Scholars@Duke
Piotr E. Marszalek

Piotr E. Marszalek

Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
Thomas Lord Department of Mechanical Engineering and Materials Science
pemar@duke.edu
3387 FCIEMAS Building, Box 90300, Durham, NC 27708-0300
3387 FCIEMAS Building, Box 90300, Durham, NC 27708

Research Interests

Investigating relationships between structural and mechanical properties of biopolymers (polysaccharides, DNA, proteins), at a single molecule level.

Selected Grants

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1994 - 2027

Transition to Excellence: From Single-Molecule Force Spectroscopy to Single-Particle Cryogenic Electron Microscopy

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2021 - 2025

EAGER: Exploring the Quantum-Mechanical Basis of Odorant Detection by Olfactory Receptors

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2021 - 2024

Acquisition of a VRS1250 Video-Rate Imaging Module for a Shared-Use Asylum-Cypher Atomic Force Microscope (AFM)

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2023 - 2024

Molecular Mechanisms of Spontaneous and Hsp70-assisted Renaturation of Misfolded Proteins

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2018 - 2023

LUMICKS C-TRAP

EquipmentMajor User · Awarded by National Institutes of Health · 2022 - 2023

Progress and Prospects of Single Molecule Force Spectroscopy in Biological and Chemical Sciences Conference

ConferencePrincipal Investigator · Awarded by National Science Foundation · 2019 - 2020

Vectorial Folding of Large, Multidomain Proteins

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2015 - 2018

Investigating DNA Mismatch Repair with Single-Molecule Techniques

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2005 - 2017

Forces and Long-Distance Coupling along DNA in the Mismatch Repair (MMR) Pathway

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2016

Structural Biology and Biophysics Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2015

Design and Implementation of Genetically Encoded Myosin Based Force Sensors

ResearchCollaborator · Awarded by National Institutes of Health · 2012 - 2015

Vectorial Folding of Protiens and Nascent Polypeptide Chains by AFM and Computer Simulations

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2011 - 2014

Nanomechanics of Spiral Proteins

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2013

Chemo-mechanical Nano-scale Mechanisms of Aging

ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2007 - 2012

Conformations of Polysaccharides and Nucleic Acids by Single Molecule Force Spectroscopy

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2007 - 2011

Training in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2009

Nanoscale DNA Diagnostics by Single Molecule AFM

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2008

Construction of a High-Precision, Low Cost Atomic Force Microscope by Undergraduate Students for Undergraduate Research

Institutional SupportPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2006 - 2007

Force-induced Conformational Transitions in Single Polysaccharide Molecules by AFM

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2002 - 2007