Priyatham S Mettu | Scholars@Duke

Priyatham S Mettu
Assistant Professor of Ophthalmology

Dr. Mettu, MD is a fellowship-trained ophthalmologist, specializing in the diagnosis, treatment, and research of macular diseases. His clinical practice focuses on the medical treatment of diabetic retinopathy, age-related macular degeneration, and retinal vascular diseases. He has an active clinical and laboratory research program at the Duke Center for Macular Diseases as part of the National Institutes of Health-sponsored K12 program. Dr. Mettu is actively involved in clinical trials of new therapies for macular diseases. He is developing novel imaging technologies that will facilitate customized treatment plans for patients with diabetic macular edema and age-related macular degeneration. Dr. Mettu is a recipient of the prestigious Heed Foundation Fellowship and the Isbey Award for excellence in clinical care, ethics, and research.

Current Appointments & Affiliations

Assistant Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2012

Contact Information

DUMC 3802, Durham, NC 27710
Duke Eye Center, 2351 Erwin Road, Durham, NC 27705
(919) 684-9010

Background
Education, Training, & Certifications
- 3-Year Residency, Ophthalmology, Duke University 2006 - 2009
- Intern- Preliminary Medicine, Medicine, Duke University 2005 - 2006
- M.D., Duke University 2005
- B.A., Duke University 1999
Duke Appointment History
- Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2009 - 2012
Research
Selected Grants
- An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects with Intermediate Age-Related Macular Degeneration awarded by Stealth BioTherapeutics 2016 - 2021
- PAN-01-102 awarded by PanOptica 2018 - 2020
- Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
- Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases awarded by Eyedesis Biosciences LLC 2017 - 2018
- Computer Aided Classification of Diabetic Macular Edema awarded by National Institutes of Health 2012 - 2018
- Macrophages Drive Neovascular Remodeling in NVAMD awarded by BrightFocus Foundation 2014 - 2016
- NEI Mentored Clinical Scientist Development Program Award (K12) awarded by National Institutes of Health 2004 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Allingham, MJ, Tserentsoodol, N, Saloupis, P, Mettu, PS, and Cousins, SW. "Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice." Investigative Ophthalmology & Visual Science 59, no. 8 (July 2018): 3355-3365. Full Text
  - Oellers, P, Mowery, YM, Perez, BA, Stinnett, S, Mettu, P, Vajzovic, L, Light, K, Steffey, BA, Cai, J, Dutton, JJ, Buckley, EG, Halperin, EC, Marks, LB, Kirsch, DG, and Mruthyunjaya, P. "Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma." American Journal of Ophthalmology 186 (February 2018): 32-40. Full Text
  - Wang, Y, Tooley, AA, Mehta, VJ, Garrity, JA, Harrison, AR, and Mettu, P. "Thyroid Orbitopathy." International Ophthalmology Clinics 58, no. 2 (January 2018): 137-179. (Review) Full Text
  - Allingham, MJ, Mukherjee, D, Lally, EB, Rabbani, H, Mettu, PS, Cousins, SW, and Farsiu, S. "A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study." Translational vision science & technology 6, no. 2 (March 21, 2017): 7-. Full Text
  - Mettu, P, Griffith, M, Yohe, S, and Harrison, AR. "Nodular Lymphocyte Predominant Hodgkin Lymphoma Presenting With Unilateral Orbital Involvement." Ophthalmic Plastic and Reconstructive Surgery 33, no. 2 (March 2017): e29-e31. Full Text
