Scholars@Duke
Paul Anthony Dennis

Paul Anthony Dennis

Associate Professor in Population Health Sciences
Population Health Sciences
paul.dennis@duke.edu
Box 3625, Durham, NC 27710
Box 3625, Durham, NC 27710

Selected Publications

Informing a home time measure reflective of quality of life: A data driven investigation of time frames and settings of health care utilization.

Journal Article Health Serv Res · December 2023 OBJECTIVE: To evaluate short- and long-term measures of health care utilization-days in the emergency department (ED), inpatient (IP) care, and rehabilitation in a post-acute care (PAC) facility-to understand how home time (i.e., days alive and not in an a ... Full text Link to item Cite

Inhibition of the NOTCH and mTOR pathways by nelfinavir as a novel treatment for T cell acute lymphoblastic leukemia.

Journal Article Int J Oncol · November 2023 T cell acute lymphoblastic leukemia (T‑ALL), a neoplasm derived from T cell lineage‑committed lymphoblasts, is characterized by genetic alterations that result in activation of oncogenic transcription factors and the NOTCH1 pathway activation. The NOTCH is ... Full text Link to item Cite

Interpersonal stress and nonsuicidal self-injury disorder in veterans: An ecological momentary assessment study.

Journal Article Suicide Life Threat Behav · August 2023 INTRO: Nonsuicidal self-injury (NSSI) is associated with marked functional impairment and is a robust predictor of suicide attempts. Prevalence rates of NSSI, and self-directed violence more broadly, are elevated among military veterans. Despite the inclus ... Full text Link to item Cite

BMI Trends for Veterans Up to 10 Years After VA Enrollment Following Military Discharge.

Journal Article J Gen Intern Med · May 2023 BACKGROUND: Obesity (body mass index [BMI]≥30kg/m2) among US adults has tripled over the past 45 years, but it is unclear how this population-level weight change has occurred. OBJECTIVE: We sought to identify distinct long-term BMI trajectories and examine ... Full text Link to item Cite

Affective states and nonsuicidal self-injury (NSSI): Results from an ecological momentary assessment study of veterans with NSSI disorder.

Journal Article Suicide Life Threat Behav · April 2022 BACKGROUND: The affective states most strongly associated with nonsuicidal self-injury (NSSI) remain poorly understood, particularly among veterans. This study used ecological momentary assessment (EMA) to examine relationships between affect ratings and N ... Full text Link to item Cite

Outcomes with durvalumab after chemoradiotherapy in stage IIIA-N2 non-small-cell lung cancer: an exploratory analysis from the PACIFIC trial.

Journal Article ESMO Open · April 2022 BACKGROUND: The phase III PACIFIC trial (NCT02125461) established consolidation durvalumab as standard of care for patients with unresectable, stage III non-small-cell lung cancer (NSCLC) and no disease progression following chemoradiotherapy (CRT). In som ... Full text Link to item Cite

Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study.

Journal Article Exp Clin Psychopharmacol · February 2022 Exploration of the real-time relationship between substance use and delay discounting may reveal potential mechanisms driving high-risk behaviors. We conducted an ecological momentary assessment (EMA) study to investigate the effects of substance use on de ... Full text Link to item Cite

Ambulatory Heart Rate Variability Monitoring: Comparisons Between the Empatica E4 Wristband and Holter Electrocardiogram.

Journal Article Psychosom Med · February 2022 OBJECTIVE: Heart rate variability (HRV) is a useful index of psychological and physiological stress. Although several wristband devices have purported to measure HRV, none have demonstrated reliability when compared with the criterion-standard Holter monit ... Full text Link to item Cite

Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown.

Journal Article Cancer Discov · November 2021 Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non-small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associated with r ... Full text Link to item Cite

A Comparison of Group Anger Management Treatments for Combat Veterans With PTSD: Results From a Quasi-Experimental Trial.

Journal Article J Interpers Violence · October 2021 Difficulty controlling anger is a significant concern among combat veterans with posttraumatic stress disorder (PTSD), yet few controlled studies have examined the efficacy of anger treatments for this population. This study examined the effects of a group ... Full text Link to item Cite

Association of Posttraumatic Stress Disorder and Incident Ischemic Heart Disease in Women Veterans.

Journal Article JAMA Cardiol · June 1, 2021 IMPORTANCE: Posttraumatic stress disorder (PTSD) is associated with greater risk of ischemic heart disease (IHD) in predominantly male populations or limited community samples. Women veterans represent a growing, yet understudied, population with high leve ... Full text Link to item Cite

Real-World Utilization and Outcomes of the Veterans Health Administration's Smoking Cessation Text Message Program.

Journal Article Nicotine Tob Res · May 24, 2021 INTRODUCTION: Smoking cessation mobile health (mHealth) programs are effective and have been recommended for integration into health care services but have not been evaluated in real-world health care settings. The Veterans Health Administration, a safety ... Full text Link to item Cite

Anger precedes and predicts nonsuicidal self-injury in veterans: Findings from an ecological momentary assessment study.

Journal Article J Psychiatr Res · March 2021 Veterans have high rates of suicide, and nonsuicidal self-injury (NSSI) is one of the strongest predictors of suicide risk; however, there is presently little known about antecedents of NSSI that might inform intervention efforts. Accumulating research sug ... Full text Link to item Cite

Mobile Neurofeedback for Pain Management in Veterans with TBI and PTSD.

Journal Article Pain Med · February 23, 2021 OBJECTIVE: Chronic pain is common in military veterans with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Neurofeedback, or electroencephalograph (EEG) biofeedback, has been associated with lower pain but requires frequent travel ... Full text Link to item Cite

Military Sexual Trauma and Adverse Mental and Physical Health and Clinical Comorbidity in Women Veterans.

Journal Article Womens Health Issues · 2021 INTRODUCTION: Military sexual trauma (MST)-exposure to sexual harassment or assault during military service-is a major health priority for the Veterans Health Administration (VHA). We examined the health correlates of MST in the largest sample of U.S. wome ... Full text Link to item Cite

Assessing the Influence of Subsequent Immunotherapy on Overall Survival in Patients with Unresectable Stage III Non–Small Cell Lung Cancer from the PACIFIC Study

Journal Article Current Therapeutic Research - Clinical and Experimental · January 1, 2021 Background: Historically, the standard of care for patients with unresectable, Stage III non–small cell lung cancer had been concurrent chemoradiotherapy. However, outcomes had been poor, with approximately 15% to 32% of patients alive at 5 years. In the p ... Full text Cite

Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors.

Journal Article Anticancer Res · January 2021 BACKGROUND/AIM: Small-cell lung cancer (SCLC) is aggressive and confers poor prognosis. Although SCLC shows more response to chemotherapy than other types of lung cancer, it is difficult to cure because of its frequent recurrence. New drugs and molecular t ... Full text Link to item Cite

Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors.

Journal Article In Vivo · 2021 BACKGROUND/AIM: Nelfinavir is a human immunodeficiency virus protease inhibitor that is currently being repositioned as an anticancer drug. Chloroquine, an anti-malarial lysosomotropic drug, inhibits autophagy. It has been reported that the combination of ... Full text Link to item Cite

Post-traumatic symptom severity mediates the association between combat exposure and suicidal ideation in veterans.

