Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • 3-Year Residency, Ophthalmology, Duke University 2006 - 2009
  • Intern- Preliminary Medicine, Medicine, Duke University 2005 - 2006
  • M.D., Duke University 2005
  • B.A., Duke University 1999
• 

  Duke Appointment History

  • Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2009 - 2012
• Research
• 

  Selected Grants

  • An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects with Intermediate Age-Related Macular Degeneration awarded by Stealth BioTherapeutics 2016 - 2021
  • PAN-01-102 awarded by PanOptica 2018 - 2020
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases awarded by Eyedesis Biosciences LLC 2017 - 2018
  • Computer Aided Classification of Diabetic Macular Edema awarded by National Institutes of Health 2012 - 2018
  • Macrophages Drive Neovascular Remodeling in NVAMD awarded by BrightFocus Foundation 2014 - 2016
  • NEI Mentored Clinical Scientist Development Program Award (K12) awarded by National Institutes of Health 2004 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Lad, EM, Koreen, L, Pecen, P, Vickers, L, Mettu, P, Paulus, YM, Nguyen, C, and Kim, MJ. "Medical retina." In The Ophthalmology Clinical Trials Handbook, 49-196. January 1, 2015.
    • Martel, J, Pecen, P, Mettu, P, and Kolomeyer, AM. "Surgical retina." In The Ophthalmology Clinical Trials Handbook, 197-244. January 1, 2015.

  • Conference Papers

    • Foster, ML, Lane, RL, Oh, A, Nagar, S, McGahan, MC, Mettu, PS, Cousins, SW, and Mowat, FM. "The retinal pigment epithelium of the canine area centralis is uniquely susceptible to mitochondrial toxicant damage." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017.  Link to Item
    • Jindal, S, Cousins, SW, and Mettu, PS. "Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for Treatment of Serous Pigment Epithelium Detachments in Neovascular Age-Related Macular Degeneration." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017.  Link to Item
    • Mettu, PS, Allingham, MJ, Nicholas, P, and Cousins, SW. "Adjunctive Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for the Treatment of Persistent Disease Activity in Neovascular AMD." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017.  Link to Item
    • Mowat, FM, Oh, A, Foster, ML, Mettu, PS, and Cousins, SW. "Repetitive periocular delivery of hydroquinone in canines results in dysfunction of central retinal cone photoreceptors." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Baltimore, MD. May 7, 2017 - May 11, 2017.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, June 1, 2017.  Link to Item
    • Allingham, MJ, Mukherjee, D, Lally, E, Rabbani, H, Mettu, PS, Cousins, SW, and Farsiu, S. "A quantitative approach to predict differential effects of anti-VEGF treatment on diffuse and focal leakage in patients with diabetic macular edema." September 2016.  Link to Item
    • Cousins, SW, Saloupis, P, Brahmajoti, MV, and Mettu, PS. "Mitochondrial Dysfunction in Experimental Mouse Models of SubRPE Deposit Formation and Reversal by the Mito-Reparative Drug MTP-131." September 2016.  Link to Item
    • Mettu, PS, Allingham, MJ, Nicholas, PC, and Cousins, SW. "Neovascular Morphology by ICG Angiography and Response to Loading-Dose Anti-VEGF Therapy in Patients with Neovascular AMD." September 2016.  Link to Item
    • Nicholas, PC, Mettu, PS, and Cousins, SW. "Feasibility and acceptance of retinal imaging in a medical clinic by non-expert imagers." September 2016.  Link to Item
    • Allingham, MJ, Izatt, D, Nie, Q, Lad, EM, Mettu, PS, Cousins, SW, and Farsiu, S. "Robust, easy-to-use, semiautomated software quantifies lesion rim area hyperautofluorescence and predicts progression of geographic atrophy." June 2015.  Link to Item
    • Cousins, SW, Mettu, PS, and Brahmajothi, MV. "The mitochondria-targeted peptide MTP-131 prevents hydroquinone-mediated persistent injury phenotype in cultured retinal pigment epithelium cells." June 2015.  Link to Item
    • Dale, SB, Blanco, T, Mathew, R, Mettu, PS, Cousins, SW, Calder, VL, and Saban, D. "CD11b(+) Classical Dendritic Cells (cDC) Directly Effect Fibrosis in Ocular Surface Inflammation." June 2015.  Link to Item
    • Hess, R, Brahmajothi, MV, Saloupis, P, Mettu, PS, and Cousins, SW. "Repetitive periocular injection of hydroquinone promotes mitochondrial dysfunction in retinal pigment epithelium of mouse eyes." June 2015.  Link to Item
    • Mettu, PS, Saloupis, P, Saban, D, and Cousins, SW. "Increased Frequency of Nonclassical Monocytes in the Blood is Correlated with Development of Neovascular Remodeling in Experimental Choroidal Neovascularization." June 2015.  Link to Item
    • Mettu, PS, Saloupis, P, and Cousins, SW. "PAMP Stimulation of Macrophages Promotes Neovascular Remodeling in Experimental Choroidal Neovascularization." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Wen, JC, Overby, DR, Madekurozwa, M, Chu, B, Mettu, PS, Schuman, SG, Challa, P, Cousins, SW, and Allingham, RR. "The effect of anti-VEGF injections on tonographic aqueous outflow facility and a novel method to calculate facility using the post-injection IOP decay curve." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Mettu, PS, Pendurthi, B, Epstein, DL, and Rao, PV. "Role of soluble guanylate cyclase in the modulation of aqueous humor outflow facility." April 2004.  Link to Item
    • Mettu, PS, Deng, PF, Kumar, J, Epstein, DL, and Rao, PV. "Role of lysophospholipid growth factors and Edg receptors in the regulation of aqueous humor outflow facility." May 2003.  Link to Item

