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Phyllis Carolyn Leppert

Professor Emeritus of Obstetrics and Gynecology
Obstetrics and Gynecology
Box 3084 Med Ctr, Durham, NC 27710
329 Baker House, Durham, NC 27710

Selected Publications


Letter to the Editor

Journal Article Nursing Outlook · May 1, 2024 Full text Cite

A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids.

Journal Article Reprod Sci · September 2021 Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however, collagenase had not been evaluated in vivo ... Full text Link to item Cite

FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery.

Journal Article Am J Obstet Gynecol · February 2019 BACKGROUND: Uterine leiomyomas (fibroid tumors) cause considerable symptoms in 30-50% of women and are the leading cause of hysterectomy in the United States. Women with uterine fibroid tumors often seek uterine-preserving treatments, but comparative effec ... Full text Link to item Cite

Evidence of biomechanical and collagen heterogeneity in uterine fibroids.

Journal Article PLoS One · 2019 OBJECTIVE: Uterine fibroids (leiomyomas) are common benign tumors of the myometrium but their molecular pathobiology remains elusive. These stiff and often large tumors contain abundant extracellular matrix (ECM), including large amounts of collagen, and c ... Full text Link to item Cite

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis.

Journal Article Am J Obstet Gynecol · May 2017 BACKGROUND: Uterine fibroids are a common problem for reproductive-aged women, yet little comparative effectiveness research is available to guide treatment choice. Uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surger ... Full text Link to item Cite

Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.

Journal Article Curr Protein Pept Sci · 2017 Utilizing both primary myometrial cells and a myometrial cell line, we show here that myometrial cells undergo transition to a myofibroblast-like phenotype after a biological insult of 72 hours serum starvation and serum add-back (SB: 1% to 10% FBS). We al ... Full text Link to item Cite

Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.

Journal Article Am J Obstet Gynecol · November 2016 BACKGROUND: Uterine fibroids are a significant health problem. These common benign tumors occur in 70-80% of women before age 50 years and often cause bleeding and pain and can interfere considerably with daily life. Current treatment options are limited. ... Full text Link to item Cite

Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial.

Journal Article Am J Obstet Gynecol · September 2016 BACKGROUND: Uterine fibroids are an important source of morbidity for reproductive-aged women. Despite an increasing number of alternatives, hysterectomies account for about 75% of all fibroid interventional treatments. Evidence is lacking to help women an ... Full text Link to item Cite

"Feeling the force" in reproduction: Mechanotransduction in reproductive processes.

Journal Article Connect Tissue Res · May 2016 Reproductive biologists are well-versed in many types of biochemical signaling, and indeed, there are almost innumerable examples in reproduction, including steroid and peptide hormone signaling, receptor-ligand and secondary messenger-mediated signaling, ... Full text Link to item Cite

Dynamic reciprocity between cells and their microenvironment in reproduction.

Journal Article Biol Reprod · January 2015 Dynamic reciprocity (DR) refers to the ongoing, bidirectional interaction between cells and their microenvironment, specifically the extracellular matrix (ECM). The continuous remodeling of the ECM exerts mechanical force on cells and modifies biochemical ... Full text Link to item Cite

Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management.

Journal Article F1000Res · 2015 Uterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred o ... Full text Link to item Cite

Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids.

Journal Article Reprod Sci · December 2014 Purified Clostridium histolyticum collagenase (CHC), an Food and Drug Administration-approved drug that does not affect nerves or blood vessels, was assessed as a potential treatment for fibroids in this proof-of-principle study. Fibroids (1-4 cm, capsules ... Full text Link to item Cite

Mechanical signaling in reproductive tissues: mechanisms and importance.

Journal Article Reprod Sci · September 2014 The organs of the female reproductive system are among the most dynamic tissues in the human body, undergoing repeated cycles of growth and involution from puberty through menopause. To achieve such impressive plasticity, reproductive tissues must respond ... Full text Link to item Cite

Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential.

Journal Article J Clin Endocrinol Metab · March 2014 CONTEXT: Clinical evidence supports a role for progestins in the growth of leiomyomata (fibroids). The mechanism(s) for this is thought to involve gene regulation via the nuclear progesterone receptors. Recently a mitochondrial progesterone receptor (PR-M) ... Full text Link to item Cite

Letter to the Editor

Journal Article Nursing Outlook · May 1, 2024 Full text Cite

A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids.

Journal Article Reprod Sci · September 2021 Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however, collagenase had not been evaluated in vivo ... Full text Link to item Cite

FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery.

Journal Article Am J Obstet Gynecol · February 2019 BACKGROUND: Uterine leiomyomas (fibroid tumors) cause considerable symptoms in 30-50% of women and are the leading cause of hysterectomy in the United States. Women with uterine fibroid tumors often seek uterine-preserving treatments, but comparative effec ... Full text Link to item Cite

Evidence of biomechanical and collagen heterogeneity in uterine fibroids.

