J., Dennis, P. A., … Kaye, F. J. (2005). Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res, 65(16), 7137–7144. https://doi.org/10.1158/0008-5472.CAN-05-1125Full Text Link to Item
-
Tsurutani, J., Castillo, S. S., Brognard, J., Granville, C. A., Zhang, C., Gills, J. J., … Dennis, P. A. (2005). Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis, 26(7), 1182–1195. https://doi.org/10.1093/carcin/bgi072Full Text Link to Item
-
Li, Z., Jaboin, J., Dennis, P. A., & Thiele, C. J. (2005). Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. Cancer Res, 65(6), 2070–2075. https://doi.org/10.1158/0008-5472.CAN-04-3606Full Text Link to Item
-
Fiala, E. S., Sohn, O. S., Wang, C.-X., Seibert, E., Tsurutani, J., Dennis, P. A., … Aliaga, C. (2005). Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E. Carcinogenesis, 26(3), 605–612. https://doi.org/10.1093/carcin/bgh341Full Text Link to Item
-
Granville, C. A., & Dennis, P. A. (2005). An overview of lung cancer genomics and proteomics. Am J Respir Cell Mol Biol, 32(3), 169–176. https://doi.org/10.1165/rcmb.F290Full Text Link to Item
-
Carón, R. W., Yacoub, A., Li, M., Zhu, X., Mitchell, C., Hong, Y., … Dent, P. (2005). Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther, 4(2), 257–270.Link to Item
-
Tsurutani, J., & Dennis, P. A. (2004). Re: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst, 96(23), 1795. https://doi.org/10.1093/jnci/djh342Full Text Link to Item
-
Dennis, P. A. (2004). Disparities in cancer funding. Science, 305(5689), 1401–1402. https://doi.org/10.1126/science.305.5689.1401eFull Text Link to Item
-
Gills, J. J., & Dennis, P. A. (2004). The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. Expert Opin Investig Drugs, 13(7), 787–797. https://doi.org/10.1517/13543784.13.7.787Full Text Link to Item
-
Castillo, S. S., Brognard, J., Petukhov, P. A., Zhang, C., Tsurutani, J., Granville, C. A., … Dennis, P. A. (2004). Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. Cancer Res, 64(8), 2782–2792. https://doi.org/10.1158/0008-5472.can-03-1530Full Text Link to Item
-
Gills, J. J., Granville, C. A., & Dennis, P. A. (2004). Targeting aberrant signal transduction pathways in lung cancer. Cancer Biol Ther, 3(2), 147–155. https://doi.org/10.4161/cbt.3.2.612Full Text Link to Item
-
West, K. A., Linnoila, I. R., Belinsky, S. A., Harris, C. C., & Dennis, P. A. (2004). Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. Cancer Res, 64(2), 446–451. https://doi.org/10.1158/0008-5472.can-03-3241Full Text Link to Item
-
Lorenzo, P. S., & Dennis, P. A. (2003). Modulating protein kinase C (PKC) to increase the efficacy of chemotherapy: stepping into darkness. Drug Resist Updat, 6(6), 329–339. https://doi.org/10.1016/j.drup.2003.10.003Full Text Link to Item
-
Bianco, R., Shin, I., Ritter, C. A., Yakes, F. M., Basso, A., Rosen, N., … Arteaga, C. L. (2003). Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene, 22(18), 2812–2822. https://doi.org/10.1038/sj.onc.1206388Full Text Link to Item
-
Clark, A. S., West, K. A., Blumberg, P. M., & Dennis, P. A. (2003). Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. Cancer Res, 63(4), 780–786.Link to Item
-
Kozikowski, A. P., Sun, H., Brognard, J., & Dennis, P. A. (2003). Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J Am Chem Soc, 125(5), 1144–1145. https://doi.org/10.1021/ja0285159Full Text Link to Item
-
West, K. A., Brognard, J., Clark, A. S., Linnoila, I. R., Yang, X., Swain, S. M., … Dennis, P. A. (2003). Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest, 111(1), 81–90. https://doi.org/10.1172/JCI16147Full Text Link to Item
-
