Philip Martin Rosoff | Scholars@Duke

Philip Martin Rosoff
Professor of Pediatrics

My main interests are clinical ethics with a concentration on the equitable allocation of scarce resources (rationing). In this area, I have done work on planning for pandemic influenza and allocation of drugs during shortages. I play a major role in the Clinical Ethics Service at Duke Hospital and chair the hospital's Ethics Committee.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2008
Professor of Medicine, Medicine, Medical Oncology, Medicine 2008
Core Faculty in the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2018

Contact Information

108 Seeley G. Mudd Building, Box 3040, Durham, NC 27710
108 Seeley G. Mudd, Box 3040, Durham, NC 27710
philip.rosoff@duke.edu (919) 668-9000

Background
Education, Training, & Certifications
- M.D., Case Western Reserve University 1978
Duke Appointment History
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1995 - 2014
- Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 1996 - 2008
- Associate Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1996 - 2008
- Chief, Division of Pediatric Hematology/Oncology, Pediatrics, Hematology-Oncology, Pediatrics 1995 - 2005
- Associate Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1996
- Instructor, Temporary of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1995 - 1996
Leadership & Clinical Positions at Duke
- Chair, Duke Hospital Ethics Committee 2005 - present
Academic Positions Outside Duke
- Adjunct Professor, Dept. of Clinical Sciences, NC State College of Veterinary Medicine. 2018 - 2025
Recognition
In the News
- FEB 4, 2015 The Conversation
  
  Dr. Philip Rosoff: The Affordable Care Act is another way to ration health care
- FEB 4, 2015 The Conversation
  
  The Affordable Care Act is another way to ration health care
- JAN 6, 2015 The Conversation
  
  Dr. Philip Rosoff: What should a hospital do when critical drugs are in short supply?
- JAN 6, 2015 The Conversation
  
  What Should a Hospital Do When Drugs are in Short Supply?
- DEC 18, 2014 The News & Observer
  
  Dr. Philip Rosoff: When doctors take part in torture
- DEC 18, 2014
  
  When Doctors Take Part in Torture
- NOV 13, 2014 ABC News, AP
  
  Dr. Philip Rosoff comments: Ebola drug testing sparks ethics debate
- OCT 31, 2014 Duke Research Blog
  
  Rationing Health Care Is Not a Four-Letter Word
- OCT 14, 2014 The Dallas Morning News
  
  Clinical Trials Needed for Anti-Ebola Drugs
- OCT 14, 2014 The Dallas Morning News
  