Journal Article PLoS One · 2019 OBJECTIVE: Uterine fibroids (leiomyomas) are common benign tumors of the myometrium but their molecular pathobiology remains elusive. These stiff and often large tumors contain abundant extracellular matrix (ECM), including large amounts of collagen, and c ... Full text Link to item Cite

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis.

Journal Article Am J Obstet Gynecol · May 2017 BACKGROUND: Uterine fibroids are a common problem for reproductive-aged women, yet little comparative effectiveness research is available to guide treatment choice. Uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surger ... Full text Link to item Cite

Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.

Journal Article Curr Protein Pept Sci · 2017 Utilizing both primary myometrial cells and a myometrial cell line, we show here that myometrial cells undergo transition to a myofibroblast-like phenotype after a biological insult of 72 hours serum starvation and serum add-back (SB: 1% to 10% FBS). We al ... Full text Link to item Cite

Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.

Journal Article Am J Obstet Gynecol · November 2016 BACKGROUND: Uterine fibroids are a significant health problem. These common benign tumors occur in 70-80% of women before age 50 years and often cause bleeding and pain and can interfere considerably with daily life. Current treatment options are limited. ... Full text Link to item Cite

Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial.

Journal Article Am J Obstet Gynecol · September 2016 BACKGROUND: Uterine fibroids are an important source of morbidity for reproductive-aged women. Despite an increasing number of alternatives, hysterectomies account for about 75% of all fibroid interventional treatments. Evidence is lacking to help women an ... Full text Link to item Cite

"Feeling the force" in reproduction: Mechanotransduction in reproductive processes.

Journal Article Connect Tissue Res · May 2016 Reproductive biologists are well-versed in many types of biochemical signaling, and indeed, there are almost innumerable examples in reproduction, including steroid and peptide hormone signaling, receptor-ligand and secondary messenger-mediated signaling, ... Full text Link to item Cite

Dynamic reciprocity between cells and their microenvironment in reproduction.

Journal Article Biol Reprod · January 2015 Dynamic reciprocity (DR) refers to the ongoing, bidirectional interaction between cells and their microenvironment, specifically the extracellular matrix (ECM). The continuous remodeling of the ECM exerts mechanical force on cells and modifies biochemical ... Full text Link to item Cite

Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management.

Journal Article F1000Res · 2015 Uterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred o ... Full text Link to item Cite

Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids.

Journal Article Reprod Sci · December 2014 Purified Clostridium histolyticum collagenase (CHC), an Food and Drug Administration-approved drug that does not affect nerves or blood vessels, was assessed as a potential treatment for fibroids in this proof-of-principle study. Fibroids (1-4 cm, capsules ... Full text Link to item Cite

Mechanical signaling in reproductive tissues: mechanisms and importance.

Journal Article Reprod Sci · September 2014 The organs of the female reproductive system are among the most dynamic tissues in the human body, undergoing repeated cycles of growth and involution from puberty through menopause. To achieve such impressive plasticity, reproductive tissues must respond ... Full text Link to item Cite

Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential.

Journal Article J Clin Endocrinol Metab · March 2014 CONTEXT: Clinical evidence supports a role for progestins in the growth of leiomyomata (fibroids). The mechanism(s) for this is thought to involve gene regulation via the nuclear progesterone receptors. Recently a mitochondrial progesterone receptor (PR-M) ... Full text Link to item Cite

The extracellular matrix contributes to mechanotransduction in uterine fibroids.

Journal Article Obstet Gynecol Int · 2014 The role of the extracellular matrix (ECM) and mechanotransduction as an important signaling factor in the human uterus is just beginning to be appreciated. The ECM is not only the substance that surrounds cells, but ECM stiffness will either compress cell ... Full text Open Access Link to item Cite

Myometrial hyperplasia mimics the clinical presentation of uterine fibroids: a report of 3 cases.

Journal Article Int J Gynecol Pathol · November 2013 The clinical diagnosis of fibroid uterus is based on physical examination findings and/or ultrasound. However, it is not uncommon for routine pathology examination to report no significant fibroids in such cases. Myometrial hyperplasia (MMH) is a structura ... Full text Link to item Cite

Comparison of characteristics of fibroids in African American and white women undergoing premenopausal hysterectomy.

Journal Article Fertil Steril · March 1, 2013 OBJECTIVE: To compare pathologic characteristics and epidemiologic risk factors for uterine fibroids in African American and white women undergoing hysterectomy. DESIGN: Cross-sectional analysis of women undergoing premenopausal hysterectomy. SETTING: Two ... Full text Link to item Cite

Understanding Uterine Fibroids

Journal Article Fibroids · 2013 Uterine leiomyoma, commonly called fibroids, consist of abundant, altered extracellular matrix. Fibroids are benign monoclonal tumors believed to be of myometrial origin. They develop in women of reproductive age, a fact that led to the concept that their ... Full text Cite

A look at uterine wound healing through a histopathological study of uterine scars.

Journal Article Reprod Sci · May 2012 BACKGROUND: Few histopathologic studies of uterine wound healing have been published compared with similar healing in other tissues. Our objective was to examine the histopathology resulting from iatrogenic trauma to the myometrium to acquire a better unde ... Full text Link to item Cite

Maternal and neonatal outcomes of grand multiparas over two decades in Mali.

Journal Article Acta Obstet Gynecol Scand · May 2012 OBJECTIVE: To analyze the association between grand multiparity and maternal and neonatal morbidity and mortality. DESIGN: Retrospective cross-sectional study. SETTING: Point G National Hospital, a tertiary care hospital in Bamako, Mali. POPULATION: All si ... Full text Link to item Cite

High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples.

Journal Article Hum Reprod · March 2012 BACKGROUND: Although histological dating of endometrial biopsies provides little help for prediction or diagnosis of infertility, analysis of individual endometrial proteins, proteomic profiling and transcriptome analysis have suggested several biomarkers ... Full text Link to item Cite

Treatment for Uterine Fibroids: Searching for Effective Drug Therapies.

Journal Article Drug Discov Today Ther Strateg · 2012 Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids ... Full text Link to item Cite

CDB-4124 does not cause apoptosis in cultured fibroid cells.

Journal Article Reprod Sci · September 2011 OBJECTIVE: Selective progesterone receptor modulators (SPRMs), such as asoprisnil (J867) and ulipristal (CDB-2914), have been shown to reduce fibroid volume in vivo and to induce apoptosis in vitro. CDB-4124 (telapristone), a SPRM with different side group ... Full text Link to item Cite

Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: reducing symptoms today and tomorrow (FIRSTT) trial.

Journal Article Fertil Steril · September 2011 OBJECTIVE: To present the rationale, design, and methodology of the Fibroid Interventions: Reducing Symptoms Today and Tomorrow (FIRSTT) study. DESIGN: Randomized clinical trial. SETTING: Two academic medical centers. PATIENT(S): Premenopausal women with s ... Full text Link to item Cite

Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells.

Conference REPRODUCTIVE SCIENCES · March 1, 2010 Link to item Cite

Predictors of pregnancy in women with polycystic ovary syndrome

Journal Article Obstetrical and Gynecological Survey · January 1, 2010 Full text Cite

Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas.

Journal Article Reprod Sci · December 2009 Featured Publication Uterine leiomyoma are common, benign tumors that are enriched in extracellular matrix. The tumors are characterized by a disoriented and loosely packed collagen fibril structure similar to other diseases with disrupted Transforming growth factor beta (TGF- ... Full text Link to item Cite

GnRH: Authors' response

Journal Article Journal of Women's Health · September 1, 2009 Full text Cite

Predictors of pregnancy in women with polycystic ovary syndrome.

Journal Article J Clin Endocrinol Metab · September 2009 Featured Publication CONTEXT: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The selection of first-line therapies for ovulation induction is empiric. OBJECTIVE: The aim of the study was to develop a clinically useful predictive model of ... Full text Link to item Cite

Sample size calculation for microarray experiments with blocked one-way design.

Journal Article BMC Bioinformatics · May 28, 2009 Featured Publication BACKGROUND: One of the main objectives of microarray analysis is to identify differentially expressed genes for different types of cells or treatments. Many statistical methods have been proposed to assess the treatment effects in microarray experiments. R ... Full text Link to item Cite

Keeping clinicians in clinical research: the Clinical Research/Reproductive Scientist Training Program.

Journal Article Fertil Steril · March 2009 Featured Publication In recent years the need for translational and clinical research has increased, whereas the number of physicians involved in clinical research has diminished. There is clearly a need for formalized academic training in the quantitative and methodologic pri ... Full text Link to item Cite

Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis.

Journal Article J Womens Health (Larchmt) · March 2009 Featured Publication PURPOSE: Treatment with cyclophosphamide (CYC) confers up to a 40% risk of ovarian failure in women of reproductive age. The use of GnRH agonists (GnRHa) to preserve ovarian function has been investigated in several small studies. We performed a systematic ... Full text Link to item Cite

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.

Journal Article Fertil Steril · October 2008 Featured Publication We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphe ... Full text Link to item Cite

Mechanical homeostasis is altered in uterine leiomyoma.

Journal Article Am J Obstet Gynecol · April 2008 Featured Publication OBJECTIVE: Uterine leiomyoma produce an extracellular matrix (ECM) that is abnormal in its volume, content, and structure. Alterations in ECM can modify mechanical stress on cells and lead to activation of Rho-dependent signaling and cell growth. Here we s ... Full text Link to item Cite

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

Journal Article J Clin Endocrinol Metab · March 2008 Featured Publication CONTEXT: Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood. OBJECTIVE: Our objective was to ... Full text Link to item Cite

Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.