Journal Article Suicide Life Threat Behav · December 2020 OBJECTIVE: Previous studies of military veterans have produced mixed findings regarding whether combat exposure is directly related to suicidal ideation or is indirectly related to suicidal ideation via its influence on other factors. The present study use ... Full text Link to item Cite

Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade.

Journal Article Cancer Discov · December 2020 The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment (n = 171) ctDNA samples across 16 advanced-stage tumor types f ... Full text Link to item Cite

Relationship Between Progression-Free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune Checkpoint Blockade: A Meta-Analysis.

Journal Article Clin Pharmacol Ther · December 2020 PD-1/PD-L1 immune checkpoint blockade (ICB) has improved overall survival (OS) in solid tumor trials; however, parallel improvements in Response Evaluation Criteria in Solid Tumors (RECIST)-based surrogate end points, progression-free survival (PFS), and o ... Full text Link to item Cite

Final overall survival and safety update for durvalumab in third- or later-line advanced NSCLC: The phase II ATLANTIC study.

Journal Article Lung Cancer · September 2020 INTRODUCTION: In the phase II ATLANTIC study, durvalumab provided durable responses with acceptable tolerability in heavily pretreated patients with advanced NSCLC, across three independent patient cohorts defined by EGFR/ALK status and tumour PD-L1 expres ... Full text Link to item Cite

Comparison of referral methods into a smoking cessation program.

Journal Article J Comp Eff Res · August 2020 Rational, aims & objectives: The goal of this observational study was to compare three referral methods and determine which led to the highest utilization of the Duke Smoking Cessation Program (DSCP). Materials & methods: We conducted two assessments withi ... Full text Open Access Link to item Cite

Health benefits and economic advantages associated with increased utilization of a smoking cessation program.

Journal Article J Comp Eff Res · August 2020 Rationale, aim & objective: The goal of this study was to examine the health and economic impacts related to increased utilization of the Duke Smoking Cessation Program resulting from the addition of two relatively new referral methods - Best Practice Advi ... Full text Open Access Link to item Cite

Intervention strategies for microbial therapeutics in cancer immunotherapy

Journal Article Immuno-Oncology and Technology · June 1, 2020 Immunotherapies have drastically improved clinical outcomes in a wide range of malignancies. Nevertheless, patient responses remain highly variable, and reliable biomarkers that predict responses accurately are not yet fully understood. Compelling evidence ... Full text Cite

Anger mediates the relationship between posttraumatic stress disorder and suicidal ideation in veterans.

Journal Article J Affect Disord · May 15, 2020 BACKGROUND: Theoretical models and cross-sectional empirical studies of suicide indicate that anger is a factor that may help explain the association between posttraumatic stress disorder (PTSD) and suicide, but to date no longitudinal studies have examine ... Full text Link to item Cite

A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226.

Journal Article Lung Cancer · May 2020 This multicenter phase Ib study aimed to establish a recommended phase II dose for durvalumab (Du) ± tremelimumab (Tr) in combination with standard platinum-doublet chemotherapy. Eligible patients were enrolled into one of six dose levels (DL) of Du ± Tr w ... Full text Link to item Cite

A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN.

Journal Article Oncologist · December 2019 LESSONS LEARNED: This is the first human interventional study in patients with Cowden syndrome that is driven by inactivation of germline PTEN gene.Single-agent sirolimus, a mTOR inhibitor, suppressed mTOR signaling in surrogate human tissues without signi ... Full text Link to item Cite

Why are caffeinated alcoholic beverages especially risky?

Journal Article Addict Behav · November 2019 PURPOSE: Evidence suggests that people drink more alcohol and experience more adverse alcohol-related consequences (ARCs) on occasions when they also consume caffeine. The current study examined whether this increase in risk is a result of caffeine attenua ... Full text Link to item Cite

Prognostic Significance of Liver Metastasis in Durvalumab-Treated Lung Cancer Patients.

Journal Article Clin Lung Cancer · November 2019 INTRODUCTION: Two clinical studies (Study 1108 and ATLANTIC) were analyzed to evaluate the prognostic value of baseline liver metastases (LMs) in advanced/metastatic non-small-cell lung cancer patients treated with durvalumab 10 mg/kg every 2 weeks. PATIEN ... Full text Link to item Cite

Negative Affect-Related Autonomic Arousal Mediates the Association between Baroreflex Dysfunction and Insulin Resistance in Non-Diabetic Young Adults.

Journal Article J Psychophysiol · October 2019 Autonomic dysfunction, in particular under-regulation of heart rate (HR) by the baroreflex, is implicated in development of insulin resistance (IR). According to reactivity hypothesis, sympathetic response to stressors may be more sensitive at predicting I ... Full text Link to item Cite

Impact of Patient Characteristics, Prior Therapy, and Sample Type on Tumor Cell Programmed Cell Death Ligand 1 Expression in Patients with Advanced NSCLC Screened for the ATLANTIC Study.

Journal Article J Thorac Oncol · August 2019 INTRODUCTION: We evaluated the impact of patient characteristics, sample types, and prior non-immunotherapy treatment on tumor cell (TC) programmed cell death ligand 1 (PD-L1) expression using samples from patients with advanced NSCLC. METHODS: Patients (N ... Full text Link to item Cite

Examining the relationship between negative affect and posttraumatic stress disorder symptoms among smokers using ecological momentary assessment.

Journal Article J Affect Disord · June 15, 2019 BACKGROUND: Posttraumatic stress disorder (PTSD) and negative affect (e.g., anger, depression, anxiety), are highly co-occurring. It remains unclear whether changes in PTSD symptoms subsequently impact negative affect, or vice versa. This study assessed as ... Full text Link to item Cite

Racial Disparities in the Administration of ECT in Texas, 1998-2013.

Journal Article J ECT · June 2019 OBJECTIVE: Electroconvulsive therapy (ECT) is a treatment of choice for severe depression but has been underutilized among black patients. This study investigates racial disparities in the administration of ECT in the state of Texas between 1998 and 2013 u ... Full text Link to item Cite

Regulation of RhoB gene expression during tumorigenesis and aging process and its potential applications in these processes

Journal Article Cancers · June 1, 2019 RhoB, a member of the Ras homolog gene family and GTPase, regulates intracellular signaling pathways by interfacing with epidermal growth factor receptor (EGFR), Ras, and phosphatidylinositol 3-kinase (PI3K)/Akt to modulate responses in cellular structure ... Full text Cite

A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer

Journal Article Translational Lung Cancer Research · June 1, 2019 Background: Single-agent pemetrexed is a treatment for recurrent non-squamous non-small cell lung cancer (NSCLC) that provides limited benefit. Preclinical studies showed promising synergistic effects when the mammalian target of rapamycin (mTOR) inhibitor ... Full text Cite

Nonsuicidal Self-Injury and Borderline Personality Features as Risk Factors for Suicidal Ideation Among Male Veterans With Posttraumatic Stress Disorder.