  - Wen, JC, Reina-Torres, E, Sherwood, JM, Challa, P, Liu, KC, Li, G, Chang, JYH, Cousins, SW, Schuman, SG, Mettu, PS, Stamer, WD, Overby, DR, and Allingham, RR. "Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration." Investigative Ophthalmology & Visual Science 58, no. 3 (March 2017): 1893-1898. Full Text
  - Khan, TT, Colon-Acevedo, B, Mettu, P, DeLorenzi, C, and Woodward, JA. "An Anatomical Analysis of the Supratrochlear Artery: Considerations in Facial Filler Injections and Preventing Vision Loss." Aesthetic surgery journal 37, no. 2 (February 2017): 203-208. Full Text
  - Polans, J, Cunefare, D, Cole, E, Keller, B, Mettu, PS, Cousins, SW, Allingham, MJ, Izatt, JA, and Farsiu, S. "Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients." Optics Letters 42, no. 1 (January 2017): 17-20. Full Text
  - Aboobakar, IF, Mettu, P, and El-Dairi, MA. "Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features." Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 36, no. 4 (December 2016): 402-403. Full Text
  - Mettu, P, Bhatti, MT, El-Dairi, MA, Price, EB, Lin, AY, Alaraj, A, Setabutr, P, and Moss, HE. "Orbito-Masticatory Syndrome." Journal of Neuro Ophthalmology : the Official Journal of the North American Neuro Ophthalmology Society 36, no. 3 (September 2016): 308-312. Full Text
  - Ahadome, SD, Mathew, R, Reyes, NJ, Mettu, PS, Cousins, SW, Calder, VL, and Saban, DR. "Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy." JCI insight 1, no. 12 (August 2016). Full Text
  - Meekins, LC, Mettu, P, and Bhatti, MT. "Man With Painful Proptosis of the Left Eye." JAMA ophthalmology 134, no. 6 (June 2016): 705-706. Full Text
  - Allingham, MJ, Nie, Q, Lad, EM, Izatt, DJ, Mettu, PS, Cousins, SW, and Farsiu, S. "Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration." Investigative Ophthalmology & Visual Science 57, no. 4 (April 2016): 2283-2289. Full Text
  - Shubhakaran, K, Bhatti, MT, Maldonado, RS, Mettu, P, and El-Dairi, M. "The application of optical coherence tomography in neurologic diseasesAuthors Respond:." Neurology: Clinical Practice 6, no. 1 (February 2016): 9-10. Full Text
  - Estrada, R, Allingham, MJ, Mettu, PS, Cousins, SW, Tomasi, C, and Farsiu, S. "Retinal Artery-Vein Classification via Topology Estimation." Ieee Transactions on Medical Imaging 34, no. 12 (December 2015): 2518-2534. Full Text
  - Maldonado, RS, Mettu, P, El-Dairi, M, and Bhatti, MT. "The application of optical coherence tomography in neurologic diseases." Neurology. Clinical Practice 5, no. 5 (October 2015): 460-469. Full Text
  - Aboobakar, IF, Mettu, P, and El-Dairi, MA. "Optic Nerve Head Pit With Sectoral Inner Retinal Hypoplasia: A Bottomless Pit." Jama Ophthalmology 133, no. 6 (June 11, 2015): e1572-null. Full Text
  - Chiu, SJ, Allingham, MJ, Mettu, PS, Cousins, SW, Izatt, JA, and Farsiu, S. "Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema." Biomedical Optics Express 6, no. 4 (April 2015): 1172-1194. Full Text
  - Rabbani, H, Allingham, MJ, Mettu, PS, Cousins, SW, and Farsiu, S. "Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema." Investigative Ophthalmology & Visual Science 56, no. 3 (January 29, 2015): 1482-1492. Full Text
  - Srinivasan, PP, Kim, LA, Mettu, PS, Cousins, SW, Comer, GM, Izatt, JA, and Farsiu, S. "Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images." Biomedical Optics Express 5, no. 10 (October 2014): 3568-3577. Full Text
  - Perez, BA, Mettu, P, Vajzovic, L, Rivera, D, Alkaissi, A, Steffey, BA, Cai, J, Stinnett, S, Dutton, JJ, Buckley, EG, Halperin, E, Marks, LB, Mruthyunjaya, P, and Kirsch, DG. "Uveal melanoma treated with iodine-125 episcleral plaque: An analysis of dose on disease control and visual outcomes." International Journal of Radiation Oncology Biology Physics 89, no. 1 (May 1, 2014): 127-136. Full Text