  Dr. Philip Rosoff: Clinical trials needed for anti-Ebola drugs
Awards & Honors
Research
Selected Grants
- FitFab 4 Survivors awarded by National Institutes of Health 2011 - 2014
- Gamete Preservation in Males Receiving Gametotoxic Chemotherapy awarded by Josiah Charles Trent Memorial Foundation 2002 - 2003
- Pediatric Oncology Group awarded by National Institutes of Health 1998 - 1999
- Pediatric Oncology Group Studies awarded by National Institutes of Health 1997 - 1999
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
Publications & Artistic Works
Selected Publications
- Books
  - Rosoff, PM. Drawing the Line: Healthcare Rationing and the Cutoff Problem (Accepted). New York: Oxford University Press, 2017.
  - Rosoff, PM. Rationing Is Not a Four-Letter Word Setting Limits on Healthcare. MIT Press, July 18, 2014.
- Academic Articles
  - Hedges, CE, and Rosoff, PM. "Transplants for non-lethal conditions: a case against hand transplantation in minors." Journal of Medical Ethics 44, no. 10 (October 2018): 661-665. Full Text
  - Rosoff, PM. "Discriminatory Demands by Patients." Hastings Center Report 48, no. 4 (July 1, 2018): 7-11. Full Text
  - Rosoff, PM. "When Religion and Medicine Clash: Non-beneficial Treatments and Hope for a Miracle." Hec Forum : an Interdisciplinary Journal on Hospitals' Ethical and Legal Issues (June 7, 2018). Full Text
  - Rosoff, PM, Moga, J, Keene, B, Adin, C, Fogle, C, Ruderman, R, Hopkinso, H, and Weyhrauch, C. "Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model." The American journal of bioethics : AJOB 18, no. 2 (February 2018): 41-53. Full Text
  - Rosoff, PM, Ruderman, R, Moga, J, Keene, B, Adin, C, Fogle, C, Hopkinson, H, and Weyhrauch, C. "Response to Open Peer Commentaries on "Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model"." The American journal of bioethics : AJOB 18, no. 2 (February 2018): W7-W10. Full Text
  - Rosoff, PM. "Compulsory Organ Retrieval: Morally, But Not Socially, Justified." Cambridge Quarterly of Healthcare Ethics : Cq : the International Journal of Healthcare Ethics Committees 27, no. 1 (January 2018): 36-51. Full Text
  - Rosoff, PM. "Licensing Surrogate Decision-Makers." HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues 29, no. 2 (June 2017): 145-169. Full Text
  - Rosoff, PM. "Do Pediatric Patients Have a Right to Know?." AMA journal of ethics 19, no. 5 (May 2017): 426-435. Full Text
  - Waweru-Siika, W, Clement, ME, Lukoko, L, Nadel, S, Rosoff, PM, Naanyu, V, and Kussin, PS. "Brain death determination: the imperative for policy and legal initiatives in Sub-Saharan Africa." Global public health 12, no. 5 (May 2017): 589-600. Full Text Open Access Copy
  - Rosoff, PM, and Schneiderman, LJ. "Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish." The American journal of bioethics : AJOB 17, no. 2 (February 2017): 26-34. Full Text
  - Rosoff, PM, and Schneiderman, LJ. "Response to Open Peer Commentaries on "Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish"." The American Journal of Bioethics : Ajob 17, no. 2 (February 2017): W1-W3. Full Text
  - Rosoff, PM. "Who Should Ration?." AMA journal of ethics 19, no. 2 (February 2017): 164-173. Full Text
  - Hinson, AP, and Rosoff, PM. "Where Children Die: Obstacles to Quality End-of-Life Care." Clinical pediatrics 55, no. 2 (February 2016): 101-106. (Review) Full Text
  - Rosoff, PM. "Making Sausage." Narrative Inquiry in Bioethics 6, no. 1 (January 2016): 31-33. Full Text
  - Rosoff, PM. "In defense of (some) altered standards of care for Ebola infections in developed countries." HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues 27, no. 1 (March 2015): 1-9. Full Text
