Philip Martin Rosoff | Scholars@Duke

Philip Martin Rosoff
Professor of Pediatrics

My main interests are clinical ethics with a concentration on the equitable allocation of scarce resources (rationing). In this area, I have done work on planning for pandemic influenza and allocation of drugs during shortages. I play a major role in the Clinical Ethics Service at Duke Hospital and chair the hospital's Ethics Committee.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2008
Professor of Medicine, Medicine, Medical Oncology, Medicine 2008

Contact Information

108 Seeley G. Mudd Building, Box 3040, Durham, NC 27710
108 Seeley G. Mudd, Box 3040, Durham, NC 27710
philip.rosoff@duke.edu (919) 668-9000

Background
Education, Training, & Certifications
- M.D., Case Western Reserve University 1978
Duke Appointment History
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1995 - 2014
- Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 1996 - 2008
- Associate Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1996 - 2008
- Chief, Division of Pediatric Hematology/Oncology, Pediatrics, Hematology-Oncology, Pediatrics 1995 - 2005
- Associate Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1996
- Instructor, Temporary of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1995 - 1996
Recognition
In the News
- FEB 4, 2015 The Conversation
  
  Dr. Philip Rosoff: The Affordable Care Act is another way to ration health care
- FEB 4, 2015 The Conversation
  
  The Affordable Care Act is another way to ration health care
- JAN 6, 2015 The Conversation
  
  Dr. Philip Rosoff: What should a hospital do when critical drugs are in short supply?
- JAN 6, 2015 The Conversation
  
  What Should a Hospital Do When Drugs are in Short Supply?
- DEC 18, 2014 The News & Observer
  
  Dr. Philip Rosoff: When doctors take part in torture
- DEC 18, 2014
  
  When Doctors Take Part in Torture
- NOV 13, 2014 ABC News, AP
  
  Dr. Philip Rosoff comments: Ebola drug testing sparks ethics debate
- OCT 31, 2014 Duke Research Blog
  
  Rationing Health Care Is Not a Four-Letter Word
- OCT 14, 2014 The Dallas Morning News
  
  Clinical Trials Needed for Anti-Ebola Drugs
- OCT 14, 2014 The Dallas Morning News
  