Journal Article Reprod Sci · December 2007 Featured Publication Uterine fibroids are composed of altered collagen fibrils and represent an arrested response to injury-initiating fibrosis. In many tissues, TSP-1 is secreted by adult macrophages and monocytes upon wounding and is involved in the activation of transformin ... Full text Link to item Cite

Hysterectomy and loss of fertility: implications for women's mental health.

Journal Article J Psychosom Res · September 2007 Featured Publication OBJECTIVE: The objective of this study was to assess the percentage of women scheduled for hysterectomy who would have liked to have had a child or more children and associated factors. METHODS: The study sample included 1140 premenopausal women having hys ... Full text Link to item Cite

Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death.

Journal Article Am J Obstet Gynecol · March 2007 Featured Publication OBJECTIVE: The purpose of this study was to determine whether progesterone exerts a protective effect in chorion and decidua cells when exposed to calcimycin. STUDY DESIGN: Fetal membrane samples were collected from term elective repeat cesarean deliveries ... Full text Link to item Cite

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.

Journal Article N Engl J Med · February 8, 2007 Featured Publication BACKGROUND: The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior. METHODS: We randomly assigned 626 infe ... Full text Link to item Cite

Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome.

Journal Article Fertil Steril · February 2007 Featured Publication We investigated the prevalence of abnormal screening results (questionnaire and testing for other causes of oligo-ovulation, male or tubal factor infertility) in a group of 1,313 oligo-ovulatory women (included and excluded subjects) whose condition was sc ... Full text Link to item Cite

The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects.

Journal Article Fertil Steril · October 2006 Featured Publication OBJECTIVE: To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS). DESIGN: Double-blind, randomized trial of three treatment regimens (with extended re ... Full text Link to item Cite

P-564

Conference Fertility and Sterility · September 2006 Full text Cite

P-561

Conference Fertility and Sterility · September 2006 Full text Cite

The promise and perils of microarray analysis.

Journal Article Am J Obstet Gynecol · August 2006 Featured Publication Microarray analysis has provided a novel means of identifying clues into the mechanisms of disease development. As a methodology, microarray analysis holds the promise for genome-wide screening in which 2 tissues (diseased and normal) are compared, and mol ... Full text Link to item Cite

A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.

Journal Article Am J Obstet Gynecol · August 2006 Featured Publication This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecu ... Full text Link to item Cite

Epidemiology of myomas.

Journal Article Obstet Gynecol Clin North Am · March 2006 Fibroids are a prevalent disorder occurring in at least half of American reproductive-age women. In general, the incidence and size increases with age. Most women never attribute or report any symptoms from their fibroids, and because of this the actual co ... Full text Link to item Cite

Preparation for motherhood: A vital component of primary care for women [3]

Journal Article Journal of Midwifery and Women's Health · 2005 Full text Cite

A dual mechanism of biomechanical change in rat cervix in gestation and postpartum: Applied vascular mechanics

Journal Article Cardiovascular Engineering · 2005 Biomechanical studies were designed to determine the dynamic progression of the uterine cervix of pregnant rats at various stages of gestation and to determine its functions in retaining the fetus while at the same time undergoing characteristic softening ... Full text Cite

21st century--Reproductive Medicine Network (RMN).

Journal Article Fertil Steril · December 2004 Featured Publication Full text Link to item Cite

Histological dating of timed endometrial biopsy tissue is not related to fertility status.

Journal Article Fertil Steril · November 2004 Featured Publication OBJECTIVE: To assess the ability of histological dating to discriminate between women of fertile and infertile couples. The utility of histological dating of endometrium in the evaluation of infertile couples is uncertain. DESIGN: Prospective multicenter s ... Full text Link to item Cite

Absence of secretory endometrium after false-positive home urine luteinizing hormone testing.

Journal Article Fertil Steril · November 2004 Featured Publication OBJECTIVE: To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing. DESIGN: Multicenter clinical trial of the usefulness of endometrial biopsy in the evaluation of infertility, with women ... Full text Link to item Cite

Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women.

Journal Article Fertil Steril · November 2004 OBJECTIVE: To assess effects of biopsy timing and fertility status on inter- and intraobserver variability in dating of the endometrium. DESIGN: Endometrial biopsy slides randomly selected from a multicenter study testing the utility of biopsy in the diagn ... Full text Link to item Cite

Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium.

Journal Article Fertil Steril · October 2004 Featured Publication OBJECTIVE: To examine the ultrastructural characteristics of extracellular matrix and mature collagen fibrils in uterine leiomyomas and compare them with those in adjacent normal myometrium. DESIGN: Analysis of paired leiomyoma-myometrium in surgical speci ... Full text Link to item Cite

Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids.

Journal Article Genes Chromosomes Cancer · July 2004 Featured Publication Uterine leiomyomas are prevalent estrogen-responsive clonal tumors, but the specific genetic alterations that contribute to their development have not been elucidated. To identify genes involved in the formation of leiomyomas, we used global expression pro ... Full text Link to item Cite

Gene expression studies in leiomyomata: new directions for research.

