Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • 3-Year Residency, Ophthalmology, Duke University 2006 - 2009
  • Intern- Preliminary Medicine, Medicine, Duke University 2005 - 2006
  • M.D., Duke University 2005
  • B.A., Duke University 1999
• 

  Medical Licensure

  • 0101247236. Virginia. 2010
  • 2009-00557. North Carolina. 2009
• 

  Duke Appointment History

  • Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2009 - 2012
• 

  Leadership & Clinical Positions at Duke

  • Director, Medical Retina Fellowship, 2016 - present
• Research
• 

  Selected Grants

  • An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects with Intermediate Age-Related Macular Degeneration awarded by Stealth BioTherapeutics 2016 - 2021
  • PAN-01-102 awarded by PanOptica 2018 - 2020
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases awarded by Eyedesis Biosciences LLC 2017 - 2018
  • Computer Aided Classification of Diabetic Macular Edema awarded by National Institutes of Health 2012 - 2018
  • Macrophages Drive Neovascular Remodeling in NVAMD awarded by BrightFocus Foundation 2014 - 2016
  • NEI Mentored Clinical Scientist Development Program Award (K12) awarded by National Institutes of Health 2004 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Allingham, Michael J., Nomingerel Tserentsoodol, Peter Saloupis, Priyatham S. Mettu, and Scott W. Cousins. “Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice..” Investigative Ophthalmology & Visual Science 59, no. 8 (July 2018): 3355–65. https://doi.org/10.1167/iovs.17-23073.
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    • Oellers, Patrick, Yvonne M. Mowery, Bradford A. Perez, Sandra Stinnett, Pradeep Mettu, Lejla Vajzovic, Kim Light, et al. “Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma..” American Journal of Ophthalmology 186 (February 2018): 32–40. https://doi.org/10.1016/j.ajo.2017.11.008.
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    • Wang, Yao, Andrea A. Tooley, Viraj J. Mehta, James A. Garrity, Andrew R. Harrison, and Pradeep Mettu. “Thyroid Orbitopathy..” International Ophthalmology Clinics 58, no. 2 (January 2018): 137–79. https://doi.org/10.1097/iio.0000000000000219.
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    • Allingham, Michael J., Dibyendu Mukherjee, Erin B. Lally, Hossein Rabbani, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study..” Translational Vision Science & Technology 6, no. 2 (March 21, 2017). https://doi.org/10.1167/tvst.6.2.7.
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    • Mettu, Pradeep, Megan Griffith, Sophia Yohe, and Andrew R. Harrison. “Nodular Lymphocyte Predominant Hodgkin Lymphoma Presenting With Unilateral Orbital Involvement..” Ophthalmic Plastic and Reconstructive Surgery 33, no. 2 (March 2017): e29–31. https://doi.org/10.1097/iop.0000000000000678.
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    • Wen, Joanne C., Ester Reina-Torres, Joseph M. Sherwood, Pratap Challa, Katy C. Liu, Guorong Li, Jason Y. H. Chang, et al. “Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration..” Invest Ophthalmol Vis Sci 58, no. 3 (March 1, 2017): 1893–98. https://doi.org/10.1167/iovs.16-20786.
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    • Khan, Tanya T., Betsy Colon-Acevedo, Pradeep Mettu, Claudio DeLorenzi, and Julie A. Woodward. “An Anatomical Analysis of the Supratrochlear Artery: Considerations in Facial Filler Injections and Preventing Vision Loss..” Aesthetic Surgery Journal 37, no. 2 (February 2017): 203–8. https://doi.org/10.1093/asj/sjw132.
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    • Polans, James, David Cunefare, Eli Cole, Brenton Keller, Priyatham S. Mettu, Scott W. Cousins, Michael J. Allingham, Joseph A. Izatt, and Sina Farsiu. “Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients..” Opt Lett 42, no. 1 (January 1, 2017): 17–20. https://doi.org/10.1364/OL.42.000017.