  Dr. Philip Rosoff: Clinical trials needed for anti-Ebola drugs
Awards & Honors
Research
Selected Grants
- FitFab 4 Survivors awarded by National Institutes of Health 2011 - 2014
- Gamete Preservation in Males Receiving Gametotoxic Chemotherapy awarded by Josiah Charles Trent Memorial Foundation 2002 - 2003
- Pediatric Oncology Group awarded by National Institutes of Health 1998 - 1999
- Pediatric Oncology Group Studies awarded by National Institutes of Health 1997 - 1999
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
Publications & Artistic Works
Selected Publications
- Books
  - Rosoff, PM. Drawing the Line: Healthcare Rationing and the Cutoff Problem (Accepted). New York: Oxford University Press, 2017.
  - Rosoff, PM. Rationing Is Not a Four-Letter Word Setting Limits on Healthcare. MIT Press, July 18, 2014.
- Conference Papers
  - Demark-Wahnefried, W, Werner, C, Clipp, EC, Guill, AB, Bonner, M, and Rosoff, PM. "Childhood cancer survivors: Health behaviors and receptivity to health promotion interventions." November 2004. Link to Item
- Journal Articles
  - Rosoff, PM, Moga, J, Keene, B, Adin, C, Fogle, C, Ruderman, R, Hopkinso, H, and Weyhrauch, C. "Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model." The American journal of bioethics : AJOB 18, no. 2 (February 2018): 41-53. Full Text
  - Rosoff, PM, Ruderman, R, Moga, J, Keene, B, Adin, C, Fogle, C, Hopkinson, H, and Weyhrauch, C. "Response to Open Peer Commentaries on "Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model"." The American journal of bioethics : AJOB 18, no. 2 (February 2018): W7-W10. Full Text
  - Rosoff, PM. "Compulsory Organ Retrieval: Morally, But Not Socially, Justified." Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees 27, no. 1 (January 2018): 36-51. Full Text
  - Rosoff, PM. "Licensing Surrogate Decision-Makers." HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues 29, no. 2 (June 2017): 145-169. Full Text
  - Rosoff, PM. "Do Pediatric Patients Have a Right to Know?." AMA journal of ethics 19, no. 5 (May 2017): 426-435. Full Text
  - Waweru-Siika, W, Clement, ME, Lukoko, L, Nadel, S, Rosoff, PM, Naanyu, V, and Kussin, PS. "Brain death determination: the imperative for policy and legal initiatives in Sub-Saharan Africa." Global public health 12, no. 5 (May 2017): 589-600. Full Text Open Access Copy
  - Rosoff, PM, and Schneiderman, LJ. "Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish." The American journal of bioethics : AJOB 17, no. 2 (February 2017): 26-34. Full Text
  - Rosoff, PM, and Schneiderman, LJ. "Response to Open Peer Commentaries on "Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish"." The American journal of bioethics : AJOB 17, no. 2 (February 2017): W1-W3. Full Text
  - Rosoff, PM. "Who Should Ration?." AMA journal of ethics 19, no. 2 (February 2017): 164-173. Full Text
  - Hinson, AP, and Rosoff, PM. "Where Children Die: Obstacles to Quality End-of-Life Care." Clinical pediatrics 55, no. 2 (February 2016): 101-106. (Review) Full Text
  - Rosoff, PM. "Making Sausage." Narrative inquiry in bioethics 6, no. 1 (January 2016): 31-33. Full Text
  - Rosoff, PM. "In defense of (some) altered standards of care for Ebola infections in developed countries." HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues 27, no. 1 (March 2015): 1-9. Full Text
  - Rosoff, PM, and Leong, KM. "An Ethical and Legal Framework for Physicians as Surrogate Decision-Makers for Their Patients." The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 43, no. 4 (January 2015): 857-877. Full Text Open Access Copy