Journal Article J Trauma Stress · February 2019 U.S. veterans are at increased risk for suicide compared to their civilian counterparts and account for approximately 20% of all deaths by suicide. Posttraumatic stress disorder (PTSD) and borderline personality features (BPF) have each been associated wit ... Full text Link to item Cite

Shame as a mediator between posttraumatic stress disorder symptoms and suicidal ideation among veterans.

Journal Article J Affect Disord · January 15, 2019 BACKGROUND: Suicidal ideation is a problem that disproportionately affects veterans. Moreover, veterans with posttraumatic stress disorder (PTSD) appear to be at particularly high risk for suicide. OBJECTIVE: The purpose of the present research was to exam ... Full text Link to item Cite

Roles of Guilt Cognitions in Trauma-Related Sleep Disturbance in Military Veterans With Posttraumatic Stress Disorder.

Journal Article Behav Sleep Med · 2019 Objective/Background: Despite a well-established role of guilt cognitions in the maintenance and treatment of posttraumatic stress disorder (PTSD), relationships of guilt cognitions to nightmares are not well understood. This study investigated the ways in ... Full text Link to item Cite

Cognitive Rehabilitation With Mobile Technology and Social Support for Veterans With TBI and PTSD: A Randomized Clinical Trial.

Journal Article J Head Trauma Rehabil · 2019 OBJECTIVE: To investigate effects of cognitive rehabilitation with mobile technology and social support on veterans with traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD). PARTICIPANTS: There were 112 dyads, comprised by a veteran and a ... Full text Link to item Cite

Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment.

Journal Article J Addict Med · 2019 OBJECTIVE/BACKGROUND: Posttraumatic stress disorder (PTSD) and smoking are often comorbid. Combining PTSD and smoking cessation treatments could increase access to each treatment and could provide improved rates of smoking cessation through reductions in P ... Full text Link to item Cite

Three-year overall survival update from the PACIFIC trial

Conference ONCOLOGY RESEARCH AND TREATMENT · 2019 Cite

Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab.

Journal Article Clin Cancer Res · December 15, 2018 PURPOSE: Immunotherapy has transformed the treatment of many solid tumors, with some patients deriving long-term benefit, but how to identify such patients remains unclear. Somatic mutations detected in circulating tumor DNA (ctDNA) from plasma can be an i ... Full text Link to item Cite

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC.

Journal Article N Engl J Med · December 13, 2018 BACKGROUND: An earlier analysis in this phase 3 trial showed that durvalumab significantly prolonged progression-free survival, as compared with placebo, among patients with stage III, unresectable non-small-cell lung cancer (NSCLC) who did not have diseas ... Full text Link to item Cite

Posttraumatic stress disorder diagnosis is associated with reduced parasympathetic activity during sleep in US veterans and military service members of the Iraq and Afghanistan wars.

Journal Article Sleep · December 1, 2018 STUDY OBJECTIVES: To determine whether high-frequency heart rate variability (HF-HRV) during sleep differs between those with and without posttraumatic stress disorder (PTSD) as a function of sleep type (non-rapid eye movement [NREM] vs. rapid eye movement ... Full text Link to item Cite

The Association Between Military Sexual Trauma and Use of VA and Non-VA Health Care Services Among Female Veterans With Military Service in Iraq or Afghanistan.

Journal Article J Interpers Violence · August 2018 Military sexual trauma (MST) has been linked with increased rates of mental health disorders among veterans. Few studies have addressed how MST is related to use of VA and non-VA health care. The purpose of the current study was to (a) examine the associat ... Full text Link to item Cite

Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study.

Journal Article Lancet Oncol · April 2018 BACKGROUND: Immune checkpoint inhibitors are a new standard of care for patients with advanced non-small-cell lung cancer (NSCLC) without EGFR tyrosine kinase or anaplastic lymphoma kinase (ALK) genetic aberrations (EGFR-/ALK-), but clinical benefit in pat ... Full text Link to item Cite

Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status.

Journal Article Clin Pharmacol Ther · April 2018 The objectives of this analysis were to develop a population pharmacokinetics (PK) model of durvalumab, an anti-PD-L1 antibody, and quantify the impact of baseline and time-varying patient/disease characteristics on PK. Pooled data from two studies (1,409 ... Full text Link to item Cite

Characterizing anger-related affect in individuals with posttraumatic stress disorder using ecological momentary assessment.

Journal Article Psychiatry Res · March 2018 This study employed secondary analyses of existing ecological momentary assessment (EMA) data to characterize hostile and irritable affect in the day-to-day experience of 52 smokers with, and 65 smokers without, posttraumatic stress disorder (PTSD). EMA mo ... Full text Link to item Cite

Low Income as a Multiplicative Risk Factor for Oral Pain and Dental Problems Among U.S. Veteran Smokers.

Journal Article Int J Behav Med · February 2018 PURPOSE: Compared to the United States (U.S.) general population, military veterans are at an increased risk of experiencing dental problems. This study documented associations between cigarette use and measures of dental/oral concern in a population of U. ... Full text Link to item Cite

A Randomized Clinical Trial of Nicotine Preloading for Smoking Cessation in People with Posttraumatic Stress Disorder.

Journal Article J Dual Diagn · 2018 OBJECTIVE: The aim of this research was to determine whether augmenting standard smoking cessation treatment by wearing an active nicotine patch before the smoking quit date improves rates of smoking cessation in individuals with posttraumatic stress disor ... Full text Link to item Cite

Validation of Veterans Affairs Electronic Medical Record Smoking Data Among Iraq- and Afghanistan-Era Veterans.

Journal Article J Gen Intern Med · November 2017 BACKGROUND: Research using the Veterans Health Administration (VA) electronic medical records (EMR) has been limited by a lack of reliable smoking data. OBJECTIVE: To evaluate the validity of using VA EMR "Health Factors" data to determine smoking status a ... Full text Link to item Cite

Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.

Journal Article Oncotarget · October 20, 2017 Poly (ADP-ribose) polymerase inhibitors (PARPi) have been developed and tested in a context of combining it with double-stranded (ds) DNA repair defects or inhibitors, as PARP inhibitor impairs single-stranded (ss) DNA break repair, resulting in the activa ... Full text Link to item Cite

A model comparison approach to trauma-related guilt as a mediator of the relationship between PTSD symptoms and suicidal ideation among veterans.

Journal Article J Affect Disord · October 15, 2017 BACKGROUND: Suicidal ideation (SI) is a serious issue affecting U.S. veterans, and those with posttraumatic stress disorder (PTSD) are at an especially high risk of SI. Guilt has been associated with both PTSD and SI and may therefore be an important link ... Full text Link to item Cite

Modified African Ngoma Healing Ceremony for Stress Reduction: A Pilot Study.

Journal Article J Altern Complement Med · October 2017 OBJECTIVE: Indigenous people's ceremonies using rhythm and dance have been used for countless generations throughout the world for healing, conflict resolution, social bonding, and spiritual experience. A previous study reported that a ceremony based on th ... Full text Link to item Cite

Cigarette Smoking and Musculoskeletal Pain Severity Among Male and Female Afghanistan/Iraq Era Veterans.

Journal Article Pain Med · September 1, 2017 OBJECTIVE: Cigarette smoking and musculoskeletal pain are prevalent among Department of Veterans Affairs (VA) health care system users. These conditions frequently co-occur; however, there is limited empirical information specific to Afghanistan/Iraq era v ... Full text Link to item Cite

Veterans Living with HIV: A High-Risk Group for Cigarette Smoking.

Journal Article AIDS Behav · July 2017 The Veterans Health Administration is the largest U.S. medical provider for persons living with HIV (PLHIV). Although HIV and veteran status are known risk factors for smoking, there are no population estimates of smoking prevalence among veteran PLHIV. Us ... Full text Link to item Cite

Trauma and Autonomic Dysregulation: Episodic-Versus Systemic-Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder.

Journal Article Psychosom Med · June 2017 OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to elevated heart rate (HR) and reduced heart rate variability (HRV) in cross-sectional research. Recent evidence suggests that this link may be driven by individual differences in autonomic a ... Full text Link to item Cite

Electroconvulsive Therapy and All-Cause Mortality in Texas, 1998-2013.

Journal Article J ECT · March 2017 INTRODUCTION: Electroconvulsive therapy (ECT) remains an effective treatment for major depressive disorder. Since 1995, Texas has maintained an ECT database including patient diagnoses and outcomes, and reporting any deaths within 14 days of receiving an E ... Full text Link to item Cite

Moral transgression during the Vietnam War: a path analysis of the psychological impact of veterans' involvement in wartime atrocities.

Journal Article Anxiety Stress Coping · March 2017 BACKGROUND AND OBJECTIVES: Involvement in wartime combat often conveys a number of deleterious outcomes, including posttraumatic stress disorder (PTSD), depression, hostility, aggression, and suicidal ideation. Less studied is the effect of engagement in w ... Full text Link to item Cite

Daily associations between PTSD, drinking, and self-appraised alcohol-related problems.

Journal Article Psychol Addict Behav · February 2017 Alcohol dependence (AD) and posttraumatic stress disorder (PTSD) are highly comorbid, yet limited research has focused on PTSD and daily drinking as they relate to self-appraised alcohol-related problems. In treatment contexts, patients' appraisals of alco ... Full text Link to item Cite

Trauma and Autonomic Dysregulation: Episodic - Versus Systemic - Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder.

Journal Article Psychosom Med · December 9, 2016 OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to elevated heart rate (HR) and reduced heart-rate variability (HRV) in cross-sectional research. Recent evidence suggests that this link may be driven by individual differences in autonomic a ... Full text Link to item Cite

Aging-related gains and losses associated with word production in connected speech.

Journal Article Neuropsychol Dev Cogn B Aging Neuropsychol Cogn · November 2016 Older adults have been observed to use more nonnormative, or atypical, words than younger adults in connected speech. We examined whether aging-related losses in word-finding abilities or gains in language expertise underlie these age differences. Sixty yo ... Full text Link to item Cite

Engagement and abstinence among users of a smoking cessation text message program for veterans.

Journal Article Addict Behav · November 2016 BACKGROUND: SmokefreeVET is a text messaging smoking cessation program available to veterans enrolled in the Veterans Health Administration. SmokefreeVET was developed in collaboration with the National Cancer Institute as part of the SmokefreeTXT initiati ... Full text Link to item Cite

Circadian Contrasts in Heart Rate Variability Associated With Posttraumatic Stress Disorder Symptoms in a Young Adult Cohort.

Journal Article J Trauma Stress · October 2016 Prior research has demonstrated that individuals exposed to trauma have shown impaired autonomic function. We sought to determine if heart rate variability (HRV), a marker of impaired autonomic function, differed across periods of wake, rest, and sleep as ... Full text Link to item Cite

Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability.

Journal Article Psychosom Med · September 2016 OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to elevated heart rate (HR) and reduced heart rate variability (HRV) in cross-sectional research. Using ecological momentary assessment and minute-to-minute HRV/HR monitoring, we examined whet ... Full text Link to item Cite

Roles of inter-individual differences and intra-individual acute elevations in early smoking lapse in people with posttraumatic stress disorder.

Journal Article Addict Behav · September 2016 Existing models of the role of posttraumatic stress disorder (PTSD) symptoms and smoking have almost exclusively examined mean symptom levels, rather than the acute elevations that might trigger smoking lapse immediately or increase risk of a smoking lapse ... Full text Link to item Cite

Beyond mental illness: Targeting stronger and more direct pathways to violence

Journal Article Clinical Psychological Science · September 1, 2016 The association between violence and serious mental illness (SMI)—schizophrenia, other psychotic disorder, bipolar disorder, or major depressive disorder—was examined and guided by the I3 model to frame analysis of the National Epidemiologic Survey on Alco ... Full text Cite

Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial.

Journal Article Addict Behav · August 2016 BACKGROUND: Individuals with posttraumatic stress disorder (PTSD) are more likely to smoke and more likely to relapse following a quit attempt than individuals without PTSD. Thus, there is a significant need to study promising interventions that might impr ... Full text Link to item Cite

The prevalence of binge drinking and receipt of provider drinking advice among US veterans with military service in Iraq or Afghanistan.

Journal Article Am J Drug Alcohol Abuse · May 2016 BACKGROUND: Binge drinking is a significant public health concern linked to a number of health and psychosocial problems. Military service in Afghanistan (OEF) and Iraq (OIF) has been associated with posttraumatic stress disorder (PTSD) and increased hazar ... Full text Link to item Cite

An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder.

Journal Article J Psychosom Res · April 2016 OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to chronic inflammation, a condition that poses a risk for cardiovascular disease. Attenuated vagal activity has been proposed as a potential mediator of PTSD and inflammation, although associ ... Full text Link to item Cite

Exploring the relationship between posttraumatic stress disorder symptoms and momentary heart rate variability.

Journal Article J Psychosom Res · March 2016 OBJECTIVE: Exposure to trauma-related cues has been associated with a prolonged decrease in heart rate variability (HRV) under laboratory conditions, however the relationship between PTSD symptoms and HRV has not been evaluated during everyday life. The pr ... Full text Link to item Cite

Pilot Cases of Combined Cognitive Processing Therapy and Smoking Cessation for Smokers With Posttraumatic Stress Disorder.

Journal Article Behav Ther · January 2016 Posttraumatic stress disorder (PTSD) and smoking are often comorbid, and both problems are in need of improved access to evidence-based treatment. The combined approach could address two high-priority problems and increase patient access to both treatments ... Full text Link to item Cite

Posttraumatic Stress Disorder, Hostile Cognitions, and Aggression in Iraq/Afghanistan Era Veterans.

Journal Article Psychiatry · 2016 OBJECTIVE: Most veterans with posttraumatic stress disorder (PTSD) are not violent, yet research has demonstrated that there is a substantial minority who are at increased risk. This study tested hypotheses regarding hyperarousal symptoms and hostile cogni ... Full text Link to item Cite

Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans.

