Journal ArticlePLoS One · 2024
Lyme disease is a spatially heterogeneous tick-borne infection, with approximately 85% of US cases concentrated in the mid-Atlantic and northeastern states. Surveillance for Lyme disease and its causative agent, including public health case reporting and e ...
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Journal ArticleJAMA network open · December 2023
ImportanceStudies elucidating determinants of residential neighborhood-level health inequities are needed.ObjectiveTo quantify associations of structural racism indicators with neighborhood prevalence of chronic kidney disease (CKD), diab ...
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Journal ArticleJAMA Oncol · October 1, 2023
IMPORTANCE: Fertility preservation (FP), including oocyte and embryo cryopreservation prior to gonadotoxic therapy, is an urgent and essential component of comprehensive cancer care. Geographic proximity to a center offering FP is a critical component of e ...
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Journal ArticleJ Clin Microbiol · July 20, 2023
Escherichia coli sequence type 131 (ST131) is a globally dominant multidrug-resistant clone, although its clinical impact on patients with bloodstream infection (BSI) is incompletely understood. This study aims to further define the risk factors, clinical ...
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Journal ArticleClin Infect Dis · April 3, 2023
BACKGROUND: Staphylococcus aureus bacteremia (SAB) disproportionately affects Black patients. The reasons for this disparity are unclear. METHODS: We evaluated a prospectively ascertained cohort of patients with SAB from 1995 to 2020. Clinical characterist ...
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Journal ArticleLaryngoscope Investig Otolaryngol · October 2022
OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long-term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retro ...
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Journal ArticleZoonoses Public Health · September 2022
The epidemiological profile of rabies virus within Mongolia remains poorly characterized despite 21,302 domestic animal cases being reported between 1970-2005. This lack of knowledge is particularly concerning given that roughly 26% of the population lives ...
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Journal ArticleVector Borne Zoonotic Dis · November 2021
Background: A history of Lyme disease can complicate the interpretation of Lyme disease serology in acutely symptomatic patients. Materials and Methods: We prospectively enrolled children undergoing evaluation for Lyme disease in the emergency department o ...
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Journal ArticleInt J Pediatr Otorhinolaryngol · September 2021
INTRODUCTION: Congenital CMV (cCMV) is the leading cause of non-genetic sensorineural hearing loss. Babies with cCMV can present with hearing loss any time but failing the initial hearing screen should trigger cCMV testing. cCMV must be identified within 3 ...
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Journal ArticleJ Med Entomol · July 16, 2021
Lyme disease is the most common tick-borne disease in North America. Though human infection is mostly transmitted in a limited geography, the range has expanded in recent years. One notable area of recent expansion is in the mountainous region of southwest ...
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Journal ArticlePLoS Negl Trop Dis · July 2021
BACKGROUND: Cryptosporidium spp. and Giardia duodenalis are important zoonotic enteric pathogens of One Health concern for humans, animals, and the environment. For this study, we investigated parasite prevalence and risk factors among rural, peri-urban, a ...
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Journal ArticlePediatr Blood Cancer · June 2021
BACKGROUND: This retrospective study harnessed an institutional cancer registry to construct a childhood cancer survivorship cohort, integrate electronic health record (EHR) and geospatial data to stratify survivors based on late-effect risk, analyze follo ...
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Journal ArticleNeurology · February 9, 2021
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing the Infectious Diseases Society of America (IDSA), the American Academy of Neurology (AAN), ...
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Journal ArticleClin Infect Dis · January 27, 2021
The purpose of this guideline is to provide evidence-based guidance for the most effective strategies for the diagnosis and management of babesiosis. The diagnosis and treatment of co-infection with babesiosis and Lyme disease will be addressed in a separa ...
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Journal ArticleClin Infect Dis · January 27, 2021
The purpose of this guideline is to provide evidence-based guidance for the most effective strategies for the diagnosis and management of babesiosis. The diagnosis and treatment of co-infection with babesiosis and Lyme disease will be addressed in a separa ...
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Journal ArticleClin Infect Dis · January 23, 2021
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing the Infectious Diseases Society of America (IDSA), the American Academy of Neurology (AAN), ...
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Journal ArticleClin Infect Dis · January 23, 2021
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing the Infectious Diseases Society of America (IDSA), the American Academy of Neurology (AAN), ...
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Journal ArticleOpen Forum Infect Dis · January 2021
BACKGROUND: Emerging evidence suggests that black and Hispanic communities in the United States are disproportionately affected by coronavirus disease 2019 (COVID-19). A complex interplay of socioeconomic and healthcare disparities likely contribute to dis ...
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Journal ArticleFront Public Health · 2021
Background: Attempts to quantify effect sizes of non-pharmaceutical interventions (NPI) to control COVID-19 in the US have not accounted for heterogeneity in social or environmental factors that may influence NPI effectiveness. This study quantifies nation ...
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Journal ArticleJ Urban Health · December 2020
Drug overdoses are a national and global epidemic. However, while overdoses are inextricably linked to social, demographic, and geographical determinants, geospatial patterns of drug-related admissions and overdoses at the neighborhood level remain poorly ...
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Journal Article · August 20, 2020
ABSTRACTAlthough coronavirus disease 2019 (COVID-19) emerged in January 2020, there is no quantified effect size for non-pharmaceutical interventions (NPI) to control the outbreak in the continental US. Objective. To quanti ...
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ConferenceTrans R Soc Trop Med Hyg · June 1, 2020
BACKGROUND: Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012-2013, we documented that acute dengue was surprisingly associated with self-reported rural residence in the Souther ...
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Journal ArticleZoonoses Public Health · February 2020
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Staphylococcus sciuri is an occasional cause of human infection that has been described in the flora of numerous animal species and in environmental specimens. Here, we report a rare case of S. sciuri peritonitis in a dialysis patient who had exposure to p ...
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Journal ArticleOpen Forum Infect Dis · December 2019
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BACKGROUND: Pharyngitis due to group A Streptococcus (GAS) is a common pediatric infection. Physicians might diagnose GAS pharyngitis more accurately when given biosurveillance information about GAS activity. The availability of geographic GAS testing data ...
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Journal ArticleObstet Gynecol · July 2019
OBJECTIVE: To evaluate the first 5 years of the Human Resources for Health Rwanda program from the program onset in the July 2012-2016 academic years, and its effects on access to care through examination of: 1) the number of trained obstetrician-gynecolog ...
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Journal ArticleOpen Forum Infect Dis · July 1, 2019
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BACKGROUND: Although Lyme disease is the most common vector-borne infection in the United States, diagnostic accuracy within community settings is not well characterized. METHODS: A retrospective observational cohort study of patients referred to an academ ...
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Journal ArticleJ Racial Ethn Health Disparities · June 2019
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INTRODUCTION: To reduce the risk of recurrence, women with a history of spontaneous preterm birth (PTB) are recommended to receive 17-hydroxyprogesterone caproate (17-P) injections starting by the 20th week of pregnancy. In women eligible for 17-P, we aime ...
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Journal ArticlePediatr Infect Dis J · May 2019
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Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme-linked immunoassays, but ...
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Journal ArticleOtolaryngol Head Neck Surg · December 2018
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OBJECTIVE: Approximately 1 to 2 of every 1000 American newborns has hearing loss identified by newborn screening. This study was designed to determine if infant hearing loss is more common in socioeconomically disadvantaged communities. STUDY DESIGN: In th ...
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Journal ArticleJ Racial Ethn Health Disparities · August 2018
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BACKGROUND: Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV is more common among socially disadvantaged groups, and geographically clusters in poor communities. The Area Deprivation Index (AD ...
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Journal ArticleActa Trop · January 2018
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BACKGROUND: To better understand the epidemiology of tick-borne disease in Mongolia, a comprehensive seroprevalence study was conducted investigating exposure to Anaplasma spp. and spotted fever group (SFG) Rickettsia spp. in nomadic herders and their live ...
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Journal ArticleJ Pediatric Infect Dis Soc · September 1, 2017
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BACKGROUND: Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV is more common among socially disadvantaged groups, and it clusters geographically in poor communities. We conducted a geospatial a ...
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Journal ArticleJ Pediatric Infect Dis Soc · June 1, 2017
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We identified 620 children with peripheral facial palsy of which 211 (34%) had Lyme disease. The 140 children who had a lumbar puncture performed were more likely to be hospitalized (73% LP performed vs 2% no LP) and to receive parenteral antibiotics (62% ...
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Journal ArticleClin Infect Dis · April 15, 2017
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BACKGROUND: The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enzyme immunoassay (EIA) followed by immunoglobulin M and immunoglobulin G Western blots, performs well in late-stage LD but is insensitive in patients with erythema ...
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Journal ArticleAnn Am Thorac Soc · March 2017
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RATIONALE: Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis. OBJECTIVES: To examine the epidemiology and clinical presentation of adult patients with Noca ...
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Journal ArticleOpen Forum Infect Dis · 2017
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BACKGROUND: Most Lyme disease cases in the Midwestern United States are reported in Minnesota and Wisconsin. In recent years, however, a widening geographic extent of Lyme disease has been noted with evidence of expansion eastwards into Michigan and neighb ...
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Journal ArticleAsian Pacific Journal of Tropical Disease · January 1, 2017
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This report describes the first case fatality of imported malaria in Mongolia. The infection was acquired in Central Africa and the patient died nine days after onset of symptoms, four days after hospitalization, illustrating the need for improved familiar ...
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Journal ArticleClin Infect Dis · December 15, 2016
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BACKGROUND: Swine can harbor influenza viruses that are pathogenic to humans. Previous studies support an increased risk of human influenza cases among individuals with swine contact. North Carolina has the second-largest swine industry in the United Stat ...
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Journal ArticleJ Pediatr · July 2016
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In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive ...
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Journal ArticleOpen forum infectious diseases · December 2015
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Background. The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease be ...
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Journal ArticleOpen forum infectious diseases · December 2015
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Background. Cytomegalovirus (CMV) is a common cause of birth defects and hearing loss in infants and opportunistic infections in the immunocompromised. Previous studies have found higher CMV seroprevalence rates among minorities and among persons with low ...
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Journal ArticleClin Infect Dis · November 1, 2015
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BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS: We reviewed the medical records ...
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Journal ArticlePediatr Infect Dis J · November 2015
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By using a Lyme enzyme-linked immunosorbent assay (ELISA), we demonstrated that high ELISA index values are strongly predictive of Lyme disease. In children with clinical presentations consistent with Lyme disease, ELISA index values ≥3.0 had a positive pr ...
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Journal ArticleClin Infect Dis · June 15, 2015
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BACKGROUND: Some patients with medically unexplained symptoms or alternative medical diagnoses suspect that they chronically suffer from the tick-borne infection Lyme disease. These patients are commonly targeted by providers of alternative therapies. This ...
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Journal ArticleInfect Dis Clin North Am · June 2015
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Chronic Lyme disease is a poorly defined diagnosis that is usually given to patients with prolonged, unexplained symptoms or with alternative medical diagnoses. Data do not support the proposition that chronic, treatment-refractory infection with Borrelia ...
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Journal ArticleAm J Med · November 2014
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PURPOSE: Often, the controversial diagnosis of chronic Lyme disease is given to patients with prolonged, medically unexplained physical symptoms. Many such patients also are treated for chronic coinfections with Babesia, Anaplasma, or Bartonella in the abs ...
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Journal ArticleVector Borne Zoonotic Dis · August 2014
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BACKGROUND: Bartonella species are important emerging pathogens in human and veterinary medicine. In the context of their daily activities, veterinary professionals have frequent animal contact and arthropod exposures. Detection of Bartonella spp. using tr ...
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Journal ArticleClin Infect Dis · March 2014
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BACKGROUND: Much of the controversy that surrounds Lyme disease pertains to whether it produces prolonged, treatment-refractory infection, usually referred to as chronic Lyme disease. Some have proposed that round morphologic variants of Borrelia burgdorf ...
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Journal ArticleJ Travel Med · 2014
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BACKGROUND: Sickle cell disease (SCD) is the most common genetic disease among persons with African ancestry. This article provides a background to SCD and reviews many important aspects of travel preparation in this population. METHODS: The medical litera ...
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Journal ArticleVector Borne Zoonotic Dis · December 2013
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The skin lesion of early Lyme disease, erythema migrans (EM), is so characteristic that routine practice is to treat all such patients with antibiotics. Because other skin lesions may resemble EM, it is not known whether presumptive treatment of EM is appr ...
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Journal ArticleExpert Rev Anti Infect Ther · July 2011
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The diagnosis of chronic Lyme disease has been embroiled in controversy for many years. This is exacerbated by the lack of a clinical or microbiologic definition, and the commonality of chronic symptoms in the general population. An accumulating body of ev ...
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Journal ArticleEmerg Infect Dis · May 2011
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Only indirect or circumstantial evidence has been published to support transmission of Rickettsia rickettsii by Amblyomma americanum (lone star) ticks in North America. This study provides molecular evidence that A. americanum ticks can function, although ...
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Journal ArticleClin Infect Dis · July 1, 2010
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In April 2008, the Infectious Diseases Society of America (IDSA) entered into an agreement with Connecticut Attorney General Richard Blumenthal to voluntarily undertake a special review of its 2006 Lyme disease guidelines. This agreement ended the Attorney ...
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Journal ArticleParasit Vectors · April 8, 2010
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BACKGROUND: Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. ...
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Journal ArticleParasitology · January 2009
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Plasmodium falciparum parasites use multiple ligand-receptor interactions to invade human erythrocytes. Variant expression levels of members of the PfRh and PfEBA ligand families are associated with the use of different erythrocyte receptors, defining inva ...
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Journal ArticleTrends Parasitol · December 2007
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The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of liv ...
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Journal ArticleLeuk Lymphoma · February 2007
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A seasonal peak in hematologic malignancies may support hypotheses of infection-related precipitating events. Moderately increased incidence rates have been observed during the spring for leukemias and Hodgkin's disease but few studies have been conducted ...
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Journal ArticleSemin Pediatr Infect Dis · October 2002
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Ehrlichia are obligate intracellular bacteria that belong to the family Rickettsiaceae. Human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) are the 2 ehrlichial diseases that are of greatest health concern in the United States. The ...
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