Scholars@Duke
Philip Martin Rosoff

Philip Martin Rosoff

Professor Emeritus of Pediatrics
Pediatrics, Hematology-Oncology
philip.rosoff@duke.edu
108 Seeley G. Mudd, Box 3040, Durham, NC 27710
3435 Dover Road, Durham, NC 27707

Selected Publications

Adolescent Medical Decisionmaking Rights: Reconciling Medicine and Law.

Journal Article Am J Law Med · December 2021 Dennis Lindberg came into his aunt's care when he was in the 4th grade because his parents struggled with drug addiction and could not provide for him. At thirteen, he was baptized in his aunt's faith as a Jehovah's Witness. Just days after he turned fourt ... Full text Open Access Link to item Cite

Mila Blooms: A Mobile Phone Application and Behavioral Intervention for Promoting Physical Activity and a Healthy Diet Among Adolescent Survivors of Childhood Cancer.

Journal Article Games Health J · August 2020 Objectives: Smartphone applications ("apps") can be used to promote health behavior change and expand the reach of behavioral interventions. To date, only a few existing apps have been developed for health promotion among adolescent survivors of childhood ... Full text Link to item Cite

Can the Case Report Withstand Ethical Scrutiny?

Journal Article Hastings Cent Rep · November 2019 Since antiquity, doctors have employed case reports as an essential and ongoing part in communicating information about patients and their diseases to their colleagues and, at times, to the wider, nonmedical world. Given how useful case reports have been, ... Full text Link to item Cite

Healthcare Rationing Cutoffs and Sorites Indeterminacy.

Journal Article J Med Philos · July 29, 2019 Rationing is an unavoidable mechanism for reining in healthcare costs. It entails establishing cutoff points that distinguish between what is and is not offered or available to patients. When the resource to be distributed is defined by vague and indetermi ... Full text Link to item Cite

When Religion and Medicine Clash: Non-beneficial Treatments and Hope for a Miracle.

Journal Article HEC Forum · June 2019 Patient and family demands for the initiation or continuation of life-sustaining medically non-beneficial treatments continues to be a major issue. This is especially relevant in intensive care units, but is also a challenge in other settings, most notably ... Full text Link to item Cite

Transplants for non-lethal conditions: a case against hand transplantation in minors.

Journal Article J Med Ethics · October 2018 Human allografts for life-threatening organ failure have been demonstrated to be lifesaving and are now considered to be standard of care for many conditions. Transplantation of non-vital anatomic body parts has also been accomplished. Hand transplantation ... Full text Link to item Cite

Discriminatory Demands by Patients.

Journal Article Hastings Cent Rep · July 2018 Most of us working in health care are concerned-perhaps even appalled-when patients make demands for doctors or nurses or other caregivers that accord with their bigoted sentiments. Even though there may be some reasons to believe that matching certain cha ... Full text Link to item Cite

Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model.

Journal Article Am J Bioeth · February 2018 Technological advances in veterinary medicine have produced considerable progress in the diagnosis and treatment of numerous diseases in animals. At the same time, veterinarians, veterinary technicians, and owners of animals face increasingly complex situa ... Full text Link to item Cite

Compulsory Organ Retrieval: Morally, But Not Socially, Justified.

Journal Article Camb Q Healthc Ethics · January 2018 The number of patients with organ failure who could potentially benefit from transplantation continues to exceed the available supply of organs. Despite numerous efforts to increase the number of donors, there remains an enormous mismatch between demand an ... Full text Link to item Cite

Licensing Surrogate Decision-Makers.

Journal Article HEC Forum · June 2017 As medical technology continues to improve, more people will live longer lives with multiple chronic illnesses with increasing cumulative debilitation, including cognitive dysfunction. Combined with the aging of society in most developed countries, an ever ... Full text Link to item Cite

Brain death determination: the imperative for policy and legal initiatives in Sub-Saharan Africa.