Journal Article J Clin Psychiatry · July 2015 INTRODUCTION: Smoking rates are 80% among persons who are homeless, and these smokers have decreased odds of quitting smoking. Little is known about relapse rates among homeless smokers. More information is needed regarding both quit rates and innovative m ... Full text Link to item Cite

Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone.

Journal Article Oncotarget · May 10, 2015 Adenomatous tumors in the middle ear and temporal bone are rare but highly morbid because they are difficult to detect prior to the development of audiovestibular dysfunction. Complete resection is often disfiguring and difficult because of location and th ... Full text Link to item Cite

Orthostatic hypotension in young adults with and without posttraumatic stress disorder.

Journal Article Psychol Trauma · May 2015 The purpose of this research is (a) to evaluate differences in orthostatic hypotension (OH) among young adults with and without posttraumatic stress disorder (PTSD) and (b) to examine whether group differences may be attributable to behavioral risk factors ... Full text Link to item Cite

Impact of HIV on lung tumorigenesis in an animal model.

Journal Article AIDS · March 13, 2015 Many HIV patients on antiretroviral therapy have controlled viremia and restored (albeit partially) immunity. Yet, they have high rates of lung cancer, even after controlling for smoking. We tested the hypothesis that HIV proteins accelerate development/pr ... Full text Link to item Cite

Tobacco use trajectories among a large cohort of treated smokers with posttraumatic stress disorder.

Journal Article Addict Behav · February 2015 INTRODUCTION: This study identified distinct tobacco use trajectories across 18months in 943 veteran smokers with posttraumatic stress disorder (PTSD) in order to describe quit and relapse patterns, examine associations between trajectory groups on baselin ... Full text Link to item Cite

Latent Factor Structure of DSM-5 Posttraumatic Stress Disorder.

Journal Article Psychopathol Rev · 2015 The current study examined the latent factor structure of posttraumatic stress disorder (PTSD) based on DSM-5 criteria in a sample of participants (N = 374) recruited for studies on trauma and health. Confirmatory factor analyses (CFA) were used to compare ... Full text Link to item Cite

DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis.

Journal Article J Psychiatr Res · December 2014 Posttraumatic stress disorder (PTSD) is a significant problem among Iraq/Afghanistan-era veterans. To date, however, there has been only limited research on how the recent changes in DSM-5 influence the prevalence and factor structure of PTSD. To address t ... Full text Link to item Cite

Posttraumatic stress, heart rate variability, and the mediating role of behavioral health risks.

Journal Article Psychosom Med · October 2014 OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to reduced heart rate variability (HRV), which is in turn a risk factor for cardiovascular disease and death. Although hyperarousal and anxiety are thought to underlie this association, behavi ... Full text Link to item Cite

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors.

Journal Article Oncotarget · September 30, 2014 Nelfinavir is an HIV protease inhibitor being repurposed as an anti-cancer agent in preclinical models and in small oncology trials, yet the MTD of nelfinavir has not been determined. Therefore, we conducted a Phase Ia study to establish the maximum tolera ... Full text Link to item Cite

Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder.

Journal Article Subst Use Misuse · September 2014 The current study assessed antecedents and consequences of ad lib cigarette smoking in smokers diagnosed with attention-deficit/hyperactivity disorder (ADHD) using ecological momentary assessment (EMA). Adult smokers with ADHD (n = 17) completed 870 smokin ... Full text Link to item Cite

Examining the factor structure of the Connor-Davidson Resilience Scale (CD-RISC) in a post-9/11 U.S. military veteran sample.

Journal Article Assessment · August 2014 The present study examined the structural validity of the 25-item Connor-Davidson Resilience Scale (CD-RISC) in a large sample of U.S. veterans with military service since September 11, 2001. Participants (N = 1,981) completed the 25-item CD-RISC, a struct ... Full text Open Access Link to item Cite

Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse?

Journal Article Addict Behav · July 2014 BACKGROUND: Following a smoking cessation attempt, smokers with posttraumatic stress disorder (PTSD) experience smoking relapse at a higher and faster rate. Black ethnicity and female gender are also associated with lower success rates following smoking ce ... Full text Link to item Cite

Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia.

Journal Article J Psychosom Res · July 2014 OBJECTIVES: Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, ... Full text Link to item Cite

The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt.

Journal Article Nicotine Tob Res · June 2014 INTRODUCTION: Ecological momentary assessment (EMA) has shown that smoking behavior is linked to transient variables in the smoker's immediate context. Such research suggests that daily hassles (e.g., losing one's keys) may be more likely to lead to cigare ... Full text Link to item Cite

Nelfinavir inhibits maturation and export of herpes simplex virus 1.

Journal Article J Virol · May 2014 UNLABELLED: Nelfinavir (NFV) is an HIV-1 protease inhibitor with demonstrated antiviral activity against herpes simplex virus 1 (HSV-1) and several other herpesviruses. However, the stages of HSV-1 replication inhibited by NFV have not been explored. In th ... Full text Link to item Cite

Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt.

Journal Article Nicotine Tob Res · April 2014 INTRODUCTION: Smokers with posttraumatic stress disorder (PTSD) tend to lapse more quickly following a quit attempt, which might be explained by changes in PTSD symptoms during a quit attempt. The present study examines changes in PTSD symptoms, negative a ... Full text Link to item Cite

Molecular pathways and therapeutic targets in lung cancer.

Journal Article Oncotarget · March 30, 2014 Lung cancer is still the leading cause of cancer death worldwide. Both histologically and molecularly lung cancer is heterogeneous. This review summarizes the current knowledge of the pathways involved in the various types of lung cancer with an emphasis o ... Full text Link to item Cite

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.

Journal Article Oncotarget · February 28, 2014 Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases, and almost half of newly diagnosed patients have metastatic disease. Pemetrexed is a widely used drug for NSCLC and inhibits several folate-dependent enzymes including thymidylate ... Full text Link to item Cite

Personality assessment inventory internalizing and externalizing structure in veterans with posttraumatic stress disorder: associations with aggression.

Journal Article Aggress Behav · 2014 Posttraumatic stress disorder (PTSD) is associated with aggressive behavior in veterans, and difficulty controlling aggressive urges has been identified as a primary postdeployment readjustment concern. Yet only a fraction of veterans with PTSD commit viol ... Full text Link to item Cite

Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer.

Journal Article J Urol · December 2013 PURPOSE: Cowden syndrome is a hereditary cancer syndrome associated with a germline mutation in PTEN. Patients are predisposed to multiple malignancies including renal cell carcinoma. MATERIALS AND METHODS: Patients with Cowden syndrome were evaluated as p ... Full text Link to item Cite

Mobile contingency management as an adjunctive smoking cessation treatment for smokers with posttraumatic stress disorder.

Journal Article Nicotine Tob Res · November 2013 INTRODUCTION: Smokers with posttraumatic stress disorder (PTSD) smoke at higher prevalence rates and are more likely to relapse early in a quit attempt. Innovative methods are needed to enhance quit rates, particularly in the early quit period. Web-based c ... Full text Link to item Cite

Information content moderates positivity and negativity biases in memory.

Journal Article Psychol Aging · September 2013 Two experiments examined the impact of encoding conditions and information content in memory for positive, neutral, and negative pictures. We examined the hypotheses that the positivity effect in memory (i.e., a bias in favor of positive or against negativ ... Full text Link to item Cite

Repositioning metformin for cancer prevention and treatment.

Journal Article Trends Endocrinol Metab · September 2013 Metformin is the most commonly prescribed drug for type 2 diabetes (T2DM). Retrospective studies show that metformin is associated with decreased cancer risk. This historical correlation has driven vigorous research campaigns to determine the anticancer me ... Full text Link to item Cite

Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling

Journal Article Cancer Prevention Research · August 1, 2013 Metformin is the most commonly prescribed drug for type II diabetes and is associated with decreased cancer risk. Previously, we showed that metformin prevented tobacco carcinogen (NNK)-induced lung tumorigenesis in a non-diabetic mouse model, which was as ... Full text Cite

Management of reproductive health in Cowden syndrome complicated by endometrial polyps and breast cancer.

Journal Article Obstet Gynecol · February 2013 BACKGROUND: Cowden syndrome is an autosomal-dominant condition associated with mutations in the tumor suppressor gene PTEN. Gynecologic malignancies are common with a 5-10% risk of endometrial cancer and 25-50% risk of breast cancer. CASE: A 37-year-old wo ... Link to item Cite

Is believing seeing? The role of emotion-related beliefs in selective attention to affective cues.

Journal Article Cogn Emot · 2013 Attentional disengagement from negative affective information and engagement toward positive affective information appears to reflect an avoidant coping mechanism, one that may be associated with the belief that negative emotions are dangerous or undesirab ... Full text Link to item Cite

Lipid molecules induce p38α activation via a novel molecular switch.

Journal Article J Mol Biol · December 14, 2012 p38α mitogen-activated protein kinase (MAPK) is generally activated by dual phosphorylation but has also been shown to exhibit alternative activation modes. One of these modes included a direct interaction with phosphatidylinositol ether lipid analogues (P ... Full text Link to item Cite

Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium.

Journal Article Cancer Genet · October 2012 Li-Fraumeni syndrome (LFS) is a rare dominantly inherited cancer predisposition syndrome that was first described in 1969. In most families, it is caused by germline mutations in the TP53 gene and is characterized by early onset of multiple specific cancer ... Full text Link to item Cite

Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.

Journal Article Cell Death Dis · July 19, 2012 Exploiting protein homeostasis is a new therapeutic approach in cancer. Nelfinavir (NFV) is an HIV protease inhibitor that induces endoplasmic reticulum (ER) stress in cancer cells. Under conditions of ER stress, misfolded proteins are transported from the ... Full text Link to item Cite

Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.

Journal Article Cell Death Dis · July 5, 2012 Anticancer phospholipids that inhibit Akt such as the alkylphospholipid perifosine (Per) and phosphatidylinositol ether lipid analogs (PIAs) promote cellular detachment and apoptosis and have a similar cytotoxicity profile against cancer cell lines in the ... Full text Link to item Cite

A novel classification of lung cancer into molecular subtypes.

Journal Article PLoS One · 2012 The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. The discovery of multiple molecular mechanisms underlying the development, ... Full text Link to item Cite

Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.

Journal Article Cancer Prev Res (Phila) · November 2011 Smoking is the leading cause of preventable cancer deaths in the United States. Nicotine replacement therapies (NRT) have been developed to aid in smoking cessation, which decreases lung cancer incidence. However, the safety of NRT is controversial because ... Full text Link to item Cite

Starting with the ABCs: Akt in breast cancer.

Journal Article Mol Cancer Ther · November 2011 Full text Link to item Cite

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.

Journal Article Carcinogenesis · August 2011 Lung tumors from smokers as well as lung tumors from mice exposed to tobacco carcinogens such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), often carry mutations in K-ras, which activates downstream-signaling pathways such as PI3K/AKT/mTOR pathw ... Full text Link to item Cite

Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.

Journal Article Mol Cancer Ther · July 2011 Activation of the serine/threonine kinase Akt contributes to the formation, maintenance, and therapeutic resistance of cancer, which is driving development of compounds that inhibit Akt. Phosphatidylinositol ether lipid analogues (PIA) are analogues of the ... Full text Link to item Cite

Akt1 deletion prevents lung tumorigenesis by mutant K-ras.

Journal Article Oncogene · April 14, 2011 K-ras mutations are associated with smoking-induced lung cancer and poor clinical outcomes. In mice, K-ras mutations are sufficient to induce lung tumors, which require phosphoinoside-3-kinase (PI3K) and further downstream, mammalian target of rapamycin (m ... Full text Link to item Cite

PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

Journal Article Nat Rev Cancer · April 2011 PTEN is among the most frequently inactivated tumour suppressor genes in sporadic cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor activity is dependent on its lipid phosphatase activity, which negatively regulates th ... Full text Link to item Cite

The Influence of Family Expressiveness, Individuals' Own Emotionality, and Self-Expressiveness on Perceptions of Others' Facial Expressions

Journal Article Journal of Nonverbal Behavior · March 1, 2011 To examine individual differences in decoding facial expressions, college students judged type and emotional intensity of emotional faces at five intensity levels and completed questionnaires on family expressiveness, emotionality, and self-expressiveness. ... Full text Cite

Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance.

Journal Article PLoS One · 2011 The dismal lethality of lung cancer is due to late stage at diagnosis and inherent therapeutic resistance. The incorporation of targeted therapies has modestly improved clinical outcomes, but the identification of new targets could further improve clinical ... Full text Link to item Cite

Metformin prevents tobacco carcinogen--induced lung tumorigenesis.

Journal Article Cancer Prev Res (Phila) · September 2010 Activation of the mammalian target of rapamycin (mTOR) pathway is an important and early event in tobacco carcinogen-induced lung tumorigenesis, and therapies that target mTOR could be effective in the prevention or treatment of lung cancer. The biguanide ... Full text Link to item Cite

The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.

Journal Article Clin Cancer Res · January 1, 2010 Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use. Tobacco components promote lung tumorigenesis through genotoxic effects, as well as through biochemical modul ... Full text Link to item Cite

Akt-dependent and -independent mechanisms of mTOR regulation in cancer.

Journal Article Cell Signal · May 2009 The protein kinase mTOR (mammalian target of rapamycin) is a critical regulator of cellular metabolism, growth, and proliferation. These processes contribute to tumor formation, and many cancers are characterized by aberrant activation of mTOR. Although ac ... Full text Link to item Cite

Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas.

Journal Article Proc Natl Acad Sci U S A · April 14, 2009 To look for a direct role of ultraviolet radiation (UV) exposure in cutaneous melanoma induction, we studied xeroderma pigmentosum (XP) patients who have defective DNA repair resulting in a 1000-fold increase in melanoma risk. These XP melanomas have the s ... Full text Link to item Cite

The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers.