  - Rosoff, PM. "Caring for the suffering: meeting the Ebola crisis responsibly." The American journal of bioethics : AJOB 15, no. 4 (January 2015): 26-32. Full Text
  - Rosoff, PM. "Response to open peer commentaries on "Caring for the suffering: meeting the Ebola crisis responsibly"." The American journal of bioethics : AJOB 15, no. 4 (January 2015): W4-W7. Full Text
  - Rosoff, PM. "TADA Is Still Unfair." The American journal of bioethics : AJOB 15, no. 8 (January 2015): 56-58. Full Text
  - Falloon, K, and Rosoff, PM. "Who pays? Mandated insurance coverage for assisted reproductive technology." The virtual mentor : VM 16, no. 1 (January 2014): 63-69. Full Text
  - Rosoff, PM. "Institutional futility policies are inherently unfair." HEC Forum 25, no. 3 (September 2013): 191-209. Full Text Link to Item
  - Fuemmeler, BF, Pendzich, MK, Clark, K, Lovelady, C, Rosoff, P, Blatt, J, and Demark-Wahnefried, W. "Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma." J Pediatr Hematol Oncol 35, no. 6 (August 2013): 437-443. Full Text Link to Item
  - Raizis, AM, Van Mater, D, Aaltonen, LA, Lohmann, D, Cheale, MS, Bickley, VM, George, PM, Zhou, Y, and Rosoff, PM. "Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome." Am J Med Genet A 161A, no. 5 (May 2013): 1096-1100. Full Text Link to Item
  - Coleman, DL, and Rosoff, PM. "The legal authority of mature minors to consent to general medical treatment." Pediatrics 131, no. 4 (April 2013): 786-793. (Review) Full Text Link to Item
  - Fuemmeler, BF, Pendzich, MK, Clark, K, Lovelady, C, Rosoff, P, Blatt, J, and Demark-Wahnefried, W. "Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma." Journal of Pediatric Hematology/Oncology 35, no. 6 (2013): 437-443. Full Text
  - Raizis, AM, Mater, DV, Aaltonen, LA, Lohmann, D, Cheale, MS, Bickley, VM, George, PM, Zhou, Y, and Rosoff, PM. "Trilateral Retinoblastoma in a Patient With Peutz-Jeghers Syndrome." American Journal of Medical Genetics, Part A 161, no. 5 (2013): 1096-1100. Full Text
  - Rosoff, PM, Patel, KR, Scates, A, Rhea, G, Bush, PW, and Govert, JA. "Coping with critical drug shortages: an ethical approach for allocating scarce resources in hospitals." Arch Intern Med 172, no. 19 (October 22, 2012): 1494-1499. (Review) Full Text Link to Item
  - Arawi, T, and Rosoff, PM. "Competing duties: medical educators, underperforming students, and social accountability." J Bioeth Inq 9, no. 2 (June 2012): 135-147. Full Text Link to Item
  - Rosoff, PM. "The myth of genetic enhancement." Theor Med Bioeth 33, no. 3 (June 2012): 163-178. Full Text Link to Item
  - Rosoff, PM. "Unpredictable drug shortages: an ethical framework for short-term rationing in hospitals." Am J Bioeth 12, no. 1 (2012): 1-9. Full Text Link to Item
  - Rosoff, PM. "I'll be a monkey's uncle: a moral challenge to human genetic enhancement research." J Med Ethics 37, no. 10 (October 2011): 611-615. Full Text Link to Item
  - Rosoff, PM, and DeCamp, M. "Preparing for an influenza pandemic: are some people more equal than others?." J Health Care Poor Underserved 22, no. 3 Suppl (August 2011): 19-35. Full Text Link to Item
  - Rosoff, PM, and DeCamp, M. "Preparing for an Influenza Pandemic: Are Some People More Equal than Others?." JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED 22, no. 3 (August 2011): 19-35. Link to Item
  - Rosoff, PM, and Coleman, DL. "THE CASE FOR LEGAL REGULATION OF PHYSICIANS' OFF-LABEL PRESCRIBING." NOTRE DAME LAW REVIEW 86, no. 2 (March 2011): 649-691. Link to Item
  - Rosoff, PM, and DeCamp, M. "Preparing for an influenza pandemic: Are some people more equal than others?." Journal of Health Care for the Poor and Underserved 22, no. SUPPL. 3 (2011): 19-35. Full Text
  - Rosoff, PM. "Is medical ethics education effective?." J Med Liban 59, no. 1 (January 2011): 12-16. Link to Item
  - Paxton, RJ, Jones, LW, Rosoff, PM, Bonner, M, Ater, JL, and Demark-Wahnefried, W. "Associations between leisure-time physical activity and health-related quality of life among adolescent and adult survivors of childhood cancers." Psychooncology 19, no. 9 (September 2010): 997-1003. Full Text Link to Item
  - Rosoff, PM. "Should palliative care be a necessity or a luxury during an overwhelming health catastrophe?." J Clin Ethics 21, no. 4 (2010): 312-320. Link to Item
  - Rosoff, PM. "In search of the mommy gene: Truth and consequences in behavioral genetics." Science Technology and Human Values 35, no. 2 (2010): 200-243. Full Text
  - Bruce, CR, Flamm, AL, Leblanc, TW, and Rosoff, PM. "Is there a duty to inform patients of phase I trials? (Published online)." Virtual Mentor 11, no. 3 (March 1, 2009): 207-214. Full Text Link to Item
  - Rosoff, PM. "Physician responsibility for patients' quality of life. (Published online)" Virtual Mentor 10, no. 6 (June 1, 2008): 401-403. Full Text Link to Item
  - Rosoff, PM. "Perspective roundtable: lethal injection." N Engl J Med 358, no. 20 (May 15, 2008): 2183-. (Letter) Full Text Link to Item
  - Hardy, KK, Bonner, MJ, Masi, R, Hutchinson, KC, Willard, VW, and Rosoff, PM. "Psychosocial functioning in parents of adult survivors of childhood cancer." J Pediatr Hematol Oncol 30, no. 2 (February 2008): 153-159. Full Text Link to Item
  - Arroyave, WD, Clipp, EC, Miller, PE, Jones, LW, Ward, DS, Bonner, MJ, Rosoff, PM, Snyder, DC, and Demark-Wahnefried, W. "Childhood cancer survivors' perceived barriers to improving exercise and dietary behaviors." Oncol Nurs Forum 35, no. 1 (January 2008): 121-130. Full Text Link to Item
  - Rosoff, PM. "The ethics of care: social workers in an influenza pandemic." Soc Work Health Care 47, no. 1 (2008): 49-59. Full Text Link to Item
  - Sevilla, DW, Gong, JZ, Goodman, BK, Buckley, PJ, Rosoff, P, Gockerman, JP, and Lagoo, AS. "Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation." Am J Clin Pathol 128, no. 6 (December 2007): 981-991. Full Text Link to Item
  - Saini, S, and Rosoff, PM. "Are we finally ready for outpatient management of febrile neutropenia?." Pediatr Blood Cancer 49, no. 6 (November 2007): 765-766. Full Text Link to Item
  - Rosoff, PM. "Survivors of childhood cancer - Reply." NEW ENGLAND JOURNAL OF MEDICINE 356, no. 2 (January 11, 2007): 193-194. Link to Item
  - Rosoff, PM. "Dr. Rosoff replies [13]." New England Journal of Medicine 356, no. 2 (2007): 193-194.
  - Rosoff, PM. "The two-edged sword of curing childhood cancer." N Engl J Med 355, no. 15 (October 12, 2006): 1522-1523. Full Text Link to Item
  - Rosoff, PM. "A central role for palliative care in an influenza pandemic." J Palliat Med 9, no. 5 (October 2006): 1051-1053. Full Text Link to Item
  - Rosoff, PM, and Rosenberg, A. "How Darwinian reductionism refutes genetic determinism." Stud Hist Philos Biol Biomed Sci 37, no. 1 (March 2006): 122-135. Full Text Link to Item
  - Rosoff, PM, Larrier, N, and Rice, HE. "Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease." Pediatr Blood Cancer 45, no. 5 (October 15, 2005): 728-731. Full Text Link to Item
  - Demark-Wahnefried, W, Werner, C, Clipp, EC, Guill, AB, Bonner, M, Jones, LW, and Rosoff, PM. "Survivors of childhood cancer and their guardians." Cancer 103, no. 10 (May 15, 2005): 2171-2180. Full Text Link to Item