  - Ong, SS, Sanka, K, Mettu, PS, Brosnan, TM, Stinnett, SS, Lee, PP, and Challa, P. "Resident compliance with the american academy of ophthalmology preferred practice pattern guidelines for primary open-angle glaucoma." Ophthalmology 120, no. 12 (December 2013): 2462-2469. Full Text
  - Espinosa-Heidmann, DG, Malek, G, Mettu, PS, Caicedo, A, Saloupis, P, Gach, S, Dunnon, AK, Hu, P, Spiga, M-G, and Cousins, SW. "Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization." Investigative Ophthalmology & Visual Science 54, no. 12 (November 13, 2013): 7439-7449. Full Text
  - Condren, AB, Kumar, A, Mettu, P, Liang, KJ, Zhao, L, Tsai, J-Y, Fariss, RN, and Wong, WT. "Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function." PloS one 8, no. 1 (January 4, 2013): e53386-. Full Text
  - Mettu, PS, Wielgus, AR, Ong, SS, and Cousins, SW. "Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration." Molecular Aspects of Medicine 33, no. 4 (August 2012): 376-398. (Review) Full Text
  - Lin, P, Mettu, PS, Pomerleau, DL, Chiu, SJ, Maldonado, R, Stinnett, S, Toth, CA, Farsiu, S, and Mruthyunjaya, P. "Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast." Investigative Ophthalmology & Visual Science 53, no. 4 (April 6, 2012): 1874-1882. Full Text
  - Mettu, PS, Sarin, N, Stinnett, SS, and Toth, CA. "Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration." Retina (Philadelphia, Pa.) 31, no. 8 (September 2011): 1637-1649. Full Text
  - Meleth, AD, Mettu, P, Agrón, E, Chew, EY, Sadda, SR, Ferris, FL, and Wong, WT. "Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry." Investigative Ophthalmology & Visual Science 52, no. 2 (February 28, 2011): 1119-1126. Full Text
  - Fontainhas, AM, Wang, M, Liang, KJ, Chen, S, Mettu, P, Damani, M, Fariss, RN, Li, W, and Wong, WT. "Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission." PloS one 6, no. 1 (January 25, 2011): e15973-. Full Text
  - Mettu, P, Agrón, E, Samtani, S, Chew, EY, and Wong, WT. "Genotype-phenotype correlation in ocular von Hippel-Lindau (VHL) disease: the effect of missense mutation position on ocular VHL phenotype." Investigative Ophthalmology & Visual Science 51, no. 9 (September 2010): 4464-4470. Full Text
  - Castellano, CG, Stinnett, SS, Mettu, PS, McCallum, RM, and Jaffe, GJ. "Retinal thickening in iridocyclitis." Am J Ophthalmol 148, no. 3 (September 2009): 341-349. Full Text Link to Item
  - Mettu, PS, Deng, P-F, Misra, UK, Gawdi, G, Epstein, DL, and Rao, PV. "Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility." Invest Ophthalmol Vis Sci 45, no. 7 (July 2004): 2263-2271. Link to Item
- Book Sections
  - Lad, EM, Koreen, L, Pecen, P, Vickers, L, Mettu, P, Paulus, YM, Nguyen, C, and Kim, MJ. "Medical retina." In The Ophthalmology Clinical Trials Handbook, 49-196. January 1, 2015.
  - Martel, J, Pecen, P, Mettu, P, and Kolomeyer, AM. "Surgical retina." In The Ophthalmology Clinical Trials Handbook, 197-244. January 1, 2015.
- Conference Papers
  - Foster, ML, Lane, RL, Oh, A, Nagar, S, McGahan, MC, Mettu, PS, Cousins, SW, and Mowat, FM. "The retinal pigment epithelium of the canine area centralis is uniquely susceptible to mitochondrial toxicant damage." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017. Link to Item
  - Jindal, S, Cousins, SW, and Mettu, PS. "Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for Treatment of Serous Pigment Epithelium Detachments in Neovascular Age-Related Macular Degeneration." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017. Link to Item