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    • Aboobakar, Inas F., Pradeep Mettu, and Mays A. El-Dairi. “Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features..” Journal of Neuro Ophthalmology : The Official Journal of the North American Neuro Ophthalmology Society 36, no. 4 (December 2016): 402–3. https://doi.org/10.1097/wno.0000000000000436.
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    • Mettu, Pradeep, M Tariq Bhatti, Mays A. El-Dairi, Evan B. Price, Amy Y. Lin, Ali Alaraj, Pete Setabutr, and Heather E. Moss. “Orbito-Masticatory Syndrome..” Journal of Neuro Ophthalmology : The Official Journal of the North American Neuro Ophthalmology Society 36, no. 3 (September 2016): 308–12. https://doi.org/10.1097/WNO.0000000000000354.
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    • Ahadome, Sarah D., Rose Mathew, Nancy J. Reyes, Priyatham S. Mettu, Scott W. Cousins, Virginia L. Calder, and Daniel R. Saban. “Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy..” Jci Insight 1, no. 12 (August 2016). https://doi.org/10.1172/jci.insight.87012.
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    • Meekins, Landon C., Pradeep Mettu, and M Tariq Bhatti. “Man With Painful Proptosis of the Left Eye..” Jama Ophthalmology 134, no. 6 (June 2016): 705–6. https://doi.org/10.1001/jamaophthalmol.2015.3605.
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    • Allingham, Michael J., Qing Nie, Eleonora M. Lad, Daniel J. Izatt, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration..” Invest Ophthalmol Vis Sci 57, no. 4 (April 1, 2016): 2283–89. https://doi.org/10.1167/iovs.15-19008.
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    • Tariq Bhatti, M., R. S. Maldonado, P. Mettu, and M. El-Dairi. “Authors respond.” Neurology: Clinical Practice 6, no. 1 (February 1, 2016): 9–10. https://doi.org/10.1212/01.CPJ.0000481033.17694.e2.
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    • Estrada, Rolando, Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, Carlo Tomasi, and Sina Farsiu. “Retinal Artery-Vein Classification via Topology Estimation..” Ieee Trans Med Imaging 34, no. 12 (December 2015): 2518–34. https://doi.org/10.1109/TMI.2015.2443117.
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    • Maldonado, Ramiro S., Pradeep Mettu, Mays El-Dairi, and M Tariq Bhatti. “The application of optical coherence tomography in neurologic diseases..” Neurology. Clinical Practice 5, no. 5 (October 2015): 460–69. https://doi.org/10.1212/CPJ.0000000000000187.
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    • Aboobakar, Inas F., Pradeep Mettu, and Mays A. El-Dairi. “Optic Nerve Head Pit With Sectoral Inner Retinal Hypoplasia: A Bottomless Pit..” Jama Ophthalmology 133, no. 6 (June 11, 2015). https://doi.org/10.1001/jamaophthalmol.2015.72.
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    • Chiu, Stephanie J., Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, Joseph A. Izatt, and Sina Farsiu. “Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema..” Biomed Opt Express 6, no. 4 (April 1, 2015): 1172–94. https://doi.org/10.1364/BOE.6.001172.
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    • Rabbani, Hossein, Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema..” Investigative Ophthalmology & Visual Science 56, no. 3 (January 29, 2015): 1482–92. https://doi.org/10.1167/iovs.14-15457.
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    • Srinivasan, Pratul P., Leo A. Kim, Priyatham S. Mettu, Scott W. Cousins, Grant M. Comer, Joseph A. Izatt, and Sina Farsiu. “Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images..” Biomedical Optics Express 5, no. 10 (October 2014): 3568–77. https://doi.org/10.1364/BOE.5.003568.
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    • Perez, B. A., P. Mettu, L. Vajzovic, D. Rivera, A. Alkaissi, B. A. Steffey, J. Cai, et al. “Uveal melanoma treated with iodine-125 episcleral plaque: An analysis of dose on disease control and visual outcomes.” International Journal of Radiation Oncology Biology Physics 89, no. 1 (May 1, 2014): 127–36. https://doi.org/10.1016/j.ijrobp.2014.01.026.
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    • Ong, Sally S., Krishna Sanka, Priyatham S. Mettu, Thomas M. Brosnan, Sandra S. Stinnett, Paul P. Lee, and Pratap Challa. “Resident compliance with the american academy of ophthalmology preferred practice pattern guidelines for primary open-angle glaucoma..” Ophthalmology 120, no. 12 (December 2013): 2462–69. https://doi.org/10.1016/j.ophtha.2013.05.019.
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    • Espinosa-Heidmann, Diego G., Goldis Malek, Priyatham S. Mettu, Alejandro Caicedo, Peter Saloupis, Sarah Gach, Askia K. Dunnon, Peng Hu, Maria-Grazia Spiga, and Scott W. Cousins. “Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization..” Investigative Ophthalmology & Visual Science 54, no. 12 (November 13, 2013): 7439–49. https://doi.org/10.1167/iovs.13-12546.
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    • Condren, Audrey B., Anil Kumar, Pradeep Mettu, Katharine J. Liang, Lian Zhao, Jen-yue Tsai, Robert N. Fariss, and Wai T. Wong. “Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function..” Plos One 8, no. 1 (January 4, 2013). https://doi.org/10.1371/journal.pone.0053386.
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    • Mettu, Priyatham S., Albert R. Wielgus, Sally S. Ong, and Scott W. Cousins. “Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration..” Mol Aspects Med 33, no. 4 (August 2012): 376–98. https://doi.org/10.1016/j.mam.2012.04.006.
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    • Lin, Phoebe, Priyatham S. Mettu, Dustin L. Pomerleau, Stephanie J. Chiu, Ramiro Maldonado, Sandra Stinnett, Cynthia A. Toth, Sina Farsiu, and Prithvi Mruthyunjaya. “Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast..” Investigative Ophthalmology & Visual Science 53, no. 4 (April 6, 2012): 1874–82. https://doi.org/10.1167/iovs.11-9290.
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    • Mettu, Priyatham S., Neeru Sarin, Sandra S. Stinnett, and Cynthia A. Toth. “Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration..” Retina (Philadelphia, Pa.) 31, no. 8 (September 2011): 1637–49. https://doi.org/10.1097/iae.0b013e31821800e0.
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    • Meleth, Annal D., Pradeep Mettu, Elvira Agrón, Emily Y. Chew, Srinivas R. Sadda, Frederick L. Ferris, and Wai T. Wong. “Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry..” Investigative Ophthalmology & Visual Science 52, no. 2 (February 28, 2011): 1119–26. https://doi.org/10.1167/iovs.10-6075.
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    • Fontainhas, Aurora M., Minhua Wang, Katharine J. Liang, Shan Chen, Pradeep Mettu, Mausam Damani, Robert N. Fariss, Wei Li, and Wai T. Wong. “Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission..” Plos One 6, no. 1 (January 25, 2011). https://doi.org/10.1371/journal.pone.0015973.
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    • Mettu, Pradeep, Elvira Agrón, Sonia Samtani, Emily Y. Chew, and Wai T. Wong. “Genotype-phenotype correlation in ocular von Hippel-Lindau (VHL) disease: the effect of missense mutation position on ocular VHL phenotype..” Investigative Ophthalmology & Visual Science 51, no. 9 (September 2010): 4464–70. https://doi.org/10.1167/iovs.10-5223.
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    • Castellano, Chelsea G., Sandra S. Stinnett, Priyatham S. Mettu, Rex M. McCallum, and Glenn J. Jaffe. “Retinal thickening in iridocyclitis..” American Journal of Ophthalmology 148, no. 3 (September 2009): 341–49. https://doi.org/10.1016/j.ajo.2009.03.034.
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    • Mettu, Priyatham Sai, Pei-Feng Deng, Uma K. Misra, Govind Gawdi, David L. Epstein, and P Vasantha Rao. “Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility..” Invest Ophthalmol Vis Sci 45, no. 7 (July 2004): 2263–71.
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  • Conference Papers