  - Rosoff, PM, and Leong, KM. "An Ethical and Legal Framework for Physicians as Surrogate Decision-Makers for Their Patients." The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 43, no. 4 (January 2015): 857-877. Full Text Open Access Copy
  - Rosoff, PM. "Caring for the suffering: meeting the Ebola crisis responsibly." The American journal of bioethics : AJOB 15, no. 4 (January 2015): 26-32. Full Text
  - Rosoff, PM. "Response to open peer commentaries on "Caring for the suffering: meeting the Ebola crisis responsibly"." The American journal of bioethics : AJOB 15, no. 4 (January 2015): W4-W7. Full Text
  - Rosoff, PM. "TADA Is Still Unfair." The American journal of bioethics : AJOB 15, no. 8 (January 2015): 56-58. Full Text
  - Falloon, K, and Rosoff, PM. "Who pays? Mandated insurance coverage for assisted reproductive technology." The virtual mentor : VM 16, no. 1 (January 2014): 63-69. Full Text
  - Rosoff, PM. "Institutional futility policies are inherently unfair." HEC Forum 25, no. 3 (September 2013): 191-209. Full Text Link to Item
  - Fuemmeler, BF, Pendzich, MK, Clark, K, Lovelady, C, Rosoff, P, Blatt, J, and Demark-Wahnefried, W. "Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma." Journal of Pediatric Hematology/Oncology 35, no. 6 (August 2013): 437-443. Full Text
  - Raizis, AM, Van Mater, D, Aaltonen, LA, Lohmann, D, Cheale, MS, Bickley, VM, George, PM, Zhou, Y, and Rosoff, PM. "Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome." Am J Med Genet A 161A, no. 5 (May 2013): 1096-1100. Full Text Link to Item
  - Coleman, D, and Rosoff, P. "The Legal Authority of Mature Minors to Consent to General Medical Treatment." Pediatrics 131, no. 4 (2013): 786-793. Link to Item
  - Fuemmeler, BF, Pendzich, MK, Clark, K, Lovelady, C, Rosoff, P, Blatt, J, and Demark-Wahnefried, W. "Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma." Journal of Pediatric Hematology/Oncology 35, no. 6 (2013): 437-443. Full Text
  - Raizis, AM, Mater, DV, Aaltonen, LA, Lohmann, D, Cheale, MS, Bickley, VM, George, PM, Zhou, Y, and Rosoff, PM. "Trilateral Retinoblastoma in a Patient With Peutz-Jeghers Syndrome." American Journal of Medical Genetics, Part A 161, no. 5 (2013): 1096-1100. Full Text
  - Rosoff, PM, Patel, KR, Scates, A, Rhea, G, Bush, PW, and Govert, JA. "Coping with critical drug shortages: an ethical approach for allocating scarce resources in hospitals." Arch Intern Med 172, no. 19 (October 22, 2012): 1494-1499. (Review) Full Text Link to Item
  - Arawi, T, and Rosoff, PM. "Competing duties: medical educators, underperforming students, and social accountability." J Bioeth Inq 9, no. 2 (June 2012): 135-147. Full Text Link to Item
  - Rosoff, PM. "The myth of genetic enhancement." Theor Med Bioeth 33, no. 3 (June 2012): 163-178. Full Text Link to Item
  - Rosoff, PM. "Unpredictable drug shortages: an ethical framework for short-term rationing in hospitals." Am J Bioeth 12, no. 1 (2012): 1-9. Full Text Link to Item
  - Rosoff, PM. "I'll be a monkey's uncle: a moral challenge to human genetic enhancement research." J Med Ethics 37, no. 10 (October 2011): 611-615. Full Text Link to Item
  - Rosoff, PM, and DeCamp, M. "Preparing for an influenza pandemic: are some people more equal than others?." J Health Care Poor Underserved 22, no. 3 Suppl (August 2011): 19-35. Full Text Link to Item
  - Rosoff, PM, and DeCamp, M. "Preparing for an Influenza Pandemic: Are Some People More Equal than Others?." JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED 22, no. 3 (August 2011): 19-35. Link to Item
  - Coleman, D, and Rosoff, P. "The Case for Legal Regulation of Physicians' Off-Label Prescribing." Notre Dame Law Review 86 (2011): 649-691. Link to Item