Journal Article Glob Public Health · May 2017 The concept of brain death (BD), defined as irreversible loss of function of the brain including the brainstem, is accepted in the medical literature and in legislative policy worldwide. However, in most of Sub-Saharan Africa (SSA) there are no legal guide ... Full text Open Access Link to item Cite

Do Pediatric Patients Have a Right to Know?

Journal Article AMA J Ethics · May 1, 2017 In Western medicine, a central component of respecting a person's ability to make decisions governing what happens to herself is ensuring that she is provided with sufficient relevant information to make a rational choice. For patients who lack the cogniti ... Full text Link to item Cite

Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish.

Journal Article Am J Bioeth · February 2017 The Institute of Medicine and the American Heart Association have issued a "call to action" to expand the performance of cardiopulmonary resuscitation (CPR) in response to out-of-hospital cardiac arrest. Widespread advertising campaigns have been created t ... Full text Link to item Cite

Who Should Ration?

Journal Article AMA J Ethics · February 1, 2017 A principal component of physician decision making is judging what interventions are clinically appropriate. Due to the inexorable and steady increase of health care costs in the US, physicians are constantly being urged to exercise judicious financial ste ... Full text Link to item Cite

Drawing the Line: Healthcare Rationing and the Cutoff Problem

Book · 2017 In this book I present a detailed argument to solve the cutoff problem which I define as the challenge in deciding where to draw the line for what sorts of healthcare interventions to make available. ... Cite

Where Children Die: Obstacles to Quality End-of-Life Care.

Journal Article Clin Pediatr (Phila) · February 2016 Full text Link to item Cite

Making Sausage.

Journal Article Narrat Inq Bioeth · 2016 Full text Link to item Cite

In defense of (some) altered standards of care for Ebola infections in developed countries.

Journal Article HEC Forum · March 2015 The current outbreak of Ebola virus infection in West Africa continues to spread. Several patients have now been treated in the United States and preparations are being made for more. Because of the strict isolation required for their care, questions have ... Full text Link to item Cite

Caring for the suffering: meeting the Ebola crisis responsibly.

Journal Article Am J Bioeth · 2015 The current Ebola virus epidemic in Western Africa appears to be spiraling out of control. The worst-case projections suggested that the unchecked spread could result in almost 1.4 million cases by the end of January 2015 with a case fatality rate of at le ... Full text Link to item Cite

TADA Is Still Unfair.

Journal Article Am J Bioeth · 2015 Full text Link to item Cite

An Ethical and Legal Framework for Physicians as Surrogate Decision-Makers for Their Patients.

Journal Article J Law Med Ethics · 2015 In Western industrialized countries, it is well established that legally competent individuals may choose a surrogate healthcare decision-maker to represent their interests should they lose the capacity to do so themselves. There are few limitations on who ... Full text Open Access Link to item Cite

Rationing Is Not a Four-Letter Word Setting Limits on Healthcare

Book · July 18, 2014 A provocative argument that the best way to deliver high-quality healthcare to Americans is to institute a comprehensive and fair system of rationing. ... Cite

Summing Up

Chapter · 2014 Cite

Losers

Chapter · 2014 Cite

Fairness

Chapter · 2014 Cite

Institutional futility policies are inherently unfair.

Journal Article HEC Forum · September 2013 Featured Publication For many years a debate has raged over what constitutes futile medical care, if patients have a right to demand what doctors label as futile, and whether physicians should be obliged to provide treatments that they think are inappropriate. More recently, t ... Full text Link to item Cite

Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma.

Journal Article J Pediatr Hematol Oncol · August 2013 BACKGROUND: Children who undergo treatment for childhood acute lymphoblastic leukemia (ALL) and lymphoma are at risk for several long-term health problems. Obesity, for which survivors of ALL and lymphoma are also at risk, may further exacerbate these prob ... Full text Link to item Cite

Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome.

Journal Article Am J Med Genet A · May 2013 Germline loss of function mutations in tumor suppressor genes RB1 and LKB1/STK11 are associated with the autosomal dominant cancer predisposing syndromes familial retinoblastoma and Peutz-Jeghers syndrome (PJS), respectively. We present a rare case of a yo ... Full text Link to item Cite

The legal authority of mature minors to consent to general medical treatment.

