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Paul Wayne Sperduto

Adjunct Professor in the Department of Radiation Oncology
Radiation Oncology
30 Duke Medicine Circle, Box 3085, Durham, NC 27710
30 Duke Medicine Circle, Box 3085, Durham, NC 27710

Overview


I am a board-certified radiation oncologist, have been active in clinical research and am now an adjunct professor of radiation oncology at Duke and senior editor of the 2022 textbook, Khan’s Treatment Planning in Radiation Oncology, 5thedition. My research focus involves the treatment and prognosis of patients with brain metastases.

Current Appointments & Affiliations


Adjunct Professor in the Department of Radiation Oncology · 2022 - Present Radiation Oncology, Clinical Science Departments

Recent Publications


Management outcomes for biopsy-proven radiation necrosis in patients with brain metastases in the era of immune-checkpoint blockade.

Journal Article J Neurooncol · June 16, 2025 PURPOSE: Immunotherapy and stereotactic radiosurgery (SRS) are frequently combined in the management of brain metastases from non-small cell lung cancer (NSCLC) and melanoma. However, concurrent SRS and dual immune-checkpoint inhibition (ICPI) elevate the ... Full text Link to item Cite

Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment.

Journal Article J Clin Oncol · June 2025 PURPOSE: Survival for patients with melanoma has recently improved. The propensity of melanoma to metastasize to the brain remains a common and serious feature of this disease. The purposes of this study were to evaluate prognostic factors for patients wit ... Full text Link to item Cite
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Education, Training & Certifications


Duke University, School of Medicine · 1984 M.D.
Duke University · 1979 B.A.