  - Rosoff, PM, and DeCamp, M. "Preparing for an influenza pandemic: Are some people more equal than others?." Journal of Health Care for the Poor and Underserved 22, no. SUPPL. 3 (2011): 19-35. Full Text
  - Rosoff, PM. "Is medical ethics education effective?." J Med Liban 59, no. 1 (January 2011): 12-16. Link to Item
  - Paxton, RJ, Jones, LW, Rosoff, PM, Bonner, M, Ater, JL, and Demark-Wahnefried, W. "Associations between leisure-time physical activity and health-related quality of life among adolescent and adult survivors of childhood cancers." Psychooncology 19, no. 9 (September 2010): 997-1003. Full Text Link to Item
  - Rosoff, PM. "In Search of the Mommy Gene: Truth and Consequences in Behavioral Genetics." Science, Technology, & Human Values 35, no. 2 (March 2010): 200-243. Full Text
  - Rosoff, PM. "Should palliative care be a necessity or a luxury during an overwhelming health catastrophe?." J Clin Ethics 21, no. 4 (2010): 312-320. Link to Item
  - Bruce, CR, Flamm, AL, Leblanc, TW, and Rosoff, PM. "Is there a duty to inform patients of phase I trials? (Published online)." Virtual Mentor 11, no. 3 (March 1, 2009): 207-214. Full Text Link to Item
  - Rosoff, PM. "Physician responsibility for patients' quality of life. (Published online)" Virtual Mentor 10, no. 6 (June 1, 2008): 401-403. Full Text Link to Item
  - Rosoff, PM. "Perspective roundtable: lethal injection." N Engl J Med 358, no. 20 (May 15, 2008): 2183-. (Letter) Full Text Link to Item
  - Hardy, KK, Bonner, MJ, Masi, R, Hutchinson, KC, Willard, VW, and Rosoff, PM. "Psychosocial functioning in parents of adult survivors of childhood cancer." Journal of Pediatric Hematology/Oncology 30, no. 2 (February 2008): 153-159. Full Text
  - Arroyave, WD, Clipp, EC, Miller, PE, Jones, LW, Ward, DS, Bonner, MJ, Rosoff, PM, Snyder, DC, and Demark-Wahnefried, W. "Childhood cancer survivors' perceived barriers to improving exercise and dietary behaviors." Oncol Nurs Forum 35, no. 1 (January 2008): 121-130. Full Text Link to Item
  - Rosoff, PM. "The ethics of care: social workers in an influenza pandemic." Soc Work Health Care 47, no. 1 (2008): 49-59. Full Text Link to Item
  - Sevilla, DW, Gong, JZ, Goodman, BK, Buckley, PJ, Rosoff, P, Gockerman, JP, and Lagoo, AS. "Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation." Am J Clin Pathol 128, no. 6 (December 2007): 981-991. Full Text Link to Item
  - Saini, S, and Rosoff, PM. "Are we finally ready for outpatient management of febrile neutropenia?." Pediatr Blood Cancer 49, no. 6 (November 2007): 765-766. Full Text Link to Item
  - Rosoff, PM. "Survivors of childhood cancer - Reply." NEW ENGLAND JOURNAL OF MEDICINE 356, no. 2 (January 11, 2007): 193-194. Link to Item
  - Rosoff, PM. "Dr. Rosoff replies [13]." New England Journal of Medicine 356, no. 2 (2007): 193-194.
  - Rosoff, PM. "The two-edged sword of curing childhood cancer." N Engl J Med 355, no. 15 (October 12, 2006): 1522-1523. Full Text Link to Item
  - Rosoff, PM. "A central role for palliative care in an influenza pandemic." J Palliat Med 9, no. 5 (October 2006): 1051-1053. Full Text Link to Item
  - Rosoff, PM, and Rosenberg, A. "How Darwinian reductionism refutes genetic determinism." Stud Hist Philos Biol Biomed Sci 37, no. 1 (March 2006): 122-135. Full Text Link to Item
  - Rosoff, PM, Larrier, N, and Rice, HE. "Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease." Pediatr Blood Cancer 45, no. 5 (October 15, 2005): 728-731. Full Text Link to Item
  - Demark-Wahnefried, W, Werner, C, Clipp, EC, Guill, AB, Bonner, M, Jones, LW, and Rosoff, PM. "Survivors of childhood cancer and their guardians." Cancer 103, no. 10 (May 15, 2005): 2171-2180. Full Text Link to Item