  - Mettu, PS, Allingham, MJ, Nicholas, P, and Cousins, SW. "Adjunctive Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for the Treatment of Persistent Disease Activity in Neovascular AMD." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017. Link to Item
  - Mowat, FM, Oh, A, Foster, ML, Mettu, PS, and Cousins, SW. "Repetitive periocular delivery of hydroquinone in canines results in dysfunction of central retinal cone photoreceptors." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017. Link to Item
  - Allingham, MJ, Mukherjee, D, Lally, E, Rabbani, H, Mettu, PS, Cousins, SW, and Farsiu, S. "A quantitative approach to predict differential effects of anti-VEGF treatment on diffuse and focal leakage in patients with diabetic macular edema." September 2016. Link to Item
  - Cousins, SW, Saloupis, P, Brahmajoti, MV, and Mettu, PS. "Mitochondrial Dysfunction in Experimental Mouse Models of SubRPE Deposit Formation and Reversal by the Mito-Reparative Drug MTP-131." September 2016. Link to Item
  - Mettu, PS, Allingham, MJ, Nicholas, PC, and Cousins, SW. "Neovascular Morphology by ICG Angiography and Response to Loading-Dose Anti-VEGF Therapy in Patients with Neovascular AMD." September 2016. Link to Item
  - Nicholas, PC, Mettu, PS, and Cousins, SW. "Feasibility and acceptance of retinal imaging in a medical clinic by non-expert imagers." September 2016. Link to Item
  - Allingham, MJ, Izatt, D, Nie, Q, Lad, EM, Mettu, PS, Cousins, SW, and Farsiu, S. "Robust, easy-to-use, semiautomated software quantifies lesion rim area hyperautofluorescence and predicts progression of geographic atrophy." June 2015. Link to Item
  - Cousins, SW, Mettu, PS, and Brahmajothi, MV. "The mitochondria-targeted peptide MTP-131 prevents hydroquinone-mediated persistent injury phenotype in cultured retinal pigment epithelium cells." June 2015. Link to Item
  - Dale, SB, Blanco, T, Mathew, R, Mettu, PS, Cousins, SW, Calder, VL, and Saban, D. "CD11b(+) Classical Dendritic Cells (cDC) Directly Effect Fibrosis in Ocular Surface Inflammation." June 2015. Link to Item
  - Hess, R, Brahmajothi, MV, Saloupis, P, Mettu, PS, and Cousins, SW. "Repetitive periocular injection of hydroquinone promotes mitochondrial dysfunction in retinal pigment epithelium of mouse eyes." June 2015. Link to Item
  - Mettu, PS, Saloupis, P, Saban, D, and Cousins, SW. "Increased Frequency of Nonclassical Monocytes in the Blood is Correlated with Development of Neovascular Remodeling in Experimental Choroidal Neovascularization." June 2015. Link to Item
  - Mettu, PS, Saloupis, P, and Cousins, SW. "PAMP Stimulation of Macrophages Promotes Neovascular Remodeling in Experimental Choroidal Neovascularization." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014. Link to Item
  - Wen, JC, Overby, DR, Madekurozwa, M, Chu, B, Mettu, PS, Schuman, SG, Challa, P, Cousins, SW, and Allingham, RR. "The effect of anti-VEGF injections on tonographic aqueous outflow facility and a novel method to calculate facility using the post-injection IOP decay curve." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014. Link to Item
  - Mettu, PS, Pendurthi, B, Epstein, DL, and Rao, PV. "Role of soluble guanylate cyclase in the modulation of aqueous humor outflow facility." April 2004. Link to Item
  - Mettu, PS, Deng, PF, Kumar, J, Epstein, DL, and Rao, PV. "Role of lysophospholipid growth factors and Edg receptors in the regulation of aqueous humor outflow facility." May 2003. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers