Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • 3-Year Residency, Ophthalmology, Duke University 2006 - 2009
  • Intern- Preliminary Medicine, Medicine, Duke University 2005 - 2006
  • M.D., Duke University 2005
  • B.A., Duke University 1999
• 

  Medical Licensure

  • 0101247236. Virginia. 2010
  • 2009-00557. North Carolina. 2009
• 

  Duke Appointment History

  • Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2009 - 2012
• 

  Leadership & Clinical Positions at Duke

  • Director, Medical Retina Fellowship, 2016 - present
• Research
• 

  Selected Grants

  • An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects with Intermediate Age-Related Macular Degeneration awarded by Stealth BioTherapeutics 2016 - 2021
  • Handheld Confocal Scanning Laser Ophthalmoscope for Remote Screening of Diabetic Retinopathy awarded by National Institutes of Health 2019 - 2021
  • PAN-01-102 - Multicenter Phase I/II Study to Evaluate Safety and Tolerability of Pan-90806 Eye Drops Suspension in Treatment-Naive Participants with Neovascular Age-Related Macular Degeneration (AMD) awarded by PanOptica 2018 - 2020
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases awarded by Eyedesis Biosciences LLC 2017 - 2018
  • Computer Aided Classification of Diabetic Macular Edema awarded by National Institutes of Health 2012 - 2018
  • Macrophages Drive Neovascular Remodeling in NVAMD awarded by BrightFocus Foundation 2014 - 2016
  • NEI Mentored Clinical Scientist Development Program Award (K12) awarded by National Institutes of Health 2004 - 2016
• 