  - Rosoff, PM, Werner, C, Clipp, EC, Guill, AB, Bonner, M, and Demark-Wahnefried, W. "Response rates to a mailed survey targeting childhood cancer survivors: a comparison of conditional versus unconditional incentives." Cancer Epidemiol Biomarkers Prev 14, no. 5 (May 2005): 1330-1332. Full Text Link to Item
  - Tirado, CA, Lager, J, Rosoff, PM, Golembiski-Ruiz, V, Gong, JZ, and Goodman, BK. "A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12." Cancer Genet Cytogenet 154, no. 1 (October 1, 2004): 57-59. Full Text Link to Item
  - Rosoff, PM. "Can underpowered clinical trials be justified?." IRB 26, no. 3 (May 2004): 16-19. Link to Item
  - Ressler, IB, Cash, J, McNeill, D, Joy, S, and Rosoff, PM. "Continued parental attendance at a clinic for adult survivors of childhood cancer." J Pediatr Hematol Oncol 25, no. 11 (November 2003): 868-873. Link to Item
  - Bayliff, S, Horvatinovich, JM, Gong, JZ, and Rosoff, PM. "Lack of circulating megakaryoblasts in newborn peripheral blood: development and validation of a sensitive flow cytometric detection method." J Pediatr Hematol Oncol 25, no. 9 (September 2003): 721-725. Link to Item
  - Uram, R, and Rosoff, PM. "Isolated IgA deficiency after chemotherapy for acute myelogenous leukemia in an infant." Pediatr Hematol Oncol 20, no. 6 (September 2003): 487-492. Link to Item
  - Rosoff, PM, Tuttle-Newhall, E, and Treem, WR. "Successful treatment of immune thrombocytopenic purpura with anti-D antibody following a cadaveric liver transplant for hepatoblastoma." Med Pediatr Oncol 40, no. 6 (June 2003): 402-404. Full Text Link to Item
  - Rosoff, PM. "Industrial collaboration." N Engl J Med 348, no. 9 (February 27, 2003): 863-864. (Letter) Full Text Link to Item
  - Rosoff, PM, III, HM, Braunwald, E, and Martin, JB. "Industrial collaboration [5] (multiple letters)." New England Journal of Medicine 348, no. 9 (2003): 863-864. Full Text
  - Linardic, CM, Gong, JZ, and Rosoff, PM. "Myelodysplasia as masquerader: A woman with hypereosinophilic syndrome and twelve years of "chronic ITP"." Med Pediatr Oncol 39, no. 2 (August 2002): 137-138. Full Text Link to Item
  - Paterson, A, Bayliff, S, Bisset, GS, and Rosoff, PM. "Granulocytic sarcoma (chloroma) presenting as a dumbbell tumor." Pediatr Radiol 32, no. 5 (May 2002): 391-392. (Letter) Full Text Link to Item
  - Bruno, D, Wigfall, DR, Zimmerman, SA, Rosoff, PM, and Wiener, JS. "Genitourinary complications of sickle cell disease." J Urol 166, no. 3 (September 2001): 803-811. (Review) Link to Item
  - Sugarman, J, and Rosoff, PM. "Ethical issues in gamete preservation for children undergoing treatment for cancer." J Androl 22, no. 5 (September 2001): 732-737. Link to Item
  - Turner, CD, Shea, CR, and Rosoff, PM. "Basal cell carcinoma originating from a nevus sebaceus on the scalp of a 7-year-old boy." J Pediatr Hematol Oncol 23, no. 4 (May 2001): 247-249. (Review) Link to Item
  - McGregor, LM, and Rosoff, PM. "Follicle-derived thyroid cancer in young people: the Duke experience." Pediatr Hematol Oncol 18, no. 2 (March 2001): 89-100. Full Text Link to Item
  - Rosoff, PM, and McGregor, LM. "Papillary adenocarcinoma of the thyroid in a thyroglossal duct cyst." Pediatr Hematol Oncol 17, no. 7 (October 2000): 591-595. Link to Item
  - Rosoff, PM. "Assessing the risk of breast cancer." N Engl J Med 342, no. 26 (June 29, 2000): 2002-. (Letter) Link to Item