  • Journal Articles

    • Allingham, MJ, Tserentsoodol, N, Saloupis, P, Mettu, PS, and Cousins, SW. "Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice." Investigative Ophthalmology & Visual Science 59, no. 8 (July 2018): 3355-3365.  Full Text
    • Oellers, P, Mowery, YM, Perez, BA, Stinnett, S, Mettu, P, Vajzovic, L, Light, K, Steffey, BA, Cai, J, Dutton, JJ, Buckley, EG, Halperin, EC, Marks, LB, Kirsch, DG, and Mruthyunjaya, P. "Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma." American Journal of Ophthalmology 186 (February 2018): 32-40.  Full Text
    • Wang, Y, Tooley, AA, Mehta, VJ, Garrity, JA, Harrison, AR, and Mettu, P. "Thyroid Orbitopathy." International Ophthalmology Clinics 58, no. 2 (January 1, 2018): 137-179. (Review)  Full Text
    • Allingham, MJ, Mukherjee, D, Lally, EB, Rabbani, H, Mettu, PS, Cousins, SW, and Farsiu, S. "A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study." Translational vision science & technology 6, no. 2 (March 21, 2017): 7-.  Full Text
    • Mettu, P, Griffith, M, Yohe, S, and Harrison, AR. "Nodular Lymphocyte Predominant Hodgkin Lymphoma Presenting With Unilateral Orbital Involvement." Ophthalmic plastic and reconstructive surgery 33, no. 2 (March 2017): e29-e31.  Full Text
    • Wen, JC, Reina-Torres, E, Sherwood, JM, Challa, P, Liu, KC, Li, G, Chang, JYH, Cousins, SW, Schuman, SG, Mettu, PS, Stamer, WD, Overby, DR, and Allingham, RR. "Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration." Investigative ophthalmology & visual science 58, no. 3 (March 2017): 1893-1898.  Full Text
    • Khan, TT, Colon-Acevedo, B, Mettu, P, DeLorenzi, C, and Woodward, JA. "An Anatomical Analysis of the Supratrochlear Artery: Considerations in Facial Filler Injections and Preventing Vision Loss." Aesthetic surgery journal 37, no. 2 (February 2017): 203-208.  Full Text
    • Polans, J, Cunefare, D, Cole, E, Keller, B, Mettu, PS, Cousins, SW, Allingham, MJ, Izatt, JA, and Farsiu, S. "Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients." Optics Letters 42, no. 1 (January 2017): 17-20.  Full Text
    • Aboobakar, IF, Mettu, P, and El-Dairi, MA. "Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features." Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 36, no. 4 (December 2016): 402-403.  Full Text
    • Mettu, P, Bhatti, MT, El-Dairi, MA, Price, EB, Lin, AY, Alaraj, A, Setabutr, P, and Moss, HE. "Orbito-Masticatory Syndrome." Journal of Neuro Ophthalmology : the Official Journal of the North American Neuro Ophthalmology Society 36, no. 3 (September 2016): 308-312.  Full Text
    • Ahadome, SD, Mathew, R, Reyes, NJ, Mettu, PS, Cousins, SW, Calder, VL, and Saban, DR. "Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy." JCI insight 1, no. 12 (August 2016).  Full Text
    • Meekins, LC, Mettu, P, and Bhatti, MT. "Man With Painful Proptosis of the Left Eye." JAMA ophthalmology 134, no. 6 (June 2016): 705-706.  Full Text
    • Allingham, MJ, Nie, Q, Lad, EM, Izatt, DJ, Mettu, PS, Cousins, SW, and Farsiu, S. "Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration." Investigative Ophthalmology & Visual Science 57, no. 4 (April 2016): 2283-2289.  Full Text
    • Tariq Bhatti, M, Maldonado, RS, Mettu, P, and El-Dairi, M. "Authors respond." Neurology: Clinical Practice 6, no. 1 (February 1, 2016): 9-10. (Letter)  Full Text
    • Estrada, R, Allingham, MJ, Mettu, PS, Cousins, SW, Tomasi, C, and Farsiu, S. "Retinal Artery-Vein Classification via Topology Estimation." IEEE transactions on medical imaging 34, no. 12 (December 2015): 2518-2534.  Full Text
    • Maldonado, RS, Mettu, P, El-Dairi, M, and Bhatti, MT. "The application of optical coherence tomography in neurologic diseases." Neurology. Clinical Practice 5, no. 5 (October 2015): 460-469.  Full Text