Journal Article Semin Reprod Med · May 2004 Uterine leiomyomata (fibroids) are a leading women's health problem, resulting in significant morbidity and surgical intervention. As benign clonal tumors, leiomyomata also represent a target well suited to molecular analysis. Familial studies and genetic ... Full text Link to item Cite

The changing face of peer review at the National Institutes of Health.

Journal Article Fertil Steril · February 2004 Featured Publication OBJECTIVE: To discuss the new peer review system at the National Institutes of Health (NIH) and to present the process undertaken to accomplish these changes, with an emphasis on the reproductive sciences. DESIGN: A discussion of the many NIH committees an ... Full text Link to item Cite

Absence of secretory endometrium after false positive home urine luteinizing hormone testing.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2004 Link to item Cite

Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology.

Journal Article Fertil Steril · August 2003 Featured Publication OBJECTIVE: cDNA microarray technology identifies genes that are differentially expressed between tissues. Our previous study identified several genes that might contribute to the fibroid phenotype. We therefore sought to confirm genes involved in three dis ... Full text Link to item Cite

Overview of women's health.

Journal Article Clin Obstet Gynecol · December 2002 Featured Publication Full text Link to item Cite

Providing research and research training infrastructures for clinical research in the reproductive sciences.

Journal Article Am J Obstet Gynecol · October 2002 Featured Publication The Reproductive Sciences Branch of the National Institutes of Child Health and Human Development has created pioneering new research and research training programs that address the impending shortage of physician-scientists in obstetrics, gynecology, and ... Full text Link to item Cite

Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein.

Journal Article Xenobiotica · March 2002 1. The study investigated mechanisms underlying the pharmacokinetic differences of two zwitterionic diastereomers ((3S)-3-[(3R or 3S)-2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]pyrrolidin-1-yl]-3-quinolin-3-ylpropanoic acid) with different ... Full text Link to item Cite

Ascorbic acid status in postmenopausal women with hormone replacement therapy.

Journal Article Maturitas · January 30, 2002 Featured Publication OBJECTIVES: Hormone oral contraceptives affected ascorbic acid status adversely in young women. In vitro, estrogens and progesterone inhibited ascorbic acid accumulation in intestinal cells. This is a pilot study to examine the relation between hormone rep ... Full text Link to item Cite

A survey of past obstetrics and gynecology research fellows.

Journal Article J Soc Gynecol Investig · 2002 Featured Publication OBJECTIVE: To survey obstetrician-gynecologist-scientists to determine factors that enhanced or hindered research careers. METHODS: A pretested mail survey was sent to 107 obstetrician-gynecologists who had received research fellowship awards from professi ... Link to item Cite

Panel discussion (Part X)

Journal Article Annals of the New York Academy of Sciences · 2002 Cite

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

Journal Article J Med Chem · July 13, 2000 alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign prostatic hyperplasia (BPH). Recently, three different subtypes of thi ... Full text Link to item Cite

Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation.

Journal Article Am J Obstet Gynecol · April 2000 Featured Publication OBJECTIVE: Our purpose was to determine the histologic distribution and expression of decorin in rat cervix throughout the course of rat gestation and to correlate the findings with the known progression of collagen fiber disruption and cellular turnover i ... Full text Link to item Cite

Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone.

Journal Article Am J Obstet Gynecol · April 1998 Featured Publication OBJECTIVE: The purpose of this study was to determine the relative percentages of apoptosis and proliferation in fibroblasts and cervical smooth muscles throughout gestation and the effect of an antiprogesterone on these processes. STUDY DESIGN: Rats were ... Full text Link to item Cite

Reaction of residents to a teaching collaborative practice.

Journal Article J Nurse Midwifery · 1998 Featured Publication Using the team concept, certified nurse-midwives, nurse practitioners, and physician assistants help educate physicians in an obstetrics and gynecology residency program and help to create a balance between education and service. This program is well recei ... Full text Link to item Cite

Cell death and proliferation and its relation to collagen degradation in uterine involution of rat.

Journal Article Connect Tissue Res · 1998 Featured Publication Collagen concentration, procollagenase localization, and their association with cell proliferation and apoptosis during postpartum involution, were investigated biochemically and histochemically in postpartum day 1, 3, 5, and 7 rat uterine tissues. In cont ... Full text Link to item Cite

Medicaid managed care partnerships to improve perinatal outcomes.

Journal Article J Public Health Manag Pract · January 1998 Featured Publication New York State's Prenatal Care Assistance Program, and enhanced care program based on public health principles, is in the process of being transformed into Medicaid managed care. The program described in this article, namely, a Medicaid managed care health ... Full text Link to item Cite

Residents and nonphysician health care providers.

Journal Article Acad Med · March 1997 Featured Publication Full text Link to item Cite

The challenges and opportunities of collaborative practice.