  - Rosoff, PM, Werner, C, Clipp, EC, Guill, AB, Bonner, M, and Demark-Wahnefried, W. "Response rates to a mailed survey targeting childhood cancer survivors: a comparison of conditional versus unconditional incentives." Cancer Epidemiol Biomarkers Prev 14, no. 5 (May 2005): 1330-1332. Full Text Link to Item
  - Tirado, CA, Lager, J, Rosoff, PM, Golembiski-Ruiz, V, Gong, JZ, and Goodman, BK. "A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12." Cancer Genet Cytogenet 154, no. 1 (October 1, 2004): 57-59. Full Text Link to Item
  - Rosoff, PM. "Can underpowered clinical trials be justified?." IRB 26, no. 3 (May 2004): 16-19. Link to Item
  - Ressler, IB, Cash, J, McNeill, D, Joy, S, and Rosoff, PM. "Continued parental attendance at a clinic for adult survivors of childhood cancer." Journal of Pediatric Hematology/Oncology 25, no. 11 (November 2003): 868-873. Full Text
  - Bayliff, S, Horvatinovich, JM, Gong, JZ, and Rosoff, PM. "Lack of circulating megakaryoblasts in newborn peripheral blood: development and validation of a sensitive flow cytometric detection method." J Pediatr Hematol Oncol 25, no. 9 (September 2003): 721-725. Link to Item
  - Uram, R, and Rosoff, PM. "Isolated IgA deficiency after chemotherapy for acute myelogenous leukemia in an infant." Pediatr Hematol Oncol 20, no. 6 (September 2003): 487-492. Link to Item
  - Rosoff, PM, Tuttle-Newhall, E, and Treem, WR. "Successful treatment of immune thrombocytopenic purpura with anti-D antibody following a cadaveric liver transplant for hepatoblastoma." Med Pediatr Oncol 40, no. 6 (June 2003): 402-404. Full Text Link to Item
  - Rosoff, PM. "Industrial collaboration." N Engl J Med 348, no. 9 (February 27, 2003): 863-864. (Letter) Full Text Link to Item
  - Rosoff, PM, III, HM, Braunwald, E, and Martin, JB. "Industrial collaboration [5] (multiple letters)." New England Journal of Medicine 348, no. 9 (2003): 863-864. Full Text
  - Linardic, CM, Gong, JZ, and Rosoff, PM. "Myelodysplasia as masquerader: A woman with hypereosinophilic syndrome and twelve years of "chronic ITP"." Med Pediatr Oncol 39, no. 2 (August 2002): 137-138. Full Text Link to Item
  - Paterson, A, Bayliff, S, Bisset, GS, and Rosoff, PM. "Granulocytic sarcoma (chloroma) presenting as a dumbbell tumor." Pediatr Radiol 32, no. 5 (May 2002): 391-392. (Letter) Full Text Link to Item
  - Bruno, D, Wigfall, DR, Zimmerman, SA, Rosoff, PM, and Wiener, JS. "Genitourinary complications of sickle cell disease." The Journal of Urology 166, no. 3 (September 2001): 803-811. (Review) Full Text
  - Sugarman, J, and Rosoff, PM. "Ethical issues in gamete preservation for children undergoing treatment for cancer." J Androl 22, no. 5 (September 2001): 732-737. Link to Item
  - Turner, CD, Shea, CR, and Rosoff, PM. "Basal cell carcinoma originating from a nevus sebaceus on the scalp of a 7-year-old boy." J Pediatr Hematol Oncol 23, no. 4 (May 2001): 247-249. (Review) Link to Item
  - McGregor, LM, and Rosoff, PM. "Follicle-derived thyroid cancer in young people: the Duke experience." Pediatr Hematol Oncol 18, no. 2 (March 2001): 89-100. Full Text Link to Item
  - Rosoff, PM, and McGregor, LM. "Papillary adenocarcinoma of the thyroid in a thyroglossal duct cyst." Pediatr Hematol Oncol 17, no. 7 (October 2000): 591-595. Link to Item
  - Rosoff, PM. "Assessing the risk of breast cancer." N Engl J Med 342, no. 26 (June 29, 2000): 2002-. (Letter) Link to Item
  - Rosoff, PM, Hatcher, S, and West, DC. "Biphenotypic sarcoma with characteristics of both a Ewing sarcoma and a desmoplastic small round cell tumor." Medical and Pediatric Oncology 34, no. 6 (June 2000): 407-412. Full Text