    • Aboobakar, IF, Mettu, P, and El-Dairi, MA. "Optic Nerve Head Pit With Sectoral Inner Retinal Hypoplasia: A Bottomless Pit." Jama Ophthalmology 133, no. 6 (June 11, 2015): e1572-null.  Full Text
    • Chiu, SJ, Allingham, MJ, Mettu, PS, Cousins, SW, Izatt, JA, and Farsiu, S. "Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema." Biomedical Optics Express 6, no. 4 (April 2015): 1172-1194.  Full Text
    • Rabbani, H, Allingham, MJ, Mettu, PS, Cousins, SW, and Farsiu, S. "Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema." Investigative ophthalmology & visual science 56, no. 3 (January 29, 2015): 1482-1492.  Full Text
    • Srinivasan, PP, Kim, LA, Mettu, PS, Cousins, SW, Comer, GM, Izatt, JA, and Farsiu, S. "Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images." Biomedical Optics Express 5, no. 10 (October 2014): 3568-3577.  Full Text
    • Perez, BA, Mettu, P, Vajzovic, L, Rivera, D, Alkaissi, A, Steffey, BA, Cai, J, Stinnett, S, Dutton, JJ, Buckley, EG, Halperin, E, Marks, LB, Mruthyunjaya, P, and Kirsch, DG. "Uveal melanoma treated with iodine-125 episcleral plaque: An analysis of dose on disease control and visual outcomes." International Journal of Radiation Oncology Biology Physics 89, no. 1 (May 1, 2014): 127-136.  Full Text
    • Ong, SS, Sanka, K, Mettu, PS, Brosnan, TM, Stinnett, SS, Lee, PP, and Challa, P. "Resident compliance with the american academy of ophthalmology preferred practice pattern guidelines for primary open-angle glaucoma." Ophthalmology 120, no. 12 (December 2013): 2462-2469.  Full Text
    • Espinosa-Heidmann, DG, Malek, G, Mettu, PS, Caicedo, A, Saloupis, P, Gach, S, Dunnon, AK, Hu, P, Spiga, M-G, and Cousins, SW. "Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization." Investigative Ophthalmology & Visual Science 54, no. 12 (November 13, 2013): 7439-7449.  Full Text
    • Condren, AB, Kumar, A, Mettu, P, Liang, KJ, Zhao, L, Tsai, J-Y, Fariss, RN, and Wong, WT. "Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function." PloS one 8, no. 1 (January 4, 2013): e53386-.  Full Text
    • Mettu, PS, Wielgus, AR, Ong, SS, and Cousins, SW. "Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration." Molecular Aspects of Medicine 33, no. 4 (August 2012): 376-398. (Review)  Full Text
    • Lin, P, Mettu, PS, Pomerleau, DL, Chiu, SJ, Maldonado, R, Stinnett, S, Toth, CA, Farsiu, S, and Mruthyunjaya, P. "Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast." Investigative Ophthalmology & Visual Science 53, no. 4 (April 6, 2012): 1874-1882.  Full Text
    • Mettu, PS, Sarin, N, Stinnett, SS, and Toth, CA. "Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration." Retina 31, no. 8 (September 2011): 1637-1649.  Full Text  Link to Item
    • Meleth, AD, Mettu, P, Agrón, E, Chew, EY, Sadda, SR, Ferris, FL, and Wong, WT. "Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry." Investigative ophthalmology & visual science 52, no. 2 (February 28, 2011): 1119-1126.  Full Text
    • Fontainhas, AM, Wang, M, Liang, KJ, Chen, S, Mettu, P, Damani, M, Fariss, RN, Li, W, and Wong, WT. "Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission." PloS one 6, no. 1 (January 25, 2011): e15973-.  Full Text
    • Mettu, P, Agrón, E, Samtani, S, Chew, EY, and Wong, WT. "Genotype-phenotype correlation in ocular von Hippel-Lindau (VHL) disease: the effect of missense mutation position on ocular VHL phenotype." Investigative ophthalmology & visual science 51, no. 9 (September 2010): 4464-4470.  Full Text
    • Castellano, CG, Stinnett, SS, Mettu, PS, McCallum, RM, and Jaffe, GJ. "Retinal thickening in iridocyclitis." Am J Ophthalmol 148, no. 3 (September 2009): 341-349.  Full Text  Link to Item
    • Mettu, PS, Deng, P-F, Misra, UK, Gawdi, G, Epstein, DL, and Rao, PV. "Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility." Invest Ophthalmol Vis Sci 45, no. 7 (July 2004): 2263-2271.  Link to Item

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