Journal Article Womens Health Issues · 1997 Featured Publication Full text Link to item Cite

Analyzing strategies for developing a prenatal health care outreach program to reduce social and cultural barriers.

Journal Article J Health Hum Serv Adm · 1997 Featured Publication Beginning in March, 1994, a multi-cultural, interdisciplinary team of health care providers at Rochester General Hospital in Rochester, New York, planned and implemented a prenatal outreach program in partnership with the Rochester YWCA. The purpose of the ... Link to item Cite

Learning from the community about barriers to health care.

Journal Article Obstet Gynecol · January 1996 Featured Publication One of the major challenges facing obstetrician-gynecologists, especially those serving populations that are diverse in culture and circumstances, is to identify and address the barriers that keep women from seeking timely preventive and prenatal health ca ... Full text Link to item Cite

Learning from the community about barriers to health care [1]

Journal Article Obstetrics and Gynecology · 1996 Full text Cite

Collagen changes in rat cervix in pregnancy--polarized light microscopic and electron microscopic studies.

Journal Article Proc Soc Exp Biol Med · September 1995 Featured Publication The structural arrangement of collagen fibers in cervical ripening was studied in normal pregnant rats by picrosirius red staining and polarized light microscopy. The macromolecular arrangement of collagen fibers in the cervices of nonpregnant controls and ... Full text Link to item Cite

Epidemiology of uterine leiomyomas. With an etiologic hypothesis.

Journal Article J Reprod Med · August 1995 OBJECTIVE: The few previous epidemiologic studies of uterine myomas have relied on clinical evaluation to select controls, but we previously showed that myomas may be present in more than 75% of such uteri. STUDY DESIGN: We therefore attempted to evaluate ... Link to item Cite

Anatomy and physiology of cervical ripening.

Journal Article Clin Obstet Gynecol · June 1995 Featured Publication The uterine cervix is a unique organ composed predominately of the extracellular matrix proteins, collagen, elastin, and glycosaminoglycans. During pregnancy and labor, this organ is metabolically active, which is rare in adult tissue. The metabolism is un ... Full text Link to item Cite

C-reactive protein in normal parturients is clinically not significantly elevated

Journal Article Journal of Maternal-Fetal Medicine · 1995 The role of an inflammatory response in the cervical changes accompanying parturition has been postulated and it is known that CRP concentrations are mildly elevated in pregnancy and labor. It has been theorized that the onset of parturition, because it is ... Cite

Apoptosis in the cervix of pregnant rats in association with cervical softening.

Journal Article Gynecol Obstet Invest · 1994 Featured Publication Cervical ripening in gestation occurs spontaneously in a timely but species-specific fashion as if it were genetically programmed. This study shows that the numbers of dying smooth muscle cells in the cervix increased along with cervical softening in pregn ... Full text Link to item Cite

Effect of parturition on serum alpha 1-antiprotease (alpha 1-antitrypsin).

Journal Article Clin Chem · May 1993 Featured Publication Link to item Cite

An analysis of the reasons for Japan's low infant mortality rate.

Journal Article J Nurse Midwifery · 1993 Featured Publication Japan's infant mortality rate in 1991 was four per 1,000, the lowest in the world. Contributing factors are the universal use of the Boshi Kenko Techo (maternal-child health handbook) and universal access to care. Most births occur to women aged 25-29 year ... Full text Link to item Cite

Peripheral pulmonary artery stenosis in pregnancy. A report of two cases.

Journal Article J Reprod Med · April 1992 Peripheral pulmonary artery stenosis is a rare congenital anomaly often associated with the maternal rubella syndrome. Two patients with the disorder underwent four successful pregnancies. ... Link to item Cite

Three-dimensional structures of uterine elastic fibers: scanning electron microscopic studies.

Journal Article Connect Tissue Res · 1991 Featured Publication We report findings that demonstrate for the first time that the structure of the elastic fibers of the uterus and cervix are characteristic to these tissues. Elastic fibers of the uterine corpus and cervix were studied by scanning electron microscopy (SEM) ... Full text Link to item Cite

Obstetric-enhanced family practice residency training.

Journal Article J Fam Pract · November 1990 Featured Publication Link to item Cite

Effects of epidural analgesia: some questions and answers.

Journal Article Birth · September 1990 Featured Publication The effects of epidural analgesia on first labors have been studied by Thorp and colleagues. One study has been published and is the subject of a question-and-answer discussion, presented here. In this study 711 consecutive nulliparous women at term, with ... Full text Link to item Cite

A comparison of oral and rectal absorption of L-dopa esters in rats and mice.

Journal Article Pharm Res · April 1990 Short-chain alkyl esters of L-dopa were administered to rats and mice via oral and rectal routes. Plasma L-dopa esters and L-dopa were determined in the systemic and portal circulation by HPLC. A comparison of isopropyl, butyl, and 4-hydroxybutyl esters of ... Full text Link to item Cite

Human recombinant interleukin-1 alpha increases elastase-like enzyme in human uterine cervical fibroblasts.