    • Foster, Melanie Louise, Regan L. Lane, Annie Oh, Steven Nagar, Mary Christine McGahan, Priyatham S. Mettu, Scott W. Cousins, and Freya M. Mowat. “The retinal pigment epithelium of the canine area centralis is uniquely susceptible to mitochondrial toxicant damage.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Jindal, Sumeet, Scott W. Cousins, and Priyatham S. Mettu. “Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for Treatment of Serous Pigment Epithelium Detachments in Neovascular Age-Related Macular Degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Mettu, Priyatham S., Michael J. Allingham, Peter Nicholas, and Scott W. Cousins. “Adjunctive Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy for the Treatment of Persistent Disease Activity in Neovascular AMD.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Mowat, Freya M., Annie Oh, Melanie Louise Foster, Priyatham S. Mettu, and Scott W. Cousins. “Repetitive periocular delivery of hydroquinone in canines results in dysfunction of central retinal cone photoreceptors.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Allingham, Michael J., Dibyendu Mukherjee, Erin Lally, Hossein Rabbani, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “A quantitative approach to predict differential effects of anti-VEGF treatment on diffuse and focal leakage in patients with diabetic macular edema.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Cousins, Scott W., Peter Saloupis, Mulugu V. Brahmajoti, and Priyatham S. Mettu. “Mitochondrial Dysfunction in Experimental Mouse Models of SubRPE Deposit Formation and Reversal by the Mito-Reparative Drug MTP-131.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Mettu, Priyatham S., Michael J. Allingham, Peter C. Nicholas, and Scott W. Cousins. “Neovascular Morphology by ICG Angiography and Response to Loading-Dose Anti-VEGF Therapy in Patients with Neovascular AMD.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Nicholas, Peter C., Priyatham S. Mettu, and Scott W. Cousins. “Feasibility and acceptance of retinal imaging in a medical clinic by non-expert imagers.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Allingham, Michael J., Daniel Izatt, Qing Nie, Eleonora M. Lad, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Robust, easy-to-use, semiautomated software quantifies lesion rim area hyperautofluorescence and predicts progression of geographic atrophy.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Cousins, Scott W., Priyatham S. Mettu, and Mulugu V. Brahmajothi. “The mitochondria-targeted peptide MTP-131 prevents hydroquinone-mediated persistent injury phenotype in cultured retinal pigment epithelium cells.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Dale, Sarah B., Tomas Blanco, Rose Mathew, Priyatham S. Mettu, Scott W. Cousins, Virginia L. Calder, and Daniel Saban. “CD11b(+) Classical Dendritic Cells (cDC) Directly Effect Fibrosis in Ocular Surface Inflammation.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Hess, Riikka, Mulugu V. Brahmajothi, Peter Saloupis, Priyatham S. Mettu, and Scott W. Cousins. “Repetitive periocular injection of hydroquinone promotes mitochondrial dysfunction in retinal pigment epithelium of mouse eyes.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Mettu, Priyatham S., Peter Saloupis, Daniel Saban, and Scott W. Cousins. “Increased Frequency of Nonclassical Monocytes in the Blood is Correlated with Development of Neovascular Remodeling in Experimental Choroidal Neovascularization.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Mettu, Priyatham S., Peter Saloupis, and Scott W. Cousins. “PAMP Stimulation of Macrophages Promotes Neovascular Remodeling in Experimental Choroidal Neovascularization.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Wen, Joanne C., Darryl R. Overby, Michael Madekurozwa, Brian Chu, Priyatham S. Mettu, Stefanie G. Schuman, Pratap Challa, Scott W. Cousins, and R Rand Allingham. “The effect of anti-VEGF injections on tonographic aqueous outflow facility and a novel method to calculate facility using the post-injection IOP decay curve.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Mettu, P. S., B. Pendurthi, D. L. Epstein, and P. V. Rao. “Role of soluble guanylate cyclase in the modulation of aqueous humor outflow facility.” In Investigative Ophthalmology & Visual Science, 45:U432–U432. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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    • Mettu, P. S., P. F. Deng, J. Kumar, D. L. Epstein, and P. V. Rao. “Role of lysophospholipid growth factors and Edg receptors in the regulation of aqueous humor outflow facility.” In Investigative Ophthalmology & Visual Science, 44:U312–U312. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.
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