Paul Wayne Sperduto | Scholars@Duke

Paul Wayne Sperduto
Adjunct Professor in the Department of Radiation Oncology

I am a board-certified radiation oncologist, have been active in clinical research and am now an adjunct professor of radiation oncology at Duke and senior editor of the 2022 textbook, Khan’s Treatment Planning in Radiation Oncology, 5^th edition. My research focus involves the treatment and prognosis of patients with brain metastases.

Current Appointments & Affiliations

Adjunct Professor in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2022

Contact Information

paul.sperduto@duke.edu

Background
Education, Training, & Certifications
- M.D., Duke University School of Medicine 1984
Recognition
Awards & Honors
- Visiting Professor and Keynote Speaker. Hokkaido University, Sapporo, Japan. August 2022
- Coordinator/Moderator/Lecturer. International Stereotactic Radiosurgery Society. June 2022
- Keynote Address. Duke Center for Brain and Spine Metastases. June 2021
- Moderator. ASTRO. 2021
- Top Doctor Award, 2007, 2009, 2010, 2011, 2016, 2017, 2018, 2019, 2020. Minneapolis – St. Paul Magazine. 2020
- Visiting Professor. Weill Cornell School of Medicine, Brain Metastases Symposium. May 2019
- Visiting Professor. Duke University Medical Center, Department of Radiation Oncology. May 2018
- Health Policy Fellow. ASTRO. 2017
- Member, Nominating Committee for Community Practice. ASTRO. 2017
- Visiting Professor. Cleveland Clinic, Department of Radiation Oncology. March 2014
- Fellow. American Society of Radiation Oncology (ASTRO). 2014
- Best of ASTRO Award 2013. ASTRO. 2013
- Moderator. ASTRO. 2007
- Distinguished Alumnus Award. Wyoming High School, Wyoming, Ohio. September 2006
- Moderator. ASTRO. 2006
- Award for Excellence in Clinical Research. Society of Neuro-Oncology. November 2002
- Award of Distinction for Clinical Research. Metro-Minnesota Community Clinical Oncology Program . October 2002
- Plenary Presentation. ASTRO. October 2002
- 1999 Lane W. Adams Award. American Cancer Society . June 2000
- Chairman. Hubert H. Humphrey Fellowship Selection Committee. 1995
- Hubert H. Humphrey Fellow. Humphrey Institute of Public Affairs, University of Minnesota. 1994
- Career Development Award Recipient. American Cancer Society. 1993
- Doctor of the Day. ABC News. September 1992
- Visiting Professor. Internal Medicine, Hunan Medical College. November 1987
- Henry Luce Scholar. The Henry Luce Foundation. 1984
Publications & Artistic Works
Selected Publications
- Books
  - Faiz M Khan, P. H. D., P. H. D. KHAN, MD Mpp Fastro Paul W Sperduto, and P. H. D. John P Gibbons. KHANS TREATMENT PLAN RAD ONCOLOGY 5E. LWW, 2021.
  - Khan, Faiz. Khan's Treatment Planning in Radiation Oncology. LWW, 2016.
- Academic Articles
  - Sperduto, Paul W., April K. S. Salama, and Carey Anders. “Progress for Patients with Melanoma Brain Metastases.” Neuro Oncol, March 8, 2023. https://doi.org/10.1093/neuonc/noad050.
    Full Text Link to Item
  - Sperduto, Paul W., Brian De, Jing Li, David Carpenter, John Kirkpatrick, Michael Milligan, Helen A. Shih, et al. “Graded Prognostic Assessment (GPA) for Patients With Lung Cancer and Brain Metastases: Initial Report of the Small Cell Lung Cancer GPA and Update of the Non-Small Cell Lung Cancer GPA Including the Effect of Programmed Death Ligand 1 and Other Prognostic Factors.” International Journal of Radiation Oncology, Biology, Physics 114, no. 1 (September 2022): 60–74. https://doi.org/10.1016/j.ijrobp.2022.03.020.
    Full Text
  - Saberian, C., P. Sperduto, and M. A. Davies. “Targeted therapy strategies for melanoma brain metastasis.” Neuro Oncology Advances 3 (November 1, 2021): V75–85. https://doi.org/10.1093/noajnl/vdab131.
    Full Text
  - Wenzel, Lari, Kathryn Osann, Chelsea McKinney, David Cella, Giulia Fulci, Mary J. Scroggins, Heather A. Lankes, et al. “Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival.” J Natl Cancer Inst 113, no. 10 (October 1, 2021): 1369–78. https://doi.org/10.1093/jnci/djab034.