West, K. A., Castillo, S. S., & Dennis, P. A. (2002). Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat, 5(6), 234–248. https://doi.org/10.1016/s1368-7646(02)00120-6Full Text Link to Item
-
Brognard, J., & Dennis, P. A. (2002). Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. Cell Death Differ, 9(9), 893–904. https://doi.org/10.1038/sj.cdd.4401054Full Text Link to Item
-
Clark, A. S., West, K., Streicher, S., & Dennis, P. A. (2002). Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther, 1(9), 707–717.Link to Item
-
Cuello, M., Ettenberg, S. A., Clark, A. S., Keane, M. M., Posner, R. H., Nau, M. M., … Lipkowitz, S. (2001). Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res, 61(12), 4892–4900.Link to Item
-
Brognard, J., Clark, A. S., Ni, Y., & Dennis, P. A. (2001). Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res, 61(10), 3986–3997.Link to Item
-
Kastanos, E. K., Zajac-Kaye, M., Dennis, P. A., & Allegra, C. J. (2001). Downregulation of p21/WAF1 expression by thymidylate synthase. Biochemical and Biophysical Research Communications, 285(2), 195–200. https://doi.org/10.1006/bbrc.2001.5145Full Text
-
Dennis, P. A., & Kastan, M. B. (1998). Cellular survival pathways and resistance to cancer therapy. Drug Resist Updat, 1(5), 301–309. https://doi.org/10.1016/s1368-7646(98)80046-0Full Text Link to Item
-
Kastan, M. B., Morgan, S. E., Siliciano, J., Kirsch, D., Dennis, P., & Canman, C. E. (1997). Cell cycle and cell death after DNA damaye. Faseb Journal, 11(9).
-
Dennis, P. A., & Rifkin, D. B. (1991). Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A, 88(2), 580–584. https://doi.org/10.1073/pnas.88.2.580Full Text Link to Item
-
Rifkin, D. B., Moscatelli, D., Bizik, J., Quarto, N., Blei, F., Dennis, P., … Mignatti, P. (1990). Growth factor control of extracellular proteolysis. Cell Differ Dev, 32(3), 313–318. https://doi.org/10.1016/0922-3371(90)90045-xFull Text Link to Item
-
Dennis, P. A., & Rifkin, D. B. (1990). Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. J Cell Physiol, 144(1), 84–98. https://doi.org/10.1002/jcp.1041440112Full Text Link to Item
-
Dennis, P. A., Saksela, O., Harpel, P., & Rifkin, D. B. (1989). Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor. J Biol Chem, 264(13), 7210–7216.Link to Item
-
-
Book Sections
-
Granville, C. A., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2008). Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway. In Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (Vol. 2, pp. 966–996). https://doi.org/10.1002/9783527619665.ch38Full Text
-
-
Conference Papers
-
de Wit, M., Gray, J. E., Villegas, A., Daniel, D., Vicente, D., Murakami, S., … Reck, M. (2019). Three-year overall survival update from the PACIFIC trial. In Oncology Research and Treatment (Vol. 42, pp. 76–76).Link to Item
-
Van Voorhees, E., Dennis, P. A., Carter, L., Neal, L. C., Calhoun, P., Beckham, J., & Watkins, L. (2018). MEASURING HEART RATE VARIABILITY USING THE EMPATICA E4 WRISTBAND: RELIABILITY WITH HOLTER MONITOR. In Annals of Behavioral Medicine (Vol. 52, pp. S779–S779). OXFORD UNIV PRESS INC.Link to Item
-
Christofferson, D., Dennis, P. A., Hertzberg, J., Beckham, J. C., Hamlett-Berry, K., & Augustson, E. (2016). USE AND EFFECTS OF "KEYWORDS" COMPONENT DURING A SMOKING CESSATION TEXTING PROGRAM FOR VETERANS. In Annals of Behavioral Medicine (Vol. 50, pp. S333–S333). OXFORD UNIV PRESS INC.Link to Item
-
West, K. A., Linnoila, I. R., Brognard, J., Belinsky, S., Harris, C., & Dennis, P. A. (2004). Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo. In Chest (Vol. 125, pp. 101S-102S). United States. https://doi.org/10.1378/chest.125.5_suppl.101sFull Text Link to Item
-
-
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.