  - Rosoff, PM, and Bayliff, S. "Successful clinical response to irinotecan in desmoplastic round blue cell tumor." Med Pediatr Oncol 33, no. 5 (November 1999): 500-503. Link to Item
  - Powell, J, Traweek, T, Beatty, O, Qumsiyeh, MB, and Rosoff, PM. "A novel chromosomal rearrangement associated with therapy-related acute leukemia." Cancer Genet Cytogenet 112, no. 2 (July 15, 1999): 173-177. Link to Item
  - Warwick, AB, Haver, K, and Rosoff, PM. "Homozygous sickle cell disease and cystic fibrosis in an adolescent." Pediatr Pulmonol 26, no. 3 (September 1998): 224-227. Link to Item
  - Howrey, RP, Lipham, WJ, Schultz, WH, Buckley, EG, Dutton, JJ, Klintworth, GK, and Rosoff, PM. "Sebaceous gland carcinoma: a subtle second malignancy following radiation therapy in patients with bilateral retinoblastoma." Cancer 83, no. 4 (August 1998): 767-771. (Review) Full Text
  - Castellino, S, Traweek, T, and Rosoff, PM. "Ewing's tumor and papillary adenocarcinoma of the thyroid in a 14-year-old girl." J Pediatr Hematol Oncol 20, no. 2 (March 1998): 177-180. Link to Item
  - Trede, NS, Warwick, AB, Rosoff, PM, Rohrer, R, Bierer, BE, and Guinan, E. "Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation." Bone Marrow Transplantation 20, no. 3 (August 1997): 257-260. Full Text
  - Wong, WS, Simon, DI, Rosoff, PM, Rao, NK, and Chapman, HA. "Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87)." Immunology 88, no. 1 (May 1996): 90-97. Full Text
  - Wong, WS, and Rosoff, PM. "Pharmacology of pertussis toxin B-oligomer." Can J Physiol Pharmacol 74, no. 5 (May 1996): 559-564. Link to Item
  - Rosoff, PM. "Myelodysplasia and deficiency of uridine diphosphate-galactose 4-epimerase." J Pediatr 127, no. 4 (October 1995): 605-608. Link to Item
  - Zhang, XM, Berland, R, and Rosoff, PM. "Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor." Molecular Immunology 32, no. 5 (April 1995): 323-332. Full Text
  - WONG, WSF, RAO, NK, SIMON, DI, ROSOFF, PM, and CHAPMAN, HA. "PERTUSSIS TOXIN (PTX) STIMULATES MYELOID CELL-ADHESION TO VITRONECTIN (VN) - FUNCTIONAL-LINK BETWEEN MAC-1 (CD11B/CD18) THE UROKINASE RECEPTOR (CD87)." FASEB JOURNAL 9, no. 4 (March 10, 1995): A797-A797. Link to Item
  - Rosoff, PM. "Congenital bone marrow failure with myelodysplasia in siblings." J Pediatr Hematol Oncol 17, no. 1 (February 1995): 56-60. Link to Item
  - ROSOFF, P. "Congenital bone marrow failure with myelodysplasia in siblings." J Pediatr Hematol Oncol 17 (1995): 56-60. Full Text
  - CIFUENTES, ME, MITTLER, RS, and ROSOFF, PM. "THE CD45 TYROSINE PROTEIN-KINASE IS NOT REQUIRED FOR SIGNALING AND ACTIVATION OF HUMAN T-LYMPHOCYTES BY THE PERTUSSIS TOXIN RECEPTOR." BLOOD 84, no. 10 (November 15, 1994): A285-A285. Link to Item
  - ROSOFF, PM. "CHARACTERIZATION OF A NOVEL ECTO-ADP-RIBOSYL-TRANSFERASE IN T-LYMPHOCYTES BY THE B-SUBUNIT OF PERTUSSIS TOXIN." BLOOD 84, no. 10 (November 15, 1994): A432-A432. Link to Item
  - ZHANG, XM, BERLAND, R, and ROSOFF, PM. "THE CD3-T CELL ANTIGEN RECEPTOR COMPLEX REGULATES PERTUSSIS TOXIN RECEPTOR-STIMULATED TYROSINE PROTEIN-PHOSPHORYLATION." BLOOD 82, no. 10 (November 15, 1993): A246-A246. Link to Item
  - MASCHEK, BJ, ZHANG, W, ROSOFF, PM, and REISER, H. "MODULATION OF THE INTRACELLULAR CA2+ AND INOSITOL TRISPHOSPHATE CONCENTRATIONS IN MURINE-T LYMPHOCYTES BY THE GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEIN SGP-60." JOURNAL OF IMMUNOLOGY 150, no. 8 (April 15, 1993): 3198-3206. Link to Item
  - Maschek, BJ, Zhang, W, Rosoff, PM, and Reiser, H. "Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60." J Immunol 150, no. 8 Pt 1 (April 15, 1993): 3198-3206. Link to Item
  - O'Riordan, C, and Rosoff, PM. "Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates." Cell Calcium 14, no. 2 (February 1993): 119-133. Link to Item