  External Relationships

  • Eclipse Life Sciences
  • Eclipse Life Sciences
  • Eyedea Bio
  • Eyedesis Biosciences
  • Notal Vision
  • Pulsar Life Sciences
  • Stealth Biotherapeutics
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Rasti, Reza, Michael J. Allingham, Priyatham S. Mettu, Sam Kavusi, Kishan Govind, Scott W. Cousins, and Sina Farsiu. “Deep learning-based single-shot prediction of differential effects of anti-VEGF treatment in patients with diabetic macular edema.” Biomed Opt Express 11, no. 2 (February 1, 2020): 1139–52. https://doi.org/10.1364/BOE.379150.
       Full Text  Link to Item
    • Allingham, Michael J., Priyatham S. Mettu, and Scott W. Cousins. “Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.” Exp Eye Res 188 (November 2019): 107788. https://doi.org/10.1016/j.exer.2019.107788.
       Full Text  Link to Item
    • Hadziahmetovic, Majda, Peter Nicholas, Sumeet Jindal, Priyatham S. Mettu, and Scott W. Cousins. “Evaluation of a Remote Diagnosis Imaging Model vs Dilated Eye Examination in Referable Macular Degeneration.” Jama Ophthalmol 137, no. 7 (July 1, 2019): 802–8. https://doi.org/10.1001/jamaophthalmol.2019.1203.
       Full Text  Link to Item
    • Cousins, Scott W., Robert Machemer, Gregg T. Kokame, Priyatham Prithu S. Mettu, Nadia Khalida Waheed, and Gennady Landa. “MANAGING ANTI-VEGF-RESISTANT NEOVASCULAR AMD: IS IT POLYPOIDAL CHOROIDAL VASCULOPATHY?” Retina the Journal of Retinal and Vitreous Diseases 39 (March 1, 2019): 3–11.
       Link to Item
    • Allingham, Michael J., Nomingerel Tserentsoodol, Peter Saloupis, Priyatham S. Mettu, and Scott W. Cousins. “Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice.” Invest Ophthalmol Vis Sci 59, no. 8 (July 2, 2018): 3355–65. https://doi.org/10.1167/iovs.17-23073.
       Full Text  Link to Item
    • Allingham, Michael J., Dibyendu Mukherjee, Erin B. Lally, Hossein Rabbani, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study.” Transl Vis Sci Technol 6, no. 2 (March 2017): 7. https://doi.org/10.1167/tvst.6.2.7.
       Full Text  Open Access Copy  Link to Item
    • Wen, Joanne C., Ester Reina-Torres, Joseph M. Sherwood, Pratap Challa, Katy C. Liu, Guorong Li, Jason Y. H. Chang, et al. “Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.” Invest Ophthalmol Vis Sci 58, no. 3 (March 1, 2017): 1893–98. https://doi.org/10.1167/iovs.16-20786.
       Full Text  Link to Item
    • Polans, James, David Cunefare, Eli Cole, Brenton Keller, Priyatham S. Mettu, Scott W. Cousins, Michael J. Allingham, Joseph A. Izatt, and Sina Farsiu. “Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.” Opt Lett 42, no. 1 (January 1, 2017): 17–20. https://doi.org/10.1364/OL.42.000017.
       Full Text  Link to Item
    • Ahadome, Sarah D., Rose Mathew, Nancy J. Reyes, Priyatham S. Mettu, Scott W. Cousins, Virginia L. Calder, and Daniel R. Saban. “Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.” Jci Insight 1, no. 12 (August 4, 2016). https://doi.org/10.1172/jci.insight.87012.
       Full Text  Link to Item
    • Allingham, Michael J., Qing Nie, Eleonora M. Lad, Daniel J. Izatt, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration.” Invest Ophthalmol Vis Sci 57, no. 4 (April 1, 2016): 2283–89. https://doi.org/10.1167/iovs.15-19008.
       Full Text  Link to Item
    • Estrada, Rolando, Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, Carlo Tomasi, and Sina Farsiu. “Retinal Artery-Vein Classification via Topology Estimation.” Ieee Trans Med Imaging 34, no. 12 (December 2015): 2518–34. https://doi.org/10.1109/TMI.2015.2443117.
       Full Text  Link to Item
    • Chiu, Stephanie J., Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, Joseph A. Izatt, and Sina Farsiu. “Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema.” Biomed Opt Express 6, no. 4 (April 1, 2015): 1172–94. https://doi.org/10.1364/BOE.6.001172.
       Full Text  Link to Item
    • Rabbani, Hossein, Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema.” Invest Ophthalmol Vis Sci 56, no. 3 (January 29, 2015): 1482–92. https://doi.org/10.1167/iovs.14-15457.
       Full Text  Link to Item
    • Espinosa-Heidmann, Diego G., Goldis Malek, Priyatham S. Mettu, Alejandro Caicedo, Peter Saloupis, Sarah Gach, Askia K. Dunnon, Peng Hu, Maria-Grazia Spiga, and Scott W. Cousins. “Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization.” Invest Ophthalmol Vis Sci 54, no. 12 (November 13, 2013): 7439–49. https://doi.org/10.1167/iovs.13-12546.
       Full Text  Link to Item
    • Mettu, Priyatham S., Albert R. Wielgus, Sally S. Ong, and Scott W. Cousins. “Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration.” Mol Aspects Med 33, no. 4 (August 2012): 376–98. https://doi.org/10.1016/j.mam.2012.04.006.
       Full Text  Link to Item
    • Lin, Phoebe, Priyatham S. Mettu, Dustin L. Pomerleau, Stephanie J. Chiu, Ramiro Maldonado, Sandra Stinnett, Cynthia A. Toth, Sina Farsiu, and Prithvi Mruthyunjaya. “Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast.” Invest Ophthalmol Vis Sci 53, no. 4 (April 6, 2012): 1874–82. https://doi.org/10.1167/iovs.11-9290.
       Full Text  Link to Item
    • Mettu, Priyatham S., Neeru Sarin, Sandra S. Stinnett, and Cynthia A. Toth. “Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration.” Retina 31, no. 8 (September 2011): 1637–49. https://doi.org/10.1097/IAE.0b013e31821800e0.
       Full Text  Link to Item
    • Castellano, Chelsea G., Sandra S. Stinnett, Priyatham S. Mettu, Rex M. McCallum, and Glenn J. Jaffe. “Retinal thickening in iridocyclitis.” Am J Ophthalmol 148, no. 3 (September 2009): 341–49. https://doi.org/10.1016/j.ajo.2009.03.034.
       Full Text  Link to Item
    • Mettu, Priyatham Sai, Pei-Feng Deng, Uma K. Misra, Govind Gawdi, David L. Epstein, and P Vasantha Rao. “Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.” Invest Ophthalmol Vis Sci 45, no. 7 (July 2004): 2263–71. https://doi.org/10.1167/iovs.03-0960.
       Full Text  Link to Item