  - Rosoff, PM, Hatcher, S, and West, DC. "Biphenotypic sarcoma with characteristics of both a Ewing sarcoma and a desmoplastic small round cell tumor." Med Pediatr Oncol 34, no. 6 (June 2000): 407-412. Link to Item
  - Rosoff, PM, and Bayliff, S. "Successful clinical response to irinotecan in desmoplastic round blue cell tumor." Med Pediatr Oncol 33, no. 5 (November 1999): 500-503. Link to Item
  - Powell, J, Traweek, T, Beatty, O, Qumsiyeh, MB, and Rosoff, PM. "A novel chromosomal rearrangement associated with therapy-related acute leukemia." Cancer Genet Cytogenet 112, no. 2 (July 15, 1999): 173-177. Link to Item
  - Warwick, AB, Haver, K, and Rosoff, PM. "Homozygous sickle cell disease and cystic fibrosis in an adolescent." Pediatr Pulmonol 26, no. 3 (September 1998): 224-227. Link to Item
  - Howrey, RP, Lipham, WJ, Schultz, WH, Buckley, EG, Dutton, JJ, Klintworth, GK, and Rosoff, PM. "Sebaceous gland carcinoma: a subtle second malignancy following radiation therapy in patients with bilateral retinoblastoma." Cancer 83, no. 4 (August 15, 1998): 767-771. (Review) Link to Item
  - Castellino, S, Traweek, T, and Rosoff, PM. "Ewing's tumor and papillary adenocarcinoma of the thyroid in a 14-year-old girl." J Pediatr Hematol Oncol 20, no. 2 (March 1998): 177-180. Link to Item
  - Trede, NS, Warwick, AB, Rosoff, PM, Rohrer, R, Bierer, BE, and Guinan, E. "Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation." Bone Marrow Transplant 20, no. 3 (August 1997): 257-260. Full Text Link to Item
  - Wong, WS, Simon, DI, Rosoff, PM, Rao, NK, and Chapman, HA. "Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87)." Immunology 88, no. 1 (May 1996): 90-97. Link to Item
  - Wong, WS, and Rosoff, PM. "Pharmacology of pertussis toxin B-oligomer." Can J Physiol Pharmacol 74, no. 5 (May 1996): 559-564. Link to Item
  - Rosoff, PM. "Myelodysplasia and deficiency of uridine diphosphate-galactose 4-epimerase." J Pediatr 127, no. 4 (October 1995): 605-608. Link to Item
  - Zhang, XM, Berland, R, and Rosoff, PM. "Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor." Mol Immunol 32, no. 5 (April 1995): 323-332. Link to Item
  - WONG, WSF, RAO, NK, SIMON, DI, ROSOFF, PM, and CHAPMAN, HA. "PERTUSSIS TOXIN (PTX) STIMULATES MYELOID CELL-ADHESION TO VITRONECTIN (VN) - FUNCTIONAL-LINK BETWEEN MAC-1 (CD11B/CD18) THE UROKINASE RECEPTOR (CD87)." FASEB JOURNAL 9, no. 4 (March 10, 1995): A797-A797. Link to Item
  - Rosoff, PM. "Congenital bone marrow failure with myelodysplasia in siblings." J Pediatr Hematol Oncol 17, no. 1 (February 1995): 56-60. Link to Item
  - ROSOFF, P. "Congenital bone marrow failure with myelodysplasia in siblings." J Pediatr Hematol Oncol 17 (1995): 56-60. Full Text
  - CIFUENTES, ME, MITTLER, RS, and ROSOFF, PM. "THE CD45 TYROSINE PROTEIN-KINASE IS NOT REQUIRED FOR SIGNALING AND ACTIVATION OF HUMAN T-LYMPHOCYTES BY THE PERTUSSIS TOXIN RECEPTOR." BLOOD 84, no. 10 (November 15, 1994): A285-A285. Link to Item
  - ROSOFF, PM. "CHARACTERIZATION OF A NOVEL ECTO-ADP-RIBOSYL-TRANSFERASE IN T-LYMPHOCYTES BY THE B-SUBUNIT OF PERTUSSIS TOXIN." BLOOD 84, no. 10 (November 15, 1994): A432-A432. Link to Item
  - ZHANG, XM, BERLAND, R, and ROSOFF, PM. "THE CD3-T CELL ANTIGEN RECEPTOR COMPLEX REGULATES PERTUSSIS TOXIN RECEPTOR-STIMULATED TYROSINE PROTEIN-PHOSPHORYLATION." BLOOD 82, no. 10 (November 15, 1993): A246-A246. Link to Item
  - MASCHEK, BJ, ZHANG, W, ROSOFF, PM, and REISER, H. "MODULATION OF THE INTRACELLULAR CA2+ AND INOSITOL TRISPHOSPHATE CONCENTRATIONS IN MURINE-T LYMPHOCYTES BY THE GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEIN SGP-60." JOURNAL OF IMMUNOLOGY 150, no. 8 (April 15, 1993): 3198-3206. Link to Item
  - Maschek, BJ, Zhang, W, Rosoff, PM, and Reiser, H. "Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60." J Immunol 150, no. 8 Pt 1 (April 15, 1993): 3198-3206. Link to Item
  - O'Riordan, C, and Rosoff, PM. "Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates." Cell Calcium 14, no. 2 (February 1993): 119-133. Link to Item
  - Maschek, BJ, Zhang, W, Rosoff, PM, and Reiser, H. "Modulation of the intracellular Ca²⁺ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60." Journal of Immunology 150, no. 8 PART 1 (1993): 3198-3206.
  - Rosoff, PM, and Mohan, C. "Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex." J Immunol 149, no. 10 (November 15, 1992): 3191-3199. Link to Item
  - Prasad, KR, and Rosoff, PM. "Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae." Cell Calcium 13, no. 10 (November 1992): 615-626. Link to Item
  - Corey, SJ, and Rosoff, PM. "Unsaturated fatty acids and lipoxygenase products regulate phagocytic NADPH oxidase activity by a nondetergent mechanism." J Lab Clin Med 118, no. 4 (October 1991): 343-351. Link to Item
  - Rogers, TS, Corey, SJ, and Rosoff, PM. "Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin." J Immunol 145, no. 2 (July 15, 1990): 678-683. Link to Item
  - Dinarello, CA, Clark, BD, Ikejima, T, Puren, AJ, Savage, N, and Rosoff, PM. "Interleukin 1 receptors and biological responses." Yale J Biol Med 63, no. 2 (March 1990): 87-93. (Review) Link to Item
  - Rosoff, PM. "IL-1 receptors: structure and signals." Semin Immunol 2, no. 2 (March 1990): 129-137. (Review) Link to Item
  - Corey, SJ, and Rosoff, PM. "Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover." J Biol Chem 264, no. 24 (August 25, 1989): 14165-14171. Link to Item
  - Dinarello, CA, Clark, BD, Puren, AJ, Savage, N, and Rosoff, PM. "The interleukin 1 receptor." Immunol Today 10, no. 2 (February 1989): 49-51. (Review) Full Text Link to Item
  - Melton, LB, Lakkis, F, Moscovitch-Lopatin, M, Smith, BR, Williams, JM, Rosoff, PM, and Strom, TB. "Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells." Clin Immunol Immunopathol 50, no. 2 (February 1989): 171-183. Link to Item
  - Dinarello, CA, Clark, BD, Puren, AJ, Savage, N, and Rosoff, PM. "The interleukin 1 receptor." Immunology Today 10, no. 2 (1989): 49-51.
  - Rosoff, PM. "Characterization of the interleukin-1-stimulated phospholipase C activity in human T lymphocytes." Lymphokine Res 8, no. 4 (1989): 407-413. Link to Item
  - Rosoff, PM, Hall, C, Gramates, LS, and Terlecky, SR. "4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes." J Biol Chem 263, no. 36 (December 25, 1988): 19535-19540. Link to Item
  - Rosoff, PM, Savage, N, and Dinarello, CA. "Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism." Cell 54, no. 1 (July 1, 1988): 73-81. Link to Item
  - Rosoff, PM, Walker, R, and Winberry, L. "Pertussis toxin triggers rapid second messenger production in human T lymphocytes." J Immunol 139, no. 7 (October 1, 1987): 2419-2423. Link to Item
  - Rosoff, PM, Burakoff, SJ, and Greenstein, JL. "The role of the L3T4 molecule in mitogen and antigen-activated signal transduction." Cell 49, no. 6 (June 19, 1987): 845-853. Link to Item
  - Rosoff, PM, and Terres, G. "Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells." J Cell Biol 103, no. 2 (August 1986): 457-463. Open Access Copy Link to Item
  - ROSOFF, PM, and CANTLEY, LC. "LYMPHOCYTE-B DIFFERENTIATION - ROLE OF PHOSPHOINOSITIDES, C KINASE, AND NA+-H+ EXCHANGE." CURRENT TOPICS IN MEMBRANES AND TRANSPORT 26 (1986): 193-199. Link to Item
  - ROSOFF, PM, and HALL, CM. "RECONSTITUTION OF THE T3-T CELL ANTIGEN RECEPTOR COMPLEX ACTIVATED CA-2+ TRANSPORTER FROM HUMAN T-CELLS." JOURNAL OF CELLULAR BIOCHEMISTRY (1986): 203-203. Link to Item
  - Rosoff, PM, and Cantley, LC. "Chapter 11 B Lymphocyte Differentiation: Role of Phosphoinositides, C Kinase, and Na⁺-H⁺ Exchange." Current Topics in Membranes and Transport 26, no. C (1986): 193-199. Full Text
  - Rosoff, PM, and Terres, G. "Cyclosporine A inhibits Ca²⁺-dependent stimulation of the Na⁺/H⁺ antiport in human T cells." Journal of Cell Biology 103, no. 2 (1986): 457-463.
  - Rosoff, PM, and Cantley, LC. "Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line." J Biol Chem 260, no. 26 (November 15, 1985): 14053-14059. Link to Item
  - Rosoff, PM, and Cantley, LC. "Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes." J Biol Chem 260, no. 16 (August 5, 1985): 9209-9215. Link to Item
  - Oettgen, HC, Terhorst, C, Cantley, LC, and Rosoff, PM. "Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx." Cell 40, no. 3 (March 1985): 583-590. Link to Item
  - ROSOFF, P. "Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca^<2+> mobilization in 70Z/3 pre-B lymphocytes." J Biol Chem 260 (1985): 9209-9215.
  - ROSOFF, PM, and CANTLEY, LC. "STIMULATION OF THE T3-T CELL RECEPTOR-ASSOCIATED CA-2+ INFLUX ENHANCES THE ACTIVITY OF THE NA+/H+ EXCHANGER IN A LEUKEMIC HUMAN T-CELL LINE." JOURNAL OF BIOLOGICAL CHEMISTRY 260, no. 26 (1985): 4053-4059. Link to Item
  - Rosoff, PM, and Cantley, LC. "Ion fluxes and differentiation in transformed cell lines." Soc Gen Physiol Ser 39 (1985): 193-204. (Review) Link to Item
  - Rosoff, PM, and Cantley, LC. "The role of ion fluxes in hematopoietic cell differentiation." Prog Clin Biol Res 184 (1985): 331-339. Link to Item
  - Rosoff, PM, Stein, LF, and Cantley, LC. "Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange." J Biol Chem 259, no. 11 (June 10, 1984): 7056-7060. Link to Item
  - Cantley, LC, and Rosoff, PM. "Regulation of surface IgM expression: Role of plasma membrane Na⁺/H⁺ exchange." Federation Proceedings 43, no. 6 (1984): no.-464.
  - ROSOFF, PM. "CORRECTION." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81, no. 8 (1984): 2586-2586. Link to Item
  - Rosoff, PM, and Cantley, LC. "Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line." Proc Natl Acad Sci U S A 80, no. 24 (December 1983): 7547-7550. Link to Item
  - Newburger, PE, Robinson, JM, Pryzwansky, KB, Rosoff, PM, Greenberger, JS, and Tauber, AI. "Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst." Blood 61, no. 6 (June 1983): 1247-1257. Link to Item
  - ROSOFF, PM, and CANTLEY, LC. "INCREASING CELLULAR NA+ INDUCES DIFFERENTIATION IN A PRE-B LYMPHOCYTE CELL-LINE." JOURNAL OF GENERAL PHYSIOLOGY 82, no. 6 (1983): A30-A30. Link to Item
  - Rosoff, PM, and Cantley, LC. "Increasing the intracellular Na⁺ concentration induces differentiation in a pre-B lymphocyte cell line." Proceedings of the National Academy of Sciences of the United States of America 80, no. 24 I (1983): 7547-7550.
Teaching & Mentoring
Recent Courses
- BIOETHIC 603S: Clinical Bioethics and Health Policy 2018
Advising & Mentoring
- I would be pleased to serve as a faculty mentor to students (undergrad, grad) or post-degree professionals (post-doc, fellow, junior faculty), especially those who wish advice, supervision or collaboration on their scholarly research projects.
Available to mentor:
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- Undergraduate

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