Journal Article Gynecol Obstet Invest · 1990 Featured Publication Production of the elastase-like enzyme, Suc-(Ala)3-p-nitroanilide hydrolase, was examined in human uterine cervical fibroblasts. The metallo-dependent enzyme is present in both media and cellular fractions. Human recombinant interleukin-1 alpha stimulated ... Full text Link to item Cite

Short-chain alkyl esters of L-dopa as prodrugs for rectal absorption.

Journal Article Pharm Res · June 1989 The bioavailability of L-dopa following rectal administration of a series of short-chain alkyl esters of L-dopa was determined in rats and dogs. The esters were stable (greater than 360 min) to hydrolysis in physiological buffer. In vitro enzymatic hydroly ... Full text Link to item Cite

The effect of cocaine abuse on birth weight and gestational age.

Journal Article Obstet Gynecol · September 1988 A retrospective study of 343 women who lacked prenatal care was conducted to ascertain the effect of recent cocaine abuse on birth weight and gestational age. All pregnant women admitted in labor to a large urban teaching hospital between January 1 and Dec ... Link to item Cite

The effect of cocaine abuse on birth weight and gestational age

Journal Article Obstetrics and Gynecology · 1988 A retrospective study of 343 women who lacked prenatal care was conducted to ascertain the effect of recent cocaine abuse on birth weight and gestational age. All pregnant women admitted in labor to a large urban teaching hospital between January 1 and Dec ... Cite

Decreased elastic fibers and desmosine content in incompetent cervix.

Journal Article Am J Obstet Gynecol · November 1987 Featured Publication Incompetence of the uterine cervix is a syndrome of painless, progressive dilatation and effacement occurring between the sixteenth and twenty-fourth weeks of gestation that represents abnormal functioning. It may serve as a model to elucidate normal funct ... Full text Link to item Cite

Orientation of elastic fibers in the human cervix.

Journal Article Am J Obstet Gynecol · July 1986 Featured Publication We have determined the microanatomy of the cervix in relation to elastic fibers by serial dissection of human cervix in three tissue planes: cross, sagittal, and frontal sections. Analysis suggests that elastin is localized to specific regions of the uteri ... Full text Link to item Cite

Neonatal alloimmune thrombocytopenic purpura.

Journal Article Am J Perinatol · April 1986 Featured Publication We reviewed 58 literature reports of neonatal alloimmune thrombocytopenic purpura (NAITP). The mortality rate was 9%. The total incidence of suspected intracranial hemorrhage was 28%. We reviewed 17 sibship cases for the relation of birth order to treatmen ... Full text Link to item Cite

Pregnancy outcomes among adolescent and older women receiving comprehensive prenatal care.

Journal Article J Adolesc Health Care · March 1986 Featured Publication This study compares three birth outcomes, gestational age, birthweight, and type of delivery, among adolescent and older mothers. Data were collected from 911 women who attended a comprehensive prenatal-care program in a large urban teaching hospital. Wome ... Full text Link to item Cite

Neonatal alloimmune thrombocytopenic purpura: a case report.

Journal Article Am J Obstet Gynecol · January 1986 Featured Publication We report a case of a sibling pair with neonatal alloimmune thrombocytopenic purpura. Serial antepartum platelet alloantibody quantitation by an enzyme-linked immunoabsorbent assay revealed rising antibody titers during advancing gestation. We discuss the ... Full text Link to item Cite

Cesarean section deliveries among adolescent mothers enrolled in a comprehensive prenatal care program.

Journal Article Am J Obstet Gynecol · July 15, 1985 Featured Publication A comparison was made of the incidences of cesarean section deliveries between mothers 18 years of age or younger and those 19 to 21 years of age, all of whom were enrolled in a comprehensive program of prenatal care. Also compared were the indications for ... Full text Link to item Cite

The tendency to IUGR in preterm infants born to young women enrolled in a comprehensive prenatal program.

Journal Article Am J Perinatol · April 1985 Featured Publication Low-birthweight infants born to young women in an urban poor and multiethnic community who attended an intensive comprehensive prenatal program were studied. Of the 801 young women followed, 69 (8.6%) delivered infants weighing less than or equal to 2500 g ... Full text Link to item Cite

Nutrition for the diabetic pregnant woman.

Journal Article Curr Concepts Nutr · 1985 Featured Publication Link to item Cite

Cost averted by providing comprehensive prenatal care to teenagers.

Journal Article J Nurse Midwifery · 1985 Featured Publication Full text Link to item Cite

MULTI-USER PHYSICIAN WORKSTATION FOR OBSTETRICS AND GYNECOLOGY: A PROTOTYPE.

Journal Article Proceedings - Annual Symposium on Computer Applications in Medical Care · 1985 Using standard obstetrical records and gynecology patient record forms as a starting point, the authors have developed a concise, but complete, online medical record. Screens are designed to maximize the spatial continuity of related data, with logical tra ... Cite

Cesarean section deliveries among adolescent mothers enrolled in a comprehensive prenatal care program

Journal Article American Journal of Obstetrics and Gynecology · 1985 A comparison was made of the incidences of cesarean section deliveries between mothers 18 years of age or younger and those 19 to 21 years of age, all of whom were enrolled in a comprehensive program of prenatal care. Also compared were the indications for ... Cite

Spontaneous regression of fetal ascites in utero in an adolescent.

Journal Article J Adolesc Health Care · October 1984 Featured Publication Fetal ascites has been documented by ultrasound to progressively disappear prior to birth. This report describes a case in a nineteen-year-old in which fetal ascites was documented in the midtrimester of pregnancy and in which subsequent regression was sho ... Full text Link to item Cite

Grieving characteristics after spontaneous abortion: a management approach.

Journal Article Obstet Gynecol · July 1984 Featured Publication Twenty-two women who experienced a spontaneous abortion were treated during a 15-month period. All patients were seen for counseling sessions immediately after the spontaneous abortion. The initial counseling was followed by patient contacts and by a secon ... Link to item Cite

The effect of pregnancy on adolescent growth and development.

Journal Article Women Health · 1984 Featured Publication Adolescent pregnancy represents a triple developmental crisis to young women, that of adolescence, pregnancy, and establishing a relationship with a member of the opposite sex. Physiologically the adjustments of pregnancy are superimposed on those of pubes ... Full text Link to item Cite

The content of elastin in the uterine cervix.

Journal Article Arch Biochem Biophys · April 1, 1983 Featured Publication Mature, crosslinked elastin has been isolated from 4 human and 12 monkey uterine cervices. A modification of previous methods for determination of elastin content was devised to quantitate the low amounts of elastin in the crude connective tissue of uterin ... Full text Link to item Cite

Conclusive evidence for the presence of elastin in human and monkey cervix.

Journal Article Am J Obstet Gynecol · January 15, 1982 Featured Publication Full text Link to item Cite

Adolescent pregnancy in relation to menarche

Journal Article Medical Aspects of Human Sexuality · 1982 Cite

Comparison of human growth hormone binding to rat liver plasma and Golgi membranes.

Journal Article Horm Metab Res · November 1981 The binding characteristics of hGH to Golgi and liver plasma membranes isolated from normal adult female rats have been compared to assess the biological differences between the Golgi and plasma membrane receptor. The effect of cations and the time course ... Full text Link to item Cite

In vivo effect of human growth hormone on hepatic adenylate cyclase activity.

Journal Article Endocrinology · September 1981 Significant increases in basal, and glucagon and fluoride stimulated adenylate cyclase activity were observed in liver plasma membranes of hypophysectomized rats compared to normal adult and weanling rats. The fluoride stimulated adenylate cyclase activity ... Full text Link to item Cite

Fetus papyraceus causing dystocia: inability to detect blighted twin antenatally.

Journal Article Obstet Gynecol · September 1979 Featured Publication A case is reported of fetus papyraceus diagnosed intrapartum. There was no clinical evidence in early and midpregnancy to suggest such a diagnosis. Ultrasound examination performed 1 week prior to delivery was nondiagnostic, but an x-ray taken intrapartum ... Link to item Cite

Antecedent renal disease and the outcome of pregnancy.

Journal Article Ann Intern Med · May 1979 We assessed the effect of "healed" childhood renal disease on subsequent pregnancies by following-up a cohort of 224 children initially hospitalized with kidney disease. The pregnancy experience in this cohort was compared to two "control" cohorts comprisi ... Full text Link to item Cite

The effect of medroxyprogesterone acetate on blood pressure.

Journal Article Int J Gynaecol Obstet · July 1978 Twenty-four women (21 normotensive and 3 hypertensive) aged 16-35 years received 150-mg injections of medroxyprogesterone acetate (MPA) for contraception. Their blood pressure (BP) was measured under basal conditions by the same nurse before treatment and ... Full text Link to item Cite

Toxemia.

Journal Article Obstet Gynecol · March 1973 Featured Publication Link to item Cite

A proposal for education more nurse-midwives.

Journal Article Nurs Outlook · September 1970 Featured Publication Link to item Cite

Editorial: a proposal regarding education for nurse-midwifery.

Journal Article Bull Am Coll Nurse Midwives · February 1970 Featured Publication Link to item Cite

The merger and the "birth" of the American College of Nurse-Midwives.

Journal Article Bull Am Coll Nurse Midwives · August 1969 Featured Publication Full text Link to item Cite

Faculty exchange--why not?

Journal Article Bull Am Coll Nurse Midwifery · November 1968 Featured Publication Full text Link to item Cite

Birth films may miscarry.

Journal Article Am J Nurs · October 1968 Link to item Cite

Editorial: on personalized patient care.

Journal Article Bull Am Coll Nurse Midwifery · May 1968 Featured Publication Link to item Cite