Journal Article Pediatrics · April 2013 Featured Publication The nature and scope of mature adolescents' legal authority to consent to general medical treatment without parental involvement is often misrepresented by commentators. This state of affairs is further complicated by the law itself, which has developed a ... Full text Link to item Cite

Coping with critical drug shortages: an ethical approach for allocating scarce resources in hospitals.

Journal Article Arch Intern Med · October 22, 2012 Featured Publication The number of critical medication shortages in the United States has reached an unprecedented level, requiring decisions about allocating limited drug supplies. Ad hoc decisions are susceptible to arbitrary judgments, revealing preformed biases for or agai ... Full text Link to item Cite

The myth of genetic enhancement.

Journal Article Theor Med Bioeth · June 2012 Featured Publication The ongoing revolution in molecular genetics has led many to speculate that one day we will be able to change the expression or phenotype of numerous complex traits to improve ourselves in many different ways. The prospect of genetic enhancements has gener ... Full text Link to item Cite

Competing duties: medical educators, underperforming students, and social accountability.

Journal Article J Bioeth Inq · June 2012 Featured Publication Over the last 80 years, a major goal of medical educators has been to improve the quality of applicants to medical school and, hence, the resulting doctors. To do this, academic standards have been progressively strengthened. The Medical College Admission ... Full text Link to item Cite

Unpredictable drug shortages: an ethical framework for short-term rationing in hospitals.

Journal Article Am J Bioeth · 2012 Featured Publication Periodic and unexpected shortages of drugs, biologics, and even medical devices have become commonplace in the United States. When shortages occur, hospitals and clinics need to decide how to ration their available stock. When such situations arise, instit ... Full text Link to item Cite

I'll be a monkey's uncle: a moral challenge to human genetic enhancement research.

Journal Article J Med Ethics · October 2011 Featured Publication The potential for genetic engineering of enhancements to complex human traits has been the subject of vigorous debate for a number of years. Most of the discussion has centered on the possible moral consequences of pursuing enhancements, especially those t ... Full text Link to item Cite

Preparing for an influenza pandemic: are some people more equal than others?

Journal Article J Health Care Poor Underserved · August 2011 Featured Publication CONTEXT: Planning for a severe influenza pandemic entails facing many substantive public health challenges, especially in the area of the distribution of insufficient supplies of materials and personnel. It is anticipated that rationing of health care reso ... Full text Link to item Cite

Preparing for an Influenza Pandemic: Are Some People More Equal than Others?

Journal Article JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED · August 1, 2011 Link to item Cite

Is medical ethics education effective?

Journal Article J Med Liban · 2011 Featured Publication Link to item Cite

Associations between leisure-time physical activity and health-related quality of life among adolescent and adult survivors of childhood cancers.

Journal Article Psychooncology · September 2010 OBJECTIVE: Survivors of childhood cancer are at an increased risk for reduced quality of life (QOL), yet few studies have explored factors associated with improving health-related QOL (HRQOL) in this population. We thus explored the relationship between ph ... Full text Link to item Cite

In search of the mommy gene: Truth and consequences in behavioral genetics

Journal Article Science Technology and Human Values · March 1, 2010 Behavioral genetics has as its goal the discovery of genes that play a significant causal role in complex phenotypes that are socially relevant such a parenting, aggression, psychiatric disorders, intelligence, and even race. In this article, I present the ... Full text Cite

Should palliative care be a necessity or a luxury during an overwhelming health catastrophe?

Journal Article J Clin Ethics · 2010 Featured Publication In the event of a widespread health catastrophe in which either or both human and material resources were in critically short supply, rationing must take place, especially if the scarcity will last for some time. There are several tested allocation methods ... Link to item Cite

Is there a duty to inform patients of phase I trials?

Journal Article Virtual Mentor · March 1, 2009 Featured Publication Full text Link to item Cite

Physician responsibility for patients' quality of life.

Journal Article Virtual Mentor · June 1, 2008 Featured Publication Full text Link to item Cite

Perspective roundtable: lethal injection.

Journal Article N Engl J Med · May 15, 2008 Featured Publication Full text Link to item Cite

Psychosocial functioning in parents of adult survivors of childhood cancer.

Journal Article J Pediatr Hematol Oncol · February 2008 BACKGROUND: Although significant progress has been made in identifying long-term sequelae for adult survivors of childhood cancer, comparatively little attention has been paid to the functioning of their parents. In a previous study, we observed that a maj ... Full text Link to item Cite

The ethics of care: social workers in an influenza pandemic.

Journal Article Soc Work Health Care · 2008 Featured Publication Many healthcare organizations and government agencies are making detailed preparations for the possibility of a pandemic of highly virulent influenza. All plans to date have recognized that there will undoubtedly be a greater need for medical resources tha ... Full text Link to item Cite

Childhood cancer survivors' perceived barriers to improving exercise and dietary behaviors.

Journal Article Oncol Nurs Forum · January 2008 PURPOSE/OBJECTIVES: To determine childhood cancer survivors' barriers to increasing exercise and consuming less fat and more fruits and vegetables, whole grains, and calcium-rich foods. DESIGN: Mailed survey. SETTING: Cases from a comprehensive cancer cent ... Full text Link to item Cite

Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation.

Journal Article Am J Clin Pathol · December 2007 In the World Health Organization classification, cases with classical Burkitt morphologic features and a very high proliferation fraction but without the MYC translocation are not clearly designated as a separate entity and are usually categorized as diffu ... Full text Link to item Cite

Dr. Rosoff replies [13]

Journal Article New England Journal of Medicine · January 11, 2007 Cite

Survivors of childhood cancer - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · January 11, 2007 Link to item Cite

The two-edged sword of curing childhood cancer.

Journal Article N Engl J Med · October 12, 2006 Featured Publication Full text Link to item Cite

A central role for palliative care in an influenza pandemic.

Journal Article J Palliat Med · October 2006 Featured Publication Full text Link to item Cite

How Darwinian reductionism refutes genetic determinism.

Journal Article Stud Hist Philos Biol Biomed Sci · March 2006 Featured Publication Genetic determinism labels the morally problematical claim that some socially significant traits, traits we care about, such as sexual orientation, gender roles, violence, alcoholism, mental illness, intelligence, are largely the results of the operation o ... Full text Link to item Cite

Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease.

Journal Article Pediatr Blood Cancer · October 15, 2005 Featured Publication The risk of second malignancies after successful treatment for Hodgkin disease can be considerable. The most common malignancies are solid tumors arising in irradiated sites, such as the breast and thyroid gland after mantle field radiation. Sarcomas and o ... Full text Link to item Cite

Survivors of childhood cancer and their guardians.

Journal Article Cancer · May 15, 2005 Featured Publication BACKGROUND: Survivors of childhood cancer are at increased risk for osteoporosis, cardiovascular disease, and second malignancies-conditions for which modifiable risk factors are recognized and lifestyle interventions have shown benefit. Although some data ... Full text Link to item Cite

Response rates to a mailed survey targeting childhood cancer survivors: a comparison of conditional versus unconditional incentives.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2005 Featured Publication OBJECTIVE: Mailed surveys are widely used to collect epidemiologic and health service data. Given that nonresponse can threaten the validity of surveys, modest incentives are often used to increase response rates. A study was undertaken among childhood can ... Full text Link to item Cite

Childhood cancer survivors: Health behaviors and receptivity to health promotion interventions.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · November 1, 2004 Link to item Cite

A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12.

Journal Article Cancer Genet Cytogenet · October 1, 2004 We report the case of an 11-month-old patient with a clinical diagnosis of infantile acute lymphoblastic leukemia and an MLL (11q23) rearrangement in 69% of nuclei, revealed with interphase fluorescence in situ hybridization (FISH). Routine chromosome anal ... Full text Link to item Cite

Can underpowered clinical trials be justified?

Journal Article IRB · 2004 Featured Publication Link to item Cite

Continued parental attendance at a clinic for adult survivors of childhood cancer.

Journal Article J Pediatr Hematol Oncol · November 2003 Featured Publication PURPOSE: Adult survivors of childhood cancer have been an underserved and understudied population. Few clinics are available to take care of them, unlike the numerous ones that exist for children. The authors established a clinic that would take care of al ... Full text Link to item Cite

Lack of circulating megakaryoblasts in newborn peripheral blood: development and validation of a sensitive flow cytometric detection method.

Journal Article J Pediatr Hematol Oncol · September 2003 It is currently thought that approximately 1% of children with Down syndrome will develop a "premalignant" syndrome known as transient myeloproliferative disorder (TMD). Prospective, population-based studies of the incidence of TMD in Down syndrome infants ... Full text Link to item Cite

Isolated IgA deficiency after chemotherapy for acute myelogenous leukemia in an infant.

Journal Article Pediatr Hematol Oncol · September 2003 IgA deficiency is a relatively common congenital immunodeficiency in children. It can either be asymptomatic or lead to frequent infections, most often of the sinuses and lungs. Intensive chemotherapy for acute leukemia is also profoundly immunosuppressive ... Link to item Cite

Industrial collaboration.

Journal Article N Engl J Med · February 27, 2003 Featured Publication Full text Link to item Cite

Genitourinary complications of sickle cell disease.

Journal Article J Urol · September 2001 PURPOSE: In the last half century the molecular biology, pathophysiology and natural history of sickle cell disease have been well defined. Sickle cell disease causes microvascular occlusion, which is manifested in most organ systems. The genitourinary tra ... Link to item Cite

Basal cell carcinoma originating from a nevus sebaceus on the scalp of a 7-year-old boy.

Journal Article J Pediatr Hematol Oncol · May 2001 Basal cell carcinoma (BCC) occurs rarely in children and is most often associated with an underlying condition that predisposes patients to the development of malignancy. There have been numerous reports of BCC developing after puberty in nevus sebaceus; h ... Full text Link to item Cite

Follicle-derived thyroid cancer in young people: the Duke experience.

Journal Article Pediatr Hematol Oncol · March 2001 Follicle-derived thyroid cancer is rare in the young. The authors examined a population with a low rate of radiation exposure and who were treated at a single institution. The records of 56 patients diagnosed before the age of 25 years were analyzed. The m ... Full text Link to item Cite

Assessing the risk of breast cancer.

Journal Article N Engl J Med · June 29, 2000 Link to item Cite

Biphenotypic sarcoma with characteristics of both a Ewing sarcoma and a desmoplastic small round cell tumor.

Journal Article Med Pediatr Oncol · June 2000 BACKGROUND: The EWS gene, a transcription factor of unknown function, is involved in chromosomal translocations associated with a wide variety of tumors, particularly small round blue cell tumors such as Ewing sarcoma. It has previously been reported that ... Full text Link to item Cite

Papillary adenocarcinoma of the thyroid in a thyroglossal duct cyst.

Journal Article Pediatr Hematol Oncol · 2000 A case report is presented of an 8-year-old boy who underwent resection of a thyroglossal duct cyst to illustrate a rare, but significant, complication of a common clinical problem. Pathological examination revealed that it contained a papillary adenocarci ... Full text Link to item Cite

A novel chromosomal rearrangement associated with therapy-related acute leukemia.

Journal Article Cancer Genet Cytogenet · July 15, 1999 We describe a 7-year-old girl with therapy-related acute myeloid leukemia (AML) associated with a single and novel karyotypic abnormality. The patient had been treated with alkylating agents and etoposide for hypothalamic pilocytic astrocytoma at age 17 mo ... Full text Link to item Cite

Sebaceous gland carcinoma: a subtle second malignancy following radiation therapy in patients with bilateral retinoblastoma.

Journal Article Cancer · August 15, 1998 BACKGROUND: Second primary malignancies are common after bilateral retinoblastoma; their estimated incidence has been as high as 51% 50 years after diagnosis. Fifteen patients who developed sebaceous gland carcinoma after radiation therapy have been report ... Link to item Cite

Ewing's tumor and papillary adenocarcinoma of the thyroid in a 14-year-old girl.

Journal Article J Pediatr Hematol Oncol · 1998 PURPOSE: We describe an adolescent girl with Stage 1 Ewing's tumor and localized papillary adenocarcinoma of the thyroid gland, a previously unreported association. PATIENTS AND METHODS: A 14-year-old girl with right axillary adenopathy was evaluated. RESU ... Full text Link to item Cite

Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation.

Journal Article Bone Marrow Transplant · August 1997 Severe aplastic anemia (SAA) is a frequent complication of orthotopic liver transplantation for non-typeable viral hepatitis. Allogeneic bone marrow transplantation (BMT) may successfully reconstitute hematopoiesis but the optimal conditioning regimen and ... Full text Link to item Cite

Pharmacology of pertussis toxin B-oligomer.

Journal Article Can J Physiol Pharmacol · May 1996 Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP) ribosyltransferase activity, and the B-oligomer confers cell surface binding specificity on the toxin. ... Full text Link to item Cite

Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87).

Journal Article Immunology · May 1996 Stimulation of monoblastic U937 cells with transforming growth factor beta 1 and 1,25-(OH)2 vitamin D3 (TGF-beta 1/D3) upregulates urokinase receptor (uPAR) and confers urokinase-dependent adhesiveness to the cells for serum- or vitronectin-coated surfaces ... Full text Link to item Cite

Myelodysplasia and deficiency of uridine diphosphate-galactose 4-epimerase.

Journal Article J Pediatr · October 1995 A 4-year-old girl known to have peripheral uridine diphosphate-galactose 4-epimerase deficiency was examined for bruising and thrombocytopenia. She had dysplastic peripheral blood and bone marrow changes, with a global platelet function defect. Uridine dip ... Full text Link to item Cite

Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor.

Journal Article Mol Immunol · April 1995 In addition to the antigen receptor, resting T cells express a number of receptors that can be stimulated to generate proliferative signals. These "accessory" receptors require co-expression of the T cell receptor (TCR), suggesting that they channel their ... Full text Link to item Cite

Congenital bone marrow failure with myelodysplasia in siblings.

Journal Article J Pediatr Hematol Oncol · February 1995 PURPOSE: I describe two siblings who have a novel congenital bone marrow failure syndrome with myelodysplastic features without progression to malignancy for 13 and 20 years, respectively. PATIENTS AND METHODS: Male and female siblings were evaluated for c ... Full text Link to item Cite

Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60.

Journal Article J Immunol · April 15, 1993 Stimulation of T lymphocytes via the TCR/CD3 complex initiates a series of intracellular biochemical events. Among the earliest cellular responses are the stimulation of the turnover of phosphatidylinositol and an increase in the intracellular Ca2+ concent ... Link to item Cite

Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates.

Journal Article Cell Calcium · February 1993 The activation of T lymphocytes, like many cells, requires a rapid rise in intracellular Ca2+ secondary to both an influx and a release from intracellular stores. The latter is activated by inositol-1,4,5-trisphosphate [Ins(1,4,5)P3]. It is controversial i ... Full text Link to item Cite

Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60

Journal Article Journal of Immunology · January 1, 1993 Stimulation of T lymphocytes via the TCR/CD3 complex initiates a series of intracellular biochemical events. Among the earliest cellular responses are the stimulation of the turnover of phosphatidylinositol and an increase in the intracellular Ca2+ concent ... Cite

Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex.

Journal Article J Immunol · November 15, 1992 Prolonged exposure of many types of receptors to their cognate agonists can lead to a progressive lack of responsiveness. When this occurs after stimulation by the primary agonist for a given receptor it is termed homologous desensitization, and heterologo ... Link to item Cite

Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae.

Journal Article Cell Calcium · November 1992 The yeast mating pheromones, a and alpha factors, bind to specific G protein-coupled receptors in haploid cells and bring about both growth arrest in the early G1 phase of the cell cycle and differentiation into mating capable cells. This induces an increa ... Full text Link to item Cite

Unsaturated fatty acids and lipoxygenase products regulate phagocytic NADPH oxidase activity by a nondetergent mechanism.

Journal Article J Lab Clin Med · October 1991 Neutrophils produce reactive oxygen species (superoxide anion [O2-]) via activation of reduced nicotinamide dinucleotide phosphate oxidase. In the intact neutrophil, this enzyme can be activated by increases in cytosolic calcium, protein kinase C, and unsa ... Link to item Cite

Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin.

Journal Article J Immunol · July 15, 1990 Pertussis toxin (PTx), an exotoxin of Bordetella pertussis has been used as a molecular probe to study stimulus-response coupling in a wide variety of cells. We have previously shown that PTx activates the same signal transduction pathways as Ag or mAb dir ... Link to item Cite

IL-1 receptors: structure and signals.

Journal Article Semin Immunol · March 1990 Interleukin-1 (IL-1) is a polypeptide hormone produced by a wide variety of cells in response to immunologic challenge. It appears to play a vital role not only in the generation of an appropriate immune response but also in the pathogenesis of several dis ... Link to item Cite

Interleukin 1 receptors and biological responses.

Journal Article Yale J Biol Med · 1990 Interleukin 1 (IL-1) is a polypeptide which possesses a wide variety of biological properties. IL-1 was originally studied as "endogenous pyrogen" and "leukocytic endogenous mediator" and more recently as "lymphocyte activating factor." Within a few minute ... Link to item Cite

Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover.

Journal Article J Biol Chem · August 25, 1989 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine which produces diverse biological effects in target cells of myeloid origin. GM-CSF enhances the production of superoxide anion (O2-) by mature neutrophils in response to ... Link to item Cite

Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells.

Journal Article Clin Immunol Immunopathol · February 1989 This report provides direct evidence that protein kinase C (PKC) is activated in isolated, rigorously accessory cell (AC)-depleted T cells when the T cell antigen recognition complex is stimulated by divalent anti-CD3 monoclonal antibody. Anti-CD3 monoclon ... Full text Link to item Cite

The interleukin 1 receptor.

Journal Article Immunol Today · February 1989 Full text Link to item Cite

Characterization of the interleukin-1-stimulated phospholipase C activity in human T lymphocytes.

Journal Article Lymphokine Res · 1989 We have previously shown that interleukin-1 (IL-1) rapidly stimulates the hydrolysis of phosphatidylcholine in the human T lymphocyte cell line, Jurkat (Rosoff, et al., Cell 54: 73-81, 1988). This was apparently mediated by a phospholipase-C catalyzed mech ... Link to item Cite

4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes.

Journal Article J Biol Chem · December 25, 1988 Stimulation of the CD3-T cell antigen receptor complex on T lymphocytes results in a rapid rise in intracellular calcium from both intra- and extracellular sources. The former is thought to be released from the endoplasmic reticulum in response to inositol ... Link to item Cite

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism.

Journal Article Cell · July 1, 1988 We have investigated the biochemical mechanism by which interleukin-1 (IL-1) serves as a comitogen with agents that directly activate the antigen receptor in T lymphocytes. We have studied the human T cell line Jurkat, which can be stimulated to produce In ... Full text Link to item Cite

Pertussis toxin triggers rapid second messenger production in human T lymphocytes.

Journal Article J Immunol · October 1, 1987 Pertussis toxin (PT) is a known mitogen for T lymphocytes. The mechanism by which the toxin stimulates proliferation has remained obscure and paradoxical because, in some types of cells, the toxin also inhibits growth factor-mediated signal transduction. I ... Link to item Cite

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction.

Journal Article Cell · June 19, 1987 We investigated the role of the L3T4 molecule in mitogen and antigen-initiated signal transduction in the L3T4(+) murine T cell hybridoma, 3DT52.5.9 and an L3T4(-) variant, 3DT52.5.24. Both Concanavalin A (Con A) and specific antigen stimulated increases i ... Full text Link to item Cite

Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells.

Journal Article J Cell Biol · August 1986 The cyclic undecapeptide cyclosporine A (CsA) is a potent immunosuppressive agent that inhibits the initial activation of T lymphocytes. This agent appears to be most effective in blocking the action of mitogens such as concanavalin A and the calcium ionop ... Full text Open Access Link to item Cite

Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells

Journal Article Journal of Cell Biology · 1986 The cyclic undecapeptide cyclosporine A (CsA) is a potent immunosuppressive agent that inhibits the initial activation of T lymphocytes. This agent appears to be most effective in blocking the action of mitogens such as concanavalin A and the calcium ionop ... Cite

B Lymphocyte Differentiation: Role of Phosphoinositides, C Kinase, and Na+-H+ Exchange

Journal Article Current Topics in Membranes and Transport · January 1, 1986 Full text Cite

LYMPHOCYTE-B DIFFERENTIATION - ROLE OF PHOSPHOINOSITIDES, C KINASE, AND NA+-H+ EXCHANGE

Journal Article CURRENT TOPICS IN MEMBRANES AND TRANSPORT · January 1, 1986 Link to item Cite

Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.

Journal Article J Biol Chem · November 15, 1985 Three monoclonal antibodies reactive with different structural domains of the T3-T cell receptor complex of the human T cell leukemia line, HPB-ALL, were previously shown to activate a membrane potential-sensitive, La3+-inhibitable Ca2+ influx (Oettgen, H. ... Link to item Cite

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

Journal Article J Biol Chem · August 5, 1985 We have recently shown that both lipopolysaccharide (LPS) and the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA) induce differentiation in the transformed murine pre-B lymphocyte cell line 70Z/3 by enhancing Na+-H+ exchange across the plasma me ... Link to item Cite

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx.

Journal Article Cell · March 1985 Three monoclonal antibodies selected for their recognition of parts of the T3-T cell receptor complex on human T lymphocytes were found to induce an increase in cytoplasmic free Ca2+ (Ca2+i) in the T cell leukemia line HPB-ALL as measured by Quin2 fluoresc ... Full text Link to item Cite

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

Journal Article J Biol Chem · June 10, 1984 The murine pre-B-lymphocyte cell line 70Z /3 may be induced to differentiate to a surface immunoglobulin-positive phenotype by the polyclonal B-cell mitogen, lipopolysaccharide. This is accomplished via activation of an amiloride-sensitive Na+-uptake syste ... Link to item Cite

Regulation of surface IgM expression: Role of plasma membrane Na+/H+ exchange

Journal Article Federation Proceedings · January 1, 1984 Cite

CORRECTION

Journal Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES · January 1, 1984 Link to item Cite

Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line.

Journal Article Proc Natl Acad Sci U S A · December 1983 The ability of lipopolysaccharide (LPS), a polyclonal B-cell mitogen, to induce differentiation in the pre-B cell tumor line 70Z/3 can be mimicked by drugs that increase the intracellular Na+ concentration. Pharmacologically increasing the cellular Na+ con ... Full text Link to item Cite

Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst.

Journal Article Blood · June 1983 We describe a patient whose peripheral blood neutrophils and bone marrow precursors (beyond promyelocytes) contained multiple large azurophilic granules. There were also giant granules in eosinophils, basophils, melanocytes, renal tubules, thyroid, and neu ... Link to item Cite

INCREASING CELLULAR NA+ INDUCES DIFFERENTIATION IN A PRE-B LYMPHOCYTE CELL-LINE

Journal Article JOURNAL OF GENERAL PHYSIOLOGY · January 1, 1983 Link to item Cite

Fair healthcare rationing and the sorites paradox

Journal Article Journal of Medicine and Philosophy Cite