  - Maschek, BJ, Zhang, W, Rosoff, PM, and Reiser, H. "Modulation of the intracellular Ca²⁺ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol- anchored protein sgp-60." Journal of Immunology 150, no. 8 I (January 1, 1993): 3198-3206.
  - Rosoff, PM, and Mohan, C. "Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex." J Immunol 149, no. 10 (November 15, 1992): 3191-3199. Link to Item
  - Prasad, KR, and Rosoff, PM. "Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae." Cell Calcium 13, no. 10 (November 1992): 615-626. Link to Item
  - Corey, SJ, and Rosoff, PM. "Unsaturated fatty acids and lipoxygenase products regulate phagocytic NADPH oxidase activity by a nondetergent mechanism." J Lab Clin Med 118, no. 4 (October 1991): 343-351. Link to Item
  - Rogers, TS, Corey, SJ, and Rosoff, PM. "Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin." J Immunol 145, no. 2 (July 15, 1990): 678-683. Link to Item
  - Dinarello, CA, Clark, BD, Ikejima, T, Puren, AJ, Savage, N, and Rosoff, PM. "Interleukin 1 receptors and biological responses." Yale J Biol Med 63, no. 2 (March 1990): 87-93. (Review) Link to Item
  - Rosoff, PM. "IL-1 receptors: structure and signals." Semin Immunol 2, no. 2 (March 1990): 129-137. (Review) Link to Item
  - Corey, SJ, and Rosoff, PM. "Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover." J Biol Chem 264, no. 24 (August 25, 1989): 14165-14171. Link to Item
  - Dinarello, CA, Clark, BD, Puren, AJ, Savage, N, and Rosoff, PM. "The interleukin 1 receptor." Immunol Today 10, no. 2 (February 1989): 49-51. (Review) Full Text Link to Item
  - Melton, LB, Lakkis, F, Moscovitch-Lopatin, M, Smith, BR, Williams, JM, Rosoff, PM, and Strom, TB. "Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells." Clin Immunol Immunopathol 50, no. 2 (February 1989): 171-183. Link to Item
  - Dinarello, CA, Clark, BD, Puren, AJ, Savage, N, and Rosoff, PM. "The interleukin 1 receptor." Immunology Today 10, no. 2 (1989): 49-51.
  - Rosoff, PM. "Characterization of the interleukin-1-stimulated phospholipase C activity in human T lymphocytes." Lymphokine Res 8, no. 4 (1989): 407-413. Link to Item
  - Rosoff, PM, Hall, C, Gramates, LS, and Terlecky, SR. "4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes." J Biol Chem 263, no. 36 (December 25, 1988): 19535-19540. Link to Item
  - Rosoff, PM, Savage, N, and Dinarello, CA. "Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism." Cell 54, no. 1 (July 1, 1988): 73-81. Link to Item
  - Rosoff, PM, Walker, R, and Winberry, L. "Pertussis toxin triggers rapid second messenger production in human T lymphocytes." J Immunol 139, no. 7 (October 1, 1987): 2419-2423. Link to Item
  - Rosoff, PM, Burakoff, SJ, and Greenstein, JL. "The role of the L3T4 molecule in mitogen and antigen-activated signal transduction." Cell 49, no. 6 (June 1987): 845-853. Full Text
  - Rosoff, PM, and Terres, G. "Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells." J Cell Biol 103, no. 2 (August 1986): 457-463. Open Access Copy Link to Item
  - ROSOFF, PM, and CANTLEY, LC. "LYMPHOCYTE-B DIFFERENTIATION - ROLE OF PHOSPHOINOSITIDES, C KINASE, AND NA+-H+ EXCHANGE." CURRENT TOPICS IN MEMBRANES AND TRANSPORT 26 (1986): 193-199. Link to Item
  - ROSOFF, PM, and HALL, CM. "RECONSTITUTION OF THE T3-T CELL ANTIGEN RECEPTOR COMPLEX ACTIVATED CA-2+ TRANSPORTER FROM HUMAN T-CELLS." JOURNAL OF CELLULAR BIOCHEMISTRY (1986): 203-203. Link to Item
  - Rosoff, PM, and Cantley, LC. "B Lymphocyte Differentiation: Role of Phosphoinositides, C Kinase, and Na⁺-H⁺ Exchange." Current Topics in Membranes and Transport 26, no. C (January 1, 1986): 193-199. Full Text
