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Paul Wayne Sperduto

Adjunct Professor in the Department of Radiation Oncology
Radiation Oncology
30 Duke Medicine Circle, Box 3085, Durham, NC 27710
30 Duke Medicine Circle, Box 3085, Durham, NC 27710

Overview


I am a board-certified radiation oncologist, have been active in clinical research and am now an adjunct professor of radiation oncology at Duke and senior editor of the 2022 textbook, Khan’s Treatment Planning in Radiation Oncology, 5thedition. My research focus involves the treatment and prognosis of patients with brain metastases.

Current Appointments & Affiliations


Adjunct Professor in the Department of Radiation Oncology · 2022 - Present Radiation Oncology, Clinical Science Departments

Recent Publications


Broadening clinical trial inclusivity of patients with lung cancer and brain metastases utilizing the Graded Prognostic Assessment (GPA): A call to action.

Journal Article Lung Cancer · April 2026 Brain metastases (BM) occur in 30-50% of non-small cell lung cancer (NSCLC) and up to 80% of small cell lung cancer (SCLC) patients, yet historically over 80% of clinical trials excluded this population. Current eligibility requirements often mandate compl ... Full text Link to item Cite

Comparison of Local Medicare Guidance and Medicare Advantage Plans for Stereotactic Radiosurgery for Brain Metastases.

Journal Article Adv Radiat Oncol · February 2026 PURPOSE: Medicare Advantage operates under a capitated payment model, where Medicare Advantage Organizations (MAOs) must provide services that meet or exceed Medicare Parts A and B standards, ensuring actuarial equivalence. MAOs are mandated to base their ... Full text Link to item Cite

Neurocognitive outcomes in patients with brain metastases: a systematic review.

Journal Article Lancet Oncol · December 2025 Multimodality therapy, including surgery, radiotherapy, and systemic therapy, has significantly improved overall survival for patients with brain metastases. However, treatment-related neurocognitive sequelae remain a major challenge in survivorship. Altho ... Full text Link to item Cite
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Education


Duke University, School of Medicine · 1984 M.D.
Duke University · 1979 B.A.