    Full Text Link to Item
  - Mulford, Kellen, Chuyu Chen, Kathryn Dusenbery, Jianling Yuan, Matthew A. Hunt, Clark C. Chen, Paul Sperduto, Yoichi Watanabe, and Christopher Wilke. “A radiomics-based model for predicting local control of resected brain metastases receiving adjuvant SRS.” Clin Transl Radiat Oncol 29 (July 2021): 27–32. https://doi.org/10.1016/j.ctro.2021.05.001.
    Full Text Link to Item
  - Sperduto, Paul W., and Emil Lou. “The past, present, and future management of brain metastases in EGFR-mutant non-small cell lung cancer.” Neuro Oncol 23, no. 6 (June 1, 2021): 867–68. https://doi.org/10.1093/neuonc/noab054.
    Full Text Link to Item
  - Song, Chang W., Eli Glatstein, Lawrence B. Marks, Bahman Emami, Jimm Grimm, Paul W. Sperduto, Mi-Sook Kim, Susanta Hui, Kathryn E. Dusenbery, and L Chinsoo Cho. “Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death.” Int J Radiat Oncol Biol Phys 110, no. 1 (May 1, 2021): 21–34. https://doi.org/10.1016/j.ijrobp.2019.02.047.
    Full Text Link to Item
  - Sperduto, Paul W., Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, et al. “Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.” J Clin Oncol 38, no. 32 (November 10, 2020): 3773–84. https://doi.org/10.1200/JCO.20.01255.
    Full Text Link to Item
  - Sperduto, Paul W., Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, et al. “Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival.” Neuro Oncol 22, no. 9 (September 29, 2020): 1359–67. https://doi.org/10.1093/neuonc/noaa025.
    Full Text Link to Item
  - Sperduto, Paul W., Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, et al. “Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today.” Int J Radiat Oncol Biol Phys 107, no. 2 (June 1, 2020): 334–43. https://doi.org/10.1016/j.ijrobp.2020.01.051.
    Full Text Link to Item
  - Moravan, Michael J., Peter E. Fecci, Carey K. Anders, Jeffrey M. Clarke, April K. S. Salama, Justus D. Adamson, Scott R. Floyd, et al. “Current multidisciplinary management of brain metastases.” Cancer 126, no. 7 (April 1, 2020): 1390–1406. https://doi.org/10.1002/cncr.32714.
    Full Text Link to Item
  - Patrikidou, Anna, Loic Chaigneau, Nicolas Isambert, Kyriaki Kitikidou, Ryan Shanley, Isabelle Ray-Coquard, Thibaud Valentin, et al. “Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases (Sarcoma-GPA).” Bmc Cancer 20, no. 1 (February 12, 2020): 117. https://doi.org/10.1186/s12885-020-6548-6.
    Full Text Link to Item
  - Song, Chang W., Stephanie Terezakis, Bahman Emami, Robert J. Griffin, Paul W. Sperduto, Mi-Sook Kim, and L Chinsoo Cho. “Indirect cell death and the LQ model in SBRT and SRS.” J Radiosurg Sbrt 7, no. 1 (2020): 1–4.
    Link to Item
  - Sperduto, Paul W., Penny Fang, Jing Li, William Breen, Paul D. Brown, Daniel Cagney, Ayal Aizer, et al. “Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA).” Clin Transl Radiat Oncol 18 (September 2019): 39–45. https://doi.org/10.1016/j.ctro.2019.06.007.
    Full Text Link to Item
  - Sperduto, Paul W., Penny Fang, Jing Li, William Breen, Paul D. Brown, Daniel Cagney, Ayal Aizer, et al. “Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases: have we made progress?” Transl Res 208 (June 2019): 63–72. https://doi.org/10.1016/j.trsl.2019.02.011.
    Full Text Link to Item
  - Bezjak, Andrea, Rebecca Paulus, Laurie E. Gaspar, Robert D. Timmerman, William L. Straube, William F. Ryan, Yolanda I. Garces, et al. “Safety and Efficacy of a Five-Fraction Stereotactic Body Radiotherapy Schedule for Centrally Located Non-Small-Cell Lung Cancer: NRG Oncology/RTOG 0813 Trial.” J Clin Oncol 37, no. 15 (May 20, 2019): 1316–25. https://doi.org/10.1200/JCO.18.00622.
    Full Text Link to Item
  - Brooks, Rebecca A., David S. Tritchler, Kathleen M. Darcy, Heather A. Lankes, Ritu Salani, Paul Sperduto, Saketh Guntupalli, et al. “GOG 8020/210: Risk stratification of lymph node metastasis, disease progression and survival using single nucleotide polymorphisms in endometrial cancer: An NRG oncology/gynecologic oncology group study.” Gynecol Oncol 153, no. 2 (May 2019): 335–42. https://doi.org/10.1016/j.ygyno.2019.02.028.
    Full Text Link to Item
  - Sperduto, Paul W., Brian J. Deegan, Jing Li, Krishan R. Jethwa, Paul D. Brown, Natalie Lockney, Kathryn Beal, et al. “Estimating survival for renal cell carcinoma patients with brain metastases: an update of the Renal Graded Prognostic Assessment tool.” Neuro Oncol 20, no. 12 (November 12, 2018): 1652–60. https://doi.org/10.1093/neuonc/noy099.
    Full Text Link to Item
  - Rice, Stephanie R., Søren M. Bentzen, Andrew Hanna, Enid Choi, Drexell H. Boggs, Young Kwok, Jalal Hyder, et al. “Prognostic models for patients with brain metastases after stereotactic radiosurgery with or without whole brain radiotherapy: a validation study.” J Neurooncol 140, no. 2 (November 2018): 341–49. https://doi.org/10.1007/s11060-018-2958-6.
    Full Text Link to Item
  - Kruser, Tim J., Vinai Gondi, Paul W. Sperduto, Paul D. Brown, and Minesh P. Mehta. “Omitting radiosurgery in melanoma brain metastases: a drastic and dangerous de-escalation.” Lancet Oncol 19, no. 8 (August 2018): e366. https://doi.org/10.1016/S1470-2045(18)30439-X.
    Full Text Link to Item
  - Sperduto, Paul W., Brian J. Deegan, Jing Li, Krishan R. Jethwa, Paul D. Brown, Natalie Lockney, Kathryn Beal, et al. “Effect of Targeted Therapies on Prognostic Factors, Patterns of Care, and Survival in Patients With Renal Cell Carcinoma and Brain Metastases.” Int J Radiat Oncol Biol Phys 101, no. 4 (July 15, 2018): 845–53. https://doi.org/10.1016/j.ijrobp.2018.04.006.
    Full Text Link to Item
  - Sperduto, Paul W. “In Regard to Churilla et al.” Int J Radiat Oncol Biol Phys 101, no. 1 (May 1, 2018): 238–39. https://doi.org/10.1016/j.ijrobp.2018.01.017.
    Full Text Link to Item
  - Sperduto, Paul W., and Minesh P. Mehta. “Brain Metastases in Lung Cancer With Targetable Mutations-Reply.” Jama Oncol 4, no. 3 (March 1, 2018): 422–23. https://doi.org/10.1001/jamaoncol.2017.3375.
    Full Text Link to Item
  - Yuan, Jianling, Richard Lee, Kathryn Ellen Dusenbery, Chung K. Lee, Damien C. Mathew, Paul Wayne Sperduto, and Yoichi Watanabe. “Cumulative Doses to Brain and Other Critical Structures After Multisession Gamma Knife Stereotactic Radiosurgery for Treatment of Multiple Metastatic Tumors.” Front Oncol 8 (2018): 65. https://doi.org/10.3389/fonc.2018.00065.
    Full Text Link to Item
  - Sperduto, Paul W., Wen Jiang, Paul D. Brown, Steve Braunstein, Penny Sneed, Daniel A. Wattson, Helen A. Shih, et al. “Estimating Survival in Melanoma Patients With Brain Metastases: An Update of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA).” Int J Radiat Oncol Biol Phys 99, no. 4 (November 15, 2017): 812–16. https://doi.org/10.1016/j.ijrobp.2017.06.2454.
    Full Text Link to Item
  - Sperduto, Paul W., Wen Jiang, Paul D. Brown, Steve Braunstein, Penny Sneed, Daniel A. Wattson, Helen A. Shih, et al. “The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.” Int J Radiat Oncol Biol Phys 98, no. 5 (August 1, 2017): 1069–77. https://doi.org/10.1016/j.ijrobp.2017.03.030.
    Full Text Link to Item
  - Hurwitz, Mark D., Jonathan Harris, Oliver Sartor, Ying Xiao, Bobby Shayegan, Paul W. Sperduto, Kasra R. Badiozamani, et al. “Adjuvant radiation therapy, androgen deprivation, and docetaxel for high-risk prostate cancer postprostatectomy: Results of NRG Oncology/RTOG study 0621.” Cancer 123, no. 13 (July 1, 2017): 2489–96. https://doi.org/10.1002/cncr.30620.
    Full Text Link to Item
  - Sperduto, Paul W., T Jonathan Yang, Kathryn Beal, Hubert Pan, Paul D. Brown, Ananta Bangdiwala, Ryan Shanley, et al. “Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).” Jama Oncol 3, no. 6 (June 1, 2017): 827–31. https://doi.org/10.1001/jamaoncol.2016.3834.
    Full Text Link to Item
  - Sperduto, P. W., W. Jiang, P. D. Brown, S. E. Braunstein, P. K. Sneed, D. A. Wattson, H. A. Shih, et al. “The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): S178. https://doi.org/10.1016/j.ijrobp.2016.06.447.
    Full Text Link to Item
  - Sperduto, Paul W., T Jonathan Yang, Kathryn Beal, Hubert Pan, Paul D. Brown, Ananta Bangdiwala, Ryan Shanley, et al. “The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases.” Int J Radiat Oncol Biol Phys 96, no. 2 (October 1, 2016): 406–13. https://doi.org/10.1016/j.ijrobp.2016.06.006.
    Full Text Link to Item
  - Lou, Emil, and Paul W. Sperduto. “Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?” Ann Transl Med 4, no. 2 (January 2016): 36. https://doi.org/10.3978/j.issn.2305-5839.2015.12.42.
    Full Text Link to Item
  - Sperduto, Paul W., Chang W. Song, John P. Kirkpatrick, and Eli Glatstein. “A hypothesis: indirect cell death in the radiosurgery era.” Int J Radiat Oncol Biol Phys 91, no. 1 (January 1, 2015): 11–13. https://doi.org/10.1016/j.ijrobp.2014.08.355.
    Full Text Link to Item
  - Song, Chang W., Mi-Sook Kim, L Chinsoo Cho, Kathryn Dusenbery, and Paul W. Sperduto. “Radiobiological basis of SBRT and SRS.” Int J Clin Oncol 19, no. 4 (August 2014): 570–78. https://doi.org/10.1007/s10147-014-0717-z.
    Full Text Link to Item
  - Kondziolka, Douglas, Phillip V. Parry, L Dade Lunsford, Hideyuki Kano, John C. Flickinger, Susan Rakfal, Yoshio Arai, et al. “The accuracy of predicting survival in individual patients with cancer.” J Neurosurg 120, no. 1 (January 2014): 24–30. https://doi.org/10.3171/2013.9.JNS13788.
    Full Text Link to Item
  - Sperduto, Paul W. “In reply to Robins et al.” Int J Radiat Oncol Biol Phys 86, no. 5 (August 1, 2013): 810. https://doi.org/10.1016/j.ijrobp.2013.04.003.
    Full Text Link to Item
  - Sperduto, Paul W., Norbert Kased, David Roberge, Samuel T. Chao, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer.” J Neurooncol 112, no. 3 (May 2013): 467–72. https://doi.org/10.1007/s11060-013-1083-9.
    Full Text Link to Item
  - Sperduto, Paul W., Meihua Wang, H Ian Robins, Michael C. Schell, Maria Werner-Wasik, Ritsuko Komaki, Luis Souhami, et al. “A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320.” Int J Radiat Oncol Biol Phys 85, no. 5 (April 1, 2013): 1312–18. https://doi.org/10.1016/j.ijrobp.2012.11.042.
    Full Text Link to Item
  - Sperduto, Paul W., Penny K. Sneed, David Roberge, Ryan Shanley, Xianghua Luo, Robert J. Weil, John Suh, et al. “In regard to Yamamoto et al.” Int J Radiat Oncol Biol Phys 84, no. 4 (November 15, 2012): 875–76. https://doi.org/10.1016/j.ijrobp.2012.03.050.
    Full Text Link to Item
  - Sperduto, P. W., N. Kased, D. Roberge, Z. Xu, R. Shanley, X. Luo, P. K. Sneed, et al. “Reply to M.C. Chamberlain et al.” Journal of Clinical Oncology 30, no. 26 (September 10, 2012): 3316–17. https://doi.org/10.1200/JCO.2012.43.0256.
    Full Text
  - Barnholtz-Sloan, Jill S., Changhong Yu, Andrew E. Sloan, Jaime Vengoechea, Meihua Wang, James J. Dignam, Michael A. Vogelbaum, et al. “A nomogram for individualized estimation of survival among patients with brain metastasis.” Neuro Oncol 14, no. 7 (July 2012): 910–18. https://doi.org/10.1093/neuonc/nos087.
    Full Text Link to Item
  - Sperduto, Paul W., Norbert Kased, David Roberge, Zhiyuan Xu, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases.” Int J Radiat Oncol Biol Phys 82, no. 5 (April 1, 2012): 2111–17. https://doi.org/10.1016/j.ijrobp.2011.02.027.
    Full Text Link to Item
  - Sperduto, Paul W., Norbert Kased, David Roberge, Zhiyuan Xu, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases.” J Clin Oncol 30, no. 4 (February 1, 2012): 419–25. https://doi.org/10.1200/JCO.2011.38.0527.
    Full Text Link to Item
  - Tsao, May N., Dirk Rades, Andrew Wirth, Simon S. Lo, Brita L. Danielson, Laurie E. Gaspar, Paul W. Sperduto, et al. “Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline.” Pract Radiat Oncol 2, no. 3 (2012): 210–25. https://doi.org/10.1016/j.prro.2011.12.004.
    Full Text Link to Item
  - Sperduto, P. W., S. T. Chao, J. Suh, P. K. Sneed, X. Luo, D. Roberge, A. Bhatt, et al. “Reply to Drs. mulvenna and holt.” International Journal of Radiation Oncology Biology Physics 81, no. 4 (November 15, 2011): 1194–95. https://doi.org/10.1016/j.ijrobp.2010.09.047.
    Full Text
  - Sperduto, Paul W. “What is your patient's GPA and why does it matter? Managing brain metastases and the cost of hope.” Int J Radiat Oncol Biol Phys 77, no. 3 (July 1, 2010): 643–44. https://doi.org/10.1016/j.ijrobp.2010.02.038.
    Full Text Link to Item
  - Sperduto, Paul W., Samuel T. Chao, Penny K. Sneed, Xianghua Luo, John Suh, David Roberge, Amit Bhatt, et al. “Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients.” Int J Radiat Oncol Biol Phys 77, no. 3 (July 1, 2010): 655–61. https://doi.org/10.1016/j.ijrobp.2009.08.025.
    Full Text Link to Item
  - Sperduto, Christina Maria, Arnab Chakravarti, Ken Aldape, Peter Burger, Gail Bender Papermaster, and Paul Sperduto. “Twenty-year survival in glioblastoma: a case report and molecular profile.” Int J Radiat Oncol Biol Phys 75, no. 4 (November 15, 2009): 1162–65. https://doi.org/10.1016/j.ijrobp.2008.12.054.
    Full Text Link to Item
  - Sperduto, Christina Maria, Yoichi Watanabe, John Mullan, Terry Hood, Gregg Dyste, Charles Watts, Gail Papermaster Bender, and Paul Sperduto. “A validation study of a new prognostic index for patients with brain metastases: the Graded Prognostic Assessment.” J Neurosurg 109 Suppl (December 2008): 87–89. https://doi.org/10.3171/JNS/2008/109/12/S14.
    Full Text Link to Item
  - Sperduto, P. W., B. Berkey, L. E. Gaspar, M. Mehta, and W. Curran. “In Reply to Drs. Nieder and Molls.” International Journal of Radiation Oncology Biology Physics 72, no. 5 (December 1, 2008): 1619. https://doi.org/10.1016/j.ijrobp.2008.06.1915.
    Full Text
  - Sperduto, P. W., B. Berkey, L. E. Gaspar, M. Mehta, and W. Curran. “In Reply to Drs. Weltman and Brandt.” International Journal of Radiation Oncology Biology Physics 70, no. 4 (March 15, 2008): 1292–93. https://doi.org/10.1016/j.ijrobp.2007.11.025.
    Full Text
  - Sperduto, Paul W., Brian Berkey, Laurie E. Gaspar, Minesh Mehta, and Walter Curran. “A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database.” Int J Radiat Oncol Biol Phys 70, no. 2 (February 1, 2008): 510–14. https://doi.org/10.1016/j.ijrobp.2007.06.074.
    Full Text Link to Item
  - Andrews, D. W., C. B. Scott, P. W. Sperduto, A. E. Flanders, L. E. Gaspar, M. C. Schell, M. Werner-Wasik, et al. “Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial.” Cancer/Radiotherapie 9, no. 2 (January 1, 2005): 199–200. https://doi.org/10.1016/j.canrad.2005.01.001.
    Full Text
  - Andrews, David W., Charles B. Scott, Paul W. Sperduto, Adam E. Flanders, Laurie E. Gaspar, Michael C. Schell, Maria Werner-Wasik, et al. “Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial.” Lancet 363, no. 9422 (May 22, 2004): 1665–72. https://doi.org/10.1016/S0140-6736(04)16250-8.
    Full Text Link to Item
  - Sperduto, Paul W. “A review of stereotactic radiosurgery in the management of brain metastases.” Technol Cancer Res Treat 2, no. 2 (April 2003): 105–10. https://doi.org/10.1177/153303460300200205.
    Full Text Link to Item
  - Sneed, Penny K., John H. Suh, Steven J. Goetsch, Seema N. Sanghavi, Richard Chappell, John M. Buatti, William F. Regine, et al. “A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases.” Int J Radiat Oncol Biol Phys 53, no. 3 (July 1, 2002): 519–26. https://doi.org/10.1016/s0360-3016(02)02770-0.
    Full Text Link to Item
  - Sanghavi, S. N., S. S. Miranpuri, R. Chappell, J. M. Buatti, P. K. Sneed, J. H. Suh, W. F. Regine, et al. “Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method.” Int J Radiat Oncol Biol Phys 51, no. 2 (October 1, 2001): 426–34. https://doi.org/10.1016/s0360-3016(01)01622-4.
    Full Text Link to Item
  - Scarantino, C., L. Berk, F. David, J. Fisher, P. Griffin, W. Hartsell, A. Konski, et al. “Radiation Therapy Oncology Group. Research Plan 2002-2006. Cancer Prevention and Control Committee.” Int J Radiat Oncol Biol Phys 51, no. 3 Suppl 2 (2001): 113–19.
    Link to Item
  - Ritz, L. J., M. J. Nissen, K. K. Swenson, J. B. Farrell, P. W. Sperduto, M. L. Sladek, R. M. Lally, and L. M. Schroeder. “Effects of advanced nursing care on quality of life and cost outcomes of women diagnosed with breast cancer.” Oncol Nurs Forum 27, no. 6 (July 2000): 923–32.
    Link to Item
  - Cangialose, C. B., A. E. Blair, J. S. Borchardt, T. B. Ades, C. L. Bennett, K. Dickersin, D. H. Gesme, et al. “Purchasing oncology services. Kerr L. White Institute/American Cancer Society Task Force on Purchasing Oncology Services.” Cancer 88, no. 12 (June 2000): 2876–86. https://doi.org/10.1002/1097-0142(20000615)88:12<2876::aid-cncr31>3.0.co;2-m.
    Full Text
  - Swenson, K. K., L. Decher, R. Haselow, J. B. Farrell, and P. W. Sperduto. “Prognostic factors after conservative surgery and radiation therapy for early stage breast cancer.” Am J Clin Oncol 21, no. 2 (April 1998): 111–16. https://doi.org/10.1097/00000421-199804000-00002.
    Full Text Link to Item
  - Murray, C. L., W. J. Ford, K. K. Swenson, D. Heros, and P. W. Sperduto. “Multifocal inflammatory leukoencephalopathy after fluorouracil and levamisole therapy for colon cancer.” Ajnr Am J Neuroradiol 18, no. 8 (September 1997): 1591–92.
    Link to Item
  - Sperduto, P. W. “35. RTOG 9508: A prospective randomized trial of stereotactic radiosurgery and whole brain radiation therapy versus whole brain radiation therapy alone in patients with 1-3 brain métastases patients; results and salvage therapy analyses.” Cancer Journal 9, no. 6 (December 1, 1996): 493.
  - Weprin, B. E., W. A. Hall, K. H. Cho, P. W. Sperduto, B. J. Gerbi, and C. Moertel. “Stereotactic radiosurgery in pediatric patients.” Pediatr Neurol 15, no. 3 (October 1996): 193–99. https://doi.org/10.1016/s0887-8994(96)00166-x.
    Full Text Link to Item
  - Sperduto, P. W., and W. A. Hall. “Radiosurgery, cost-effectiveness, gold standards, the scientific method, cavalier cowboys, and the cost of hope.” Int J Radiat Oncol Biol Phys 36, no. 2 (September 1, 1996): 511–13. https://doi.org/10.1016/s0360-3016(96)00347-1.
    Full Text Link to Item
  - Hall, W. A., H. R. Djalilian, P. W. Sperduto, K. H. Cho, B. J. Gerbi, J. P. Gibbons, M. Rohr, and H. B. Clark. “Stereotactic radiosurgery for recurrent malignant gliomas.” J Clin Oncol 13, no. 7 (July 1995): 1642–48. https://doi.org/10.1200/JCO.1995.13.7.1642.
    Full Text Link to Item
  - Roman, D. D., and P. W. Sperduto. “Neuropsychological effects of cranial radiation: current knowledge and future directions.” Int J Radiat Oncol Biol Phys 31, no. 4 (February 15, 1995): 983–98. https://doi.org/10.1016/0360-3016(94)00550-8.
    Full Text Link to Item
  - Sperduto, P. W., C. W. Song, and S. H. Levitt. “The in vitro radiosensitization of human glioblastoma with pentoxifylline.” Am J Clin Oncol 16, no. 5 (October 1993): 407–11. https://doi.org/10.1097/00000421-199310000-00007.
    Full Text Link to Item
  - Sperduto, P. W., T. F. DeLaney, G. Thomas, P. Smith, L. J. Dachowski, A. Russo, R. Bonner, and E. Glatstein. “Photodynamic therapy for chest wall recurrence in breast cancer.” Int J Radiat Oncol Biol Phys 21, no. 2 (July 1991): 441–46. https://doi.org/10.1016/0360-3016(91)90793-4.
    Full Text Link to Item
  - Sperduto, P., A. Vaezy, A. Bridgman, and L. Wilkie. “Spontaneous regression of squamous cell lung carcinoma with adrenal metastasis.” Chest 94, no. 4 (October 1988): 887–89. https://doi.org/10.1378/chest.94.4.887.
    Full Text Link to Item
  - Nunley, J. A., and P. W. Sperduto. “Knee flexion contractures in myelodysplasia.” South Med J 79, no. 7 (July 1986): 818–21. https://doi.org/10.1097/00007611-198607000-00009.
    Full Text Link to Item
- Book Sections
  - Sperduto, P. W. “Classification of Brain Metastases.” In Central Nervous System Metastases: Diagnosis and Treatment, 83–93, 2020. https://doi.org/10.1007/978-3-030-42958-4_6.
    Full Text
  - Sperduto, P. W. “Prognostic indices for patients with brain metastases.” In Central Nervous System Metastases, 385–96, 2019. https://doi.org/10.1007/978-3-030-23417-1_30.
    Full Text
  - Sperduto, P. W. “Prognostic classification systems for brain metastases.” In Adult CNS Radiation Oncology: Principles and Practice, 419–30, 2018. https://doi.org/10.1007/978-3-319-42878-9_30.
    Full Text
  - Knisely, J. P. S., and P. W. Sperduto. “Pituitary and pituitary region tumors: Viewpoint—fractionated radiation therapy.” In Principles and Practice of Stereotactic Radiosurgery, 391–402, 2015. https://doi.org/10.1007/978-1-4614-8363-2_28.
    Full Text
- Conference Papers
  - Sperduto, Paul W., Shane Mesko, Daniel Cagney, Eric Nesbit, Jason Chan, Jessica Lee, Will Breen, et al. “Tumor subtype and other prognostic factors in breast cancer patients with brain metastases: The updated graded prognostic assessment (Breast-GPA).” In Journal of Clinical Oncology, 37:1079–1079. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.1079.
    Full Text
  - Sperduto, P. W., P. Fang, J. Li, W. Breen, P. D. Brown, D. N. Cagney, S. D. Myrehaug, et al. “Survival and Prognostic Factors in Patients with Gastrointestinal Cancers and Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 102:e314–15. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.980.
    Full Text
  - Sperduto, P. W., B. J. Deegan, J. Li, K. R. Jethwa, P. D. Brown, N. A. Lockney, K. Beal, et al. “Prognostic Factors in Patients with Renal Cell Carcinoma and Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 99:S169–70. Elsevier BV, 2017. https://doi.org/10.1016/j.ijrobp.2017.06.429.
    Full Text
  - Doll, Corinne M., Jennifer Moughan, Alexander Klimowicz, Clement K. Ho, Elizabeth N. Kornaga, Susan P. Lees-Miller, Jaffer A. Ajani, et al. “Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811.” In Int J Radiat Oncol Biol Phys, 97:554–62, 2017. https://doi.org/10.1016/j.ijrobp.2016.11.021.
    Full Text Link to Item
  - Sperduto, P. W., W. Jiang, P. D. Brown, S. E. Braunstein, P. K. Sneed, D. A. Wattson, H. A. Shih, et al. “The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases.” In International Journal of Radiation Oncology Biology Physics, 96:S178–S178, 2016.
    Link to Item
  - Sperduto, Paul, T Jonathan Yang, Kathryn Beal, Hubert Pan, Paul Brown, Ananta Bangdiwala, Ryan Shanley, et al. “IMPROVED SURVIVAL AND PROGNOSTIC ABILITY IN LUNG CANCER PATIENTS WITH BRAIN METASTASES: AN UPDATE OF THE GRADED PROGNOSTIC ASSESSMENT FOR LUNG CANCER USING MOLECULAR MARKERS (LUNG-molGPA).” In Neuro Oncology, 18:27–27, 2016.
    Link to Item
  - Sperduto, P. W., T. J. Yang, K. Beal, H. Y. Pan, P. D. Brown, Y. Y. Ho, N. Yeh, et al. “The Effect of Gene Mutations on Survival in Patients With Adenocarcinoma of the Lung Following the Development of Brain Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 93:S37–38. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.092.
    Full Text
  - Song, Chang W., Yoon-Jin Lee, Robert J. Griffin, Inhwan Park, Nathan A. Koonce, Susanta Hui, Mi-Sook Kim, Kathryn E. Dusenbery, Paul W. Sperduto, and L Chinsoo Cho. “Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery.” In Int J Radiat Oncol Biol Phys, 93:166–72, 2015. https://doi.org/10.1016/j.ijrobp.2015.05.016.
    Full Text Link to Item
  - Sperduto, Paul W., Ryan Shanley, Xianghua Luo, David Andrews, Maria Werner-Wasik, Richard Valicenti, Jean-Paul Bahary, Luis Souhami, Minhee Won, and Minesh Mehta. “Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1-3 brain metastases; poststratified by the graded prognostic assessment (GPA).” In Int J Radiat Oncol Biol Phys, 90:526–31, 2014. https://doi.org/10.1016/j.ijrobp.2014.07.002.
    Full Text Link to Item
  - Sperduto, P. W., R. Shanley, N. Kased, D. Roberge, S. T. Chao, A. W. Jensen, H. A. Shih, J. Kirkpatrick, L. E. Gaspar, and M. Mehta. “The Effect of Tumor Subtype on the Time From Primary Diagnosis to Development of Brain Metastases and Survival in Women With Breast Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 84:S142–S142. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.368.
    Full Text
  - Sperduto, Paul W., Ryan Shanley, Xianghua Luo, Norbert Kased, Penny K. Sneed, David Roberge, Samuel Chao, et al. “EVIDENCE OF INTERACTION BETWEEN HER2 AND ESTROGEN/PROGESTERONE (ER/PR) RECEPTOR STATUS IN PATIENTS WITH BREAST CANCER AND BRAIN METASTASES.” In Neuro Oncology, 14:66–67. OXFORD UNIV PRESS INC, 2012.
    Link to Item
  - Sperduto, Paul W., Norbert Kased, David Roberge, Zhiyuan Xu, Ryan Shanley, Xianghua Luo, Penny K. Sneed, et al. “THE EFFECT OF TUMOR SUBTYPE ON SURVIVAL AND THE GRADED PROGNOSTIC ASSESSMENT (GPA) FOR PATIENTS WITH BREAST CANCER AND BRAIN METASTASES.” In Neuro Oncology, 13:82–82. OXFORD UNIV PRESS INC, 2011.
    Link to Item
  - Sperduto, P. W., N. Kased, D. Roberge, R. Shanley, S. T. Chao, A. K. Bhatt, P. D. Brown, H. A. Shih, J. Kirkpatrick, and L. E. Gaspar. “The effect of tumor subtype on survival and the graded prognostic assessment (GPA) for patients with breast cancer and brain metastases.” In Journal of Clinical Oncology, 29:238–238. American Society of Clinical Oncology (ASCO), 2011. https://doi.org/10.1200/jco.2011.29.27_suppl.238.
    Full Text
  - Sperduto, P. W., Z. Xu, P. Sneed, X. Luo, D. Roberge, A. K. Bhatt, A. W. Jensen, H. A. Shih, J. Kirkpatrick, and L. E. Gaspar. “The Graded Prognostic Assessment for Women with Brain Metastases from Breast Cancer (GPA-Breast): A Diagnosis-specific Prognostic Index.” In International Journal of Radiation Oncology*Biology*Physics, 78:S6–7. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.057.
    Full Text
  - Bernad, Daniel M., Paul W. Sperduto, Luis Souhami, Ashley W. Jensen, and David Roberge. “Stereotactic radiosurgery in the management of brain metastases from primary thyroid cancers.” In J Neurooncol, 98:249–52, 2010. https://doi.org/10.1007/s11060-010-0175-z.
    Full Text Link to Item
  - Sperduto, P. W., Z. Xu, P. Sneed, X. Luo, D. Roberge, A. K. Bhatt, A. W. Jensen, H. A. Shih, J. Kirkpatrick, and L. E. Gaspar. “A graded prognostic assessment (GPA) for women with breast cancer and brain metastases.” In Journal of Clinical Oncology, 28:1028–1028. American Society of Clinical Oncology (ASCO), 2010. https://doi.org/10.1200/jco.2010.28.15_suppl.1028.
    Full Text
  - Sperduto, P. W., S. T. Chao, P. K. Sneed, X. Luo, D. Roberge, A. Bhatt, A. Jensen, H. Shih, J. Kirkpatrick, and A. Schwer. “Diagnosis-specific Prognostic Factors, Indices, and Treatment Outcomes for Patients with Newly-diagnosed Brain Metastases: A Multi-institutional Analysis of over 5000 Patients.” In International Journal of Radiation Oncology*Biology*Physics, 75:S225–S225. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.519.
    Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Awards & Honors

Selected Publications

Books

Academic Articles

Book Sections

Conference Papers