Journal Article Cancer Prev Res (Phila) · April 2009 Myoinositol is an isomer of glucose that has chemopreventive activity in animal models of cancer. In a recent phase I clinical trial, myoinositol administration correlated with a statistically significant regression of preexisting bronchial dysplastic lesi ... Full text Link to item Cite

Perifosine: update on a novel Akt inhibitor.

Journal Article Curr Oncol Rep · March 2009 The PI3K/Akt/mTOR pathway is aberrantly active in most human cancers and contributes to cell growth, proliferation, and survival. Akt is a nodal regulator of cellular survival pathways and an attractive target in cancer therapy. Many inhibitors of Akt are ... Full text Link to item Cite

A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.

Journal Article PLoS One · 2009 BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung ade ... Full text Link to item Cite

Repositioning HIV protease inhibitors as cancer therapeutics

Journal Article Current Opinion in HIV and AIDS · November 1, 2008 PURPOSE OF REVIEW: Although designed to target only the HIV protease, HIV protease inhibitors induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that protease inhibitors have other targets in mammalian cells. Akt contro ... Full text Cite

PTEN hamartoma tumor syndromes.

Journal Article Eur J Hum Genet · November 2008 The PTEN hamartoma tumor syndromes (PHTS) are a collection of rare clinical syndromes characterized by germline mutations of the tumor suppressor PTEN. These syndromes are driven by cellular overgrowth, leading to benign hamartomas in virtually any organ. ... Full text Link to item Cite

Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.

Journal Article Neoplasia · August 2008 Pten is a negative regulator of the Akt pathway, and its inactivation is believed to be an etiological factor in many tumor types. Pten+/- mice are susceptible to a variety of spontaneous tumor types, depending on strain background. Pten+/- mice, in lung t ... Full text Link to item Cite

Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.

Journal Article Cancer Res · January 15, 2008 Loss of function of the tumor suppressor LKB1 occurs in 30% to 50% of lung adenocarcinomas. Because LKB1 activates AMP-activated protein kinase (AMPK), which can negatively regulate mTOR, AMPK activation might be desirable for cancer therapy. However, no k ... Full text Link to item Cite

Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy.

Journal Article Autophagy · January 2008 The development of cancer drugs is slow and costly. One approach to accelerate the availability of new drugs is to reposition drugs approved for other indications as anti-cancer agents. HIV protease inhibitors (HIV PIs) are useful in treating HIV infection ... Full text Link to item Cite

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.

Journal Article Drug Resist Updat · 2008 The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated in many types of cancer. Mechanisms for pathway activation include loss of tumor suppressor PTEN function, amplification or mutation of PI3K, amplification or mutat ... Full text Link to item Cite

PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development.

Journal Article Crit Rev Oncol Hematol · September 2007 Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene located on chromosome 10q22-23 that negatively regulates the pro-survival PI3K/Akt/mTOR pathway by functioning as a lipid phosphatase. Signaling through this pathwa ... Full text Link to item Cite

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.

Journal Article Clin Cancer Res · September 1, 2007 PURPOSE: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because these drugs cause toxicities that can be associated with inhibition of Akt, an emerging target in c ... Full text Link to item Cite

Targeting Akt in cancer therapy.

Journal Article Anticancer Drugs · September 2007 In an effort to improve therapeutic options in cancer, many investigational drugs are being developed to inhibit signaling pathways that promote the survival of cancer cells. The prototypic pathway that promotes cellular survival is the phosphoinositide 3' ... Full text Link to item Cite

Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.

Journal Article Clin Cancer Res · April 1, 2007 PURPOSE: Human and murine preneoplastic lung lesions induced by tobacco exposure are characterized by increased activation of the Akt/mammalian target of rapamycin (mTOR) pathway, suggesting a role for this pathway in lung cancer development. To test this, ... Full text Link to item Cite

Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma.

Journal Article Lung Cancer · January 2007 PURPOSE: Lung cancer is the leading cause of cancer related mortality in the world. Bronchioloalveolar carcinoma (BAC) is a subset of NSCLC that has recently gained attention because of distinct biological and clinical features, increased incidence, and en ... Full text Link to item Cite

Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.

Journal Article Clin Cancer Res · June 1, 2006 PURPOSE: Thalidomide has gained renewed interest as a cancer therapeutic due to its potential antiangiogenic effects. The thalidomide analogues CPS11 and CPS49 are active in preclinical angiogenesis assays and xenograft model systems, but the biochemical b ... Full text Link to item Cite

Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.

Journal Article Mol Cancer Ther · March 2006 The serine/threonine kinase Akt is a promising target in cancer. We previously identified five phosphatidylinositol ether lipid analogues (PIA) that inhibited Akt activation and selectively killed lung and breast cancer cells with high levels of Akt activi ... Full text Link to item Cite

Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway.

Journal Article Clin Cancer Res · February 1, 2006 The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis ... Full text Link to item Cite

Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.

Journal Article J Clin Oncol · January 10, 2006 PURPOSE: Akt is a serine/threonine kinase that has been implicated in lung tumorigenesis and lung cancer therapeutic resistance. Full activation of Akt requires two phosphorylation events, but only one site of phosphorylation (S473) has been evaluated thus ... Full text Link to item Cite

Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.

Journal Article Cancer Res · September 15, 2005 The fact that small cell lung cancer (SCLC) is commonly incurable despite being initially responsive to chemotherapy, combined with disappointing results from a recent SCLC clinical trial with imatinib, has intensified efforts to identify mechanisms of SCL ... Full text Link to item Cite

Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.

Journal Article Cancer Res · August 15, 2005 Malignant salivary gland tumors can arise from a t(11;19) translocation that fuses 42 residues from Mect1/Torc1, a cyclic AMP (cAMP)/cAMP-responsive element binding protein (CREB)-dependent transcriptional coactivator, with 982 residues from Maml2, a NOTCH ... Full text Link to item Cite

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.

Journal Article Carcinogenesis · July 2005 Retrospective studies have shown that patients with tobacco-related cancers who continue to smoke after their diagnoses have lower response rates and shorter median survival compared with patients who stop smoking. To provide insight into the biologic basi ... Full text Link to item Cite

Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death.

Journal Article Cancer Res · March 15, 2005 Patients whose neuroblastoma tumors express high levels of brain-derived neurotrophic factor (BDNF) and TrkB have an unfavorable prognosis. Our previous studies indicated that BDNF activation of the TrkB signal transduction pathway blocked the cytotoxic ef ... Full text Link to item Cite

Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E.

Journal Article Carcinogenesis · March 2005 The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by the availability of suitable laboratory animal models. Here we report that male Hartley guinea pigs treated with cigarette smoke ... Full text Link to item Cite

An overview of lung cancer genomics and proteomics.

Journal Article Am J Respir Cell Mol Biol · March 2005 Lung cancer is the cause of nearly 170,000 cancer deaths in the United States each year, accounting for nearly 25% of all deaths from cancer. The 5-yr survival rate for lung cancer is < 15% from the time of diagnosis. This is largely due to the late stage ... Full text Link to item Cite

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

Journal Article Mol Cancer Ther · February 2005 The abilities of mutated active RAS proteins to modulate cell survival following exposure to ionizing radiation and small molecule kinase inhibitors were examined. Homologous recombination in HCT116 cells to delete the single allele of K-RAS D13 resulted i ... Link to item Cite

Disparities in cancer funding.

Journal Article Science · September 3, 2004 Full text Link to item Cite

The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.

Journal Article Expert Opin Investig Drugs · July 2004 The serine/threonine kinase Akt is a component of the phosphatidylinositol 3'-kinase/Akt signal transduction pathway that is activated by receptor tyrosine kinases, activated Ras and integrins. As Akt regulates many processes crucial to carcinogenesis, and ... Full text Link to item Cite

Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.

Journal Article Cancer Res · April 15, 2004 Activation of the PI3k/Akt pathway controls key cellular processes and contributes to tumorigenesis in vivo, but investigation of the PI3k/Akt pathway has been limited by the lack of specific inhibitors directed against Akt. To develop Akt inhibitors, we u ... Full text Link to item Cite

Targeting aberrant signal transduction pathways in lung cancer.

Journal Article Cancer Biol Ther · February 2004 Lung cancer is the deadliest form of cancer in the world and is most commonly associated with smoking. Current treatment strategies are largely ineffective due to advanced stage at diagnosis and the inherent therapeutic resistance of lung cancer cells. To ... Full text Link to item Cite

Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.

Journal Article Cancer Res · January 15, 2004 The role of the phosphatidylinositol 3'-kinase (PI3K)/Akt pathway during tobacco carcinogen-induced transformation is unknown. To address this question, we evaluated this pathway in isogenic immortalized or tumorigenic human bronchial epithelial cells in v ... Full text Link to item Cite

Modulating protein kinase C (PKC) to increase the efficacy of chemotherapy: stepping into darkness.

Journal Article Drug Resist Updat · December 2003 The identification of molecules that promote chemotherapeutic resistance would allow rationally designed approaches to abrogate this resistance, thereby possibly improving clinical outcomes for patients with cancer. In this regard, the PKC family is attrac ... Full text Link to item Cite

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.

Journal Article Oncogene · May 8, 2003 We have examined the possible mechanisms of resistance to the epidermal growth factor receptor (EGFR) inhibitors in tumor cells with variable levels of EGFR. ZD1839 (Iressa) is a small-molecular-weight, ATP-mimetic that specifically inhibits the EGFR tyros ... Full text Link to item Cite

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.

Journal Article Cancer Res · February 15, 2003 Drugs that target protein kinase C (PKC) are now being evaluated in patients with non-small cell lung cancer (NSCLC), but the role of PKC in NSCLC cells remains unclear. We report here that NSCLC cell lines show enhanced phosphorylation and altered express ... Link to item Cite

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

Journal Article J Am Chem Soc · February 5, 2003 The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1, ... Full text Link to item Cite

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.

Journal Article J Clin Invest · January 2003 Tobacco-related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400,000 deaths per year occurring in the US. Genotoxic effects of tobacco components have been described, but effects on signaling pathways in normal ce ... Full text Link to item Cite

Activation of the PI3K/Akt pathway and chemotherapeutic resistance.

Journal Article Drug Resist Updat · December 2002 The resistance of many types of cancer to conventional chemotherapies is a major factor undermining successful cancer treatment. In this review, the role of a signal transduction pathway comprised of the lipid kinase, phosphatidylinositol 3-kinase (PI3K), ... Full text Link to item Cite

Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.

Journal Article Cell Death Differ · September 2002 To evaluate the role of the MEK/ERK pathway in NSCLC survival, we analyzed NSCLC cell lines that differed in tumor histology and status of p53, Rb, and K-ras. Constitutive ERK1/2 activity was demonstrated in 17 of 19 cell lines by maintenance of ERK1/2 pho ... Full text Link to item Cite

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Journal Article Mol Cancer Ther · July 2002 To evaluate the role of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in breast cancer cell survival and therapeutic resistance, we analyzed a panel of six breast cancer cell lines that varied in erbB2 and estrogen receptor status. Akt activity was ... Link to item Cite

Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.

Journal Article Cancer Res · June 15, 2001 We investigated whether combined treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and trastuzumab could enhance the specific killing of cells that overexpress the erbB-2 receptor. The combination resulted in an enhancement of ... Link to item Cite

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

Journal Article Cancer Res · May 15, 2001 To evaluate the role of Akt/PKB in non-small cell lung cancer (NSCLC) survival, we analyzed NSCLC cell lines that differed in tumor histology as well as p53, Rb, and K-ras status. Constitutive Akt/protein kinase B (PKB) activity was demonstrated in 16 of 1 ... Link to item Cite

Downregulation of p21/WAF1 expression by thymidylate synthase

Journal Article Biochemical and Biophysical Research Communications · January 1, 2001 We developed a cell system where expression of thymidylate synthase (TS), an enzyme essential for DNA synthesis, can be modulated by a Zn2+-inducible promoter in MCF-7 cells. We found that overexpression of TS resulted in downregulation of p21 protein and ... Full text Cite

Cellular survival pathways and resistance to cancer therapy.

Journal Article Drug Resist Updat · 1998 Chemotherapy and irradiation induce programmed cell death (apoptosis) in their target cells. Dysregulated apoptosis is a feature that is selected for during tumor formation and contributes to therapeutic resistance. Cell survival in the face of cytotoxic t ... Full text Link to item Cite

Cell cycle and cell death after DNA damaye

Journal Article FASEB Journal · December 1, 1997 A variety of cellular responses to DNA damage influence cellular fate, such as whether heritable genetic alterations are passed on to daughter cells and whether the cell survives the damaging insult. The p53 and ATM gene products play critical roles in mod ... Cite

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

Journal Article Proc Natl Acad Sci U S A · January 15, 1991 The activation of latent transforming growth factor beta (LTGF-beta) normally seen in cocultures of bovine aortic endothelial and bovine smooth muscle cells can be inhibited by coculturing the cells with either mannose 6-phosphate (Man-6-P) or antibodies d ... Full text Link to item Cite

Growth factor control of extracellular proteolysis.

Journal Article Cell Differ Dev · December 2, 1990 The involvement of proteases and growth factors in angiogenesis is complex. The angiogenic factor basic fibroblast growth factor (bFGF) induces increased synthesis of both plasminogen activator and collagenase in endothelial cells. In addition, bFGF increa ... Full text Link to item Cite

Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth.

Journal Article J Cell Physiol · July 1990 Affinity-purified polyclonal rabbit antibodies prepared against recombinant basic fibroblast growth factor (bFGF) neutralized the ability of bFGF to stimulate plasminogen activator (PA) production and endothelial cell migration in vitro. After iodination a ... Full text Link to item Cite

Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor.

Journal Article J Biol Chem · May 5, 1989 After incubation with human serum or plasma, 125I-basic fibroblast growth factor (bFGF) (molecular mass 18.5 kDa) exhibits molecular mass forms greater than 200 kDa as determined by nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis foll ... Link to item Cite