  - Rosoff, PM, and Terres, G. "Cyclosporine A inhibits Ca²⁺-dependent stimulation of the Na⁺/H⁺ antiport in human T cells." Journal of Cell Biology 103, no. 2 (1986): 457-463.
  - Rosoff, PM, and Cantley, LC. "Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line." J Biol Chem 260, no. 26 (November 15, 1985): 14053-14059. Link to Item
  - Rosoff, PM, and Cantley, LC. "Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes." The Journal of Biological Chemistry 260, no. 16 (August 1985): 9209-9215.
  - Oettgen, HC, Terhorst, C, Cantley, LC, and Rosoff, PM. "Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx." Cell 40, no. 3 (March 1985): 583-590. Full Text
  - ROSOFF, P. "Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca^<2+> mobilization in 70Z/3 pre-B lymphocytes." J Biol Chem 260 (1985): 9209-9215.
  - ROSOFF, PM, and CANTLEY, LC. "STIMULATION OF THE T3-T CELL RECEPTOR-ASSOCIATED CA-2+ INFLUX ENHANCES THE ACTIVITY OF THE NA+/H+ EXCHANGER IN A LEUKEMIC HUMAN T-CELL LINE." Journal of Biological Chemistry 260, no. 26 (January 1, 1985): 4053-4059. (Academic Article) Link to Item
  - Rosoff, PM, and Cantley, LC. "Ion fluxes and differentiation in transformed cell lines." Soc Gen Physiol Ser 39 (1985): 193-204. (Review) Link to Item
  - Rosoff, PM, and Cantley, LC. "The role of ion fluxes in hematopoietic cell differentiation." Prog Clin Biol Res 184 (1985): 331-339. Link to Item
  - Rosoff, PM, Stein, LF, and Cantley, LC. "Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange." The Journal of Biological Chemistry 259, no. 11 (June 1984): 7056-7060.
  - Cantley, LC, and Rosoff, PM. "Regulation of surface IgM expression: Role of plasma membrane Na⁺/H⁺ exchange." Federation Proceedings 43, no. 6 (1984): no.-464.
  - ROSOFF, PM. "CORRECTION." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81, no. 8 (1984): 2586-2586. Link to Item
  - Rosoff, PM, and Cantley, LC. "Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line." Proceedings of the National Academy of Sciences of the United States of America 80, no. 24 (December 1983): 7547-7550. Full Text
  - Newburger, PE, Robinson, JM, Pryzwansky, KB, Rosoff, PM, Greenberger, JS, and Tauber, AI. "Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst." Blood 61, no. 6 (June 1983): 1247-1257.
  - ROSOFF, PM, and CANTLEY, LC. "INCREASING CELLULAR NA+ INDUCES DIFFERENTIATION IN A PRE-B LYMPHOCYTE CELL-LINE." JOURNAL OF GENERAL PHYSIOLOGY 82, no. 6 (1983): A30-A30. Link to Item
  - Rosoff, PM, and Cantley, LC. "Increasing the intracellular Na⁺ concentration induces differentiation in a pre-B lymphocyte cell line." Proceedings of the National Academy of Sciences of the United States of America 80, no. 24 I (1983): 7547-7550.
  - Rosoff, PM. "Fair healthcare rationing and the sorites paradox." Journal of Medicine and Philosophy in press: in press-in press.
- Conference Papers
  - Demark-Wahnefried, W, Werner, C, Clipp, EC, Guill, AB, Bonner, M, and Rosoff, PM. "Childhood cancer survivors: Health behaviors and receptivity to health promotion interventions." November 2004. Link to Item
Teaching & Mentoring
Recent Courses
- BIOETHIC 603S: Clinical Bioethics and Health Policy 2018
Advising & Mentoring
- I would be pleased to serve as a faculty mentor to students (undergrad, grad) or post-degree professionals (post-doc, fellow, junior faculty), especially those who wish advice, supervision or collaboration on their scholarly research projects.
Available to mentor:
- Affiliate
- Faculty
- Masters
- PhD
- Post-Doc
- Resident
- Undergraduate

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

In the News

Awards & Honors

Selected Grants

Selected Publications

Books

Academic Articles

Conference Papers

Recent Courses

Advising & Mentoring

Available to mentor: