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Transplants for non-lethal conditions: a case against hand transplantation in minors.

Publication ,  Journal Article
Hedges, CE; Rosoff, PM
Published in: J Med Ethics
October 2018

Human allografts for life-threatening organ failure have been demonstrated to be lifesaving and are now considered to be standard of care for many conditions. Transplantation of non-vital anatomic body parts has also been accomplished. Hand transplantation after limb loss in adults has been shown to offer some promising benefits in both functional and psychological measures in preliminary studies. It has been suggested to expand eligibility criteria to include minors, with one such operation having already been performed. With this in mind, we examine the current state of hand transplantation research in the context of available alternatives. We examine the ethics of carrying out these operations in minors, including under the protections of clinical research. We argue that children should not be considered for this surgery due to the substantial risks of immunosuppressive medication, the likelihood that the graft will need to be replaced during the patient's lifetime and the lack of significant compensatory advantages over modern prosthetics.

Duke Scholars

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Published In

J Med Ethics

DOI

EISSN

1473-4257

Publication Date

October 2018

Volume

44

Issue

10

Start / End Page

661 / 665

Location

England

Related Subject Headings

  • Transplantation Immunology
  • Risk Assessment
  • Postoperative Complications
  • Patient Selection
  • Minors
  • Humans
  • Hand Transplantation
  • Graft Rejection
  • Child, Preschool
  • Child
 

Citation

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Hedges, C. E., & Rosoff, P. M. (2018). Transplants for non-lethal conditions: a case against hand transplantation in minors. J Med Ethics, 44(10), 661–665. https://doi.org/10.1136/medethics-2018-104819
Hedges, Charles E., and Philip M. Rosoff. “Transplants for non-lethal conditions: a case against hand transplantation in minors.J Med Ethics 44, no. 10 (October 2018): 661–65. https://doi.org/10.1136/medethics-2018-104819.
Hedges CE, Rosoff PM. Transplants for non-lethal conditions: a case against hand transplantation in minors. J Med Ethics. 2018 Oct;44(10):661–5.
Hedges, Charles E., and Philip M. Rosoff. “Transplants for non-lethal conditions: a case against hand transplantation in minors.J Med Ethics, vol. 44, no. 10, Oct. 2018, pp. 661–65. Pubmed, doi:10.1136/medethics-2018-104819.
Hedges CE, Rosoff PM. Transplants for non-lethal conditions: a case against hand transplantation in minors. J Med Ethics. 2018 Oct;44(10):661–665.

Published In

J Med Ethics

DOI

EISSN

1473-4257

Publication Date

October 2018

Volume

44

Issue

10

Start / End Page

661 / 665

Location

England

Related Subject Headings

  • Transplantation Immunology
  • Risk Assessment
  • Postoperative Complications
  • Patient Selection
  • Minors
  • Humans
  • Hand Transplantation
  • Graft Rejection
  • Child, Preschool
  • Child