  • Conference Papers

    • Allingham, Michael John, Priyatham S. Mettu, and Scott W. Cousins. “Elamipretide, a Mitochondrial-Targeted Drug, for the Treatment of Vision Loss in Dry AMD with High Risk Drusen: Results of the Phase 1 ReCLAIM Study.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
       Link to Item
    • Cousins, Scott W., Michael John Allingham, and Priyatham S. Mettu. “Elamipretide, a Mitochondria-Targeted Drug, for the Treatment of Vision Loss in Dry AMD with Noncentral Geographic Atrophy: Results of the Phase 1 ReCLAIM Study.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
       Link to Item
    • Hadziahmetovic, Majda, Priyatham S. Mettu, and Scott W. Cousins. “Remote diagnosis of referable macular pathology in high disease prevalence communities.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
       Link to Item
    • Mettu, Priyatham S., Michael John Allingham, and Scott W. Cousins. “Effects of the Mitochondria-Targeted Drug Elamipretide on Leakage-Independent Vision Loss in Fellow Eyes with Neovascular AMD in the ReCLAIM Study.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
       Link to Item
    • Foster, Melanie Louise, Regan L. Lane, Annie Oh, Steven Nagar, Mary Christine McGahan, Priyatham S. Mettu, Scott W. Cousins, and Freya M. Mowat. “The retinal pigment epithelium of the canine area centralis is uniquely susceptible to mitochondrial toxicant damage.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
       Link to Item
    • Jindal, Sumeet, Scott W. Cousins, and Priyatham S. Mettu. “Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for Treatment of Serous Pigment Epithelium Detachments in Neovascular Age-Related Macular Degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
       Link to Item
    • Mettu, Priyatham S., Michael J. Allingham, Peter Nicholas, and Scott W. Cousins. “Adjunctive Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for the Treatment of Persistent Disease Activity in Neovascular AMD.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
       Link to Item
    • Mowat, Freya M., Annie Oh, Melanie Louise Foster, Priyatham S. Mettu, and Scott W. Cousins. “Repetitive periocular delivery of hydroquinone in canines results in dysfunction of central retinal cone photoreceptors.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
       Link to Item
    • Allingham, Michael J., Dibyendu Mukherjee, Erin Lally, Hossein Rabbani, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “A quantitative approach to predict differential effects of anti-VEGF treatment on diffuse and focal leakage in patients with diabetic macular edema.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
       Link to Item
    • Cousins, Scott W., Peter Saloupis, Mulugu V. Brahmajoti, and Priyatham S. Mettu. “Mitochondrial Dysfunction in Experimental Mouse Models of SubRPE Deposit Formation and Reversal by the Mito-Reparative Drug MTP-131.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
       Link to Item
    • Mettu, Priyatham S., Michael J. Allingham, Peter C. Nicholas, and Scott W. Cousins. “Neovascular Morphology by ICG Angiography and Response to Loading-Dose Anti-VEGF Therapy in Patients with Neovascular AMD.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
       Link to Item
    • Nicholas, Peter C., Priyatham S. Mettu, and Scott W. Cousins. “Feasibility and acceptance of retinal imaging in a medical clinic by non-expert imagers.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
       Link to Item
    • Allingham, Michael J., Daniel Izatt, Qing Nie, Eleonora M. Lad, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Robust, easy-to-use, semiautomated software quantifies lesion rim area hyperautofluorescence and predicts progression of geographic atrophy.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
       Link to Item
    • Cousins, Scott W., Priyatham S. Mettu, and Mulugu V. Brahmajothi. “The mitochondria-targeted peptide MTP-131 prevents hydroquinone-mediated persistent injury phenotype in cultured retinal pigment epithelium cells.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
       Link to Item
    • Dale, Sarah B., Tomas Blanco, Rose Mathew, Priyatham S. Mettu, Scott W. Cousins, Virginia L. Calder, and Daniel Saban. “CD11b(+) Classical Dendritic Cells (cDC) Directly Effect Fibrosis in Ocular Surface Inflammation.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
       Link to Item
    • Hess, Riikka, Mulugu V. Brahmajothi, Peter Saloupis, Priyatham S. Mettu, and Scott W. Cousins. “Repetitive periocular injection of hydroquinone promotes mitochondrial dysfunction in retinal pigment epithelium of mouse eyes.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
       Link to Item
    • Mettu, Priyatham S., Peter Saloupis, Daniel Saban, and Scott W. Cousins. “Increased Frequency of Nonclassical Monocytes in the Blood is Correlated with Development of Neovascular Remodeling in Experimental Choroidal Neovascularization.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
       Link to Item
    • Mettu, Priyatham S., Peter Saloupis, and Scott W. Cousins. “PAMP Stimulation of Macrophages Promotes Neovascular Remodeling in Experimental Choroidal Neovascularization.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
       Link to Item
    • Wen, Joanne C., Darryl R. Overby, Michael Madekurozwa, Brian Chu, Priyatham S. Mettu, Stefanie G. Schuman, Pratap Challa, Scott W. Cousins, and R Rand Allingham. “The effect of anti-VEGF injections on tonographic aqueous outflow facility and a novel method to calculate facility using the post-injection IOP decay curve.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
       Link to Item
    • Mettu, P. S., B. Pendurthi, D. L. Epstein, and P. V. Rao. “Role of soluble guanylate cyclase in the modulation of aqueous humor outflow facility.” In Investigative Ophthalmology & Visual Science, 45:U432–U432. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
       Link to Item
    • Mettu, P. S., P. F. Deng, J. Kumar, D. L. Epstein, and P. V. Rao. “Role of lysophospholipid growth factors and Edg receptors in the regulation of aqueous humor outflow facility.” In Investigative Ophthalmology & Visual Science, 44:U312–U312. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.